Nucleic acid expression using subcutaneous administration

ABSTRACT

Provided herein are compositions, systems, kits, and methods for treating a subject, and/or a subject&#39;s pre-adipocytes and/or adipocytes, with a composition containing a nucleic acid sequence encoding a protein or other biologically active nucleic acid-encoded molecule (BANEM), or a vector containing the nucleic acid sequence, wherein the treating comprises: a) injecting the composition into one or more subcutaneous (SC) regions of the subject such that one or more protein, or other BANEM, is detectable in a blood, serum, or plasma sample from the subject; and/or b) injecting the composition into one or more SC regions of the subject such that in-vivo transfected pre-adipocytes and/or adipocytes (e.g., transfected cells of fat cell origin) are generated; and/or c) performing the following: i) contacting pre-adipocytes and/or adipocytes (e.g., cells of fat cell origin) from the subject ex-vivo with the composition such that ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and ii) injecting the ex-vivo transfected pre-adipocytes and/or adipocytes into one or more SC regions of the subject.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Application No. 63/291,727, filed on Dec. 20, 2021, the entirely of which is incorporated herein by reference.

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY

This application contains a computer readable Sequence Listing which has been submitted in XML file format via Patent Center, the entire content of which is incorporated by reference herein in its entirety. The Sequence Listing XML file submitted via Patent Center is entitled “14755-007-999_SEQ_LISTING.xml”, was created on Dec. 17, 2022, and is 3,985,876 bytes in size.

FIELD

Provided herein are compositions, systems, kits, and methods for treating a subject, and/or a subject's pre-adipocytes and/or adipocytes, with a composition containing a nucleic acid sequence encoding a protein or other biologically active nucleic acid-encoded molecule (BANEM), or a vector containing the nucleic acid sequence, wherein the treating comprises: a) injecting the composition into one or more subcutaneous (SC) regions of the subject such that one or more protein, or other BANEM, is detectable in a blood, serum, or plasma sample from the subject; and/or b) injecting the composition into one or more SC regions of the subject such that in-vivo transfected pre-adipocytes and/or adipocytes (e.g., transfected cells of fat cell origin) are generated; and/or c) performing the following: i) contacting pre-adipocytes and/or adipocytes (e.g., cells of fat cell origin) from the subject ex-vivo with the composition such that ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and ii) injecting the ex-vivo transfected pre-adipocytes and/or adipocytes into one or more SC regions of the subject.

BACKGROUND

The simplest non-viral gene delivery system uses naked expression vector DNA. Direct injection of free DNA into certain tissues, particularly muscle, has been shown to produce high levels of gene expression, and the simplicity of this approach has led to its adoption in a number of clinical protocols. In particular, this approach has been applied to the gene therapy of cancer where the DNA can be injected either directly into the tumor or can be injected into muscle cells in order to express tumor antigens that might function as a cancer vaccine.

Although direct injection of plasmid DNA into muscle has been shown to lead to gene expression, the overall level of expression is much lower than with either viral or liposomal vectors. Systemic administration of naked DNA is also generally thought to be unsuitable for systemic administration due to the presence of serum nucleases. As a result, direct injection of plasmid DNA appears to be limited to only a few applications involving tissues that are easily accessible to direct injection such as skin and muscle cells.

SUMMARY

Provided herein are compositions, systems, kits, and methods for treating a subject, and/or a subject's adipocytes, with a composition (e.g., liquid composition) containing a nucleic acid sequence encoding a protein or a biologically active nucleic acid molecule (BANEM), or a vector containing the nucleic acid sequence, wherein the treating comprises: a) injecting the composition into one or more subcutaneous

(SC) regions of the subject such that the at least one protein, or BANEM, is detectable in a blood, serum, or plasma sample from the subject; and/or b) injecting the composition into one or more subcutaneous (SC) regions of the subject such that in-vivo transfected pre-adipocytes and/or adipocytes (e.g., transfected cells of fat cell origin) are generated; and/or c) performing the following: i) contacting transfected cells of fat cell origin from the subject ex-vivo with the composition such that ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and ii) injecting the ex-vivo transfected pre-adipocytes and/or adipocytes into one or more SC regions of the subject.

Also provided herein is a method comprising treating a subject, and/or said subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein said composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing said nucleic acid sequence, wherein said nucleic acid sequence encodes at least one protein or at least one biologically active nucleic acid molecule, and

wherein said treating comprises at least one of the following:

-   a) injecting said composition into one or more subcutaneous regions     of said subject such that said at least one protein, or said at     least one biologically active nucleic acid molecule, is detectable     in a blood, serum, or plasma sample from said subject; and/or -   b) injecting said composition into one or more subcutaneous regions     of said subject such that a plurality of in-vivo transfected     pre-adipocytes and/or adipocytes are generated in said subcutaneous     region; and/or -   c) performing the following:     -   i) contacting a plurality said pre-adipocytes and/or adipocytes         from said subject ex-vivo with said composition such that a         plurality of ex-vivo transfected pre-adipocytes and/or         adipocytes are generated, and     -   ii) injecting at least some of said plurality of ex-vivo         transfected pre-adipocytes and/or adipocytes into one or more         subcutaneous regions of said subject.

Also provided herein is a method for the prevention, management or treatment of a disease or condition in a subject. In some embodiments, the disease or condition is associated with lipid storage disorders, such as but are not limited to Fabry disease, Gaucher disease, multiple sulfatase deficiency, Farber's lipogranulomatosis, Niemann-Pick disease, Wolman disease. In some embodiments, the disease or condition associated with lysosomal storage disorders, such as but are not limited to Schindler disease, Fucosidosis, Pompe disease, and Galactosialidosis. In some embodiments, the disease or condition is associated with a genetic disorder. In some embodiments, the disease or condition is associated with infection by a pathogen.

Also provided herein is a system comprising:

-   a) a plurality of transfected and enlarged adipocytes or     pre-adipocytes, wherein each of said plurality of transfected and     enlarged adipocytes or pre-adipocytes comprises an exogenous nucleic     acid sequence, or a vector containing said nucleic acid sequence,     wherein said nucleic acid sequence encodes at least one protein or     at least one biologically active nucleic acid molecule, and -   b) a first container, wherein said plurality of transfected and     enlarged adipocytes or pre-adipocytes are present in said first     container.

BRIEF DESCRIPTION OF THE FIGURES

The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawings will be provided by the Office upon request and payment of the necessary fee.

FIG. 1 shows the results from EXAMPLE 1, which shows serum expression levels (of anti-Sars-CoV-2 antibody) in mice receiving subcutaneously injected plasmids without any expression aid. Some mice also received a neutral lipid injection.

FIG. 2 shows the results from EXAMPLE 1, which shows serum expression levels (of human GCSF (h-GCSF)) in mice receiving subcutaneously injected plasmids encoding h-GCSF without any expression aid. Some mice also received chloroquine or neutral liposome.

FIG. 3 shows the results from EXAMPLE 2, which shows serum expression levels in rats receiving subcutaneously injected plasmids, with or without hyaluronidase.

FIG. 4 shows the results from EXAMPLE 3, which shows serum expression levels in rats receiving subcutaneously injected plasmids, with and without various pre-treatments.

FIG. 5 shows the results from EXAMPLE 4, which shows serum expression levels in rats receiving subcutaneously injected plasmids, with and without, lipid Pre-Treatment.

FIG. 6 shows the results from EXAMPLE 2, which shows long-term follow up of serum expression levels in rats receiving subcutaneously injected plasmids.

FIG. 7 shows the results from EXAMPLE 3, which shows serum protein level in rats receiving subcutaneously injected plasmids over 50 days, with or without hyaluronidase or pre-treatment with rituximab to deplete B cells.

FIG. 8 shows the results from EXAMPLE 4, which shows the level of the anti-Cov2 monoclonal antibody (209K) in female Sprague-Dawley rats (about 300 gram) receiving subcutaneously injected plasmids over an observation window of 106 days.

FIG. 9 shows the results from EXAMPLE 5, which shows in vitro transfection of human derived preadipocyte cells with a plasmid encoding 209K (anti-Cov2 antibody) using expifectamine (Expi), Polyethylenimine (PEI) or Dotap (DP). Cells were transfected via a direct (D) or thin-film (TF) method and a sample was collected every three days and assayed via hIgG ELISA. Values are mean SEM (n=2).

FIG. 10 shows the results from EXAMPLE 6, which shows in vitro transfection of human derived preadipocyte at various stages of the differentiation process towards adipocyte. Each stage of the differentiation cycle, starting with undifferentiated preadipocytes up to mature adipocytes, was transfected with the 209K (anti-CoV2 antibody) encoding plasmid using expifectamine. The media was changed out every three days and assayed via hIgG ELISA. Values are mean SEM (n=2).

FIG. 11 shows the results from EXAMPLE 7, which shows in vitro transfection of human adipocytes with 209K (anti-CoV-2 antibody) encoding plasmid using expifectamine (Expi), Polyethylenimine (PEI) or Dotap (DP). Cells were transfected via a direct (D) or thin-film (TF) method with either 1 or 5 μg plasmid DNA. Samples were collected every two days and assayed via hIgG ELISA. Values are mean SEM (n=2).

FIG. 12 shows the results from EXAMPLE 8, which shows the absolute neutrophil count (ANC) in obese mice 15 days after subcutaneous injection of plasmids encoding hGH-hGCSF.

FIG. 13 shows the results from EXAMPLE 9, which shows the hGLA expression level over 119 days in mice receiving subcutaneous injection of plasmids encoding hGLA-1×L-hyFc in 1 mL solution.

FIG. 14 shows the results from EXAMPLE 10, which shows high and long-term expression of hGLA in mice by subcutaneous injection of plasmids encoding hGLA-1×L-hyFc in smaller volumes.

FIG. 15 shows the results from EXAMPLE 11, which shows no expression of Factor VIII or IX in mice receiving subcutaneous injection of the encoding plasmid.

FIG. 16 shows the results from EXAMPLE 12, which shows the expression of antibody against SARS-CoV-2 by inguinal injections of plasmids at different doses and concentrations.

FIG. 17 shows the lack of correlation between the expression level of SARS-CoV-2 antibody and the body weight of the mice. No clear correlation between expression level and mice weight is observed.

FIG. 18 shows the results from EXAMPLE 13, which shows the expression level of SARS-CoV-2 antibody in mice administrated with the plasmid by surgical incision into the fat pad.

FIG. 19 shows the results from EXAMPLE 14, which shows the expression level of SARS-CoV-2 antibody in mice previously injected with a different plasmid.

FIG. 20 shows the results from EXAMPLE 15, which shows the expression level of hGLA in mice at various plasmid concentrations and hyaluronidase conditions.

FIG. 21 shows the lack of correlation between hGLA expression level and the body weight of mice. No clear correlation is observed.

FIG. 22 shows the results from EXAMPLE 17, which shows the expression level of hGLA with or without pretreatment with dexamethasone or TGF-beta3.

FIG. 23A shows the vector map for the base vector which is 1206 base pairs in length.

FIG. 23B illustrates the nucleic acid sequence for the base vector (SEQ ID NO:10).

FIG. 24A shows the vector map for the GLA-1×L-hyFc-Amp vector which is 5596 base pairs in length.

FIG. 24B illustrates the nucleic acid sequence for the GLA-1×L-hyFc-Amp vector (SEQ ID NO:11).

FIG. 25A shows the vector map for the GLA-1×L-hyFc-BV2 vector which is 4146 base pairs in length.

FIG. 25B illustrates the nucleic acid sequence for the GLA-1×L-hyFc-BV2 vector (SEQ ID NO:12).

FIG. 26A shows the vector map for the aCoV2-209 (H-P2A-L)-BV3 vector which is 5533 base pairs in length.

FIG. 26B illustrates the nucleic acid sequence for the aCoV2-209 (H-P2A-L)-BV3 vector (SEQ ID NO:13).

FIG. 27A shows the vector map for the aCoV2-209 (H-L)-BV3 vector which is 7298 base pairs in length.

FIG. 27B illustrates the nucleic acid sequence for the aCoV2-209 (H-L)-BV3 vector (SEQ ID NO:14).

FIG. 28A shows the vector map for the GHFc-GLA1×LhyFc-BV2 vector which is 6396 base pairs in length.

FIG. 28B illustrates the nucleic acid sequence for the GHFc-GLA1×LhyFc-BV2 vector (SEQ ID NO:15).

FIG. 29A shows the vector map for the GLA-hyFc-BV2 vector which is 4131 base pairs in length.

FIG. 29B illustrates the nucleic acid sequence for the GLA-hyFc-BV2 vector (SEQ ID NO:46).

FIG. 30A shows the vector map for the GLA-2×L-hyFc-BV2 vector which is 4161 base pairs in length.

FIG. 30B illustrates the nucleic acid sequence for the GLA-2×L-hyFc-BV2 vector (SEQ ID NO:47).

FIG. 31A shows the vector map the GLA-3×L-hyFc-BV2 vector which is 4176 base pairs in length.

FIG. 31B illustrates the nucleic acid sequence for the GLA-3×L-hyFc-BV2 vector (SEQ ID NO:48).

FIG. 32 shows the amino acid sequences of the encoded polypeptides: GLA-hyFc (SEQ ID NO:49), GLA-1×L-hyFc (SEQ ID NO:50), GLA-2×L-hyFc (SEQ ID NO:51) and GLA-3×L-hyFc (SEQ ID NO:52), respectively.

DETAILED DESCRIPTION Definitions

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art. All patents, applications, published applications and other publications are incorporated by reference in their entirety. In the event that there are a plurality of definitions for a term herein, those in this section prevail unless stated otherwise.

As used herein, and in the specification and the accompanying claims, the indefinite articles “a” and “an” and the definite article “the” include plural as well as single referents, unless the context clearly indicates otherwise.

As used herein, the term “or” is to be interpreted as an inclusive “or” meaning any one or any combination. Therefore, “A, B or C” means any of the following: “A; B; C; A and B; A and C; B and C; A, B and C”. An exception to this definition will occur only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.

As used herein, the phrase “and/or” as used in a phrase such as “A and/or B” herein is intended to include both A and B; A or B; A (alone); and B (alone). Likewise, the phrase “and/or” as used in a phrase such as “A, B, and/or C” is intended to encompass each of the following embodiments: A, B, and C; A, B, or C; A or C; A or B; B or C; A and C; A and B; B and C; A (alone); B (alone); and C (alone).

As used herein, the term “about” or “approximately” means an acceptable error for a particular value as determined by one of ordinary skill in the art, which depends in part on how the value is measured or determined. In certain embodiments, the term “about” or “approximately” means within 1, 2, 3, or 4 standard deviations. In certain embodiments, the term “about” or “approximately” means within 50%, 25%, 20%, 15%, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, 0.5%, or 0.05% of a given value or range.

As used herein, the terms “comprising” and “including” can be used interchangeably. The terms “comprising” and “including” are to be interpreted as specifying the presence of the stated features or components as referred to, but does not preclude the presence or addition of one or more features, or components, or groups thereof. Additionally, the terms “comprising” and “including” are intended to include examples encompassed by the term “consisting of”. Consequently, the term “consisting of” can be used in place of the terms “comprising” and “including” to provide for more specific embodiments.

The term “composition” is intended to encompass a product containing the specified ingredients (e.g., a nucleic acid encoding a protein or other BANEM) in, optionally, the specified amounts.

“Carriers” as used herein include pharmaceutically acceptable carriers, excipients, or stabilizers that are nontoxic to the cell or mammal being exposed thereto at the dosages and concentrations employed. Often the physiologically acceptable carrier is an aqueous pH buffered solution. Examples of physiologically acceptable carriers include buffers, such as phosphate, citrate, and other organic acids; antioxidants, including ascorbic acid; low molecular weight (e.g., fewer than about 10 amino acid residues) polypeptide; proteins, such as serum albumin, gelatin, or immunoglobulins; hydrophilic polymers, such as polyvinylpyrrolidone; amino acids, such as glycine, glutamine, asparagine, arginine, or lysine; monosaccharides, disaccharides, and other carbohydrates, including glucose, mannose, or dextrins; chelating agents, such as EDTA; sugar alcohols, such as mannitol or sorbitol; salt-forming counterions, such as sodium; and/or nonionic surfactants and other tonicity adjusting agents, such as TWEEN™, polyethylene glycol (PEG), and PLURONICS™. The term “carrier” can also refer to a diluent, adjuvant (e.g., Freund's adjuvant (complete or incomplete)), excipient, or vehicle. Such carriers, including pharmaceutical carriers, can be sterile liquids, such as water and oils, including those of petroleum, animal, vegetable, or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil, and the like. Water is an exemplary carrier when a composition is administered intravenously. Saline solutions and aqueous dextrose and glycerol solutions can also be employed as liquid carriers, particularly for injectable solutions, such as Ringer's solution or lactated Ringer's solution. Suitable excipients (e.g., pharmaceutical excipients) include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol, and the like. The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. Compositions can take the form of solutions, suspensions, emulsion, tablets, pills, capsules, powders, sustained-release formulations, and the like. Oral compositions, including formulations, can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, etc. Examples of suitable pharmaceutical carriers are described in Remington and Gennaro, Remington's Pharmaceutical Sciences (18th ed. 1990).

The term “pharmaceutically acceptable” as used herein means being approved by a regulatory agency of the Federal or a state government, or listed in United States Pharmacopeia, European Pharmacopeia, or other generally recognized Pharmacopeia for use in animals, and more particularly in humans.

The term “excipient” refers to an inert substance which is commonly used as a diluent, vehicle, preservative, binder, or stabilizing agent, and includes, but is not limited to, proteins (e.g., serum albumin, etc.), amino acids (e.g., aspartic acid, glutamic acid, lysine, arginine, glycine, histidine, etc.), fatty acids and phospholipids (e.g., alkyl sulfonates, caprylate, etc.), surfactants (e.g., SDS, polysorbate, nonionic surfactant, etc.), saccharides (e.g., sucrose, maltose, trehalose, etc.), and polyols (e.g., mannitol, sorbitol, etc.). See, also, Remington and Gennaro, Remington's Pharmaceutical Sciences (18th ed. 1990), which is hereby incorporated by reference in its entirety.

The term “diluent” refers to chemical compounds that are used to dilute the compound of interest prior to delivery. Diluents can also be used to stabilize compounds because they can provide a more stable environment. Salts dissolved in buffered solutions (which also can provide pH control or maintenance) are utilized as diluents in the art, including, but not limited to a phosphate buffered saline solution. In certain embodiments, diluents increase bulk of the composition to facilitate compression or create sufficient bulk for homogenous blending. Such compounds include e.g., lactose, starch, mannitol, sorbitol, dextrose, cellulose, calcium phosphate, lactose; starch, mannitol, dextrates, amylose, cellulose, and the like.

As used herein, the term “subject” refers to an animal, including, but not limited to, a primate (e.g., human), cow, sheep, goat, horse, dog, cat, rabbit, rat, or mouse. The terms “subject” and “patient” are used interchangeably herein in reference, for example, to a mammalian subject, such as a human subject. In one embodiment, the subject is a mammal. In one embodiment, the subject is a human.

As used herein, the terms “treat,” “treating,” and “treatment” refer to the eradication or amelioration of a disease or disorder, or of one or more symptoms associated with the disease or disorder. In general, treatment occurs after the onset of the disease or disorder. In certain embodiments, the terms refer to minimizing the spread or worsening of the disease or disorder resulting from the administration of one or more prophylactic or therapeutic agents to a subject with such a disease or disorder.

As used herein, the term “administration” refers to the act of giving a composition as described herein to a subject. Exemplary routes of administration to the human body can be through the mouth (oral), skin (transdermal, topical), nose (nasal), lungs (inhalant), oral mucosa (buccal), by injection (e.g., intravenously, subcutaneously, intratumorally, intraocular, intraperitoneally, etc.), by transplantation (e.g. through an incision surgery) and the like.

As used herein, the terms “prevent,” “preventing,” and “prevention” refer to the prevention of the onset, recurrence or spread of a disease or disorder, or of one or more symptoms thereof. In general, prevention occurs prior to the onset of the disease or disorder.

As used herein, and unless otherwise specified, the terms “manage,” “managing,” and “management” refer to preventing or slowing the progression, spread or worsening of a disease or disorder, or of one or more symptoms thereof. Sometimes, the beneficial effects that a subject derives from a prophylactic or therapeutic agent do not result in a cure of the disease or disorder.

As used herein, and unless otherwise specified, the term “therapeutically effective amount” are meant to include the amount of a compound that, when administered, is sufficient to prevent development of, or alleviate to some extent, one or more of the symptoms of the disorder, disease, or condition being treated. The term “therapeutically effective amount” also refers to the amount of a compound that is sufficient to elicit the biological or medical response of a cell, tissue, system, animal, or human, which is being sought by a researcher, veterinarian, medical doctor, or clinician.

The term “fat pad” as used herein refers to any cushions made of a pocket of fascia and filled with fat deposits (e.g. fatty acids in fat cells) that are present in humans or mammalians.

The term “adipocytes” as used herein refers to the functional cell type of fat, or adipose tissue, that is found throughout the body, particularly under the skin. Adipocytes store and synthesize fat or triglycerides for energy, thermal regulation and cushioning against mechanical shock. Without bound by the theory, it appears that mesenchymal stem cells can differentiate into two types of lipoblasts, one that give rise to white adipocytes and the other to brown adipocytes. Both types of adipocytes store fat. Adipose tissue may be brown or white adipose tissue, derived from, for example, subcutaneous, omental/visceral, mammary, gonadal, periorgan or other adipose tissue site. In some embodiments, adipose tissue is subcutaneous white adipose tissue. The adipose tissue may be from any organism having fat tissue. In some embodiments, the adipose tissue is mammalian. In some embodiments, the adipose tissue is in a human subject. A convenient source of adipose tissue is liposuction surgery. In some embodiments, adipocyte cells as described herein are desired for autologous transplantation into a subject. In some embodiments, the adipose tissue can be isolated from that subject.

The term “pre-adipocyte” as used herein refers to adipocyte precursor cells that, under the action of hormones such as insulin and glucocorticoid, divide and differentiate into adipocytes. Morphologically, pre-adipocytes are fibroblast-looking (i.e., thin and spindle-shaped) and devoid of triglyceride vesicles in their cytoplasm. As compared to adipocytes, pre-adipocytes contain low levels of insulin receptor and relatively high levels of IGF-1 receptors for receiving mitogenic and differentiating signals.

The term “subcutaneous” refer to “under the skin,” i.e., administered into the subcutis, the layer of skin directly below the dermis and epidermis (collectively referred to as the cutis), above muscle. In some embodiments, a composition as described herein is delivered to a subject subcutaneously, such as with the use of a standard needle and syringe. In some embodiments, the syringe is a pre-filled syringe. In some embodiments, a pen delivery device or autoinjector is used for subcutaneous delivery. Non-limiting examples of disposable pen delivery devices having applications in subcutaneous delivery include the SOLOSTAR™ pen (sanofi-aventis), the FLEXPEN™ (Novo Nordisk), and the KWIKPEN™ (Eli Lilly) and the SURECLICK™ Autoinjector (Amgen, Thousand Oaks, Calif.). In some embodiments, a composition as described herein is delivered to a subject subcutaneously, such as through transplantation in an incision surgery. In some embodiments, a subcutaneous incision is made in a subject to expose the fat tissue, and a solid medium (e.g., a sterile strip carrying effective amount of a therapeutic composition containing plasmid DNA) is placed into or near the fat tissue before the incision is closed up through a standard surgical procedure.

The term “incision” refers to a cut, opening, flap or penetration, typically in the course of minimally invasive or less-invasive surgery. An incision can be made with, for example, a knife, needle, blade, lancet, scalpel, laser, or other mechanism. In some embodiments, the incision is performed by lifting up the skin. In some embodiments, an incision extends beyond the dermal layer of a subject's skin. In some embodiments, the site of incision exposes adipocytes or pre-adipocytes. In some embodiments, the site of incision has damaged cells. In some embodiments, a composition described herein is administrated by incision.

The term “vector” refers to a vehicle into which a polynucleotide encoding a protein may be operably inserted so as to bring about the expression of that protein. A vector may be used to transform, transduce, or transfect a host cell so as to bring about expression of the genetic element it carries within the host cell. Non-limiting examples of vectors include plasmids, phagemids, cosmids, artificial chromosomes such as yeast artificial chromosome (YAC), bacterial artificial chromosome (BAC), or P1-derived artificial chromosome (PAC), bacteriophages such as lambda phage or M13 phage, and animal viruses. Categories of animal viruses used as vectors include retrovirus (including lentivirus), adenovirus, adeno-associated virus, herpesvirus (e.g., herpes simplex virus), poxvirus, baculovirus, papillomavirus, and papovavirus. A vector may contain a variety of elements for controlling expression, including promoter sequences, transcription initiation sequences, enhancer sequences, selectable elements, and reporter genes. In addition, the vector may contain an origin of replication. A vector may also include materials to aid in its entry into the cell, including but not limited to a viral particle, a liposome, or a protein coating.

The term “nucleic acid” refers to at least two or more ribo- or deoxy-ribonucleic acid base pairs (nucleotides/nucleosides) that are linked through a phosphoester bond or equivalent. Nucleic acids include polynucleotides. Nucleic acids include single, double or triplex, circular or linear, molecules. Exemplary nucleic acids include but are not limited to: RNA, DNA, cDNA, genomic nucleic acid, naturally occurring and non-naturally occurring nucleic acid, e.g., synthetic nucleic acid. Nucleic acids can be of various lengths. Nucleic acid lengths typically range from about 20 bases to 20 Kilobases (Kb), or any numerical value or range within or encompassing such lengths, 10 bases to 10 Kb, 1 to 5 Kb or less, 1000 to about 500 bases or less in length. Nucleic acids can also be shorter, for example, 100 to about 500 bases, or from about 12 to 24, 24 to 45, 45 to 90, 90 to 250, or about 250 to 500 bases in length. In some embodiments, a nucleic acid sequence has a length from about 10-20, 20-30, 30-50, 50-100, 100-150, 150-200, 200-250, 250-300, 300-400, 400-500, 500-1000, 1000-3000 bases. Shorter nucleic acids are commonly referred to as “oligonucleotides”. In some embodiment, nucleic acid sequences further include nucleotide and nucleoside substitutions, additions and deletions, as well as derivatized forms and fusion/chimeric sequences (e.g., encoding recombinant polypeptide. Nucleic acids can be produced using various techniques that includes, but are not limited to nucleic acid amplification, e.g., polymerase chain reaction (PCR). Nucleic acids can also be produced by chemical synthesis, such as solid phase phosphoramidite synthesis. The sequences produced can then be translated in vitro, or cloned into a plasmid and propagated and then expressed in a cell.

The term “CpG-reduced” as used herein refers to a nucleic acid sequence or expression vector that has less CpG di-nucleotides than present in the wild-type versions of the sequence or vector. “CpG-free” means the subject nucleic acid sequence or vector does not have any CpG di-nucleotides. An initial sequence, that contains CpG dinucleotides (e.g., wild-type version of an anti-SARS-CoV-2 antibody), may be modified to remove CpG dinucleotides by altering the nucleic acid sequence. Such CpG di-nucleotides can be suitably reduced or eliminated not just in a coding sequence, but also in the non-coding sequences, including, e.g., 5′ and 3′ untranslated regions (UTRs), promoter, enhancer, polyA, ITRs, introns, and any other sequences present in the nucleic acid molecule or vector. In certain embodiments, the nucleic acid sequences employed herein are CpG-reduced or CpG-free.

The term “plasmid” as used herein refers to an extrachromosomal nucleic acid, e.g., DNA, construct that is not integrated into a bacterial cell's genome. Plasmids are usually circular and capable of autonomous replication. Plasmids may be low-copy, medium-copy, or high-copy. Plasmids may optionally comprise a selectable marker, such as an antibiotic resistance gene to help select for bacterial cells containing the plasmid and which ensures that the plasmid is retained in the bacterial cell. A plasmid as used herein may comprise a nucleic acid sequence encoding a heterologous gene, e.g., a gene encoding a branched chain amino acid catabolism enzyme. In some embodiment, the plasmid is used as a vector.

The term “mRNA” means “messenger-RNA” and relates to a “transcript” which is generated by using a DNA template and encodes a peptide or polypeptide. Typically, an mRNA comprises a 5′-UTR, a protein coding region, and a 3′-UTR. The term “mRNA” can include precursor mRNA and mature mRNA, either the full-length mRNA or its fragment. In some embodiment, mRNA may be generated by in vitro transcription from a DNA template. the stability and translation efficiency of RNA may be modified as required. In some embodiments, mRNA is stabilized and its translation increased by one or more modifications having a stabilizing effects and/or increasing translation efficiency of RNA. Such modifications are described, for example, in PCT/EP2006/009448 incorporated herein by reference. The modification maybe within the coding region, i.e. the sequence encoding the expressed peptide or protein, preferably without altering the sequence of the expressed peptide or protein, so as to increase the GC-content to increase mRNA stability and to perform a codon optimization and thereby enhance translation in cells.

The term “antibody,” “immunoglobulin,” or “Ig” is used interchangeably herein, and is used in the broadest sense and specifically encompasses, for example, individual monoclonal antibodies (including agonist, antagonist, neutralizing antibodies, full length or intact monoclonal antibodies), antibody compositions with polyepitopic or monoepitopic specificity, polyclonal or monovalent antibodies, multivalent antibodies, multispecific antibodies (e.g., bispecific antibodies so long as they exhibit the desired biological activity), formed from at least two intact antibodies, single chain antibodies, and fragments of antibodies, as described below. An antibody can be human, humanized, chimeric and/or affinity matured, as well as an antibody from other species, for example, mouse and rabbit, etc. The term “antibody” is intended to include a polypeptide product of B cells within the immunoglobulin class of polypeptides that is able to bind to a specific molecular antigen and is composed of two identical pairs of polypeptide chains, wherein each pair has one heavy chain (about 50-70 kDa) and one light chain (about 25 kDa), each amino-terminal portion of each chain includes a variable region of about 100 to about 130 or more amino acids, and each carboxy-terminal portion of each chain includes a constant region. See, e.g., Antibody Engineering (Borrebaeck ed., 2d ed. 1995); and Kuby, Immunology (3d ed. 1997). In specific embodiments, the specific molecular antigen can be bound by an antibody provided herein, including a protein, a fragment of a protein, or an epitope of a protein. Antibodies also include, but are not limited to, synthetic antibodies, recombinantly produced antibodies, camelized antibodies, intrabodies, anti-idiotypic (anti-Id) antibodies, and functional fragments (e.g., antigen-binding fragments or antigen binding portions) of any of the above, which refers to a portion of an antibody heavy or light chain polypeptide that retains some or all of the binding activity of the antibody from which the fragment was derived. Non-limiting examples of functional fragments (e.g., antigen-binding fragments) include single-chain Fvs (scFv) (e.g., including monospecific, bispecific, etc.), Fab fragments, F(ab′) fragments, F(ab)₂ fragments, F(ab′)₂ fragments, disulfide-linked Fvs (dsFv), Fd fragments, Fv fragments, diabody, triabody, tetrabody, and minibody. In particular, antibodies provided herein include immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, for example, antigen-binding domains or molecules that contain an antigen-binding site that binds to an antigen (e.g., one or more CDRs of an antibody). Such antibody fragments can be found in, for example, Harlow and Lane, Antibodies: A Laboratory Manual (1989); Mol. Biology and Biotechnology: A Comprehensive Desk Reference (Myers ed., 1995); Huston et al., 1993, Cell Biophysics 22:189-224; Plückthun and Skerra, 1989, Meth. Enzymol. 178:497-515; and Day, Advanced Immunochemistry (2d ed. 1990). The antibodies provided herein can be of any class (e.g., IgG, IgE, IgM, IgD, and IgA) or any subclass (e.g., IgG1, IgG2, IgG3, IgG4, IgA1, and IgA2) of immunoglobulin molecule. Antibodies may be agonistic antibodies or antagonistic antibodies.

The term “monoclonal antibody” or “mAb” as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations that may be present in minor amounts. Monoclonal antibodies are highly specific, being directed against a single antigenic site. In contrast to polyclonal antibody preparations, which include different antibodies directed against different determinants (epitopes), each monoclonal antibody is directed against a single determinant on the antigen. In addition to their specificity, the monoclonal antibodies are advantageous in that they may be synthesized uncontaminated by other antibodies. The modifier “monoclonal” indicates the character of the antibody as being obtained from a substantially homogeneous population of antibodies. Monoclonal antibody as used herein is not limited to antibodies produced through hybridoma technology. A monoclonal antibody can be derived from a single clone, including any eukaryotic, prokaryotic, or phage clone, by any means available or known in the art.

The term “humanized monoclonal antibody” as used herein refers to that all or most of the amino acid sequences of the murine monoclonal antibodies (including the framework region sequence in the variable region), except complementarity-determining regions (CDR) are substituted by the amino acid sequences of human immunoglobulins, to reduce the immunogenicity of the murine monoclonal antibody by genetic engineering methods.

The term “glycosidase” as used herein refers to an agent that cleaves a covalent bond between sequential sugars in a glycan or between the sugar and the backbone moiety (e.g. between sugar and peptide backbone of glycoprotein). In some embodiments, a glycosidase is an enzyme. In certain embodiments, a glycosidase is a protein (e.g., a protein enzyme) comprising one or more polypeptide chains.

The term “galactosidase” as used herein refers to a class of enzymes that catalyze the hydrolysis and cleave terminal galactose residues. Galactosidases include “beta-galactosidase” that catalyzes the hydrolysis of beta-galactosides to form monosaccharides and “alpha-galactosidase” that catalyzes the hydrolysis of alpha-galactosides to form monosaccharides. Substrates of beta-galactosidases includes, but are not limited to, ganglioside GM1, lactosylceramides, lactose, and various glycoproteins.

The term “antigen” refers to a molecule that is capable of being bound specifically by an antibody, or otherwise provokes an immune response. This immune response may involve either antibody production, or the activation of specific immunologically-competent cells, or both. It is known in the art that any macromolecule, including virtually all proteins or peptides, can serve as an antigen.

The term “pathogen” refers to an organism or an infectious agent whose infection of cells of viable plant tissue elicits a disease response. In some embodiments, the pathogen is a bacteria. In some embodiments, the pathogen is a virus, particularly coronavirus.

The term “coronavirus” is a term of art which refers to an enveloped virus with a positive-sense single-stranded RNA genome and a helical symmetry. The genomic size of coronaviruses ranges from approximately 27 to 32 kilobases. Large Spike (S) glycoproteins protrude from the virus particle giving coronaviruses a distinctive corona-like appearance when visualized by electron microscopy. Coronaviruses infect a wide variety of species, including canine, feline, porcine, murine, bovine, avian and human. Coronaviruses typically bind to target cells through Spike-receptor interactions and enter cells by receptor mediated endocytosis or fusion with the plasma membrane. The Spike-receptor interaction is a strong determinant of species specificity.

The term “transfection” refers to the uptake of foreign DNA by a cell. A cell has been “transfected” when exogenous DNA has been introduced inside the cell membrane. A number of transfection techniques are generally known in the art. See, e.g., Graham et al. (1973) Virology, 52:456, Sambrook et al. (2001) Molecular Cloning, a laboratory manual, 3rd edition, Cold Spring Harbor Laboratories, New York, Davis et al. (1995) Basic Methods in Molecular Biology, 2nd edition, McGraw-Hill, and Chu et al. (1981) Gene 13:197. Such techniques can be used to introduce one or more exogenous DNA moieties into suitable host cells. The term refers to both stable and transient uptake of the genetic material.

The term “lipid” as used herein refers to a synthetic or naturally-occurring compound which is generally amphipathic and biocompatible. The lipids typically comprise a hydrophilic component and a hydrophobic component. Exemplary lipids include, for example, fatty acids, neutral fats, phosphatides, glycolipids, surface-active agents (surfactants), aliphatic alcohols, waxes, terpenes, and steroids. In some embodiments, the lipid is a phospholipid. Exemplary phospholipids that can form part of the liposomes as used herein include but are not limited to 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-phosphocholine (DMPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC).

The term “cationic lipid” includes lipids and synthetic lipids having both polar and non-polar domains and which are capable of being positively charged at or around physiological pH and which bind to polyanions, such as nucleic acids. In some embodiments, cationic lipids include saturated and unsaturated alkyl and alicyclic ethers and esters of amines, amides, or derivatives thereof. In some embodiments, cationic lipids comprise straight-chain, branched alkyl, alkenyl groups, or any combination of the foregoing. In some embodiments, cationic lipids contain from 1 to about 25 carbon atoms. In some embodiments, cationic lipids contain more than 25 carbon atoms. In some embodiments, straight chain or branched alkyl or alkene groups have six or more carbon atoms. In some embodiment, the cationic lipid is a cationic phospholipid. In some embodiments, the cationic lipid is N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP).

The term “neutral lipid” refers to any of a number of lipid species which exist either in an uncharged or neutral zwitterionic form a physiological pH. Such lipids include, for example, diacylphosphatidylcholine, diacylphosphatidylethanolamine, ceramide, sphingomyelin, cephalin, cholesterol, cerebrosides and diacylglycerols. Certain neutral lipids, including cholesterol and other sterol derivatives, are known to increase the stability of liposomes and are referred to as “liposomes stabilizing lipids”.

The term “liposome” as used herein, refers to a vesicle composed of amphiphilic lipids arranged in at least one bilayer, e.g., one bilayer or a plurality of bilayers. Liposomes include unilamellar and multilamellar vesicles (MLV)that have a membrane formed from a lipophilic material and an aqueous interior. Multilamellar vesicles have more than one layer of membranes. Unilamellar vesicles have one single layer of membrane. The unilamellar vesicles may be large unilamellar vesicles (LUVs) or small unilamellar vesicles (SUVs). The term “large unilamellar vesicles” or “LUVs” as used herein means unilamellar vesicles having a diameter of between about 0.1 to 1 μm. The term “small unilamellar vesicles” or “SUV” as used herein means unilamellar vesicles having a diameter of less than 100 nm. The lipophilic material of liposome isolates the aqueous interior from an aqueous exterior. Liposomes are useful for the transfer and delivery of active ingredients to the site of action. Because the liposomal membrane is structurally similar to biological membranes, when liposomes are applied to a tissue, the liposomal bilayer fuses with bilayer of the cellular membranes, thereby facilitating the delivery of therapeutic payloads on or inside the liposome. In some embodiment, the liposome used herein is small unilamellar vesicle (SUV). In some embodiment, the liposome used herein is multilamellar vesicle (MLV).

The term “cationic liposome” refers to liposomes that are made in whole or part from positively charged lipids, or more specifically a lipid that comprises both a cationic group and a lipophilic portion. The positively charged moieties of cationic lipids used in cationic liposomes provide advantageous structural features. For instance, the lipophilic portion of the cationic lipid is hydrophobic and thus may direct itself away from the aqueous interior of the liposome and associate with other nonpolar and hydrophobic species, or conversely, the cationic moiety may associate with polar molecules and species with which it can complex in the aqueous interior of the cationic liposome. The positively charged liposomes may interact with the negatively charged nucleic acid molecules to form a stable complex. Positively charged liposomes can bind to negatively charged cell surface constituents (e.g., heparin sulfate proteoglycans and integrins) and trigger cellular uptake mainly by endocytosis.

The term “neutral liposomes” refers to liposomes that contain lipid components that have an overall neutral charge at physiological pH. Neutral liposomes are less susceptible to interaction with negative constituents in the circulation after systemic delivery, compared to cationic liposomes. Cationic liposomes bind to and are taken up by endothelial cells after systemic delivery, while anionic and neutral liposomes are generally not.

As used herein, “empty liposomes” refers to liposomes that do not contain nucleic acid molecules but that may contain other bioactive molecules (e.g., liposomes that are only composed of the lipid molecules themselves, or only lipid molecules and a small molecule drug). In certain embodiments, empty liposomes are used with any of the methods or compositions described herein.

As used herein, “empty cationic micelles” refers to cationic micelles that do not contain nucleic acid molecules but that may contain other bioactive molecules (e.g., micelles that are only composed of lipid and surfactant molecules themselves, or only lipid and surfactant molecules and a small molecule drug). In certain embodiments, empty cationic micelles are used with any of the methods or compositions described herein.

As used herein, “empty cationic emulsions” refers to cationic emulsions or micro-emulsions that do not contain nucleic acid molecules but that may contain other bioactive molecules. In certain embodiments, empty cationic emulsions are used with any of the methods or compositions described herein.

The term “hyaluronidase” as used herein refers to an enzyme that decomposes hyaluronic acid. The hyaluronidase may be derived from mice, sheep, cattle, or humans. The hyaluronidase may be human hyaluronidase or recombinant human hyaluronidase. The term hyaluronidase as used herein includes its salts and derivatives which retain its enzymatic activity. A recombinant form of hyaluronidase for human injection, sold under the, trademark Hylenex® (Halozyme, Inc., San Diego, Calif.), is an FDA approved enzyme. Without bound by the theory, hyaluronidase hydrolyzes hyaluronic acid by cleaving the 0-1,4 bond between the glucosamine and glucuronic acid.

The term “isotonic” as used herein refers to a solution wherein the osmotic pressure gradient across the cell membrane is essentially balanced. An isotonic formulation is one which has essentially the same osmotic pressure as the blood of a subject. Isotonic formulations will generally have an osmotic pressure from about 250 mOsm/kg to 350 mOsm/kg.

The term “hypertonic” as used herein refers to a fluid having an osmotic concentration and a density greater than the osmotic concentration and density of blood of a subject. The physiologic, isotonic concentration of human blood is about 290 milli-osmols. In some embodiment, a hypertonic solution comprises a salt, such as a potassium salt, a sodium salt or a calcium salt. In some embodiment, a hypertonic solution comprises glucose and/or nonelectrolytes, such as mannitol. The term “hypertonic saline” as used herein refers to a solution of sodium chloride in water having a concentration of sodium chloride greater than 0.9% w/v.

The term “hypotonic” as used herein refers to a fluid having an osmotic concentration and a density lower than the osmotic concentration and density of blood of a subject. When a cell is immersed into a hypotonic solution, water flows into the cell in order to balance the concentration of the solutes. In some embodiments, the hypotonic solution comprises a salt. In one embodiment, the salt is sodium chloride. In one embodiment, the salt is potassium chloride. In one embodiment, the hypotonic solution comprises electrolytes. The term “hypotonic saline” as used herein refers to a solution of sodium chloride in water having an osmolality lower than 290 milli-osmols or a concentration of sodium chloride lower than 0.9% w/v.

As used herein, the term “alkyl” means a straight or branched saturated hydrocarbon chain containing from 1 to 30 carbon atoms, for example 1 to 16 carbon atoms (C₁-C₁₆ alkyl), 1 to 14 carbon atoms (C₁-C₁₄ alkyl), 1 to 12 carbon atoms (C₁-C₁₂ alkyl), 1 to 10 carbon atoms (C₁-C₁₀ alkyl), 1 to 8 carbon atoms (C₁-C₈ alkyl), 1 to 6 carbon atoms (C₁-C₆ alkyl), 1 to 4 carbon atoms (C₁-C₄ alkyl), or 5 to 23 carbon atoms (C₅-C₂₃ alkyl). Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, 3-methylhexyl, 2,2-dimethylpentyl, 2,3-dimethylpentyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl, and n-dodecyl.

As used herein, the term “alkenyl” refers to a straight or branched hydrocarbon chain containing from 2 to 30 carbon atoms and containing at least one carbon-carbon double bond, for example 2 to 16 carbon atoms (C₂-C₁₆ alkyl), 2 to 14 carbon atoms (C₂-C₁₄ alkyl), 2 to 12 carbon atoms (C₂-C₁₂ alkyl), 2 to 10 carbon atoms (C₂-C₁₀ alkyl), 2 to 8 carbon atoms (C₂-C₈ alkyl), 2 to 6 carbon atoms (C₂-C₆ alkyl), 2 to 4 carbon atoms (C₂-C₄ alkyl), or 5 to 23 carbon atoms (C₅-C₂₃ alkyl). Representative examples of alkenyl include, but are not limited to, ethenyl, 2-propenyl, 2-methyl-2-propenyl, 3-butenyl, 4-pentenyl, 5-hexenyl, 2-heptenyl, 2-methyl-1-heptenyl, and 3-decenyl.

Methods and Compositions

Provided herein are compositions, systems, kits, and methods for treating a subject, and/or a subject's adipocytes, with a composition containing a nucleic acid sequence encoding a protein or a biologically active nucleic acid encoded molecule (BANEM), or a vector containing the nucleic acid sequence, wherein the treating comprises: a) injecting the composition into a subcutaneous (SC) region of the subject such that the at least one protein, or BANEM, is detectable in a blood, serum, or plasma sample from the subject; and/or b) injecting the composition into an SC region of the subject such that in-vivo transfected pre-adipocytes and/or adipocytes (e.g., cells of fat cell origin) are generated; c) performing the following: i) contacting adipocytes pre-adipocytes and/or adipocytes (e.g., cells of fat cell origin) from the subject ex-vivo with the composition such that ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and ii) injecting the ex-vivo transfected pre-adipocytes and/or adipocytes into one or more SC regions of the subject; and/or d) implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject.

In one embodiment, provided herein is a method of treating a subject. In one embodiment, provided herein is a method of treating the subcutaneous pre-adipocytes of a subject. In one embodiment, provided herein is a method of treating the subcutaneous adipocytes of a subject. In one embodiment, provided herein is a method of treating the subcutaneous pre-adipocytes and adipocytes of a subject.

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises at least one of the following:

a) injecting the composition into one or more subcutaneous regions of the subject (e.g., fat pad, buttocks, stomach, etc.) such that the at least one protein, or the at least one biologically active nucleic acid encoded molecule, is detectable in a blood, serum, or plasma sample from the subject; and/or

b) injecting the composition into one or more subcutaneous regions of the subject such that a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in the subcutaneous region(s);

c) performing the following:

-   -   i) contacting a plurality of the pre-adipocytes and/or         adipocytes from the subject ex-vivo with the composition such         that a plurality of ex-vivo transfected pre-adipocytes and/or         adipocytes are generated, and     -   ii) injecting at least some of the plurality of ex-vivo         transfected pre-adipocytes and/or adipocytes into one or more         subcutaneous regions of the subject; and/or

d) implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject.

Nucleic Acid Containing Compositions

In one embodiment, the composition comprises a nucleic acid sequence. In one embodiment, the nucleic acid sequence is comprised in a vector. In some embodiments, the vector is a transfection vector. In some embodiments, the vector is an expression vector. In one embodiment, the vector comprises a non-viral vector. In one embodiment, the vector comprises a plasmid. In one embodiment, the plasmid is a Resistance plasmid. In one embodiment, the plasmid is a Fertility plasmid. In one embodiment, the plasmid is a Col plasmid. In one embodiment, the plasmid is a Degradative plasmid. In some embodiments, the vector comprising the nucleic acid sequence is not attached to or encapsulated in, any delivery agent.

In one embodiment, the nucleic acid sequence comprises DNA. In one embodiment, the nucleic acid sequence comprises plasmid DNA. In one embodiment, the nucleic acid sequence comprises linear DNA. In one embodiment, the nucleic acid sequence comprises circular DNA. In one embodiment, the nucleic acid sequence comprises supercoiled DNA.

In one embodiment, the nucleic acid comprises mRNA, and wherein the mRNA is optionally capped and composed of at least some modified bases that reduce immunogenicity.

In some embodiments, the vector comprises a nucleic acid sequence encoding for at least one protein. In one embodiment, the nucleic acid sequence encodes one protein. In one embodiment, the nucleic acid sequence encodes two proteins. In one embodiment, the nucleic acid sequence encodes three proteins. In one embodiment, the nucleic acid sequence encodes four proteins. In one embodiment, the nucleic acid sequence encodes five proteins. In one embodiment, the nucleic acid sequence encodes six proteins. In one embodiment, the nucleic acid sequence encodes seven proteins. In one embodiment, the nucleic acid sequence encodes eight proteins. In one embodiment, the nucleic acid sequence encodes nine proteins. In one embodiment, the nucleic acid sequence encodes ten proteins. In one embodiment, the nucleic acid sequence encodes twelve proteins. In one embodiment, the nucleic acid sequence encodes fourteen proteins. In one embodiment, the nucleic acid sequence encodes sixteen proteins. In one embodiment, the nucleic acid sequence encodes eighteen proteins. In one embodiment, the nucleic acid sequence encodes twenty or more proteins. In some embodiments, the two or more proteins encoded by the nucleic acid sequence are configured to function cooperatively. In particular embodiments, a first of the two or more proteins encoded by the nucleic acid sequence is an antibody heavy chain or an antigen binding fragment of the heavy chain, while a second of the two or more proteins encoded by the nucleic acid sequence is an antibody light chain or an antigen binding fragment of the light chain, where the two proteins form a functional antibody or antigen binding portion of an antibody.

In one embodiment, the nucleic acid sequence encodes one or more BANEMs. In one embodiment, the nucleic acid sequence encodes two BANEMs. In one embodiment, the nucleic acid sequence encodes three BANEMs. In one embodiment, the nucleic acid sequence encodes four BANEMs. In one embodiment, the nucleic acid sequence encodes five BANEMs. In one embodiment, the nucleic acid sequence encodes six BANEMs. In one embodiment, the nucleic acid sequence encodes seven BANEMs. In one embodiment, the nucleic acid sequence encodes eight BANEMs. In one embodiment, the nucleic acid sequence encodes nine BANEMs. In one embodiment, the nucleic acid sequence encodes ten BANEMs. In one embodiment, the nucleic acid sequence encodes twelve BANEMs. In one embodiment, the nucleic acid sequence encodes fourteen BANEMs. In one embodiment, the nucleic acid sequence encodes sixteen BANEMs. In one embodiment, the nucleic acid sequence encodes eighteen BANEMs. In one embodiment, the nucleic acid sequence encodes twenty or more BANEMs. In one embodiment, the BANEM comprises an RNA. In one embodiment, the BANEM comprises a therapeutic RNA. In one embodiment, the BANEM comprises an mRNA. In one embodiment, the BANEM comprises an siRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises miRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises piRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises snoRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises tsRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises srRNA. In one embodiment, the BANEM comprises an shRNA. In one embodiment, the BANEM comprises a CRISPR single guide RNA sequence (sgRNA). In one embodiment, the BANEM comprises an antisense sequence.

In some embodiments, the vector encodes an mRNA. In one embodiment, the mRNA is a monocistronic mRNA that comprises only one ORF. In certain embodiments, the monocistronic mRNA encodes a peptide or protein comprising at least one epitope of a selected antigen (e.g., a pathogenic antigen or a tumor associated antigen). In other embodiments, the mRNA is a multicistronic mRNA that comprises two or more ORFs. In one embodiment, the multiecistronic mRNA encodes two or more peptides or proteins that can be the same or different from each other. In one embodiment, each peptide or protein encoded by a multicistronic mRNA comprises at least one epitope of a selected antigen.

In one embodiment, the vector comprises at least one expression cassette of at least one protein. In one embodiment, the vector comprises a single expression cassette. In one embodiment, the vector comprises single expression cassette of a single protein. In one embodiment, the vector comprises single expression cassette of a single monoclonal antibody (mAb). In one embodiment, the vector comprises two expression cassettes of a single protein. In one embodiment, the vector comprises two expression cassettes of a single mAb. In one embodiment, the vector comprises two expression cassettes of two therapeutic genes.

In some embodiments, the composition comprises one or more vectors. In one embodiment, each vector encodes one antibody. In one embodiment, the vector encodes two antibodies. In one embodiment, the vector encodes three antibodies. In one embodiment, the vector encodes four antibodies. In one embodiment, the vector encodes five antibodies. In one embodiment, the vector encodes six antibodies. In one embodiment, the vector encodes seven antibodies. In one embodiment, the vector encodes eight antibodies. In one embodiment, the vector encodes nine antibodies. In one embodiment, the vector encodes ten antibodies. In one embodiment, the vector encodes eleven antibodies. In one embodiment, the vector encodes twelve or more antibodies.

In some embodiments, the composition comprises one or more vectors. In some embodiments, the composition comprises two vectors, and each vector encodes one antibody. In some embodiments, the composition comprises one or more vectors. In some embodiments, the composition comprises two vectors, and each vector encodes two antibodies. In some embodiments, the composition comprises two vectors, and each vector encodes three antibodies. In some embodiments, the composition comprises two vectors, and each vector encodes four antibodies. As described herein, a vector encoding an antibody (or antigen binding fragment thereof) can encode both the heavy chain and light chain of the antibody (or variable regions of the heavy and light chains.)

In one embodiment, the vector comprises at least one expression cassette of at least one protein. In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition is responsible for lipid metabolism in the subject. In some embodiments, the at least one protein is responsible for lipid synthesis. In some embodiments, the at least one protein is responsible for lipid transportation. In some embodiments, the at least one protein is responsible for lipid storage. In some embodiments, the at least one protein is responsible for lipid degradation or consumption. In some embodiments, the at least one protein in an enzyme catalyzing one or more of the lipid biosynthesis, transportation and/or degradation pathways in the subject.

In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition is responsible for fat metabolism in the subject. In some embodiments, the at least one protein is responsible for fat synthesis. In some embodiments, the at least one protein is responsible for fat transportation. In some embodiments, the at least one protein is responsible for fat storage. In some embodiments, the at least one protein is responsible for fat degradation or consumption. In some embodiments, the at least one protein in an enzyme catalyzing the fat biosynthesis, transportation and/or degradation pathways in the subject.

In specific embodiment, the at least one protein comprises glycosidase. In specific embodiment, the at least one protein comprises galactosidase. In specific embodiment, the at least one protein comprises beta-galactosidase. In specific embodiment, the at least one protein comprises alpha-galactosidase. In specific embodiment, the at least one protein comprises a mixture of alpha-galactosidase and beta-galactosidase. In specific embodiment, the at least one protein comprises a glucocerebrosidase. In specific embodiment, the at least one protein comprises a beta-glucocerebrosidase. In specific embodiment, the at least one protein comprises sulfatase enzymes. In specific embodiment, the at least one protein comprises formylglycine-generating enzymes. In specific embodiment, the at least one protein comprises ceramidase. In specific embodiment, the at least one protein comprises acid ceramidase. In specific embodiment, the at least one protein comprises neutral ceramidase. In specific embodiment, the at least one protein comprises alkaline ceramidase 1, alkaline ceramidase 2, or alkaline ceramidase 3. In specific embodiment, the at least one protein comprises lipase. In specific embodiment, the at least one protein comprises pancreatic lipase. In specific embodiment, the at least one protein comprises hepatic lipase. In specific embodiment, the at least one protein comprises pharyngeal lipase. In specific embodiment, the at least one protein comprises alpha-N-acetylgalactosaminidase (other names: alpha-NAGA or alpha-galactosidase B). In specific embodiment, the at least one protein comprises alpha-L-fucosidase. In specific embodiment, the at least one protein comprises acid alpha-glucosidase (other names: alpha-1,4-glucosidase, acid maltase).

In some embodiments, the at least one protein is a galactosidase or glycosidase. In some embodiments, the at least one protein is selected from alpha-galactosidase A (GLA), GBA (beta-glucocerebrosidase), FGE (formylglycine-generating enzyme), ASAH (acid ceramidase), SMPD1 (sphingomyelin phosphodiesterase 1) or NPC1 (Niemann-Pick C1 cholesterol transporter) or NPC2 (Niemann-Pick C2 cholesterol transporter), and LAL. In some embodiments, the at least one protein is a lipase. In some embodiments, the at least one protein is a phospholipase.

In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises an antibody or an antigen binding portion of an antibody that target a pathogenic antigen. In some embodiments, the antibody or antigen binding portion thereof targets an infectious pathogen. In some embodiments, the infectious pathogen is selected from bacteria, virus, fungus, and parasite. In some embodiments, the pathogen is a coronavirus (e.g., SARS, SARS-Cov-2, MERS) or influenza. In one embodiment, the pathogen is a SARS. In one embodiment, the pathogen is SARS-Cov-2. In one embodiment, the pathogen is a MERS. In one embodiment, the pathogen is influenza. In one embodiment, the pathogen is influenza A. In one embodiment, the pathogen is influenza B.

In some embodiment, the antibody or antigen binding portion thereof is an anti-viral antigen or antigen binding portion thereof. In some embodiments, the antibody or antigen binding portion thereof is a neutralizing antibody targeting a virus. In one embodiment, the antibody, or antigen binding portion thereof, is specific for SARS-CoV-2. In one embodiment, the antibody is an anti-CoV-2 monoclonal antibody. In one embodiment, the antibody, or antigen binding portion thereof, is specific for an influenza. In one embodiment, the antibody is an anti-influenza monoclonal antibody. In one embodiment, the antibody is the 5J8 monoclonal antibody. In one embodiment, the antibody, or antigen binding portion thereof, is specific for a cytokine. In one embodiment, the antibody is a humanized monoclonal antibody targeting human interleukin-5 (hIL-5). In one embodiment, the monoclonal antibody is mepolizumab.

In one embodiment, the at least one protein comprises at least one anti-SARS-CoV-2 monoclonal antibody, or antigen-binding portion thereof. In some embodiment, the anti-SARS-CoV-2 antibody, or antigen-binding portion thereof, comprises at least four, or at least eight, or at least 11, anti-SARS-CoV-2 antibodies and/or antigen-binding portions thereof. In one embodiment, the anti-SARS-CoV-2 comprises four antibodies. In one embodiment, the anti-SARS-CoV-2 comprises five antibodies. In one embodiment, the anti-SARS-CoV-2 comprises six antibodies. In one embodiment, the anti-SARS-CoV-2 comprises seven antibodies. In one embodiment, the anti-SARS-CoV-2 comprises eight antibodies. In one embodiment, the anti-SARS-CoV-2 comprises nine antibodies. In one embodiment, the anti-SARS-CoV-2 comprises ten antibodies. In one embodiment, the anti-SARS-CoV-2 comprises eleven antibodies. In one embodiment, the anti-SARS-CoV-2 comprises twelve antibodies. In specific embodiments, the at least one protein comprises one or more selected from the group consisting of: REGN10933, REGN10987, VIR-7831, LY-CoV1404, LY3853113, Zost 2355K, CV07-209K, C121L, Zost 2504L, CV38-183L, COVA215K, RBD215, CV07-250L, C144L, COVA118L, C135K, and B38.

In one embodiment, the at least one protein comprises REGN10933. In one embodiment, the at least one protein comprises REGN10987. In one embodiment, the at least one protein comprises VIR-7831. In one embodiment, the protein comprises LY-CoV1404. In one embodiment, the at least one protein comprises LY3853113. In at least one protein embodiment, the at least one protein comprises Zost 2355K. In one embodiment, the at least one protein comprises CV07-209K. In one embodiment, the at least one protein comprises C121L. In one embodiment, the at least one protein comprises Zost 2504L. In one embodiment, the at least one protein comprises CV38-183L. In one embodiment, the at least one protein comprises CV38-183L. In one embodiment, the at least one protein comprises COVA215K. In one embodiment, the at least one protein comprises RBD215. In one embodiment, the at least one protein comprises CV07-250L. In one embodiment, the at least one protein comprises C144L. In one embodiment, the protein comprises COVA118L. In one embodiment, the at least one protein comprises C135K. In one embodiment, the protein comprises B38. In one embodiment, the at least one protein comprises COVA118L. In some embodiments, the at least one protein is one or more selected from Table 5 and Table 7.

In alternative embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises a pathogenic antigen. In particular embodiments, the pathogenic antigen is processed to remove or reduce pathogenicity (i.e., ability to cause a disease or symptom). In some embodiments, the pathogenic antigen retains antigenicity (i.e., ability to illicit immune response targeting the pathogen).

In some embodiment, the at least one protein encoded by the nucleic acid molecule in the composition is selected from the group consisting of: human growth hormone, G-CSF protein (e.g., human GCSF), erythropoietin, Etanercept, Bevacizumab, Rituximab, Adalimumab, Infliximab, Trastuzumab, Insulin, Insulin glargine, Epoetin alfa, Pegfilgrastim, Ranibizumab, Darbepoetin alfa, Interferon beta-1a, Interferon beta-1a (Rebif), Insulin aspart, Rhu insulin, Octocog alfa, Insulin lispro, Cetuximab, Peginterferon alfa-2a, Interferon beta-1b, Eptacog alfa, Insulin aspart, OnabotulinumtoxinA, Epoetin beta, Rec antihemophilic factor, Filgrastin, Insulin detemir, Natalizumab, Insulin (humulin), ACE2, anti-SARS-CoV-2, anti-flu, anti-HIV and/or anti-malaria, Palivizumab, and a-galactosidase A (GLA) (e.g., human GLA). In some embodiments, the at least one protein comprises human GLA.

In one embodiment, the at least one protein encoded by the nucleic acid molecule comprises GLA-hyFc (SEQ ID NO:49). In one embodiment, the protein comprises GLA-1×L-hyFc (SEQ ID NO:50). In one embodiment, the protein comprises GLA-2×L-hyFc (SEQ ID NO:51). In one embodiment, the protein comprises GLA-3×L-hyFc (SEQ ID NO:52). In one embodiment, the protein comprises a linker peptide comprising the amino acid sequence of SEQ ID NO:27. In one embodiment, the protein comprises a linker peptide comprising the amino acid sequence of SEQ ID NO:28. In one embodiment, the protein expression level is affected by the length of the linker. In one embodiment, longer linker improves the expression level of protein.

In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises an antibody or an antigen binding portion of an antibody that targets an antigen associated with a diseased cell. In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises an antibody or an antigen binding portion of an antibody listed in Column A of Table 4. In alternative embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises an antigen associated with a diseased cell. In some embodiments, the at least one protein encoded by the nucleic acid molecule in the composition comprises a disease associated antigen listed in Column E of Table 4. In some embodiments, the antigen associated with the diseased cell is an antigen associated with a cancerous cell, such as a tumor cell. In some embodiments, the antigen that is targeted by the antibody or antigen binding portion thereof encoded by the nucleic acid in the composition is a tumor associated antigen. In some embodiments, the antigen that is encoded by the nucleic acid in the composition is a tumor associated antigen.

In specific embodiments, the at least one protein encoded comprises a linker peptide. In specific embodiment, the linker is 1× linker. In specific embodiment, the linker is a 2× linker. In specific embodiment, the linker comprises a sequence as set forth in SEQ ID NO: 27 or SEQ ID NO: 28.

In some embodiments, the vector further comprises one or more non-coding sequences. In one embodiment, the vector comprises an enhancer. In one embodiment, the enhancer is a murine CMV enhancer (M-CmvEnh) listed in Table 3B. In one embodiment, the enhancer is a human CMV enhancer (H-CmvEnh) listed in Table 3B. In some embodiment, the super-enhancer is selected from the enhancer sequences of hr3, SE1, SE2, SE3, SE4 or SE5 listed in Table 3B. In one embodiment, the plasmid comprises a super-enhancer.

In one embodiment, the vector comprises a promoter. In one embodiment, the promoter is selected from the promoter sequences of H-CMV, H-FerH, M-FABP2, H-CBOX1, H-REG1 and H-TDOX listed in Table 3B.

In one embodiment, the vector comprises at least one Matrix Attachment Region (MAR). In some embodiments, the MAR is selected from the MAR sequences of βGlo MAR and IFNβ S/MAR listed in Table 3B.

In one embodiment, the vector comprises a long terminal repeat (LTR). In some embodiments, the LTR is within an intron. In one embodiment, the LTR is selected from the LTR sequences of PPRV, MV, SNV and RU5 listed in Table 3B.

In one embodiment, the vector comprises a Nuclear Localization Sequence (NLS). In some embodiments, the vector comprises a MicroTubule-Associated Sequence (MTAS). In one embodiment, the plasmid comprises an NLS-MTAS as listed in Table 3B.

In specific embodiment, the vector comprises an enhancer. In specific embodiment, the enhancer comprises a sequence as set forth in SEQ ID NO: 16 or SEQ ID NO: 17. In specific embodiment, the vector as used herein comprises a promoter. In specific embodiment, the promoter comprises a sequence as set forth in SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25 or SEQ ID NO: 26. In specific embodiment, the vector as used herein comprises a matrix-attachment region (MAR). In specific embodiment, the MAR comprises a sequence as set forth in SEQ ID NO: 29, SEQ ID NO: 30 or SEQ ID NO: 31. In specific embodiment, the vector as used herein comprises a super-enhancer. In specific embodiment, the super-enhancer comprises a sequence as set forth in SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 37. In specific embodiment, the vector as used herein comprises a long-term repeat (LTR) within intron. In specific embodiment, the LTR comprises a sequence as set forth in SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40 or SEQ ID NO: 41. In specific embodiment, the vector as used herein comprises a nucleus localization sequence-microtubule-associated sequence (NLS-MTAS). In specific embodiment, the NLS-MTAS further comprises a hydrophilic linker and modified neck domain peptide (NDP). In specific embodiment, the NLS-MTAS comprises a sequence as set forth in SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44 or SEQ ID NO: 45.

In one embodiment, the nucleic acid sequence or vector is CPG-free. In one embodiment, the nucleic acid sequence or vector is CPG-reduced. In some embodiments, the present disclosure employs CpG-reduced or CpG-free nucleic acid sequences and/or expression vectors. An initial sequence that contains CpG dinucleotides (e.g., wild-type version of an anti-SARS-CoV-2 antibody), may be modified to remove CpG dinucleotides by altering the nucleic acid sequence. Such CpG di-nucleotides can be suitably reduced or eliminated not just in a coding sequence, but also in the non-coding sequences, including, e.g., 5′ and 3′ untranslated regions (UTRs), promoter, enhancer, polyA, ITRs, introns, and any other sequences present in the nucleic acid molecule or vector. CpG di-nucleotides may be located within a codon triplet for a selected amino acid. There are five amino acids (serine, proline, threonine, alanine, and arginine) that have one or more codon triplets that contain a CpG di-nucleotide. All five of these amino acids have alternative codons not containing a CpG di-nucleotide that can be changed to, to avoid the CpG but still code for the same amino acid as shown in Table 1 below. Therefore, the CpG di-nucleotides allocated within a codon triplet for a selected amino acid may be changed to a codon triplet for the same amino acid lacking a CpG di-nucleotide.

In one embodiment, 0.05-60 mg/mL of the vectors are present in the composition. In one embodiment, 0.05-0.5 mg/mL of the vectors are present in the composition. In one embodiment, 0.5-1 mg/mL of the vectors are present in the composition. In one embodiment, 1-10 mg/mL of the vectors are present in the composition. In one embodiment, 10-20 mg/mL of the vectors are present in the composition. In one embodiment, 20-30 mg/mL of the vectors are present in the composition. In one embodiment, 30-40 mg/mL of the vectors are present in the composition. In one embodiment, 40-50 mg/mL of the vectors are present in the composition. In one embodiment, 50-60 mg/mL of the vectors are present in the composition.

In one embodiment, the composition comprising a nucleic acid sequence encoding a protein or other BANEM is free of any reagents that serve as aids to transfection. In one embodiment, the composition is free of any reagents that serve as aids to transfection (e.g., the composition comprises water and the nucleic acid sequence or vector containing the nucleic acid sequence, and no other ingredients or only inert other ingredients).

In one embodiment, the composition comprising a nucleic acid sequence encoding a protein or other BANEM is free of transfection agents. In one embodiment, the composition is free of viral transfection agents. In one embodiment, the composition is free of non-viral transfection agents. In one embodiment, the composition is free of chemical-based transfection agents, such as cationic polymers. In one embodiment, the composition is free of DNA transfection agents. In one embodiment, the composition is free of RNA transfection agents.

In one embodiment, the composition comprising a nucleic acid sequence encoding a protein or other BANEM further comprises one or more carriers, excipients, or diluents.

In some embodiments, the composition further comprises a sugar. In some embodiments, the sugar is selected from glucose, mannose, and dextrins. In some embodiments, the composition further comprises water for injection.

In some embodiments, the composition comprises a saline solution. In one embodiment, the composition comprises hypertonic saline. In one embodiment, the composition comprises the nucleic acid molecule dissolved in a Ringer's solution. In one embodiment, the composition comprises the nucleic acid molecule dissolved in a Lactated Ringer's solution. In one embodiment, the composition comprises the nucleic acid molecule dissolved in a hypotonic Ringer's solution. In one embodiment, the composition comprises the nucleic acid molecule dissolved in a hypotonic Lactated Ringer's solution.

In one embodiment, the composition comprises a hypertonic saline. In one embodiment, the composition comprises 3% (w/w) hypertonic saline. In one embodiment, the composition comprises 4% (w/w) hypertonic saline. In one embodiment, the composition comprises 5% (w/w) hypertonic saline. In one embodiment, the composition comprises 6% (w/w) hypertonic saline. In one embodiment, the composition comprises 7% (w/w) hypertonic saline. In one embodiment, the composition comprises 3% (w/w) hypertonic Ringer's solution. In one embodiment, the composition comprises 4% (w/w) hypertonic Ringer's solution. In one embodiment, the composition comprises 5% (w/w) hypertonic Ringer's solution. In one embodiment, the composition comprises 6% (w/w) hypertonic Ringer's solution. In one embodiment, the composition comprises 7% (w/w) hypertonic Ringer's solution. In one embodiment, the hypertonic solution is a 2× isotonic Ringer's solution, 2.5× isotonic Ringer's solution, 3× isotonic Ringer's solution, 4× isotonic Ringer's solution, 5× isotonic Ringer's solution, 6× isotonic Ringer's solution, or 7× isotonic Ringer's solution.

In one embodiment, the composition comprising a nucleic acid sequence encoding a protein or other BANEM further comprises a second active ingredient. In alternative embodiments, the composition comprising a nucleic acid sequence encoding a protein or other BANEM is used in combination with a second composition (e.g., a pre-treatment composition as described herein) comprising a second active ingredient. In some embodiments, the second active ingredient aids expression of the nucleic acid encoding the protein or other BANEM in the composition. In some embodiments, the second active ingredient reduces degradation of the nucleic acid encoding the protein or other BANEM in the composition. In some embodiments, the second active ingredient increases transportation of the nucleic acid encoding the protein or other BANEM into the cells. In some the second active ingredient increases permeability of cell membranes. In some embodiments, the second active ingredient is an anti-inflammation agent. In specific embodiments, the second ingredient is selected from lipids, dexamethasone, hyaluronidase, chloroquine, and TGF-β3.

In specific embodiments, the composition comprising a nucleic acid sequence encoding a protein or other BANEM further comprises hyaluronidase. In specific embodiments, hyaluronidase is comprised in the composition in the amount of at least 10 units, at least 20 units, at least 30 units, at least 40 units, at least 50 units, at least 60 units, at least 70 units, at least 80 units, at least 90 units, at least 100 units, at least 120 units, at least 140 units, at least 150 units, at least 200 units, or at least 300 units.

Methods of Administration

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises at least one of the following:

a) injecting the composition into one or more subcutaneous regions of the subject (e.g., fat pad, buttocks, stomach, etc.) such that the at least one protein, or the at least one biologically active nucleic acid encoded molecule, is detectable in a blood, serum, or plasma sample from the subject; and/or

b) injecting the composition into one or more subcutaneous regions of the subject such that a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in the subcutaneous region(s);

c) performing the following:

-   -   i) contacting a plurality of the pre-adipocytes and/or         adipocytes from the subject ex-vivo with the composition such         that a plurality of ex-vivo transfected pre-adipocytes and/or         adipocytes are generated, and     -   ii) injecting at least some of the plurality of ex-vivo         transfected pre-adipocytes and/or adipocytes into one or more         subcutaneous regions of the subject; and/or

d) implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject.

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises injecting the composition into one or more subcutaneous regions of the subject (e.g., fat pad, buttocks, stomach, etc.) such that the at least one protein, or the at least one biologically active nucleic acid encoded molecule, is detectable in a blood, serum, or plasma sample from the subject.

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises injecting the composition into one or more subcutaneous regions of the subject such that a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in the subcutaneous region(s).

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises:

i) contacting a plurality of the pre-adipocytes and/or adipocytes from the subject ex-vivo with the composition such that a plurality of ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and

ii) injecting at least some of the plurality of ex-vivo transfected pre-adipocytes and/or adipocytes into one or more subcutaneous regions of the subject.

In one embodiment, the method comprises the injection of ex-vivo transfected pre-adipocytes or adipocytes into a subject. In one embodiment, the method further comprises the use of ex-vivo transfected pre-adipocytes or adipocytes as cell therapies. In some embodiments, the pre-adipocytes or adipocytes are isolated from a subject, ex-vivo transfected and then transferred back to the same subject. In alternative embodiments, the pre-adipocytes or adipocytes are isolated from a donor subject, ex-vivo transfected, and then transferred to a different recipient subject.

In one embodiment, the ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 60 pg of lipid (e.g., at least 60 . . . 70 . . . 90 . . . 100 . . . 110 ug . . . etc.). In further embodiments, the plurality of the ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 80 ug of lipid (e.g., at least 90 . . . 100 . . . 110 ug . . . etc.). In further embodiments, the plurality of the ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 70 μm (e.g., at least 70 . . . 80 . . . 90 . . . 100 . . . 110 μm). In additional embodiments, the plurality of the ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 90 μm (e.g., at least 90 . . . 100 . . . 110 . . . 120 μm).

In certain embodiments, the transfected and enlarged adipocytes contain, on average, at least 60 μg of lipid (e.g., 60 . . . 70 . . . 80 . . . 90 . . . ug). In some embodiments, the plurality transfected pre-adipocytes and/or adipocytes contain, on average, at least 80 μg of lipid. In other embodiments, the transfected pre-adipocytes and/or adipocytes have, on average, a diameter of at least 70 μm. In additional embodiments, the transfected pre-adipocytes and/or adipocytes have, on average, a diameter of at least 90 μm. In additional embodiments, the transfected pre-adipocytes and/or adipocytes are derived from one or more subcutaneous regions of a subject.

In one embodiment, the plurality of ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 60 μg of lipid. In one embodiment, they contain at least 65 μg of lipid. In one embodiment, they contain at least 70 μg of lipid. In one embodiment, they contain at least 70 μg of lipid. In one embodiment, they contain at least 75 μg of lipid. In one embodiment, they contain at least 80 μg of lipid. In one embodiment, they contain at least 85 μg of lipid. In one embodiment, they contain at least 90 μg of lipid. In one embodiment, they contain at least 95 μg of lipid. In one embodiment, they contain at least 100 μg of lipid. In one embodiment, they contain at least 110 μg of lipid. In one embodiment, they contain at least 120 μg of lipid. In one embodiment, they contain at least 130 μg of lipid. In one embodiment, they contain at least 150 μg of lipid. In one embodiment, they contain at least 200 μg of lipid.

In one embodiment, the plurality of ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 70 μm. In one embodiment, they have a diameter of at least 75 μm. In one embodiment, they have a diameter of at least 80 μm. In one embodiment, they have a diameter of at least 85 μm. In one embodiment, they have a diameter of at least 90 μm. In one embodiment, they have a diameter of at least 95 μm. In one embodiment, they have a diameter of at least 100 μm. In one embodiment, they have a diameter of at least 120 μm. In one embodiment, they have a diameter of at least 150 μm. In one embodiment, they have a diameter of at least 200 μm. In one embodiment, they have a diameter of at least 250 μm.

In one embodiment, the plurality of ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 90 μm.

In one embodiment, the ex-vivo transfected pre-adipocytes and/or adipocytes have normal sizes.

In one embodiment, provided herein is a method comprising: treating a subject, and/or the subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein the composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein (e.g., one, two, three, four, five, six, or more proteins), or at least one biologically active nucleic acid molecule (e.g., one, two, three, four, five, six, or more biologically active nucleic acid molecules), and wherein the treating comprises implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject.

In some embodiments, the treating comprises implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject, and wherein the at least one protein, or the at least one biologically active nucleic acid encoded molecule, is detectable in a blood, serum, or plasma sample from the subject. In some embodiments, the treating comprises implanting a solid medium carrying the composition into one or more subcutaneous regions of the subject, and wherein a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in the subcutaneous region(s).

In some embodiments, the implanting is performed via an incision surgery. In some embodiments, the solid medium carrying the composition is a biocompatible membrane. In some embodiments, the solid medium carrying the composition is a biocompatible hydrogel. In some embodiments, the solid medium carrying the composition comprises nanoparticles. In some embodiments, the solid medium carrying the composition is configured for slow release of the composition at the site of implantation. In some embodiments, the site of implantation comprises at least one fat tissue. In some embodiments, the site of implantation comprises at least one fat cell. In some embodiments, the site of implantation comprises at least one pre-adipocyte. In some embodiments, the site of implantation comprises at least one adipocyte.

According to the present disclosure, the injecting in a), b), or c) ii) or the implanting in d) can be performed once or multiple times to a single subject. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed once. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed twice. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed three times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed four times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed five times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed six times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed seven times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed eight times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed nine times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed ten times. In one embodiment, the injecting in a), b), or c) ii) or the implanting in d) is performed more than ten times.

In some embodiments, the injecting in a), b), or c) ii) or the implanting in d) is performed multiple times at a frequency of once per day, or once per every two days, or once per every three days, or once per every four days, or once per every five days, or once per every six days, or once per week, or biweekly, or monthly, or once every two months, or once every three months, or once every four months, or once every five months, or twice a year, or annually, or other repeating frequencies.

In one embodiment, 1-1000 mg of the vectors are administrated. In one embodiment, 1-50 mg of the vectors are administrated. In one embodiment, 50-100 mg of the vectors are administrated. In one embodiment, 100-200 mg of the vectors are administrated. In one embodiment, 200-300 mg of the vectors are administrated. In one embodiment, 300-400 mg of the vectors are administrated. In one embodiment, 400-500 mg of the vectors are administrated. In one embodiment, 500-600 mg of the vectors are administrated. In one embodiment, 600-700 mg of the vectors are administrated. In one embodiment, 700-800 mg of the vectors are administrated. In one embodiment, 800-900 mg of the vectors are administrated. In one embodiment, 900-1000 mg of the vectors are administrated.

In one embodiment, a composition comprising the nucleic acid encoding at least one protein or other BANEM or a composition comprising ex-vivo transfected adipocytes or preadipocytes is injected or transplanted subcutaneously to a subject. In some embodiments, the composition is injected or transplanted subcutaneously and become accessible to at least one fat tissue in the subject. In some embodiments, the composition is injected or transplanted subcutaneously and become accessible to a population of preadipocytes in the subject. In some embodiments, the composition is injected or transplanted subcutaneously and become accessible to a population of adipocytes in the subject.

In one embodiment, the composition comprising the nucleic acid encoding at least one protein or other BANEM or a composition comprising ex-vivo transfected adipocytes or preadipocytes is injected or transplanted into one or more subcutaneous regions of a subject. In one embodiment, the composition is injected or transplanted into two subcutaneous regions. In one embodiment, the composition is injected or transplanted into three subcutaneous regions. In one embodiment, the composition is injected or transplanted into four subcutaneous regions. In one embodiment, the composition is injected or transplanted into five subcutaneous regions. In one embodiment, the composition is injected or transplanted into six subcutaneous regions. In one embodiment, the composition is injected or transplanted into seven subcutaneous regions. In one embodiment, the composition is injected or transplanted into eight or more subcutaneous regions.

In one embodiment, the subcutaneous region is in a fat pad. In one embodiment, the subcutaneous region is in buttock. In one embodiment, the subcutaneous region is in stomach.

In one embodiment, the composition is implanted at site of incision. In one embodiment, the incision is at the dermal layer of a subject's skin. In one embodiment, the incision extends beyond the dermal layer of a subject's skin. In one embodiment, the site of incision exposes adipocytes or pre-adipocytes. In one embodiment, the composition contacts the adipocytes or pre-adipocytes at site of incision. In one embodiment, the composition contacts basal cells at site of incision. In one embodiment, the composition contacts melanocytes at site of incision.

In one embodiment, the injecting in a), b), or c) ii) is into a fat pad of the subject. In one embodiment, the injecting is into a first fat pad of the subject. In one embodiment, the injecting is into a second fat pad of the subject. In one embodiment, the injecting is into a third fat pad of the subject. In one embodiment, the injecting is into a fourth fat pad of the subject. In one embodiment, the injecting is into a fifth fat pad of the subject. In one embodiment, the injecting in a), b), or c) ii) is into the same fat pad of the subject. In one embodiment, the injecting in a), b), or c) ii) is into different fat pads of the subject.

In one embodiment, the injecting in a), b), or c) ii) or the implantation in d) is performed at a plurality of sites in the subject. In additional embodiments, the injecting in a) and/or b) causes the subject to receive between 1 and 60 micrograms (e.g., 1.0 . . . 10 . . . 20 . . . 30 . . . 40 . . . 50 . . . or 60 micrograms), or between 0.00001 and 1.0 micrograms (e.g., 0.00001 . . . 0.0001 . . . 0.001 . . . 0.01 . . . 0.1 . . . and 1.0 micrograms), per microliter of the composition (e.g., aqueous composition) of the nucleic acid sequence, or the vector containing the nucleic acid sequence.

In one embodiment, wherein injection in a) and/or b) causes the subject to receive between 1 and 60 micrograms (μg), or between 0.00001 and 1.0 micrograms (μg), per microliter (μL) of the composition of the nucleic acid sequence, or the vector containing the nucleic acid sequence. In one embodiment, the subject receives 1 to 5 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 0.00001 to 0.0001 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 0.0001 to 0.001 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 0.001 to 0.01 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 0.01 to 0.1 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 0.1 to 1 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 1 to 5 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 5 to 10 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 10 to 15 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 15 to 20 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 20 to 25 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 25 to 30 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 30 to 35 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 35 to 40 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 40 to 45 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 45 to 50 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 50 to 60 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 1 μg/μL of nucleic acid in the composition.

In one embodiment, the subject receives 2 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 4 μg/μL of nucleic acid in the composition. In one embodiment, the subject receives 8 μg/μL of nucleic acid in the composition.

In one embodiment, the injection in a), b), or c) ii) or the implantation of d) is performed at a plurality of sites in the subject. In one embodiment, the injection is performed at a single site in the subject. In one embodiment, the injection is performed at two sites in the subject. In one embodiment, the injection is performed at two sites in the subject.

Pre-Treatment

In one embodiment, the methods further comprise one or more pre-treatment process, prior to the injecting in a), b), or c) ii) or the implantation of d).

In one embodiment, the methods further comprise, prior to the injecting in a), b), or c) ii) or the implantation of d) administering a pre-treatment solution.

In one embodiment, the pre-treatment solution comprises cationic liposomes. In one embodiment, the pre-treatment solution comprises neutral liposomes. In one embodiment, the pre-treatment solution comprises both cationic liposomes and neutral liposomes. In one embodiment, the liposome comprises Small Unilamellar Vesicles (SUV). In one embodiment, the liposome comprises Multilamellar Vesicles (MLV). In one embodiment, the pre-treatment solution comprises SUV. In one embodiment, the pre-treatment solution comprises MLV. In one embodiment, the pre-treatment solution comprises SUV. In one embodiment, the pre-treatment solution comprises a mixture of SUV and MLV. In one embodiment, the pre-treatment solution comprises a mixture of cationic SUV and neutral MLV. In one embodiment, the pre-treatment solution comprises a mixture of DOTAP SUV and DMPC MLV.

In one embodiment, the pre-treatment solution comprises a micelle. In one embodiment, the pre-treatment solution comprises an emulsion. In one embodiment, the pre-treatment solution comprises an empty micelle. In one embodiment, the pre-treatment solution comprises an empty emulsion.

In one embodiment, the pre-treatment solution comprises an anti-inflammatory agent (AIL). In some embodiments, the anti-inflammatory agent is selected from the group consisting of: dexamethasone, dexamethasone palmitate, a dexamethasone fatty acid ester, Docosahexaenoic Acid (DHA), Eicosapenaenoic Acid (EPA), Alpha Linolenic Acid (ALA), Lipoxin A4 (LA4), 15-deoxy-12,14-Prostaglandin J2 (15d), Arachidonic Acid (AA), Docosapentaenoic Acid (DPA), Retinoic Acid (RA), Diallyl Disulfide (DADS), Oleic Acid (OA), Alpha Tocopherol (AT), Sphingosine-1-Phosphate (S-1-P), Palmitoyl Sphingomyelin (SPH), an anti-TNFa antibody or antigen binding fragment thereof, a heparinoid, N-Acetyl-De-O-Sulfated Heparin, Chloroquine, and TGF-β3. In some embodiments, the anti-inflammatory agent is a lymphocyte depletion agent.

In one embodiment, the pre-treatment solution comprises liposome and anti-inflammatory agent. In one embodiment, the liposome and anti-inflammatory agent are injected together. In one embodiment, the liposome and anti-inflammatory agent are injected separated. In one embodiment, the anti-inflammatory agent is injected before the liposome. In one embodiment, the anti-inflammatory agent is injected after the liposome.

In one embodiment, the pre-treatment solution comprises Chloroquine.

In one embodiment, the pre-treatment solution comprises TGF-β3. In some embodiments, the pre-treatment solution comprises at least 10 ng, at least 20 ng, at least 30 ng, at least 40 ng, at least 50 ng, at least 100 ng, at least 150 ng, at least 200 ng, at least 250 ng, at least 300 ng, at least 500 ng TGF-β3.

In one embodiment, the pre-treatment solution comprises one or more lymphocyte depleting agent. In some embodiments, the lymphocyte depleting agent comprises one or more antibodies. In some embodiments, the lymphocyte depleting agent reduces matured B cell and/or T cell from the subject after administration.

In one embodiment, the pre-treatment solution comprises dexamethasone and/or dexamethasone palmitate. In one embodiment, the dexamethasone is water-soluble dexamethasone. In one embodiment, the dexamethasone is complexed to cyclodextrin to make it soluble in water. In one embodiment, the dexamethasone palmitate is dexamethasone 21-palmitate. In one embodiment, the dexamethasone palmitate is attached to a liposome. In one embodiment, the dexamethasone 21-palmitate is attached to a liposome. In one embodiment, the dexamethasone 21-palmitate is attached to a cationic liposome. In one embodiment, the dexamethasone 21-palmitate is attached to a neutral liposome. In one embodiment, the pre-treatment solution comprises liposome comprising dexamethasone palmitate. In one embodiment, the pre-treatment solution comprises cationic liposome comprising dexamethasone palmitate.

In one embodiment, the pre-treatment solution comprises neutral liposome comprising dexamethasone palmitate. In one embodiment, the pre-treatment solution comprises a mixture of cationic liposome comprising dexamethasone palmitate and neutral liposome comprising dexamethasone palmitate. In one embodiment, the pre-treatment solution comprises a mixture of cationic SUV comprising dexamethasone palmitate and neutral MLV comprising dexamethasone palmitate. In one embodiment, the pre-treatment solution comprises a mixture of DOTAP SUV comprising dexamethasone palmitate and DMPC MLV comprising dexamethasone palmitate.

In one embodiment, the pre-treatment solution is free or essentially free of nucleic acid.

In one embodiment, the liposome and dexamethasone are injected together. In one embodiment, the liposome and dexamethasone palmitate are injected together. In one embodiment, the liposome and dexamethasone are injected separately. In one embodiment, the dexamethasone is injected before the liposome. In one embodiment, the dexamethasone is injected after the liposome.

In one embodiment, the administration of the cationic and/or neutral liposomes is performed intravenously or subcutaneously. In one embodiment, the liposomes are administrated intravenously. In one embodiment, the liposomes are administrated subcutaneously. In one embodiment, the liposomes are administrated intranasally. In one embodiment, the liposomes are administrated intraperitoncally. In one embodiment, the liposomes are administrated intramuscularly. In one embodiment, the liposomes are administrated intratracheally. In one embodiment, the liposomes are administrated intradermally,

In one embodiment, the pre-treatment process further comprises injecting a nucleic acid. In one embodiment, the pre-treatment process further comprises injecting a DNA. In one embodiment, the pre-treatment process further comprises injecting a plasmid DNA. In one embodiment, the pre-treatment process further comprises injecting a nucleic acid intravenously. In one embodiment, the pre-treatment process further comprises injecting a plasmid DNA intravenously.

In one embodiment, the pre-treatment process comprises injecting a liposome, followed by injecting a nucleic acid. In one embodiment, the pre-treatment process comprises injecting a liposome intravenously, followed by injecting a nucleic acid intravenously. In one embodiment, the pre-treatment process comprises injecting a liposome comprising dexamethasone intravenously, followed by injecting a nucleic acid intravenously. In one embodiment, the pre-treatment process comprises injecting a mixture of cationic liposome comprising dexamethasone and a neutral liposome comprising dexamethasone intravenously, followed by injecting a nucleic acid intravenously.

In some embodiments, an agent, such as an anti-inflammatory agent or bioactive lipid, is used to increase the expression level and/or duration of any the therapeutic protein (or biologically active nucleic acid molecules) expressed from the vectors in the methods herein. In certain embodiments, anti-inflammatory agents (AILs) and bioactive lipids in Table 6 below can be used in the compositions and pre-treatment solutions herein. In some embodiments, the anti-inflammatory agent is selected from the group consisting of: dexamethasone, dexamethasone palmitate, a dexamethasone fatty acid ester, Docosahexaenoic Acid (DHA), Eicosapenaenoic Acid (EPA), Alpha Linolenic Acid (ALA), Lipoxin A4 (LA4), 15-deoxy-12,14-Prostaglandin J2 (15d), Arachidonic Acid (AA), Docosapentaenoic Acid (DPA), Retinoic Acid (RA), Diallyl Disulfide (DADS), Oleic Acid (OA), Alpha Tocopherol (AT), Sphingosine-1-Phosphate (S-1-P), Palmitoyl Sphingomyelin (SPH), an anti-TNFa antibody or antigen binding fragment thereof, a heparinoid, and N-Acetyl-De-O-Sulfated Heparin. In one embodiment, the anti-inflammatory agent is dexamethasone. In one embodiment, the anti-inflammatory agent is dexamethasone palmitate. In one embodiment, the anti-inflammatory agent is a dexamethasone fatty acid ester. In one embodiment, the anti-inflammatory agent is TGF-β3.

In certain embodiments, the present disclosure employs polycationic structures (e.g., empty cationic liposomes, empty cationic micelles, or empty cationic emulsions) not containing vector DNA, which are administered to a subject prior to administration of the composition containing the nucleic acid or vector containing the nucleic acid. In certain embodiments, the polycationic structures are cationic lipids and/or are provided as an emulsion. The present disclosure is not limited to the cationic lipids employed, which can be composed, in some embodiments, of one or more of the following: DDAB, dimethyldioctadecyl ammonium bromide; DPTAP (1,2-dipalmitoyl 3-trimethylammonium propane); DHA; prostaglandin, N-[1-(2,3-Dioloyloxy)propyl]-N,N,N-trimethylammonium methylsulfate; 1,2-diacyl-3-trimethylammonium-propanes, (including but not limited to, dioleoyl (DOTAP), dimyristoyl, dipalmitoyl, disearoyl); 1,2-diacyl-3-dimethylammonium-propanes, (including but not limited to, dioleoyl, dimyristoyl, dipalmitoyl, disearoyl) DOTMA, N-[1-[2,3-bis(oleoyloxy)]propyl]-N,N,N-trimethylammoniu-m chloride; DOGS, dioctadecylamidoglycylspermine; DC-cholesterol, 3.beta.-[N—(N′,N′-dimethylaminoethane)carbamoyl]cholesterol; DOSPA, 2,3-dioleoyloxy-N-(2(sperminecarboxamido)-ethyl)-N,N-dimethyl-1-propanami-nium trifluoroacetate; 1,2-diacyl-sn-glycero-3-ethylphosphocholines (including but not limited to dioleoyl (DOEPC), dilauroyl, dimyristoyl, dipalmitoyl, distearoyl, palmitoyl-oleoyl); beta-alanyl cholesterol; CTAB, cetyl trimethyl ammonium bromide; diC14-amidine, N-t-butyl-N′-tetradecyl-3-tetradecylaminopropionamidine; 14Dea2, O,O′-ditetradecanolyl-N-(trimethylammonioacetyl) diethanolamine chloride; DOSPER, 1,3-dioleoyloxy-2-(6-carboxy-spermyl)-propylamide; N,N,N′,N′-tetramethyl-N,N′-bis(2-hydroxylethyl)-2,3-dioleoyloxy-1,4-butan-ediammonium iodide; 1-[2-acyloxy)ethyl]2-alkyl (alkenyl)-3-(2-hydroxyethyl-) imidazolinium chloride derivatives such as 1-[2-(9(Z)-octadecenoyloxy)eth-yl]-2-(8(Z)-heptadecenyl-3-(2-hydroxyethyl)imidazolinium chloride (DOTIM), 1-[2-(hexadecanoyloxy)ethyl]-2-pentadecyl-3-(2-hydroxyethyl)imidazolinium chloride (DPTIM); 1-[2-tetradecanoyloxy)ethyl]-2-tridecyl-3-(2-hydroxyeth-yl)imidazolium chloride (DMTIM) (e.g., as described in Solodin et al. (1995) Biochem. 43:13537-13544, herein incorporated by reference); 2,3-dialkyloxypropyl quaternary ammonium compound derivates, containing a hydroxyalkyl moiety on the quaternary amine, such as 1,2-dioleoyl-3-dimethyl-hydroxyethyl ammonium bromide (DORI); 1,2-dioleyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide (DORIE); 1,2-dioleyloxypropyl-3-dimethyl-hydroxypropyl ammonium bromide (DORIE-HP), 1,2-dioleyloxypropyl-3-dimethyl-hydroxybutyl ammonium bromide (DORIE-HB); 1,2-dioleyloxypropyl-3-dimethyl-hydroxypentyl ammonium bromide (DORIE-HPe); 1,2-dimyristyloxypropyl-3-dimethyl-hydroxylethyl ammonium bromide (DMRIE); 1,2-dipalmityloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide (DPRIE); 1,2-disteryloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide (DSRIE) (e.g., as described in Felgner et al. (1994) J. Biol. Chem. 269:2550-2561, herein incorporated by reference in its entirety). Many of the above-mentioned lipids are available commercially from, e.g., Avanti Polar Lipids, Inc.; Sigma Chemical Co.; Molecular Probes, Inc.; Northern Lipids, Inc.; Roche Molecular Biochemicals; and Promega Corp.

In certain embodiments, the neutral lipids employed (e.g., pre-injected prior to any subcutaneous injections) with the methods, compositions, systems, and kits includes diacylglycerophosphorylcholine wherein the acyl chains are generally at least 12 carbons in length (e.g., 12 . . . 14 . . . 20 . . . 24 . . . or more carbons in length) and may contain one or more cis or trans double bonds. Examples of the compounds include, but are not limited to, distearoyl phosphatidyl choline (DSPC), dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), palmitoyl oleoyl phosphatidylcholine (POPC), palmitoyl stearoyl phosphatidylcholine (PSPC), egg phosphatidylcholine (EPC), hydrogenated or non-hydrogenated soya phosphatidylcholine (HSPC), or sunflower phosphatidylcholine.

In certain embodiments, the neutral lipids include, for example, up to 70 mol diacylglycerophosphorylethanolamine/100 mol phospholipid (e.g., 10/100 mol 25/100 mol . . . 50/100 . . . 70/100 mol). In some embodiments, the diacylglycerophosphorylethanolamine has acyl chains that are generally at least 12 carbons in length (e.g., 12 . . . 14 . . . 20 . . . 24 . . . or more carbons in length), and may contain one or more cis or trans double bonds. Examples of such compounds include, but are not limited to distearoylphosphatidylethanolamine (DSPE), dimyristoylphosphatidylethanolamine (DMPE), dipalmitoylphosphatidylethanolamine (DPPE), palmitoyloleoylphosphatidylethanolamine (POPE), egg phosphatidylethanolamine (EPE), and transphosphatidylated phosphatidylethanolamine (t-EPE), which can be generated from various natural or semisynthetic phosphatidylcholines using phospholipase D.

In one embodiment, the cationic and neutral lipids (e.g., in the pre-treatment solution) are selected from the group consisting of: distearoyl phosphatidyl choline (DSPC); hydrogenated or non-hydrogenated soya phosphatidylcholine (HSPC); distearoylphosphatidylethanolamine (DSPE); egg phosphatidylcholine (EPC); 1,2-Distearoyl-sn-glycero-3-phospho-rac-glycerol (DSPG); dimyristoyl phosphatidylcholine (DMPC); 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG); 1,2-Dipalmitoyl-sn-glycero-3-phosate (DPPA); trimethylammonium propane lipids; DOTIM (1-[2-9(2)-octadecenoylloxy)ethyl]-2-(8(2)-heptadecenyl)-3-(2-hydroxyethyl) midizolinium chloride) lipids; and mixtures of two or more thereof.

In one embodiment, the cationic and neutral lipids are selected from the group consisting of: DOTAP (1,2-dioleoyl-3-trimethylammonium-propane); distearoyl phosphatidyl choline (DSPC); hydrogenated or non-hydrogenated soya phosphatidylcholine (HSPC); distearoylphosphatidylethanolamine (DSPE); egg phosphatidylcholine (EPC); 1,2-Distearoyl-sn-glycero-3-phospho-rac-glycerol (DSPG); dimyristoyl phosphatidylcholine (DMPC); 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG); 1,2-Dipalmitoyl-sn-glycero-3-phosphate (DPPA); trimethylammonium propane lipids; DOTIM (1-[2-9(2)-octadecenoylloxy)ethyl]-2-(8(2)-heptadecenyl)-3-(2-hydroxyethyl) midizolinium chloride) lipids; and mixtures of two or more thereof.

In one embodiment, the lipid comprises DOTAP. In one embodiment, the lipid comprises DMPC.

In some embodiments, the polycationic structure or cationic liposomes comprise lipids selected from the group consisting of: 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP); 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC); 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS); and 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-L-serine.

In one embodiment, the polycationic structure or cationic liposome further comprises an anti-inflammatory agent. In one embodiment, the polycationic structure or cationic liposome further comprises dexamethasone or dexamethasone palmitate. In one embodiment, the polycationic structure or cationic liposome further comprises dextrose. In one embodiment, the amount of dextrose is 1-20% (w/w). In one embodiment, the amount of dextrose is 1-10% (w/w).

In one embodiment, the amount of dextrose is 1-5% (w/w). In one embodiment, the amount of dextrose is 5% (w/w).

In some embodiments, prior to the injecting, the subject is treated with dexamethasone fatty acid ester.

In some embodiments, the dexamethasone fatty acid ester employed has the following Formula:

wherein R¹ is C₅-C₂₃ alkyl or C₅-C₂₃ alkenyl.

In one embodiment, the dexamethasone fatty acid ester is dexamethasone palmitate. In one embodiment, the dexamethasone fatty acid ester is dexamethasone acetate.

In one embodiment, the pre-treatment solution comprises water soluble dexamethasone. In one embodiment, the pre-treatment solution comprises dexamethasone-cyclodextrin inclusion complex (see Sigma Aldrich SKU D2915). In one embodiment, the pre-treatment solution comprises dexamethasone sodium phosphate.

In some embodiments, the subject has lung, cardiovascular, and/or multi-organ inflammation. In some embodiments, the subject is on a ventilator. In some embodiments, the composition further comprises a physiologically tolerable buffer or intravenous solution. In other embodiments, the composition further comprises lactated Ringer's solution or saline solution.

In one embodiment, the composition further comprises a physiologically tolerable buffer or intravenous solution.

In some embodiments, prior to the administration of the nucleic acid encoding the at least one protein or the BANEM, the method further comprises administering a solution to the subject comprising liposomes comprising the polycationic structures, wherein the liposomes further comprising one or more macrophage targeting moieties selected from the group consisting of: mannose moieties, maleimide moieties, a folate receptor ligand, folate, folate receptor antibody or fragment thereof, formyl peptide receptor ligands, N-formyl-Met-Leu-Phe, tetrapeptide Thr-Lys-Pro-Arg, galactose, lactobionic acid, a lipid bi-layer integrating peptide and/or a target peptide.

In some embodiments, a fatty acid ester of dexamethasone is employed. In some embodiments, the fatty acid ester is a C₆-C₂₄ fatty acid ester, such as hexanoate (caproate), heptanoate (enanthate), octanoate (caprylate), nonanoate (pelargonate), decanoate (caprate), undecanoate, dodecanoate (laurate), tetradecanoate (myristate), octadecenoate (stearate), icosanoate (arachidate), docosanoate (behenate), and tetracosanoate (lignocerate). Accordingly, in some embodiments, the compound is selected from dexamethasone caproate, dexamethasone enanthate, dexamethasone caprylate, dexamethasone pelargonate, dexamethasone caprate, dexamethasone undecanoate, dexamethasone laurate, dexamethasone myristate, dexamethasone palmitate, dexamethasone stearate, dexamethasone arachidate, dexamethasone behenate, and dexamethasone lignocerate.

Therapeutic Use

In some embodiment, the method is used for treating, managing or preventing a disease, a condition or a symptom in a subject.

In some embodiments, the method is used for treating, managing or preventing lipid storage disorders. In one embodiment, the method is used for treating, managing or preventing Fabry disease. In one embodiment, the method is used for treating, managing or preventing Gaucher disease. In one embodiment, the method is used for treating, managing or preventing multiple sulfatase deficiency. In one embodiment, the method is used for treating, managing or preventing Farber's lipogranulomatosis. In one embodiment, the method is used for treating, managing or preventing Niemann-Pick disease. In one embodiment, the method is used for treating, managing or preventing Wolman disease. In one embodiment, the method is used for treating, managing or preventing lysosomal storage disorders. In one embodiment, the method is used for treating, managing or preventing Galactosialidosis. In one embodiment, the method is used for treating, managing or preventing Schindler disease. In one embodiment, the method is used for treating Fucosidosis. In one embodiment, the method is used for treating, managing or preventing Pompe disease. In some embodiments, the method is used for treating, managing or preventing Tay-Sachs disease. In some embodiments, the method is used for treating, managing or preventing Sandhoff's disease. In some embodiments, the method is used for treating, managing or preventing metachromatic leukodystrophy. In some embodiments, the method is used for treating, managing or preventing cholesterol ester storage disease. In some embodiments, the method is used for treating, managing or preventing type 2 diabetes. In some embodiments, the method is used for treating, managing or preventing non-alcoholic or alcoholic fatty liver disease. In some embodiments, the method is used for treating, managing or preventing cancers.

In one embodiment, the method is used for treating, managing or preventing infectious diseases caused by a pathogen. In some embodiments the infectious pathogen is selected from virus, bacteria, fungi or parasite. In one embodiment, the method is used for treating, managing or preventing viral infection. In one embodiment, the method is used for treating, managing or preventing SARS-Cov-2 infection. In one embodiment, the method is used for treating, managing or preventing influenza infection. In one embodiment, the method is used for treating, managing or preventing influenza A infection. In one embodiment, the method is used for treating, managing or preventing influenza B infection.

In one embodiment, the method is used for treating, managing or preventing a genetic disease. In some embodiments, the method is used for treating, managing or preventing a cancer.

In other embodiment, the method is used for treating, managing or preventing conditions as listed in column F of Table 4.

In one embodiment, the subject is a human or livestock. In one embodiment, the subject is a human.

In one embodiment, the subject is overweight by BMI standards (e.g., a BMI of 25 . . . 27 . . . 29, 30 . . . 35 . . . 40 or more) and/or is overweight or obese (e.g., clinically obese). In some embodiments, the injecting (e.g., with a syringe) in a), b), or c) ii) is into a fat pad of the subject (e.g., a location where millions of pre-adipocytes and/or adipocytes are located).

In one embodiment, the subject is overweight by BMI standards and/or is clinically obese. In one embodiment, described here in a method of treatment a subject that is overweight.

In one embodiment, the subject is overweight by BMI standards. In one embodiment, the subject has a BMI of at least 25. In one embodiment, the subject has a BMI of at least 26. In one embodiment, the subject has a BMI of at least 27. In one embodiment, the subject has a BMI of at least 28. In one embodiment, the subject has a BMI of at least 29. In one embodiment, the subject has a BMI of at least 30. In one embodiment, the subject has a BMI of at least 32. In one embodiment, the subject has a BMI of at least 34. In one embodiment, the subject has a BMI of at least 36. In one embodiment, the subject has a BMI of at least 38. In one embodiment, the subject has a BMI of at least 40. In one embodiment, the subject is clinically obese. In one embodiment, the subject is both overweight by BMI standards and clinically obese.

In one embodiment, the subject has a normal weight by BMI standards. In one embodiment, the subject has a BMI between 18.5 to 25. In one embodiment, the subject has a BMI of 19, 20, 21, 22, 23, 24 or 25. In one embodiment, described here in a method of treatment a subject that is has normal weight.

In one embodiment, the subject is underweight by BMI standards. In one embodiment, the subject has a BMI lower than 18.5. In one embodiment, described here in a method of treatment a subject that is underweight.

Effect of Administration

In some embodiments, upon subcutaneous administration of the composition comprising the nucleic acid encoding at least one protein or other BANEM to a subject, the encoded at least one protein and/or BANEM is expressed in the subject at a therapeutic level for a sustained period of time. In some embodiments, upon administration of the composition comprising the ex-vivo transfected adipocyte and/or pre-adipocyte, the encoded at least one protein and/or BANEM is expressed in the subject at a therapeutic level for a sustained period of time. In some embodiments, the at least one protein and/or BANEM is expressed in the subject at a level sufficient to induce a therapeutic effect in the subject.

In some embodiments, the encoded protein is expressed in the blood of the subject at a level of at least 50 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 50 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 100 ng/ml.

In one embodiment, the protein is expressed in the blood of the subject at a level of at least 200 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 300 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 400 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 500 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 600 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 700 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 800 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 900 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 1000 ng/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 1 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 10 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 50 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 100 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 150 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 500 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 800 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 900 μg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 1 mg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 2 mg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 3 mg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 4 mg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 5 mg/ml. In one embodiment, the protein is expressed in the blood of the subject at a level of at least 10 mg/ml. In some embodiments, the protein expression level is measured from a blood sample, such as a whole blood sample, a serum sample or a plasma sample taken from the subject.

In some embodiments, the encoded protein and/or BANEM is expressed in the subject at a therapeutic level for a sustained period of time. In specific embodiments, the encoded protein and/or BANEM is expressed in the subject at a therapeutic level for at least 50, at least 60, at least 70, at least 80, at least 90, at least 100 days, at least 120 days or at least 150 days after receiving the last dose of administration subcutaneously. In some embodiments, the subject is a mouse or a rat. In some embodiments, the encoded protein and/or BANEM is expressed in the subject at a therapeutic level for a period of time equivalent to at least one month, two months, four months, six months, eight months, ten months, twelve months, 2 years, 5 years, a decade or more in human after receiving the last dose of administration subcutaneously.

In one embodiment, the expression level of protein and/or BANEM is maintained in the subject for at least one month without any further treatment. In one embodiment, the expression level is maintained for at least two months without any further treatment. In one embodiment, the expression level is maintained for at least four months without any further treatment. In one embodiment, the expression level is maintained for at least six months without any further treatment. In one embodiment, the expression level is maintained for at least eight months without any further treatment. In one embodiment, the expression level is maintained for at least ten months without any further treatment. In one embodiment, the expression level is maintained for at least twelve months without any further treatment. In one embodiment, the expression level is maintained for at least 2 years without any further treatment. In one embodiment, the expression level is maintained for at least 4 years without any further treatment. In one embodiment, the expression level is maintained for at least 6 years without any further treatment. In one embodiment, the expression level is maintained for at least 8 years without any further treatment. In one embodiment, the expression level is maintained for at least 10 years without any further treatment.

In one embodiment, the expression of protein and/or biologically active nucleic acid is detectable in the subject for at least one month without any further treatment. In one embodiment, the expression is detectable for at least two months without any further treatment. In one embodiment, the expression is detectable for at least four months without any further treatment. In one embodiment, the expression is detectable for at least six months without any further treatment. In one embodiment, the expression is detectable for at least eight months without any further treatment. In one embodiment, the expression is detectable for at least ten months without any further treatment. In one embodiment, the expression is detectable for at least twelve months without any further treatment. In one embodiment, the expression is detectable for at least 2 years without any further treatment. In one embodiment, the expression is detectable for at least 4 years without any further treatment. In one embodiment, the expression is detectable for at least 6 years without any further treatment. In one embodiment, the expression is detectable for at least 8 years without any further treatment. In one embodiment, the expression is detectable for at least 10 years without any further treatment.

In some embodiments, upon administration of the composition comprising the nucleic acid encoding at least one protein or other BANEM in a subject, a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in the subcutaneous region(s) receiving the injection or implantation.

In one embodiment, in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 60 μg of lipid (e.g., at least 60 . . . 70 . . . 90 . . . 100 . . . 110 ug . . . etc.). In further embodiments, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 80 ug of lipid (e.g., at least 90 . . . 100 . . . 110 ug . . . etc.). In further embodiments, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 70 μm (e.g., at least 70 . . . 80 . . . 90 . . . 100 . . . 110 μm). In additional embodiments, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 90 μm (e.g., at least 90 . . . 100 . . . 110 . . . 120 μm).

In certain embodiments, the transfected and enlarged adipocytes contain, on average, at least 60 μg of lipid (e.g., 60 . . . 70 . . . 80 . . . 90 . . . ug). In some embodiments, the plurality transfected pre-adipocytes and/or adipocytes contain, on average, at least 80 μg of lipid. In other embodiments, the transfected pre-adipocytes and/or adipocytes have, on average, a diameter of at least 70 μm. In additional embodiments, the transfected pre-adipocytes and/or adipocytes have, on average, a diameter of at least 90 μm. In additional embodiments, the transfected pre-adipocytes and/or adipocytes are derived from one or more subcutaneous regions of a subject.

In one embodiment, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 60 μg of lipid. In one embodiment, they contain at least 65 μg of lipid. In one embodiment, they contain at least 70 μg of lipid. In one embodiment, they contain at least 70 μg of lipid. In one embodiment, they contain at least 75 μg of lipid. In one embodiment, they contain at least 80 μg of lipid. In one embodiment, they contain at least 85 μg of lipid. In one embodiment, they contain at least 90 μg of lipid. In one embodiment, they contain at least 95 μg of lipid. In one embodiment, they contain at least 100 μg of lipid. In one embodiment, they contain at least 110 μg of lipid. In one embodiment, they contain at least 120 μg of lipid. In one embodiment, they contain at least 130 μg of lipid. In one embodiment, they contain at least 150 μg of lipid. In one embodiment, they contain at least 200 μg of lipid.

In one embodiment, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 70 μm. In one embodiment, they have a diameter of at least 75 μm. In one embodiment, they have a diameter of at least 80 μm. In one embodiment, they have a diameter of at least 85 μm. In one embodiment, they have a diameter of at least 90 μm. In one embodiment, they have a diameter of at least 95 μm. In one embodiment, they have a diameter of at least 100 μm. In one embodiment, they have a diameter of at least 120 μm. In one embodiment, they have a diameter of at least 150 μm. In one embodiment, they have a diameter of at least 200 μm. In one embodiment, they have a diameter of at least 250 μm.

In one embodiment, the plurality of in-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 90 μm.

In one embodiment, the in-vivo transfected pre-adipocytes and/or adipocytes have normal sizes.

In specific embodiments, the encoded protein comprises a therapeutic antibody or antigen-binding portion thereof targeting an pathogenic antigen (e.g., a anti-SARS-CoV-2 antibody), and the expression of such antibody in the subject is at an expression level sufficient to reduce: i) the load of the pathogen in the subject, and/or ii) at least one symptom in the subject caused by the infectious antigen.

In one embodiment, the expression level of the therapeutic antibody in the subject is greater than 1 Unit/mL. In one embodiment, the expression level is greater than 10 Unit/mL. In one embodiment, the expression level is greater than 10 Unit/mL. In one embodiment, the expression level is greater than 100 Unit/mL. In one embodiment, the expression level is greater than 200 Unit/mL. In one embodiment, the expression level is greater than 500 Unit/mL. In one embodiment, the expression level is greater than 1000 Unit/mL. In one embodiment, the expression level is greater than 2000 Unit/mL.

In one embodiment, the therapeutic antibody reduces the pathogen load by 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or 100% in the subject. In one embodiment, the therapeutic antibody reduces the symptom in the subject caused by the pathogenic infection. In one embodiment, the therapeutic antibody reduces risk of hospitalization or death in the subject caused by the pathogen infection.

In some embodiments, the pathogen is a coronavirus (e.g., the SARS-Cov-2 virus). In one embodiment, the antibody binds to one or more epitopes of the S protein of the coronavirus and inhibits or reduces one or more S protein function or activity. In one embodiment, binding of the S protein to its cellular receptor is reduced or inhibited. In one embodiment, binding of the coronavirus S protein to angiotensin-converting enzyme 2 (ACE2), and/or sugar on the host cell surface is reduced or inhibited. In one embodiment, attachment of the coronavirus with host cells in the subject is reduced or inhibited. In one embodiment, infection of host cells in the subject by the coronavirus is reduced or inhibited. In some embodiments, the antibody reduces the S protein function or activity by 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or 100%. In one embodiment, the antibody against the coronavirus or cells infected by the coronavirus is produced in the subject. In one embodiment, the antibody specifically binds to one or more epitopes of the N protein of the coronavirus and inhibits or reduces one or more N protein function or activity. In one embodiment, binding of the coronavirus N protein to reproduced viral genomic sequences is reduced or inhibited. In one embodiment, embodiments, reproduction of viable progenies of the coronavirus is reduced or inhibited. In one embodiment, the antibody reduces the function or activity of the virus by 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% or 100%.

Systems and Kits

Also provided here are systems and kits comprising: a) a plurality of transfected pre-adipocytes and/or adipocytes (e.g., which are enlarged), wherein each of the plurality of transfected pre-adipocytes and/or adipocytes comprises an exogenous nucleic acid sequence, or a vector containing the nucleic acid sequence, wherein the nucleic acid sequence encodes at least one protein or at least one biologically active nucleic acid molecule, and b) a first container, wherein the plurality of transfected pre-adipocytes and/or adipocytes (e.g., which are enlarged) are present in the first container.

In one embodiment, the system comprises:

-   a) a plurality of transfected and enlarged adipocytes or     pre-adipocytes, wherein each of the plurality of transfected and     enlarged adipocytes or pre-adipocytes comprises an exogenous nucleic     acid sequence, or a vector containing the nucleic acid sequence,     wherein the nucleic acid sequence encodes at least one protein or at     least one biologically active nucleic acid molecule, and -   b) a first container, wherein the plurality of transfected and     enlarged adipocytes or pre-adipocytes are present in the first     container.

In one embodiment, the first container comprises a syringe configured for injecting the plurality of transfected and enlarged adipocytes or pre-adipocytes into a subject subcutaneously. In one embodiment, the adipocytes or pre-adipocytes are enlarged.

In some embodiments, the systems or kit further comprises: c) a solution comprising at least one of the following: i) cationic liposomes, ii) neutral liposomes, iii) dexamethasone, and iv) dexamethasone palmitate. In one embodiment, the system further comprises cationic liposomes. In one embodiment, the system further comprises neutral liposomes. In one embodiment, the system further comprises dexamethasone. In one embodiment, the system further comprises dexamethasone palmitate. In one embodiment, the system further comprises both cationic liposomes and dexamethasone. In one embodiment, the system further comprises both cationic liposomes and dexamethasone palmitate. In one embodiment, the system further comprises both neutral liposomes and dexamethasone. In one embodiment, the system further comprises both neutral liposomes and dexamethasone palmitate. In one embodiment, the system further comprises cationic liposomes, dexamethasone and dexamethasone palmitate. In one embodiment, the system further comprises neutral liposomes, dexamethasone and dexamethasone palmitate. In one embodiment, the system further comprises cationic liposome, neutral liposomes, and dexamethasone palmitate.

In embodiment, the systems or kit is used for treating diseases. In embodiment, the systems or kit is used for treating genetic diseases. In embodiment, the systems or kit is used for treating infectious diseases. In embodiment, the systems or kit is used for treating infectious diseases caused by virus, particularly coronavirus. In embodiment, the systems or kit is used for treating diseases caused SARS-Cov-2. In embodiment, the systems or kit is used for treating diseases caused by influenza, particularly influenza A or influenza B. In embodiment, the systems or kit is used for treating lipid storage disorders. In embodiment, the systems or kit is used for treating lysosomal storage disorders. In embodiment, the systems or kit is used for treating Galactosialidosis. In embodiment, the systems or kit is used for treating Fabry disease. In embodiment, the systems or kit is used for treating Gaucher disease. In embodiment, the systems or kit is used for treating multiple sulfatase deficiency. In embodiment, the systems or kit is used for treating Farber's lipogranulomatosis. In embodiment, the systems or kit is used for treating Niemann-Pick disease. In embodiment, the systems or kit is used for treating Wolman disease. In embodiment, the systems or kit is used for treating Schindler disease. In embodiment, the systems or kit is used for treating Fucosidosis. In embodiment, the systems or kit is used for treating Pompe disease.

In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 60 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 70 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 80 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 90 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 100 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 120 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 140 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 160 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 180 μg of lipid. In one embodiment, the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 200 μg of lipid.

In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 70 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 80 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 90 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 100 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 120 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 140 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 160 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 180 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 200 μm. In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 250 μm.

In one embodiment, the transfected and enlarged adipocytes or pre-adipocytes are derived from one or more subcutaneous regions of a subject.

TABLE 1 DNA Codons DNA Codons Amino Acid Containing CpG Lacking CpG Serine (Ser or S) TCG TCT, TCC, TCA, AGT, AGC Proline (Pro or P) CCG CCT, CCC, CCA, Threonine (Thr or T) ACG ACA, ACT, ACC Alanine (Ala or A) GCG GCT, GCC, GCA Arginine (Arg or R) CGT, CGC, AGA, AGG CGA, CGG

In addition, within the coding region, the interface between triplets should be taken into consideration. For example, if an amino acid triplet ends in a C-nucleotide which is then followed by an amino acid triplet which can start only with a G-nucleotide (e.g., Valine, Glycine, Glutamic Acid, Alanine, Aspartic Acid), then the triplet for the first amino acid triplet is changed to one which does not end in a C-nucleotide. Methods for making CpG free sequences are shown, for example, in U.S. Pat. No. 7,244,609, which is herein incorporated herein by reference. A commercial service provided by INVIVOGEN is also available to produce CpG free (or reduced) nucleic acid sequences/vectors (plasmids). A commercial service provided by ThermoScientific produces CpG free nucleotide sequences.

Provided below in Table 2 are exemplary promoters and enhancers that may be used in the vectors described herein. Such promoters, and other promoters known in the art, may be used alone or with any of the enhancers, or enhancers, known in the art. Additionally, when multiple proteins or biologically active nucleic acid molecules (e.g., two, three, four, or more) are expressed from the same vector, the same or different promoters may be used in conjunction with the subject nucleic acid sequence. In some embodiments, a promoter selected from the following list is employed to control the expression levels of the protein or nucleic acid: FerL, FerH, Grp78, hREG1B, and cBOX1. Such promoter can be used, for example, to control production of a protein (e.g., HGH) protein production over a broad temporal range (e.g., without the use of any other modifications including Gene switches).

TABLE 2 Promoter Enhancer CMV human CMV EF1α mouse CMV Ferritin (Heavy/Light) Chain SV40 GRP94 Ubc U1 AP1 UbC hr3 Beta Actin IE2 PGK1 IE6 GRP78 E2-RS CAG MEF2 SV40 C/EBP TRE FerL FerH Grp78 hREG1B cBOX1 HNF-1

In some embodiments, compositions and systems herein are provided and/or administered (e.g., injected subcutaneously) in doses selected to elicit a therapeutic and/or prophylactic effect in an appropriate subject (e.g., mouse, human, etc.). In some embodiments, a therapeutic dose is provided. In some embodiments, a prophylactic dose is provided. Dosing and administration regimes are tailored by the clinician, or others skilled in the pharmacological arts, based upon well-known pharmacological and therapeutic/prophylactic considerations including, but not limited to, the desired level of pharmacologic effect, the practical level of pharmacologic effect obtainable, toxicity. Generally, it is advisable to follow well-known pharmacological principles for administrating pharmaceutical agents (e.g., it is generally advisable to not change dosages by more than 50% at time and no more than every 3-4 agent half-lives). For compositions that have relatively little or no dose-related toxicity considerations, and where maximum efficacy is desired, doses in excess of the average required dose are not uncommon. This approach to dosing is commonly referred to as the “maximal dose” strategy. In certain embodiments, a dose (e.g., therapeutic of prophylactic) of nucleic acid or vector is about 0.01 mg/kg to about 200 mg/kg (e.g., 0.01 mg/kg, 0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg, 0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg, 5.0 mg/kg, 10 mg/kg, 20 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg, or any ranges therebetween (e.g., 5.0 mg/kg to 100 mg/kg)). In some embodiments, a subject is between 0.1 kg (e.g., mouse) and 150 kg (e.g., human), for example, 0.1 kg, 0.2 kg, 0.5 kg, 1.0 kg, 2.0 kg, 5.0 kg, 10 kg, 20 kg, 50 kg, 100 kg, 200 kg, or any ranges therebetween (e.g., 40-125 kg). In some embodiments, a dose of nucleic acid, or vector containing the nucleic acid, comprises between 0.001 mg and 40,000 mg (e.g., 0.001 mg, 0.002 mg, 0.005 mg, 0.01 mg, 0.02 mg, 0.05 mg, 0.1 kg, 0.2 mg, 0.5 mg, 1.0 mg, 2.0 mg, 5.0 mg, 10 mg, 20 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1,000 mg, 2,000 mg, 5,000 mg, 10,000 mg, 20,000 mg, 40,000 mg, or ranges therebetween.

In certain embodiments, a target peptide is used with the cationic or neutral liposomes in the pre-treating solutions herein. Exemplary target peptides are shown in Table 3 below. In table 3, “[n]” prefix indicates the N-terminus and a “[c]” suffix indicates the C-terminus; sequences lacking either are found in the middle of the protein.

TABLE 3A Target Sequence Source protein or organism nucleus (NLS) PKKKRKV (SEQ ID NO: 1) SV40 large Tantigen (P03070) Out of nucleus (NES) IDMLIDLGLDLSD (SEQ ID NO: 2) HSV transcriptional regulator IE63 P10238 ER, secretion (signal [n]MMSFVSLLLVGILFWATEAEQLTKCE Lactalbumin (P09462) peptide) VFQ (SEQ ID NO: 3) ER, retention (KDEL) KDEL[c] (SEQ ID NO: 4) Mitochondrial matrix [n]MLSLRQSIRFFKPATRTLCSSRYLL S. cerevisiae COX4 (P04037) (SEQ ID NO: 5) Plastid [n]MVAMAMASLQSSMSSLSLSSNSFLGQ Pisum sativum RPL24 (P11893) PLSPITLSPFLQG (SEQ ID NO: 6) Folded secretion (Tat) (S/T)RRXFLK (SEQ ID NO: 7)(“X” refers Near the N terminus^([6]) to any naturally occurring amino acid) peroxisome (PTS1) SKL[c] (SEQ ID NO: 8) peroxisome (PTS2) [c]XXXXRLXXXXXHL (SEQ ID NO: 9) (“X” refers to any naturally occurring amino acid)

In one embodiment, the vector as used herein comprises at least one sequence as listed in Table 3B below.

In one embodiment, the vector as used herein comprises an enhancer. In one embodiment, the enhancer comprises a sequence as set forth in SEQ ID NO: 16 or SEQ ID NO: 17.

In one embodiment, the vector as used herein comprises a promoter. In one embodiment, the promoter comprises a sequence as set forth in SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25 or SEQ ID NO: 26.

In one embodiment, the vector as used herein encodes a linker. In one embodiment, the linker is 1× linker. In one embodiment, the linker is a 2× linker. In one embodiment, the linker comprises a sequence as set forth in SEQ ID NO: 27 or SEQ ID NO: 28.

In one embodiment, the vector as used herein comprises a matrix-attachment region (MAR). In one embodiment, the MAR comprises a sequence as set forth in SEQ ID NO: 29, SEQ ID NO: 30 or SEQ ID NO: 31.

In one embodiment, the vector as used herein comprises a super-enhancer. In one embodiment, the super-enhancer comprises a sequence as set forth in SEQ ID NO: 32, SEQ ID NO: 33, SEQ ID NO: 34,

SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 37.

In one embodiment, the vector as used herein comprises a long-term repeat (LTR) within intron. In one embodiment, the LTR comprises a sequence as set forth in SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40 or SEQ ID NO: 41.

In one embodiment, the vector as used herein comprises a nucleus localization sequence-microtubule-associated sequence (NLS-MTAS). In one embodiment, NLS-MTAS further comprises a hydrophilic linker and modified neck domain peptide (NDP). In one embodiment, the NLS-MTAS comprises a sequence as set forth in SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44 or SEQ ID NO: 45.

TABLE 3B SEQUENCE NAME (SEQ ID NO) AMINO ACID OR NUCLEIC ACID SEQUENCE Enhancer M-CmvEnh GAGTCAATGGGAAAAACCCATTGGAGCCAAGTACACTGACTCAATAG (SEQ ID NO: 16) GGACTTTCCATTGGGTTTTGCCCAGTACATAAGGTCAATAGGGGGTG AGTCAACAGGAAAGTCCCATTGGAGCCAAGTACATTGAGTCAATAGG GACTTTCCAATGGGTTTTGCCCAGTACATAAGGTCAATGGGAGGTAA GCCAATGGGTTTTTCCCATTACTGACATGTATACTGAGTCATTAGGGA CTTTCCAATGGGTTTTGCCCAGTACATAAGGTCAATAGGGGTGAATC AACAGGAAAGTCCCATTGGAGCCAAGTACACTGAGTCAATAGGGACT TTCCATTGGGTTTTGCCCAGTACAAAAGGTCAATAGGGGGTGAGTCA ATGGGTTTTTCCCATTATTGGCACATACATAAGGTCAATAGGGGTG H-CmvEnh GTTACATAACTTATGGTAAATGGCCTGCCTGGCTGACTGCCCAATGAC (SEQ ID NO: 17) CCCTGCCCAATGATGTCAATAATGATGTATGTTCCCATGTAATGCCAA TAGGGACTTTCCATTGATGTCAATGGGTGGAGTATTTATGGTAACTGC CCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTATGCCCCCTAT TGATGTCAATGATGGTAAATGGCCTGCCTGGCATTATGCCCAGTACAT GACCTTATGGGACTTTCCTACTTGGCAGTACATCTATGTATTAGTCAT TGCTATTA Promoter H-CMV CCATGGTGATGGGTTTTGGCAGTACATCAATGGGTGTGGATAGTGGT (SEQ ID NO: 18) TTGACCCATGGGGATTTCCAAGTCTCCACCCCATTGATGCCAATGGGA GTTTGTTTTGGCACCAAAATCAATGGGACTTTCCAAAATGTTGTAACA ACTCTGCCCCATTGATGGAAATGGGTGGTAGGTGTGTGTGGTGGGAG GTCTATATAAGCAGAGCTTGTTTAGTGAACTGGATGCACCTACTA H-FerL from TCAGGGCCCCAACCCCCCCAAGCCCCCATTTCACAACATGCTGGTGCT pVIVO2, 281 bp: 24 ACAGGTGTGTGACTTCCCCTTGCTTTGGGGTGGGGGGCTGAGACTCCT TG ATGTGCTCTGGATTGGTCAGGCATGGCCTTTGGCCCTGCCTCCTGCCA (SEQ ID NO: 19) CTGCAGATTGGCTGCTAGGCCTCCCTGAGTGCCCTGCCTCTGAGGGCT GGTGCACCATAAAAGAAGCTGCCCTAGCCATGTCCCCTTGCAGTTTG GTGGTCCTGTGGGTCTGTCTCAAGCTTGCTGCCAGAACACAG H-FerH from TTCTGCCAGAGTGTGTGAGGGCCTCCAGTGGCTGCCCCTCCCCCACAG pVIVO2, 182 bp: 26 CAGGGGTGGGGTCCTGTGCCCACTGGAAGGAGTGGGCTTGGGGTGGG TG TGGTGCTGATTGGCTGGGGTGGGCCTGATGCTGATGTGGCTATAAGA (SEQ ID NO: 20) GACCACAAGTGACCTGCAGGGCCAGATGTTCTTTGCTGAA Grp78 from AGTTACTGGTGGAAATGGTCTTGGGTTGAGAGGTCACCTGAGGGACA pVIVO1, 547 bp: 59 GGCAGCTGCTGAACCAATAGGACTGGTGCACAGGGTGGATGCTGCCC TG CTCATTGGTGGCTGTTGAGAGTGACCAAGAGCCAATGAGTCAGCCTG (SEQ ID NO: 21) GGGGGTGTAGCAGTGATGTAAGTTGTGGAGGAGGCTGCTTTGAATTG GCAGTGGCCAGCTTGGTGGCATGGACCAATCAGTGTCCTCCAATGAG GAGTGCCTTTGCCAATTGGAGGCCTCCATGATGGGGCTGGGGGGAGG GTATATAAGCTGAGTTGGTGGTGGTGTGCTCCACATGGGCTGAGACC ACAGTGATGGGAGTGTCTGCCTCTGTGGGGCTGAGAGGTAAGTGCTG TGGCCTGCCCTTTCCAGGCCAACTTGGAGCCTGTCTTGTGGCTCTGCC TGATTGGGGGCTCCTGTTGCCCTCAGATTGGTTGGAATGCTGTTGTGC TCTGGGACTACAAGCCTGTTGCTGGGCCTGGAGACTGCTGAAGGACT GCTGAGCACTGTCCTCAGTGCTGGCAcc M-FABP2 (Murine GTGCAGTCGACACTGTCTCAAAAACCAAACCAAACCAAAACCCAACC Fatty Acid Binding CAAACCAAACAAAGCCAAACAACAACAACAAAAACAAAAAAACCCA Protein 2) CCAAAAAAACCAAGGAAACAAAACAACCAAAAATCAAAAAACTAGG (SEQ ID NO: 22) CTACTTTAAAATGTCATTATTTATTTTGTTAAAATTCCTGAGATAAAC ACTATTCTAACAAAAGAGCCATTAAGACTAAGAATCTCTAAGATAGT TTTTATGTTCTCAAATTCAGAAGAACTAAACACATTATTGCAGTATTA ATAAAATAAAAACTCAAGATAAGAAGGTCAAATGTGTCCAAGATAAT TGTCTCCTCCACAATGAGGCAAATCCATAAGGAATAATGGGGGGAAG TTCAATGCATTAGCTTTTGACAGTCAAAACAGGAACCTTTAAAATACT CTGTTCATGGTTAAAAATAATTTGTACTCTAAGTCCAGTGATCATTGC CAGGGAGAACCAAAGTTGAGAAATTTCTATTAAAAACATGACTCAGA GGAAAACATACAGGGTCTGGTCATGAAGGAAATGATCTGGCCCCCAT TGGTCACTCCTACAGTCACATGGTCAGGGCATCTTTAAAAGTGAGCT ATCTGGACTTCAGAGGCTCATAGCACCCTCCTGTGCTGCAGCCTTTCT CACCTGGAAGATATCTCCTCC M-INB, (Mouse GCAGCTGTCGACCTGAGTTATATGCACAAGATCCTGGAATATTTTCAT Inteferon B): −807 to TATCCTGGAGACACTGTGTTACTAATAACTCTGTATTTGTTCCTGCCA +57: PCR = 864 bp GTACTTACTCTCTCCTGTGGCCCCTCATTGTCCTTGCTCCTTTAGAAGT (SEQ ID NO: 23) GGCCCAAGTTGGTTTTTCTCACTTCTCAGAGCTCCCTCTTCTGTTGCTT TGGTGAAGTGCTGGGAAACTTGGCTGCTTCTCTCTCTGTTACCCACTC ACAACCCTTCCTTCCCTGGTCTCTTGTTTTGACACTGCTCAAACTGGA CCCCCACTTTAAGCAGTTTCTCCAGGATGTGGGGTTCTCTCCCAAAGG GAGCTATGGCCCATTGATGTGCCATTTCTCTTATAGTACACTATTGTA AGCCCCCTGGGAGCTCACAGAGACCCTCTCCCACCATCCCACTATTTC AAAGGGCAGCAGCTGTGCCATCCTTTCAGGATGAGCAGCTACTCTGC CTGGCTTTTCAGTGGACACTTTGGCTGTTTGAGAGTTCTTTTATCTTCA GGGCTGTCTCCTTTCTGTTCTTCTCTCCTGGATATTTCTCTTCCTTTGCT CCAGCAATTGGTGAAACTGTACAAGATTTTATAAATCCTTAGTTTGTA TATATTTTAACCCAGTACATAGCATATAAAATAGCCAGGAGCTTGAA TAAAATGAATATTAGAAGCTGTTAGAATAAGAGAAAATGACAGAGG AAAACTGAAAGGGAGAACTGAAAGTGGGAAATTCCTCTGAGGCAGA AAGGACCATCCCTTATAAATAGCACAGGCCATGAAGGAAGATCATTC TCACTGCAGCCTTTGACAGCCTTTGCCTCATCTTGCAGATATCAGCCG AC H-CBOX1 (Human GTCGACACTCTGTCTCAAAAATAATATCAATAGTAATAATGGTAATA Carboxypeptidase CAAACAAAAATACTGATAAATCTCAAAAACATTATCTTGAATGAAAG B1) AAGCCAGAAACAAAGGAATATATATTGTATAATCTCATTTACATTAA SEQ ID NO: 24 GTTTAATACAGGCAAAATTAATGTATAAAGCCAGAAATCAGAGTAAC ATTTGCCTGAGAGGAGTACAGAAGTAGACTGGAAAAGTGCTCAAGG GAACTTGTTAGGGTGATGAAAATGTGCTATATCTTGTTTGGGATGTTT ATTACATGGGTTTACACATTTGTCAAAACTCATCAAACTTTACACTAA AATCTGTAGAACTTATTGTATGTAATTCTCAATTCAAAACAGAAAAA AATACAAAATAGATTTTATTTAAATCTAATTTACTCTCAGACTATTCA AGTTCTGATCCAAATTAAATAAGTTGAATTTGAGAGTATTTACTCTAT TTCCACAGGTGTTGAGAGAGATACCCTCTCAGACTTTACACAGCTACC AAGGCAACAATGCCAGGAAAACTATTAATCAAGATATGATAGTTCCT GTTTGCAATCAGGAGAAGAAAGCAAAGAACACTCAGGATTATAAAA GCAGATGAGACCTACCCACTAGACCTGGTCAGATATC H-REG1 (Human GTCGACTCCATGATTGTAAGTTTCCTGAGGCCTCCCCATCCTCAGGAA Regenerating Islet- AGTCTGTGAGTCAATTAAACTATGAGTCAATTAAACCTCTTTCCTTTT Derived 1B) TAAGTTACCCAGTCTCTGGTATTATCTTTATAGCAGTATGAAAAGGAC (SEQ ID NO: 25) TAATACACCTTGCCTTCTGAAGTAGGTCTTGAGAGGTTCCTGAACCTG AAAGGGAATGGAGAAATGACTTAAAGCCACCAGCTAATTGGGCTTAA TCATTTGGACTCAGTTGACTCTTCCCCTACCCCTACCCATGCCTAAAC CAAAGAAAGGATCATCCCACATTTACCTAGCACAAAGAAATCTACTC TTCTGCTCTTTCTAGGACTGCTAAAGGCCATGGGAACTGGACACCTGG ATGCTGCAGAGGAAGGGCAAAGCTCAACATCAACTTGGACAGTTTGC CAACCTGTTTGTGGTAAGTTGATGTCATTTGTGACCACTCCTAATGTG TGCCAGGAATAAGCTATTCCTGATGCCAGAATCTCTTACTGTCAGTGC CCTCTGTAGGCCTTCTGATCCTTACTCCTTGCTCCACCCATTGTTTATA TCATGTAGTTCTCTCTCAGACCCTGATATAAAGCTCCTACTCTGTCTG ACCTGACAAGCCACCTCAAGTGGACAAGGCACTTACCAACAGGTAAA GGGGCATTACAGGAGAAGAGGATATCTGAAGCTCGAGGGCTCG H-TDOX (Human GCTACGTCGACCAGGCTGGTCTTGAACTACTGTTTTAAAATTCTATAT Tryptophan 2, 3 AGGCAATGTATGCTAATGTGGATGACTGCTAGCTACCCTGTCATTGGT Dioxygenase) ATGCCACAGATGAATAGTAAACTGATAATGTTCATTTAAATTCCAAT (SEQ ID NO: 26) ACAATGTGTTGAGAGCTTAACTGCTGCTGATTATTACATGATATTTAG GTCAGAAGAACTCTGATGATTGAATGGAAGTGGGCTTTGAGCATGTA CCCAGACTTTATTATACAGTTAATTTCCCTAGAGGTGTTAAATTTCAG TTTTTGGTCTAGAAGCTGTAAGAATATTCAAATTTGAGAGAATACATA TTTGTTTTTTACAAGCTCATCATCTTATGTATCCTAATACTATGCCAAA TGTTTTCTTGGGATTGAATAAATGTAATTTTTTTAACTTGGCCTCTGTT GATTCATTGGATGTTTGTTACTTTGAATATAAAAGCAGAACTTGGCAA GTCATACAACTCAATTTGGCAGATCACTCACTCTTAGCAAATGAACTG TGCCCAACATAAATCCACTCTAAAGTTTACAGAGGTTCAGTTCTGTAC CAATGGAAATGAGAAGTTAGCTAAGAGTACAAGAAGCATGCTGATTG GCTGATGCAGGGTAAGCAGGCTACATAAAAGGCAGCTGTAGAACATC TGGGAAGGTCAATGATATCATCTG Linker 1x Linker GGTGGAGGAGGTAGT (SEQ ID NO: 27) 2x Linker GGTGGAGGAGGTAGTGGGGGTGGAGGTTCA (SEQ ID NO: 28) Matrix Attachment Regions (MARs) βGlo MAR TTAATTAAAATTATCTCTAAGGCATGTGAACTGGCTGTCTTGGTTTTCAT SEQ ID NO: 29 CTGTACTTCATCTGCTACCTCTGTGACCTGAAACATATTTATAATTCCAT TAAGCTGTGCATATGATAGATTTATCATATGTATTTTCCTTAAAGGATTTT TGTAAGAACTAATTGAATTGATACCTGTAAAGTCTTTATCACACTACCC AATAAATAATAAATCTCTTTGTTCAGCTCTCTGTTTCTATAAATATGTAC CAGTTTTATTGTTTTTAGTGGTAGTGATTTTATTCTCTTTCTATATATATAC ACACACATGTGTGCATTCATAAATATATACAATTTTTATGAATAAAAAAT TATTAGCAATCAATATTGAAAACCACTGATTTTTGTTTATGTGAGCAAA CAGCAGATTAAAAGG 21421 S/MAR GAGCCCCACTGTGTTCATCTTACAGATGGAAATACTGACATTCAGAGG (SEQ ID NO: 30) AGTTAGTTAACTTGCCTAGGTGATTCAGCTAATAAGTGCAAGAAAGAT TTCAATCCAAGGTGATTTGATTCTGAAGCCTGTGCTAATCACATTACAC CAAGCTACAACTTCATTTATAAATAATAAGTCAGCTTTCAAGGGCCTTT CAGGTGTCCTGCACTTCTACAAGCTGTGCCATTTAGTGAACACAAAAT GAGCCTTCTGATGAAGTAGTCTTTTCATTATTTCAGATATTAGAACACT AAAATTCTTAGCTGCCAGCTGATTGAAGGCTGGGACAAAATTCAAACA TGCATCTACAACAATATATATCTCAATGTTAGTCTCCAAATTCTATTGAC TTCAACTCAAGAGAATATAAAGAGCTAGTCTTTATACACTCTTTAAGGT ATGATATCATCTGGAAAGTAACAAAATTGATGCAAATTTGAATGAACTT TATCATGGTGTATTTACACAATGTGTTTCTTCTCCCTGCAATGTATTTCT TTCTCTAATTCCTTCCATTTGATCTTTCATACACAATCTGGTTCTGATGT ATGTTTTTTGGATGCACTTTTCAACTCCAAAAGACAGAGCTAGTTACTT TCTTCCTGGTGCTCCAAGCACTGTATTTGTATCTGTATTCAAGCCCTTT GCAATATTGTACTGGATCATTATTTCACCTCTAGGATGGCTTCCCCAGG CAACTTGTGTTCACCCAGAGACTACATTTTGTATCTTGTTGACCTTTGA ACTTCCACCAGTGTCTAAAAATAATATGTATGCAAAATTACTTGCTATG AGAATGTATAATTAAACAATATAAAAAGGAGAAGCAAGGAGAGAAAC ACAGGTGTGTATTTGTGTTTGTGTGCTTAAAAGGCAGTGTGGAAAAGG AAGAAATGCCATTTATAGTGAGGAGACAAAGTTATATTACCTCTTATCT GGCTTTTAAGGAGATTTTGCTGAGCTAAAAATCCTATATTCATAGAAAA GCCTTACCTGAGTTGCCAATACC IFNβ S/MAR AGTCAATATGTTCACCCCAAAAAAGCTGTTTGTTAACTTGTCAACCTCA (SEQ ID NO: 31) TTCTAAAATGTATATAGAAGCCCAAAAGACAATAACAAAAATATTCTTG TAGAACAAAATGGGAAAGAATGTTCCACTAAATATCAAGATTTAGAGC AAAGCATGAGATGTGTGGGGATAGACAGTGAGGCTGATAAAATAGAGT AGAGCTCAGAAACAGACCCATTGATATATGTAAGTGACCTATGAAAAA AATATGGCATTTTACAATGGGAAAATGATGGTCTTTTTCTTTTTTAGAA AAACAGGGAAATATATTTATATGTAAAAAATAAAAGGGAACCCATATGT CATACCATACACACAAAAAAATTCCAGTGAATTATAAGTCTAAATGGA GAAGGCAAAACTTTAAATCTTTTAGAAAATAATATAGAAGCATGCCATC AAGACTTCAGTGTAGAGAAAAATTTCTTATGACTCAAAGTCCTAACCA CAAAGAAAAGATTGTTAATTAGATTGCATGAATATTAAGACTTATTTTT AAAATTAAAAAACCATTAAGAAAAGTCAGGCCATAGAATGACAGAAA ATATTTGCAACACCCCAGTAAAGAGAATTGTAATATGCAGATTATAAAA AGAAGTCTTACAAATCAGTAAAAAATAAAACTAGACAAAAATTTGAA CAGATGAAAGAGAAACTCTAAATAATCATTACACATGAGAAACTCAAT CTCAGAAATCAGAGAACTATCATTGCATATACACTAAATTAGAGAAATA TTAAAAGGCTAAGTAACATCTGTGGC Super-Enhancer HR3 AAAACAAATGACATCATTCCTGATTATAATAATTTTAATTGTGCTTTACA (SEQ ID NO: 32) AGTAGAATTCTACTTGTAAAGAGAGTTTAATTTGAAAAACAAATTAGT CATTATTAAACATGTTAACAATTGTGTATAAAAATGACATCAGTTTAATG ATGACATCATCTCTTGATTATGTTTTACAAGTAGAATTCTACTTGTAAAG CTGGTTCAGTTTTGAAAAACAAATGACATCATCTCTTGATTATGTTTTA CAAGTAGAATTCTACTTGTAAAAGTGAGTTTAGTTTTAAAAAACAAAT GACATCATTCAGTTTTGAAAAACAAATGACATCATCTCTTGATTGTGTT TTACAAGTAGAATTCTACTTGTAAAGTGAGTTCAGTTTTGAAAAACAA ATGACCCTCTCATACAATTGTTGAACAATTTTAATAAATAATCTTTACAA GATT SE1 TCCTGCAGTTAAGGAAGCCCTGGGCCTGCTGTTCTCATCCACTGAGCT (SEQ ID NO: 33) CTTCTGCCCTGGAGAAGCCCACTTGTTAGCTTATTACAGTTCATGGACA CCAGGTCCACAATGTAAGCTAACAGAAACTATGTCTGCTTTCCCATCC GTCTCAGTGACATGGAGGGGGGGGGGGGGCCACTGGCGATCCTCAAG ACCCAAACCATCCTGAGGATTTGGTTCCATTTGGCTCTCCCTAGCAGCT GCACTTGCAGGAAGAACAGCTCAGCTCACACTGCCTCTCCTCTGGCCT CACTGTGCTCAAAGGACAGGCCTCAGGCCACAGGAGGCTTTGTGCAC TGCGCCGAGTGGAGCAGTGGAGCGTCTGGGAAAAGTTGCAAACCGA GCTGGAAGACTTGCTTGGATGAGAAACTGGCGTAGGACCGAGTCTGT TTGCCCCATCAAGCTGGCCAGGCCAGATCCACCTTCCTGCCCCACAGA TGGGGAAGGCTCCTACCCATTGTTCTCCAGGATGCTTTGACAGAGAGG AAAGGGAATGTAGGCCCTGGAGACCGGAAGGTTCAGCTTCCGGGCAC CAAGCTCTGCCAGACTCACGCCTGCCCTCCAGACAGGAAGGCAGGTC CTTGGTCTCATTCTGTCCTGCCCAGCTGCTGGACCACCCCCAATCAATG CTTTCCCCTTTCTGGGCCCTTAAGGAGACGGCATACAGGAGGCTTTGT CTGTGTGCTAGCCTGGGAAGGGAATTCCAGAGGAATTGAGGAGAATA ATGCCCAAGATTTGGGGCTCCCTGGTCCCAGCTATACCATTCAGTGTAC CATTACACTCCAAGTACTGCATATGGCCACAGAAATACCTTGTATGCTC TGTGGCTGGCCTCACACATTCACATTATCAGACAAATGCCATGTGCAC AATCTTAGTTCCATATACACTC SE2 AGTGATCCTCAACTTCTGGGTCTTGATCCCTTTGGGGGCTGAACAACC (SEQ ID NO: 34) AATTAACAGGGGTAACCTACGAGCATCAGAAAACATAGATCTTTACATT ATGATTCATAGCAGTAGCAAAATGACAGCTATGAAGTAGCAACGAAAT ACTTCTATGGTTGGGGGTCACCACAACATGAAATATGGTACTAAGGGA TCGTGGCTTTAGGAAGGTTGAGAAAGCCGATCCCAGCCAGTCCTTGTC AGGCTCTGCGCTGAGCCTTTTCAGCCTGGACTTTCCAGCTTCAGGGTC CTTGGTCCTCTGGCACCACTTCCTCAACAACATTGAAAGGATGTCTGA GAGAAAGCAAGACAGCTGGGAAAGTGCTCTCAGAGGAGCTAGTCCC CCTCCGCTCTAATGGCCATTGTTCTCACCACCAGGAATGCAGTTCTTGC TCTGCTCCTTCCTGGCCTGGGACAGACTGCCCAACACCCCTCTTCCTC CTCAGGCTCCTGAGGCTGCAGCGTTAACTGCCTTAGCCTCTGGCCTCT TCGGTGGTCAAGATCATGCCCCATCCCCCCACCCTGCTCGCTCTCGAG AGTGTGCCTTCGCTCTCTCGCTCTCTCGTGTTCTCTCTCTCTCTCTCTCT CTCTCTCTCTCTCTCTCACACACACACACACACACACACACACACACA AAACCACCCCATGGGGGATCAAAACCTACACAGGACAATCTTCCTAA AACAGAACCTCTTAGTTTGAGCCCATGGTTTCAAAGCTGCTTGGGGGA CATCAGGCCACCTCTCTGACAATACCTAGTATGAAAGC SE3 ATCTGCATTTCCAACTCCTCTCTCCACCCTAATGATCCTGAGGCTTGAG (SEQ ID NO: 35) GACCATGCTCATTAAAAAAATATATTTATTTTTATTGTATGCATATTGGTA TTTTGCCTCTCTATACATCTGTGCAACCATGGGCATGCAGTGCAGGAGG GAGCCAGAAGATGGCATTAGATCCTCTGGAACCAGAGCTACAGACAC CTATTTGTGGCCAGAAAGGTACTAGTAGCAGAAACAAGGTCCTCTGGA AGAGCAACTGATGCTCTTAGGTACTGAAGCATCATCCTGCCCCAGAGA CCACTCGCATATGAAGCACACATATTCAGTCTGCCTTACTTGTGTTAAT GATTGCCAGTGTCCCTCTGACCTCCTAGCCCTGAAAAGTGTGGCCTGA AGGTCATTTCAGAGACGGGGAGAGCTGCTCAGAGAAGCCAATCGGCG AGTCTAGGACACACAGACAGGATCTAGTCCCAGAGTTCGCTAGCCTAG GTGAGCGTCCCCTGGCCCCTTATACCACTTCCTTCTCCAGCTTGCATCT AATCTGCTCTGGCAGACCATCGTGTTTCCTGTCTTCCTGGCAGCCTCCA GCACGCTCAGTGCTACTCCCTGCGCATGCGCCCTCCTCCCAGTACCTT CTCTGACTCCAGTGGGCTTGGAGTGCGAGGAGGAAGGGTGAGGAAG GGGTGAAATCAGGTATTGGATCCACAGGGGGTCTGAAGAGCACTAGC CTGGCCTTTTGGGACTGAACTTCTGCTATGAAGACCTCCACTGCCATC CCTGGAGTCCGGGGCACATCCAAGGCTTGCCTGTCCATCGTTTACTGT TTACAGATGACAACAATGACTGTGTTCGGGGCAGAAATATCCACCAGG GCTAGAGTACAAAAGGAGTTTGCATTGATGGCCGGACAGGCCCTGTCC CTGGCAGCCTGCCAGCGCTGAGTATGAGACCCAGCGGGAAGTGCTAC CCTGGCAGACGTGTCCACTGAGTACACAGACCACCAAGGCAGGCAGC TCTCGGGGAAGCTGTCTATGCTGGGCCAGCCCACCTTGAGGGCAGGG AACAGAACAGATTGTGGCAGAGAGGAAAATGTGGAGCTTCTGTTTGT TCACAGACACACGCACTCGCCCACGCACGCACGCACGCACGCACGCA CGCACGAATGCACGCACGCAGTAGTTGAATGCTATGGATTCCGCTCAG AGCTGAGAACAGCCCCAGCGACAGTTCCCTGGCCTCTCTCCTTACTCT GATGTCCTCATCTGTCTTCACATGGTCTCAGGACGCTAATACTCCATCC TAATGTACACTCCTTTCCCTGGGCCTCCGTTCCAGTTCAGTTCTCAGAG GACCTGGAGGGA SE4 TCATTATCCGCATCACCACTACCATCACCATTTCTACTTTACAGGCAGT (SEQ ID NO: 36) GGTGCTTAGGTTTGAGGAAGTCACCCACAAGAAGATTGTAGAAGTGG GACCCCGTTCTTCAGCAGCAGCCTCAGCCCCACTCCTGAGCAGGTCCT GTGACAACTCATCTCCCTGCTGGTCCTGGGGAGTGGGGAAGGGACCC CATCACTGACACTGTCTTGTTCCCAACCGGTAAGAGTCAGGGGTTCTG CCCACCATCTGGAGACCTTCGCATAGGTCCAGATTCGAGCTCTTTCTTT TAAGCACAGGGTGTTCTCTTCCACGTTATCTGTCTGCGTGGGCCACAA ACCCGGTTTATAAACAAGGCAAAAAATGGCAAGAGGAAAAAGTGAAG TCAGCCTGTGCCATTGGAGCAAGTCAAACAATACCAAGCTCGTAGCTG GCTAAGTGGCTGTCTCATTGTCCAGATATTTCCTCAGGCCATTAAACAA GCGAGGAATGATTGCCAGGTTTGATTTCAGGAAGGAAGCCCCTCCCAT TTCCCTGCCGAGCAATTCAGTGTTCATTTTCTTCTGACCCACGCTGGCT GGTTATTAGGGAAGCGCTGCATGCTTCTTTCATAAACAAAAGTTATTTG CTTCAAGATTCAAAATTCACTTCTCAACGACTGGGAAGCCCTGAGTTC CTGCCAGATGGTTTTATTATTTTGGAGGTAGGGCTAGCCCAAGTACTGG GAGCACCCTGCGACCAGAGTAGACTTTGGGGGCTGAGGGAAAGCCAT TCTGCCACTGGCCTGGAGTTCAGAGCCTTTGTCCAGAGAGCCCCTTTG GGTGGAAGACAAAGTAACTAGGTTGGTTCGGCAAAGTTCCGACGGCT GGCCCGCAGCCCTGCCTTGGGTGGCCACAGATACACACGGCCATGGG AACAGCCAGTGAACTTTTTTTTTTTTTTTTCTTAATCAGGGTCCTACTC TGCCTGTGGAGCAAGCTTGTCATTATTCTCACCTCTTGGGAGACAGTC ACTTTTTTTTTTTTTCCTTTTGAGACAAGGTTTCTCTGTGTAACAG SE5 GGGGTGGGGGCGGGGGTAGGGGAGGAGCAGGGTGCAGCTGCTCACT (SEQ ID NO: 37) GCCCTTCCCCCTCTCATGTCTCCTTGGCAGCAGCTGCCTGCTAAAGAC TAGCCCAGGCCAGGAGCTGTTTGTCTCTGCTTGTCAGAGGCGTTTCCT GATGGGTCTCTATTTTGGTTTCTGTTTTTCTCTGTGCTAACAGAGAAAG AGACGGCTCCAACGTCATGGGGTTTTCCCAGCAATTAGCCTCGGAGCA AACAGACAGCAAATCGGGATTTAATGAGTTCCTTCCCGTCCTCCTCCA TCCGCAGTGACCACTTGGTGAGCTGCCAGCCAGGGTTAGATCTGGAC CCGGTCCCCATAGCCTCCTCCAATTGTGTAGGATGAGAGACCTTGAGA ACAGGGGACCAGGCTGGCAGGCACTAGCTCATATTTAGTCATCA Longterm Repeat (LTR) within intron PPRV AGGGGCCAAGTCCATACGACAGGCCCCAGCCCGCCAGACGGAGGGCC (SEQ ID NO: 38) GCAGAAAGGAAGGAGACACGACCGCCCCAGAAGGAGGA MV AGGGCCAAGGAACATACACACCCAACAGAACCCAGACCCCGGCCCAC (SEQ ID NO: 39) GGCGCCGCGCCCCCAACCCCCGACAACCAGAGGGAGCC SNV GCCGGGTACATCTCTTGCTCGGGGTCGCCGTCCTACACATTGTTGTTGT (SEQ ID NO: 40) GACGTGCGGCCCAGATTCGAATCTGTAATAAAACCTTTTTTTTTCTGAA TCCTCAGATTGGCAGTGAGAGGAGATTTTGTTCGTGGTGTTGGCTCGC CTACTGGGTGGGCGCAGGGATCCGGACTGAATCCGTAGTACTTCGGTA CAACATTTGGGGG RU5 GGTCGCCGTCCTACACATTGTTGTTGTGACGTGCGGCCCAGATTCGAA (SEQ ID NO: 41) TCTGTATAAAACTTTTTTTTTTCTGAATCCTCAGATTGGCAGTGAGAGG AGATTTTGTTCGTGGTGTTGGCTCGCCTACTGGGTGGGCGCAGGGATC CGGACTGAATCCGTAGTACT Microtubule-associated Sequence (NLS-MTAS) NLS-MTAS GRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTR (SEQ ID NO: 42) NLS-MTAScoding GGCAGATACCTGACACAAGAGACAAACAAGGTGGAAACCTACAAAG sequence AGCAGCCCCTGAAAACCCCAGGCAAGAAGAAGAAGGGCAAGCCTGG (SEQ ID NO: 43) AAAGAGGAAAGAACAAGAGAAAAAGAAGAGAAGGACCAGA NLS-MTAS- GRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRDRDD Hydrophillic Linker- QAAWFSQY Modified Neck Domain Peptide (SEQ ID NO: 44) NLS-MTAS- GGCAGATACCTGACACAAGAGACAAACAAGGTGGAAACCTACAAAG Hydrophillic Linker- AGCAGCCCCTGAAAACCCCAGGCAAGAAGAAGAAGGGCAAGCCTGG Modified Neck AAAGAGGAAAGAACAAGAGAAAAAGAAGAGAAGGACCAGAGACAG Domain Peptide GGATGACCAGGCTGCTTGGTTTTCTCAGTAC coding sequence (SEQ ID NO: 45)

In certain embodiments, one or more (e.g., at least 3, or at least 8 antibodies) are expressed with the systems and methods herein. In some embodiments, this includes the therapeutic monoclonal antibodies (mAbs), Fabs, F(ab)2s, and scFv's that are shown in Table 4 below, as well as the anti-SARS-CoV2 antibodies 5 and antigen bindings provided at Table 5 and Table 7, which is herein incorporated by reference.

TABLE 4 A B Antibody Trade C D E F Name name Type Source Target Use 3F8 mab mouse GD2 neuroblastoma ganglioside 8H9 mab mouse B7-H3 neuroblastoma, sarcoma, metastatic brain cancers Abagovomab mab mouse CA-125 ovarian cancer (imitation) Abciximab ReoPro Fab chimeric CD41 (integrin platelet aggregation alpha-IIb) inhibitor Abituzumab mab humanized CD51 cancer Abrilumab mab human integrin α4β7 inflammatory bowel disease, ulcerative colitis, Crohn's disease Actoxumab mab human Clostridium Clostridium difficile difficile colitis Adalimumab Humira mab human TNF-α Rheumatoid arthritis, Crohn's Disease, Plaque Psoriasis, Psoriatic Arthritis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis, Hemolytic disease of the newborn Adecatumumab mab human EpCAM prostate and breast cancer Aducanumab mab human beta-amyloid Alzheimer's disease Afasevikumab mab human IL17A and — IL17F Afelimomab F(ab')₂ mouse TNF-α sepsis Afutuzumab mab humanized CD20 lymphoma Alacizumab pegol F(ab')₂ humanized VEGFR2 cancer ALD518 — humanized IL-6 rheumatoid arthritis Alemtuzumab Lemtrada, mab humanized CD52 Multiple sclerosis Campath Alirocumab mab human PCSK9 hypercholesterolemia Altumomab Hybri- mab mouse CEA colorectal cancer pentetate ceaker (diagnosis) Amatuximab mab chimeric mesothelin cancer Anatumomab Fab mouse TAG-72 non-small cell lung mafenatox carcinoma Anetumab mab human MSLN cancer ravtansine Anifrolumab mab human interferon α/β systemic lupus receptor erythematosus Anrukinzumab (= mab humanized IL-13 asthma IMA-638) Apolizumab mab humanized HLA-DR— hematological cancers Arcitumomab CEA-Scan Fab' mouse CEA gastrointestinal cancers (diagnosis) Ascrinvacumab mab human activin cancer receptor-like kinase 1 Aselizumab mab humanized L-selectin severely injured (CD62L) patients Atezolizumab mab humanized CD274 cancer Atinumab mab human RTN4 — Atlizumab (= Actemra, mab humanized IL-6 receptor rheumatoid arthritis tocilizumab) RoActemra Atorolimumab mab human Rhesus factor hemolytic disease of the newborn[citation needed] Avelumab mab human CD274 — Bapineuzumab mab humanized beta amyloid Alzheimer's disease Basiliximab Simulect mab chimeric CD25 (α chain prevention of organ of IL-2 transplant receptor) rejections Bavituximab mab chimeric phosphatidylser cancer, viral ine infections Bectumomab LymphoScan Fab' mouse CD22 non-Hodgkin's lymphoma (detection) Begelomab mab mouse DPP4 — Belimumab Benlysta, mab human BAFF non-Hodgkin LymphoSta lymphoma etc. t-B Benralizumab mab humanized CD 125 asthma Bertilimumab mab human CCL11 severe allergic (eotaxin-1) disorders Besilesomab Scintimun mab mouse CEA-related inflammatory antigen lesions and metastases (detection) Bevacizumab Avastin mab humanized VEGF-A metastatic cancer, retinopathy of prematurity Bezlotoxumab mab human Clostridium Clostridium difficile difficile colitis Biciromab FibriScint Fab' mouse fibrin II, beta thromboembolism chain (diagnosis) Bimagrumab mab human ACVR2B myostatin inhibitor Bimekizumab mab humanized IL 17A and IL — 17F Bivatuzumab mab humanized CD44 v6 squamous cell mertansine carcinoma Bleselumab mab human CD40 — Blinatumomab BiTE mouse CD19 pre-B ALL (CD 19+) Blontuvetmab Biontress mab veterinary CD20 — Blosozumab mab humanized SOST osteoporosis Bococizumab mab humanized neural dyslipidemia apoptosis- regulated proteinase 1 Brazikumab mab human IL23 Crohn's disease Brentuximab mab chimeric CD30 hematologic vedotin (TNFRSF8) cancers Briakinumab mab human IL-12, IL-23 psoriasis, rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis Brodalumab mab human IL-17 inflammatory diseases Brolucizumab mab humanized VEGFA wet age-related macular degeneration Brontictuzumab mab humanized Notch 1 cancer Burosumab mab human FGF23 X-linked hypophosphatemia Cabiralizumab mab humanized CSF1R — Canakinumab Ilaris mab human IL-1— rheumatoid arthritis Cantuzumab mab humanized mucin CanAg colorectal cancer mertansine etc. Cantuzumab mab humanized MUC1 cancers ravtansine Caplacizumab mab humanized VWF thrombotic thrombocytopenic purpura, thrombosis Capromab Prostascint mab mouse prostatic prostate cancer pendetide carcinoma cells (detection) Carlumab mab human MCP-1 oncology/immune indications Carotuximab mab chimeric endoglin — Catumaxomab Removab 3funct rat/mouse EpCAM, CD3 ovarian cancer, hybrid malignant ascites, gastric cancer cBR96- mab humanized Lewis-Y cancer doxorubicin antigen immunoconjugate Cedelizumab mab humanized CD4 prevention of organ transplant rejections, treatment of autoimmune diseases Cergutuzumab mab humanized IL2 — amunaleukin Certolizumab Cimzia Fab' humanized TNF-α Crohn's disease pegol Rheumatoid arthritis axial spondyloarthritis psoriasis arthritis Cetuximab Erbitux mab chimeric EGFR metastatic colorectal cancer and head and neck cancer Ch.14.18 mab chimeric GD2 neuroblastoma ganglioside Citatuzumab Fab humanized EpCAM ovarian cancer and bogatox other solid tumors Cixutumumab mab human IGF-1 receptor solid tumors (CD221) Clazakizumab mab humanized Oryctolagus rheumatoid arthritis cuniculus Clenoliximab mab chimeric CD4 rheumatoid arthritis Clivatuzumab hPAM4- mab humanized MUC1 pancreatic cancer tetraxetan Cide Codrituzumab mab humanized glypican 3 cancer Coltuximab mab chimeric CD19 cancer ravtansine Conatumumab mab human TRAIL-R2 cancer Concizumab mab humanized TFPI bleeding CR6261 mab human Influenza A infectious hemagglutinin disease/influenza A Crenezumab mab humanized 1-40-β-amyloid Alzheimer's disease Crotedumab mab human GCGR diabetes Dacetuzumab mab humanized CD40 hematologic cancers Daclizumab Zenapax mab humanized CD25 (α chain prevention of organ of IL-2 transplant receptor) rejections Dalotuzumab mab humanized IGF-1 receptor cancer etc. (CD221) Dapirolizumab mab humanized CD 154 — pegol (CD40L) Daratumumab mab human CD38 (cyclic cancer ADP ribose hydrolase) Dectrekumab mab human IL-13 — Demcizumab mab humanized DLL4 cancer Denintuzumab mab humanized CD19 cancer mafodotin Denosumab Prolia mab human RANKL osteoporosis, bone metastases etc. Depatuxizumab mab chimeric/ EGFR cancer mafodotin humanized Derlotuximab mab chimeric histone recurrent biotin complex glioblastoma multiforme Detumomab mab mouse B-lymphoma lymphoma cell Dinutuximab mab chimeric GD2 neuroblastoma ganglioside Diridavumab mab human hemagglutinin influenza A Domagrozumab mab humanized GDF-8 Duchenne muscular dystrophy Dorlimomab F(ab′)₂ mouse — — aritox Drozitumab mab human DR5 cancer etc. Duligotumab mab human ERBB3 testicular cancer (HER3) Dupilumab mab human IL4 atopic diseases Durvalumab mab human CD274 cancer Dusigitumab mab human ILGF2 cancer Ecromeximab mab chimeric GD3 malignant ganglioside melanoma Eculizumab Soliris mab humanized C5 paroxysmal nocturnal hemoglobinuria, atypical HUS Edobacomab mab mouse endotoxin sepsis caused by Gram-negative bacteria Edrecolomab Panorex mab mouse EpCAM colorectal carcinoma Efalizumab Raptiva mab humanized LFA-1 psoriasis (blocks T- (CD11a) cell migration) Efungumab Mycograb scFv human Hsp90 invasive Candida infection Eldelumab mab human interferon Crohn's disease, gamma- ulcerative colitis induced protein Elgemtumab mab human ERBB3 cancer (HER3) Elotuzumab mab humanized SLAMF7 multiple myeloma Elsilimomab mab mouse IL-6 — Emactuzumab mab humanized CSF1R cancer Emibetuzumab mab humanized HHGFR cancer Emicizumab mab humanized activated F9, haemophilia A F10 Enavatuzumab mab humanized TWEAK cancer etc. receptor Enfortumab mab human AGS-22M6 cancer expressing vedotin Nectin-4 Enlimomab pegol mab mouse ICAM-1 — (CD54) Enoblituzumab mab humanized CD276 cancer Enokizumab mab humanized IL9 asthma Enoticumab mab human DLL4 — Ensituximab mab chimeric 5AC cancer Epitumomab mab mouse episialin — cituxetan Epratuzumab mab humanized CD22 cancer, SLE Erenumab mab human CGRP migraine Erlizumab F(ab′)₂ humanized ITGB2 (CD18) heart attack, stroke, traumatic shock Ertumaxomab Rexomun 3funct rat/mouse HER2/neu, breast cancer etc. hybrid CD3 Etaracizumab Abegrin mab humanized integrin αvβ3 melanoma, prostate cancer, ovarian cancer etc. Etrolizumab mab humanized integrin α7 β7 inflammatory bowel disease Evinacumab mab human angiopoietin 3 dyslipidemia Evolocumab mab human PCSK9 hyper- cholesterolemia Exbivirumab mab human hepatitis B hepatitis B surface antigen Fanolesomab NeutroSpec mab mouse CD15 appendicitis (diagnosis) Faralimomab mab mouse interferon — receptor Farletuzumab mab humanized folate receptor ovarian cancer 1 Fasinumab mab human HNGF acute sciatic pain FBTA05 Lymphomun 3funct rat/mouse CD20 chronic hybrid lymphocytic leukaemia Felvizumab mab humanized respiratory respiratory syncytial virus syncytial virus infection Fezakinumab mab human IL-22 rheumatoid arthritis, psoriasis Fibatuzumab mab humanized ephrin receptor — A3 Ficlatuzumab mab humanized HGF cancer etc. Figitumumab mab human IGF-1 receptor adrenocortical (CD221) carcinoma, non- small cell lung carcinoma etc. Firivumab mab human influenza A — virus hemagglutinin Flanvotumab mab human TYRP1(glycop melanoma rotein 75) Fletikumab mab human IL 20 rheumatoid arthritis Fontolizumab HuZAF mab humanized IFN-γ Crohn's disease etc. Foralumab mab human CD3 epsilon — Foravirumab mab human rabies virus rabies glycoprotein (prophylaxis) Fresolimumab mab human TGF-β idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, cancer Fulranumab mab human NGF pain Futuximab mab chimeric EGFR cancer Galcanezumab mab humanized calcitonin migraine Galiximab mab chimeric CD80 B-cell lymphoma Ganitumab mab human IGF-1 receptor cancer (CD221) Gantenerumab mab human beta amyloid Alzheimer's disease Gavilimomab mab mouse CD147 graft versus host (basigin) disease Gemtuzumab Mylotarg mab humanized CD33 acute myelogenous ozogamicin leukemia Gevokizumab mab humanized IL-1β diabetes etc. Girentuximab Rencarex mab chimeric carbonic clear cell renal cell anhydrase 9 carcinoma[84] (CA-IX) Glembatumumab mab human GPNMB melanoma, breast vedotin cancer Golimumab Simponi mab human TNF-α rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis Gomiliximab mab chimeric CD23 (IgE allergic asthma receptor) Guselkumab mab human IL23 psoriasis Ibalizumab mab humanized CD4 HIV infection Ibritumomab Zevalin mab mouse CD20 non-Hodgkin's tiuxetan lymphoma Icrucumab mab human VEGFR-1 cancer etc. Idarucizumab mab humanized dabigatran reversal of anticoagulant effects of dabigatran Igovomab Indimacis- F(ab′)₂ mouse CA-125 ovarian cancer 125 (diagnosis) IMAB362 mab human CLDN18.2 gastrointestinal adenocarcinomas and pancreatic tumor Imalumab mab human MIF cancer Imciromab Myoscint mab mouse cardiac myosin cardiac imaging Imgatuzumab mab humanized EGFR cancer Inclacumab mab human selectin P cardiovascular disease Indatuximab mab chimeric SDC1 cancer ravtansine Indusatumab mab human GUCY2C cancer vedotin Inebilizumab mab humanized CD19 cancer, systemic sclerosis, multiple sclerosis Infliximab Remicade mab chimeric TNF-α rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, Crohn's disease, ulcerative colitis Inolimomab mab mouse CD25 (α chain graft versus host of IL-2 disease receptor) Inotuzumab mab humanized CD22 ALL ozogamicin Intetumumab mab human CD51 solid tumors (prostate cancer, melanoma) Ipilimumab Yervoy mab human CD152 melanoma Iratumumab mab human CD30 Hodgkin's (TNFRSF8) lymphoma Isatuximab mab chimeric CD38 cancer Itolizumab mab humanized CD6 — Ixekizumab mab humanized IL 17A autoimmune diseases Keliximab mab chimeric CD4 chronic asthma Labetuzumab CEA-Cide mab humanized CEA colorectal cancer Lampalizumab mab humanized CFD geographic atrophy secondary to age- related macular degeneration Lanadelumab mab human kallikrein angioedema Landogrozumab mab humanized GDF-8 muscle wasting disorders Laprituximab mab chimeric EGFR — emtansine Lebrikizumab mab humanized IL-13 asthma Lemalesomab mab mouse NCA-90 diagnostic agent (granulocyte antigen) Lendalizumab mab humanized C5 — Lenzilumab mab human CSF2 — Lerdelimumab mab human TGF beta 2 reduction of scarring after glaucoma surgery Lexatumumab mab human TRAIL-R2 cancer Libivirumab mab human hepatitis B hepatitis B surface antigen Lifastuzumab mab humanized phosphate- cancer vedotin sodium co- transporter Ligelizumab mab humanized IGHE severe asthma and chronic spontaneous urticaria Lilotomab mab mouse CD37 cancer satetraxetan Lintuzumab mab humanized CD33 cancer Lirilumab mab human KIR2D solid and hematological cancers Lodelcizumab mab humanized PCSK9 hyper- cholesterolemia Lokivetmab mab veterinary Canis lupus — familiaris IL31 Lorvotuzumab mab humanized CD56 cancer mertansine Lucatumumab mab human CD40 multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma Lulizumab pegol mab humanized CD28 autoimmune diseases Lumiliximab mab chimeric CD23 (IgE chronic receptor) lymphocytic leukemia Lumretuzumab mab humanized ERBB3 cancer (HER3) MABp1 Xilonix mab human IL1A colorectal cancer Mapatumumab mab human TRAIL-R1 cancer Margetuximab mab humanized ch4D5 cancer Maslimomab   mouse T-cell receptor — Matuzumab mab humanized EGFR colorectal, lung and stomach cancer Mavrilimumab mab human GMCSF rheumatoid arthritis receptor α- chain Mepolizumab Bosatria mab humanized IL-5 asthma and white blood cell diseases Metelimumab mab human TGF beta 1 systemic scleroderma Milatuzumab mab humanized CD74 multiple myeloma and other hematological malignancies Minretumomab mab mouse TAG-72 tumor detection (and therapy ) Mirvetuximab mab chimeric folate receptor cancer soravtansine alpha Mitumomab mab mouse GD3 small cell lung ganglioside carcinoma Mogamulizumab mab humanized CCR4 cancer Monalizumab mab humanized KLRC1 — Morolimumab mab human Rhesus factor — Motavizumab Numax mab humanized respiratory respiratory syncytial virus syncytial virus (prevention) Moxetumomab mab mouse CD22 cancer pasudotox Muromonab-CD3 Orthoclone mab mouse CD3 prevention of organ OKT3 transplant rejections Nacolomab Fab mouse C242 antigen colorectal cancer tafenatox Namilumab mab human CSF2 — Naptumomab Fab mouse 5T4 non-small cell lung estafenatox carcinoma, renal cell carcinoma Naratuximab mab chimeric CD37 — emtansine Narnatumab mab human RON cancer Natalizumab Tysabri mab humanized integrin α4 multiple sclerosis, Crohn's disease Navicixizumab mab chimeric/ DLL4 — humanized Navivumab mab human influenza A — virus hemagglutinin HA Nebacumab mab human endotoxin sepsis Necitumumab mab human EGFR non-small cell lung carcinoma Nemolizumab mab humanized IL31RA eczema[106] Nerelimomab mab mouse TNF-α — Nesvacumab mab human angiopoietin 2 cancer Nimotuzumab Theracim, mab humanized EGFR squamous cell Theraloc carcinoma, head and neck cancer, nasopharyngeal cancer, glioma Nivolumab Opdivo mab human PD-1 cancer Nofetumomab Verluma Fab mouse   cancer (diagnosis) merpentan Obiltoxaximab mab chimeric Bacillus Bacillus anthracis anthracis spores anthrax Obinutuzumab Gazyva mab humanized CD20 Chronic lymphatic leukemia Ocaratuzumab mab humanized CD20 cancer Ocrelizumab mab humanized CD20 rheumatoid arthritis, lupus erythematosus etc. Odulimomab mab mouse LFA-1 prevention of organ (CD11a) transplant rejections, immunological diseases Ofatumumab Arzerra mab human CD20 chronic lymphocytic leukemia etc. Olaratumab mab human PDGF-R α cancer Olokizumab mab humanized IL6 — Omalizumab Xolair mab humanized IgE Fc region allergic asthma Onartuzumab mab humanized human scatter cancer factor receptor kinase Ontuxizumab mab chimeric/ TEM1 cancer humanized Opicinumab mab human LINGO-1 multiple sclerosis Oportuzumab scFv humanized EpCAM cancer monatox Oregovomab OvaRex mab mouse CA-125 ovarian cancer Orticumab mab human oxLDL — Otelixizumab mab chimeric/ CD3 diabetes mellitus humanized type 1 Otlertuzumab mab humanized CD37 cancer Oxelumab mab human OX-40 asthma Ozanezumab mab humanized NOGO-A ALS and multiple sclerosis Ozoralizumab mab humanized TNF-α inflammation Pagibaximab mab chimeric lipoteichoic sepsis acid (Staphylococcus) Palivizumab Synagis, mab humanized F protein of respiratory Abbosynagis respiratory syncytial virus syncytial virus (prevention) Pamrevlumab mab human CTGF — Panitumumab Vectibix mab human EGFR colorectal cancer Pankomab mab humanized tumor specific ovarian cancer glycosylation ofMUC1 Panobacumab mab human Pseudomonas Pseudomonas aeruginosa aeruginosa infection Parsatuzumab mab human EGFL7 cancer Pascolizumab mab humanized IL-4 asthma Pasotuxizumab mab chimeric/ folate cancer humanized hydrolase Pateclizumab mab humanized LTA TNF Patritumab mab human ERBB3 cancer (HER3) Pembrolizumab mab humanized PDCD1 melanoma and other cancers Pemtumomab Theragyn   mouse MUC1 cancer Perakizumab mab humanized IL 17A arthritis Pertuzumab Omnitarg mab humanized HER2/neu cancer Pexelizumab scFv humanized C5 reduction of side effects of cardiac surgery Pidilizumab mab humanized PD-1 cancer and infectious diseases Pinatuzumab mab humanized CD22 cancer vedotin Pintumomab mab mouse adenocarcinom adenocarcinoma a antigen (imaging) Placulumab mab human human TNF pain and inflammatory diseases Plozalizumab mab humanized CCR2 diabetic nephropathy and arteriovenous graft patency Pogalizumab mab humanized TNFR — superfamily member 4 Polatuzumab mab humanized CD79B cancer vedotin Ponezumab mab humanized human beta- Alzheimer's disease amyloid Prezalizumab mab humanized ICOSL — Priliximab mab chimeric CD4 Crohn's disease, multiple sclerosis Pritoxaximab mab chimeric E. coli shiga — toxin type-1 Pritumumab mab human vimentin brain cancer PRO 140   humanized CCR5 HIV infection Quilizumab mab humanized IGHE asthma Racotumomab mab mouse N- cancer glycolylneuraminic acid Radretumab mab human fibronectin cancer extra domain-B Rafivirumab mab human rabies virus rabies glycoprotein (prophylaxis) Ralpancizumab mab humanized neural dyslipidemia apoptosis- regulated proteinase 1 Ramucirumab Cyramza mab human VEGFR2 solid tumors Ranibizumab Lucentis Fab humanized VEGF-A macular degeneration (wet form) Raxibacumab mab human anthrax toxin, anthrax protective (prophylaxis and antigen treatment) Refanezumab mab humanized myelin- recovery of motor associated function after glycoprotein stroke Regavirumab mab human cytomegalovirus cytomegalovirus glycoprotein infection B Reslizumab mab humanized IL-5 inflammations of the airways, skin and gastrointestinal tract Rilotumumab mab human HGF solid tumors Rinucumab mab human platelet-derived neovascular age- growth factor related macular receptor beta degeneration Risankizumab mab humanized IL23A — Rituximab MabThera, mab chimeric CD20 lymphomas, Rituxan leukemias, some autoimmune disorders Rivabazumab mab humanized Pseudomonas — pegol aeruginosa type III secretion system Robatumumab mab human IGF-1 receptor cancer (CD221) Roledumab mab human RHD — Romosozumab mab humanized sclerostin osteoporosis Rontalizumab mab humanized IFN-α systemic lupus erythematosus Rovalpituzumab mab humanized DLL3 — tesirine Rovelizumab LenkArrest mab humanized CD11, CD18 haemorrhagic shock etc. Ruplizumab Antova mab humanized CD154 rheumatic diseases (CD40L) Sacituzumab mab humanized tumor- cancer govitecan associated calcium signal transducer 2 Samalizumab mab humanized CD200 cancer Sapelizumab mab humanized IL6R — Sarilumab mab human IL6 rheumatoid arthritis, ankylosing spondylitis Satumomab mab mouse TAG-72 cancer (diagnosis) pendetide Secukinumab mab human IL 17A uveitis, rheumatoid arthritis psoriasis Seribantumab mab human ERBB3 cancer (HER3) Setoxaximab mab chimeric E. coli shiga — toxin type-2 Sevirumab   human cytomegalovirus cytomegalovirus infection SGN-CD19A mab humanized CD19 acute lymphoblastic leukemia and B- cell non-Hodgkin lymphoma SGN-CD33A mab humanized CD33 Acute myeloid leukemia Sibrotuzumab mab humanized FAP cancer Sifalimumab mab humanized IFN-α SLE, dermatomyositis, polymyositis Siltuximab mab chimeric IL-6 cancer Simtuzumab mab humanized LOXL2 fibrosis Siplizumab mab humanized CD2 psoriasis, graft- versus-host disease (prevention) Sirukumab mab human IL-6 rheumatoid arthritis Sofituzumab mab humanized CA-125 ovarian cancer vedotin Solanezumab mab humanized beta amyloid Alzheimer's disease Solitomab BiTE mouse EpCAM — Sonepcizumab — humanized sphingosine-1- choroidal and phosphate retinal neovascularization Sontuzumab mab humanized episialin — Stamulumab mab human myostatin muscular dystrophy Sulesomab LeukoScan Fab' mouse NCA-90 osteomyelitis (granulocyte (imaging) antigen) Suvizumab mab humanized HIV-1 viral infections Tabalumab mab human BAFF B-cell cancers Tacatuzumab AFP-Cide mab humanized alpha- cancer tetraxetan fetoprotein Tadocizumab Fab humanized integrin αIIbβ3 percutaneous coronary intervention Talizumab mab humanized IgE allergic reaction Tamtuvetmab Tactress mab veterinary CD52 — Tanezumab mab humanized NGF pain Taplitumomab mab mouse CD19 cancer[citation paptox needed] Tarextumab mab human Notch receptor cancer Tefibazumab Aurexis mab humanized clumping factor Staphylococcus A aureus infection Telimomab aritox Fab mouse — — Tenatumomab mab mouse tenascin C cancer Teneliximab mab chimeric CD40 autoimmune diseases and prevention of organ transplant rejection Teplizumab mab humanized CD3 diabetes mellitus type 1 Teprotumumab mab human IGF-1 receptor hematologic tumors (CD221) Tesidolumab mab human C5 — Tetulomab mab humanized CD37 cancer[141] Tezepelumab mab human TSLP asthma, atopic dermatitis TGN1412 — humanized CD28 chronic lymphocytic leukemia, rheumatoid arthritis Ticilimumab (= mab human CTLA-4 cancer tremelimumab) Tigatuzumab mab humanized TRAIL-R2 cancer Tildrakizumab mab humanized IL23 immunologically mediated inflammatory disorders Timolumab mab human AOC3 — Tisotumab vedotin mab human coagulation — factor III TNX-650 — humanized IL-13 Hodgkin's lymphoma Tocilizumab (= Actemra, mab humanized IL-6 receptor rheumatoid arthritis atlizumab) RoActemra Toralizumab mab humanized CD154 rheumatoid (CD40L) arthritis, lupus nephritis etc. Tosatoxumab mab human Staphylococcus — aureus Tositumomab Bexxar — mouse CD20 follicular lymphoma Tovetumab mab human CD 140a cancer Tralokinumab mab human IL-13 asthma etc. Trastuzumab Herceptin mab humanized HER2/neu breast cancer Trastuzumab Kadcyla mab humanized HER2/neu breast cancer emtansine TRBS07 Ektomab 3funct — GD2 melanoma ganglioside Tregalizumab mab humanized CD4 — Tremelimumab mab human CTLA-4 cancer Trevogrumab mab human growth muscle atrophy due differentiation to orthopedic factor 8 disuse and sarcopenia Tucotuzumab mab humanized EpCAM cancer celmoleukin Tuvirumab — human hepatitis B chronic hepatitis B virus Ublituximab mab chimeric MS4A1 cancer Ulocuplumab mab human CXCR4 hematologic (CD184) malignancies Urelumab mab human 4-1BB cancer etc. (CD137) Urtoxazumab mab humanized Escherichia diarrhoea caused by coli E. coli Ustekinumab Stelara mab human IL-12, IL-23 multiple sclerosis, psoriasis, psoriatic arthritis Utomilumab mab human 4-1BB cancer (CD137) Vadastuximab mab chimeric CD33 — talirine Vandortuzumab mab humanized STEAP1 cancer vedotin Vantictumab mab human Frizzled cancer receptor Vanucizumab mab humanized angiopoietin 2 cancer Vapaliximab mab chimeric AOC3 (VAP-1) — Varlilumab mab human CD27 solid tumors and hematologic malignancies Vatelizumab mab humanized ITGA2 — (CD49b) Vedolizumab Entyvio mab humanized integrin α4β7 Crohn's disease, ulcerative colitis Veltuzumab mab humanized CD20 non-Hodgkin's lymphoma Vepalimomab mab mouse AOC3 (VAP-1) inflammation Vesencumab mab human NRP1 solid malignancies Visilizumab Nuvion mab humanized CD3 Crohn's disease, ulcerative colitis Vobarilizumab mab humanized IL6R inflammatory autoimmune diseases Volociximab mab chimeric integrin α5β1 solid tumors Vorsetuzumab mab humanized CD70 cancer mafodotin Votumumab HumaSPE mab human tumor antigen colorectal tumors CT CTAA16.88 Xentuzumab mab IGF1, IGF2 — Zalutumumab HuMax- mab human EGFR squamous cell EGFr carcinoma of the head and neck Zanolimumab HuMax- mab human CD4 rheumatoid CD4 arthritis, psoriasis, T-cell lymphoma Zatuximab mab chimeric HER1 cancer Ziralimumab mab human CD147 — (basigin) Zolimomab aritox mab mouse CD5 systemic lupus erythematosus, graft-versus-host disease

TABLE 5 Sponsors Drug code Trial IDs Celltrion CT-P63 NCT05017168 Exevir Bio BV XVR011 NCT04884295 Jemincare Group JMB2002 ChiCTR2100042150 Luye Pharma Group Ltd LY-CovMab NA AbbVie ABBV-47D11 NCT04644120 HiFiBiO Therapeutics HFB30132A NCT04590430 Ology Bioservices ADM03820 NCT04592549 Beigene DXP604 NCT04669262 Zydus Cadila ZRC-3308 NA Hengenix Biotech Inc HLX70 NCT04561076 CORAT Therapeutics COR-101 NCT04674566 Vir Biotechnol./ VIR-7832 NCT04746183 AbCellera/Eli Lilly and LY-CoV1404, NCT04634409 Company LY3853113 Sorrento Therapeutics, COVI-AMG (STI- NCT04734860 Inc. 2020) Beigene DXP593 NCT04532294; NCT04551898 Junshi Biosciences/ JS016, LY3832479, NCT04441918; Eli Lilly LY-CoV016 NCT04441931; and Company NCT04427501 Mabwell (Shanghai) MW33 NCT04533048; Bioscience Co., Ltd. NCT04627584 Toscana Life Sciences MAD0004J08 NCT04932850; Sviluppo s.r.l. NCT04952805 Bristol-Myers Squibb, C144-LS and C-135-LS NCT04700163; Rockefeller University Activ-2 study Sinocelltech Ltd. SCTA01 NCT04483375; NCT04644185 Adagio Therapeutics ADG20 NCT04805671 NCT04859517 Brii Biosciences BRII-196 NCT04479631; Activ-3 study Brii Biosciences BRII-198 NCT04479644; Activ-3 study Tychan Pte. Ltd. TY027 NCT04429529; NCT04649515 AstraZeneca AZD7442 (AZD8895 + NCT04507256; AZD1061) NCT04625725; NCT04625972 Celltrion CT-P59 NCT04525079; NCT04593641; NCT04602000 Vir Biotechnol./ VIR-7831/ NCT04545060; Glaxo SmithKline GSK4182136 Activ-3 study AbCellera/Eli Lilly and LY-CoV555 NCT04411628 (Phase Company (LY3819253); 1); NCT04427501 (Phase 2); combination of LY- NCT04497987 CoV555 with LY- (Phase 3); CoV016 (LY3832479) NCT04501978 (Activ-3 study); NCT04518410 (Phase 2/3) Regeneron REGN-COV2 NCT04425629 (Phase (REGN10933 + 1/2); NCT04426695 REGN10987) (Phase 1/2); NCT04452318 (Phase 3)

In certain embodiments, an agent, such as an anti-inflammatory agent or bioactive lipid, is used to increase the expression level and/or duration of any the therapeutic protein (or biologically active nucleic acid molecules) expressed from the vectors in the methods herein. In certain embodiments, anti-inflammatory agents (AILs) and bioactive lipids in Table 6 below can be used in the compositions and pre-treatment solutions herein.

TABLE 6 Docosahexaenoic Acid (DHA) 3/10/15% Eicosapenaenoic Acid (EPA) 10/15% Alpha Linolenic Acid (ALA) 3/10/15% Maresin 1 (MAR1)   3% Lipoxin A4 (LA4)   2% 15-deoxy-12,14-Prostaglandin J2 (15d)   3% Arachidonic Acid (AA) 10/15% Eicosatetraynoic Acid (ETA)  10% Docosapentaenoic Acid (DPA) 10/15% Stearidonic Acid (SA)  10% Retinoic Acid (RA)  10% Trans Retinal (TA)  10% 2-Arachidonoyl Glycerol (AG)  10% Diallyl Disulfide (DADS)  10% 3,3-Diindolylmethane (DIM)  10% Prostaglandin E2 (PE2)  10% Oleic Acid (OA) 5/10/15/30/50% Alpha Tocopherol (AT) 2.5% Sphingosine-1-Phosphate (S-1-P)  10% Palmitoyl Sphingomyelin (SPH)  10%

TABLE 7 TABLE 7 Not Ab Neutral- Neutral- SEQ or Doesn't ising ising Protein + ID Name Nb Binds to Bind to Vs Vs Epitope Origin NO.: VH or VHH 0304-2F8 Ab SARS-CoV2 SARS-CoV2 S; Unk B-cells; SARS-CoV2 63 EVQLVQSGAEVSQPGESLKISCKGSGYSF (weak) Human Patient TGYWISWVRQMPGKGLEWMGIIYPGD SDTKYTPSFQGQVTISTDKSINTAYLQWS SLKASDTAMYYCARRGDGLYYYGMDV WGQGTTVTVSS 0304-3H3 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 64 EVQLVESGPGLVKPSETLSLTCTASGGSI Human Patient STYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARDRIAPVGKFFGWYFDLW GRGTLVTVSS 0304- Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 65 EVQLVESGGGLVQPGGSLRLSCAASGFT 4A10 Human Patient FSTYAMHWVRQAPGKGLEYVSGISSNG GSTYYANSVKGRFTISRDNSKNTLYIQM GSLRAEDMAVYYCARSSSRGFDYWGQ GTLVTVSS 0304-4A2 Ab SARS-CoV2 SARS-CoV2 S; S1 (non B-cells; SARS-CoV2 66 EVQLVESGPGLVKPSETLSLTCAVSGDST RBD) Human Patient SSSSSYWDWIRQPPGKGLEWIGNIYYTG TTYYNPSLKSRVTISVDTSKDQFSLKLSS VTAADTAVYYCARELFTAVAGKGGIDYW GQGTLVTVSS 0317-A1 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 67 QVQLVQSGGGVVQPGRSLRLSCAAPGF Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKDFKGGSSSWY TPEIEYGMDVWGQGTTVTVSS 0317-A2 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 68 QVQLVQSGSELKKPGASVKVSCKASGYT Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARLIRHEAHTYCSG GSCYSPDYYYGMDVWGQGTMVTVSS 0317-A3 Ab SARS-CoV2 SARS-CoV2 S; Link B-cells; SARS-CoV2 69 EVQLLQSGGGLVQPGGSLRLSCVASGFT (weak) Human Patient FSSYEMNWVRQAPGKGLEWVSYISTSG STINYADSVKGRFSISRDNAKKSLYLQM NSLRAEDTAVYYCASNPPLGEPYFDIWG QGTMVTVSS 0317-A7 Ab SARS-CoV2 SARS-CoV2 S; S1 (non B-cells; SARS-CoV2 70 EVQLLESGGGVVQPGRSLRLSCAASGFT RBD) Human Patient FSNYAMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARWGGGMQYLD VWGQGTTVTVSS 0317-A8 Ab SARS-CoV2 SARS-CoV2 S; S1 (non B-cells; SARS-CoV2 71 EVQLVQSGSELKKPGASVKVSCKASGYT (weak) RBD) Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARAGPNYDFWSGY YQTFDYWGQGTMVTVSS 0317-A9 Ab SARS-CoV2 SARS-CoV2 S; Link B-cells; SARS-CoV2 72 EVQLVQSGAEVKKPGASVKVSCKVSGYT (weak) Human Patient LTELSMHWVRQAPGKGLEWMGGFDP EDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATATAMDGYYYY YGMDVWGQGTTVTVSS 0317-B1 Ab SARS-CoV2 SARS-CoV2 S; Link B-cells; SARS-CoV2 73 EVQLVESGAEVKKPGESLKISCKGSGYSF (weak) Human Patient TSYWIGWVRQMPGEGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCASAGSSWYGDAFDIW GQGTMVTVSS 0317-C4 Ab SARS-CoV2 SARS-CoV2 S; Link B-cells; SARS-CoV2 74 QVQLVQSGAEVKKPGASVKVSCKVSGC (weak) Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATATIFGVANNW FDPWGQGTTVTVSS 0317-C9 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 75 QVQLVQSGGGVVQPGRSLRLSCAASGF Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKDLGYYDILTGQ LGGYYYYYGMDVWGQGTTVTVSS 10C10 Ab SARS-CoV2 SARS-CoV2 S; link B-cells; SARS-CoV2 76 QVQLVQSGGGLVQPGGSLRLSCAASGF Human Patient TFSSYWMSWVRQAPGKGLEWVANIN QDGSEKYYVDSVKGRFTISRDNAKNSLY LQMNSLRAEDTAVYYCARDWDYDILTG SWFGAFDIWGQGTMVTVSS 1A09 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD Immunised Mouse 77 QVQLKESGPGLVAPSQSLSITCTVSGFSL TSYAISWVRQPPGKGLEWLGVIWTGGG TNYNSALKSRLSISKDNSKSQVFLKMNSL QTDDTARYYCARKDYYYGSSYAMDYWG QGTSVTVSS 1A10 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 78 EVQLQQSGAELVRPGASVKLSCKASGYT SARS-CoV1 FSDYYINWVKQRPGQGLEWIARIYPGS GNTYYNEKFTGKATLTAEKSSSTAYMQL SSLTSEDSAVYFCARDYGSSYVDYFDYW GQGTTLTVSS 1A12 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 79 EVQLQQSGAELVRPGASVKLSCTASGFN SARS-CoV1 (weak) IKDDYMHWVKQRPEQGLEWIGWINPE NGDTEYASKFQGKAAITADTSSNTACLQ LSSLTSEDTAVYYCSTGGYGNYVDAMDY WGQGTSVTVSS 1B07 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 80 QVQLKESGPGLVAPSQSLSITCTVSGFSL SARS-CoV1 TSYAISWVRQPPGKGLEWLGVIWTGGG TNYNSALKSRLSISKDNSKSQVFLKMNSL QTDDTARYYCARKDYYGSSSNVMDYW GQGTSVTVSS 1610 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 81 QVQLKESGPGLVAPSQSLSITCTVSGFSL SARS-CoV1 TNYAINWVRQPPGKGLEWLGVIWTGG GTNYNSALRSRLSISKDNSKSQVFLKMN SLHTDDTARYYCARKDYYGSSLAMDYW GQGTSVTVSS 1C05 Ab SARS-CoV1, MERS-CoV SARS-CoV2 S; RBD Immunised Mouse 82 EVQLQQSGPELVKPGASVKISCKASGYS SARS-CoV2 (weak) FTDYYMNWVKQSPEKSLEWIGEINPST GGPTYNQKFKAKATVTVDKSSSTAYMQ LKSLTSEDSAVYYCARRNYDLYYYAMDY WGQGTSVTVSS 1C06 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 83 EVQLQQSGAELAKPGASVKLSCKASGYT SARS-CoV1 FTNYWMHWVKQRPGQGLEWIGYINPS SGYTKFNQKFNDKATLTADKSSTTAYMQ LSSPTYEDSAVYYCARSDYYGSSYVGYA MDYWGQGTSVTVSS 1C07 Ab SARS-CoV1, MERS-CoV SARS-CoV2 S; RBD Immunised Mouse 84 EVQLQQPGPELVKPGASVKISCKASGYS SARS-CoV2 FTDYYMNWVKQSPEKSLEWIGEINPST GGTSYNQKFKGKATLTVDKSSSTAYMQL KSLTSEDSAVYYCARRNYDLYYYAMDYW GQGTSVTVSS 1D04 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 85 EVQLQQSGAELVRPGASVKLSCTASGFN SARS-CoV1 IKDDYMHWVKQRPEQGLEWIGWINPE NGDTEYASKFQGKAAITADTSSNTACLQ LSSLTSEDTAVYYCSTGGYGNYVDAMDY WGQGTSVTVSS 1D05 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 86 QVQLKESGPGLVAPSQSLSITCTVSGFSL SARS-CoV1 TSYAISWVRQPPGKGLEWLGVIWTGGG TNYNSALKSRLSISKDNSKSQVFLKMNSL QTDDTARYYCARKDYYGSSSNVMDYW GQGTSVTVSS 1E02 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 87 EVQLQQPGPELVKPGASVKISCKASGYS SARS-CoV1 FTDYYMNWVKQSPEKSLEWIGEINPST GGTSYNQKFKGKATLTVDKSSSTAYMQL KSLTSEDSAVYYCSRRNYDLYYYAMDYW GQGTSVTVSS 1E07 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 88 EVQLQQSGPELVKPGASVKISCKASGYS SARS-CoV1 FTGYSMNWVKKSPEKSLEWIGEINPSTG GTTYNQKFKAKATLTVDKSSSTAYIQLKS LTSEDSAVYYCARGAGAYWGQGTLVTV SA 1E10 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 89 EVQLQQSGPELVKPGASVKISCKASGYA SARS-CoV1 FSSSWMNWVKQRPGKGLEWIGRIYPG DGDTNYNGKFKGKATLTADKSSSTAYM QLSSLTSEDSAVYFCARDHGPAWFAYRG QGTLVTVSA 1H06 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 90 EVQLQQSGPELVKPGASVKISCKASGYS SARS-CoV1 FTGYSMNWVKKSPEKSLEWIGEINPSTG GTTYNQKFKAKATLTVDKSSSTAYIQLKS LTSEDSAVYYCARGAGAYWGQGTLVTV SA 1H10 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 91 QVQLKESGPGLVAPSQSLSITCTVSGFSL SARS-CoV1 (weak) TNYAISWVRQPPGKGLEWLGVIWTGG GTNYNSALKSRLSISKDNSKSQVFLKMN SLQTDDTARYYCARISYYDYEGVDYWGQ GTTLTVSS 1M-1D2 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 92 QVQLVESGGGLVQPGGSLRLSCAASGF Human Patient TFSSYAMHWVRQAPGKGLEYVSAISGN GGSTYYAKSVKGRFTISRDNSKNTLYLQ MGSLRAEDMAVYYCARGAEYYDFWSG YYSAYFDYWGQGTLVTVSS 2B04 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 93 QVQLKQSGPGLVAPSQSLSITCTVSGFSL SARS-CoV1 INYAISWVRQPPGKGLEWLGVIWTGGG TNYNSALKSRLSISKDNSKSQVFLKMNSL QTDDTARYYCARKDYYGRYYGMDYWG QGTSVTVSS 2C02 Ab SARS-CoV1, MERS-CoV SARS-CoV2 S; RBD Immunised Mouse 94 EVQLQQPGAELVKPGASVKVSCKASGYI SARS-CoV2 FTNYWMHWVKQRPGQGLEWIGRIHPS DSDTKYNQKFKGKATLTVDKSSSTAYMQ LSSLTSEDSAVYYCAILDSYWYFDVWGT GTTVTVSS 2C03 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 95 EVQLQQSGPELVKPGASVKISCKASGYA SARS-CoV1 (weak) FSSSWMNWVKQRPGKGLEWIGRIYPG DGDTNYNGKLKGKATLTADKSSSTAYM QLSSLTSEDSAVYFCARKSYGYWHFDV WGTGTTVTVSS 2C04 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 96 EVQLQQPGPELVKPGTSVKISCKASGYT SARS-CoV1 FTDYYMNWVKQSHGKSLEWIGDINPN NGGTNYNQKFKGKATLTVDKSSSTAYM ELRSLTSEDSAVCYCAAGKGDYWGQGT TLTVSS 2D01 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 97 EVQLQQPGAELVKPGASVKVSCKASGYI SARS-CoV1 FTNYWMHWVKQRPGQGLEWIGRIHPS DSDTKYNQKFKGKATLTVDKSSSTAYMQ LSSLTSEDSAVYYCAILDSYWYFDVWGT GTTVTVSS 2D08 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 98 EVQLQQSGPELVKPGTSVKISCKASGYTF SARS-CoV1 (weak) TDYYMNWVKQSHGKSLEWIGDINPNN GGTNYNQKFKGKATLTVDKSSSTAYMEL RSLTSEDSAVYYCAAGKGDYWGQGTTL TVSS 2D11 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 99 EVQLQQSGPELVKPGASVKISCKASGYT SARS-CoV1 FTDYYMNWVKQSHGKSLEWIGDINPN NGGTSYNQKFKGKATLTVDKSSSTAYME LRSLTSEDSAVYYCARKGDGYYGGFAYW GQGTLVTVSA 2E06 Ab SARS-CoV1, MERS-CoV SARS-CoV2 S; RBD Immunised Mouse 100 EVQLQQSVADLVRPGASVKLSCTASGFN SARS-CoV2 (weak) IKNTYMHWVKQRPEQGLEWIGRIDPTN GDTKYVSKFQGKATITADTSSNTAYLQLS SLTSEDTAIYYCATYGSYYLYYYAMNYWG QGTSVTVSS 2E10 Ab SARS-CoV1, MERS-CoV SARS-CoV2 S; RBD Immunised Mouse 101 EVQLQQPGAELVRPGASVKLSCKASGYT SARS-CoV2 FTDYYINWVKQRPGQGLEWIARIYPGT GTTYYNEKFKGKATLTAEKSSSTAYMQLS SLTSEDSAVYFCARYDGNLYYYAMDYW GQGTSVTVSS 2F04 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 102 EVQLQQPGAELVKPGASVKMSCKASGY SARS-CoV1 TFTSYWITWVKQRPGQGLEWIGDIYPG SGSTKYNEKFRSEATLTVDTSSTTAYMQL SSLTSEDSAVYYCARWDFYGSRTFDYWG QGTTLTVSS 2H04 Ab SARS-CoV2 MERS-CoV, SARS-CoV2 S; RBD Immunised Mouse 103 EVQLQQSGAELVKPGASVKMSCKASGY SARS-CoV1 TFTSYWITWVKQRPGQGLEWIGDIYPG SGSTKYNEKFRSEATLTVDTSSTTAYMQL SSLTSEDSAVYYCARWDFYGSRTFDYWG QGTTLTVSS 2M- Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 104 EVQLVESGGGLVQPGGSLRLSCAASGFT 10B11 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARATWLRGVMDVW GQGTTVTVSS 2M-12D7 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 105 EVQLVESGGGLVQPGRSLRLSCAASGFT Human Patient FDDYVMHWVRQAPGKGLEWVSGINW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKDVRYCSSTSCYFS AFDIWGQGTMVTVSS 2M-13A3 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 106 EVQLVESGGGVVQPGRSLRLSCAASGFT Human Patient FSGYAMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARGGGSYYYWFDP WGQGTMVTVSS 2M- Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 107 EVQLVQWGAGLLKPSETLSLTCAVYGGS 13D11 Human Patient FSGYYWSWIRQPPGKGLEWIGEINHSG STNYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARAGYSSSWYGVRGVDP WGQGTMVTVSS 2M-14B2 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 108 QVQLLQSGGGVVQPGRSLRLSCAASGF Human Patient TFSTYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKGSDIVVVPVG NWFDPWGQGTLVTVSS 2M-14E4 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 109 QVQLQESGPGLVKPSETLSLACTVSGGS Human Patient VSSDNSYWSWIRQPPGKGLEWIGYTFH SGSANYNPSLKSRVTISVDTSKNQFSLKL SSVTAADTAVYYCARVQRYYPDSSGFYG RRFDIWGQGTLVTVSS 2M-14E5 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 110 EVQLVESGGGVVQPGRSLRLSCAASGFT Human Patient FSTYSMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ VNSLRAEDTAVYYCARSGGGSYRGPFDY WGQGTLVTVSS 2M-2D1 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-COV2 111 EVQLVESGPGLVKPSETLSLTCTVSGGSI Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYSARGDRIQLWLLDAFDIW GQGTMVTVSS 2M-2D4 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 112 EVQLVESGGGLVQPGGSLRLSCAASGFT Human Patient FSSYAMSWVRQAPGKGLEWVSAISGSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKIGLGLGGLLRRYFD YWGQGTLVTVSS 2M-2G12 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 113 QVQLVESGGGLLKPGETLSLSCAASGFTF Human Patient SDYYWSWIRQAPGKGLEWIAVINHSGS TIYYPYPVKGVFIFSRDTANNFSLKLMN MMTSDTAVYYCGTRIMITWYSRRGMD GWGKGVTVTVSS 2M-4G4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 114 EVQLVESGAEVKKPGASVKVSCKASGYT Human Patient FTSYYIHWVRQAPGQGLEWMGVINPS GGSTTYAQKFQGRVTVTRDTSTSTVYM ELSSLRSEDTAVYYCARERGDSSGYYEII TTANRRFGMDVWGQGTTVTVSS 2M-7E9 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 115 EVQLVESGAEVKKPGSSVKVSCKASGGT Human Patient FSSFAISWVRQAPGQGLEWMGGIIPIFD TTNYAQKFQGRVTITADESTRTAYMELS SLRSEDTAVYYCARIPGWDRGTDRNWN DDWGQGTTVTVSS 2M-8E7 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 116 EVQLVESGAEVKKPGSSVKVSCKASGGT Human Patient FSSYAISWVRQAPGQGLEWMGGIIPIFG TANYAQKFQGRVTVTADESTSTAYMELS SLRSEDTAVYYCARTYSFDSSGYYYDYW GQGTMVTVSS 2M-8H10 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 117 QVQLVESGGGVVLPGRSLRLSCAASGFT Human Patient FSTFAMHWVRQAPGKGLEWVAVISDE GSNKYYADSVKGRFTISRDNSRNTLYLQ MNSLRAEDTAVYYCARAFYDSNWSVGS YFDSWGQGTPVTVSS 2M-9F10 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 118 EVQLLQSGGDLIQPGRSLRLSCAASGFSF Human Patient EDYAMHWVRQAPGQGLEWVSGISYN GGSIDYVDSVKGRFTISRDNAKNALYLE MNSLRPEDTAFYYCAKDSVRREYTHARV PFDNWGLGTLVTVSS 2M-9H1 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 119 EVQLLESGGGVVQPGRSLRLSCVASGFN Human Patient FNNYGMHWVRQAPGKGLEWLAALSYE GSKEHYADSLKGRFTVSRDYSRATLHLH MNSLEPEDTAVYFCAKSSKIFYLGESREV DYWGRGTLVTVSS 31B5 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient 31B9 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient 32D4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient 413-2 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 ND RBD Human Patient 414-1 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 47D11 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV1 ND SARS-CoV2 and SARS- Human Patient CoV1 4A8 Ab SARS-CoV2 SARS-CoV2 S; S1 (non B-cells; SARS-CoV2 120 EVQLVESGAEVKKPGASVKVSCKVSGYT RBD) Human Patient LTELSMHWVRQAPGKGLEWMGGFDP EDGETMYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATSTAVAGTPDLF DYYYGMDVWGQGTTVTVSS 505-3 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 505-5 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 505-8 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 ND RBD Human Patient 515-1 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 515-5 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 ND RBD Human Patient 553-15 Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 ND SARS-CoV2 SARS-CoV2 Human Patient 553-49 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 553-60 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 553-63 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 ND Human Patient 8D2 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 121 EVQLVESGGGLVQPGGSLRLSCAASGFT Human Patient FSSYWMSWVRQAPGKGLEWVANINQ DGSEKYYVDSVKGRFTISRDNAKNSLYL QVNSLRAEDTAVYYCARDWDYDILTGS WFGAFDIWGQGTTVTVSS 8D9 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 122 EVQLLESGGGLVQPGGSLRLSCTASGFT Human Patient FSSYWMSWVRQAPGKGLEWVANIQQ DGSEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARPTIGYSYGSDY WGQGTTVTVSS 9A1 Ab SARS-CoV2 SARS-CoV2 S; S2 B-cells; SARS-CoV2 123 EVQLLESGGGVVQPGRSLRLSCVVSGFT Human Patient FNNYGMHWVRQAPGKGLEWVAVISYE GSVKYYGDHVDGRFTISRDPFKNTLYLH MNNLRPDDTAVYYCAKVSAIFWLGQGL SPIDVWGQGTTVTVSS Ab_510A Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_510A5 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_510D7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_510G Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_510H10 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_510H2 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_510H Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_510H7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511A1 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511A5 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511B11 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511B Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511D11 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511E5 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511E7 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511E9 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511G5 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511G7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511H11 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_511H7 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_51A1 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_51A3 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_51D2 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_51D3 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_51D4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_51D7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_51E10 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_51E12 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_51E7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_51F11 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_52C1 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_52C6 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_52F7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_52G9 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_53C10 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_53C5 Ab SARS-CoV2 S; RBD B-cells; SARS-COV2 ND Human Patient Ab_53F12 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_53F9 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_53H3 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_55A8 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_55C9 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_56C12 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_56D7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_56E1 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_56H11 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_56H3 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57A6 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57A8 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57A9 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57B8 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_57C4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57E11 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_57F7 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_57G9 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_58A4 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_58D2 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_58G1 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_58G6 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_59A2 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_59D6 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_81A11 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_81C3 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_81C7 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_81C8 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_81E1 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND (weak) Human Patient Ab_81E10 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_81F2 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_82B6 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_82C6 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Ab_82F6 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient Acharya Ab HIV S Glycans B-cells; HIV Human Various et al., Glycans, Patient 2020 SARS-CoV2 Glycans B38 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 124 EVQLVESGGGLVQPGGSLRLSCAASGF Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRHNSKNTLYLQM NSLRAEDTAVYYCAREAYGMDVWGQG TTVTVSS BD-236 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 125 EVQLVESGGGLIQPGGSLRLSCAASGITV Human Patient SSNYMSWVRQAPGKGLEWVSVIYSGG STDYADSVKGRFTISRDKSKNTLYLQMN SLRAEDTAVYYCARDLGEAGGMDVWG QGTTVTVSS BD-368-2 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-494 Ab SARS-CoV2 SARS-CoV2 S; Phage Display ND probably Library (Antibody, RBD human, immune - (implied CoV2) by clustering) BD-498 Ab SARS-CoV2 SARS-CoV2 S; Phage Display ND probably Library (Antibody, RBD human, immune - (implied CoV2) by clustering) BD-500 Ab SARS-CoV2 SARS-CoV2 S; B-cells; SARS-CoV2 ND probably Human Patient RBD (implied by clustering) BD-503 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-504 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-505 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-506 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-507 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-508 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-515 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient BD-604 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 126 EVQLVESGGGLIQPGGSLRLSCAASGIIV Human Patient SSNYMTWVRQAPGKGLEWVSVIYSGG STFYADSVKGRFTISRDNSKNTLYLQMSS LRAEDTAVYYCARDLGPYGMDVWGQG TTVTVSS BD-629 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 127 EVQLVESGGGLIQPGGSLRLSCAASEFIV Human Patient SRNYMSWVRQAPGKGLEWVSVIYSGG STYYADSVKGRFTISRDNSKNTLNLQMN SLRAEDTAVYYCARDYGDYYFDYWGQG TLVTVSS BD23 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 128 QVQLVQSGSELKKPGASVKVSCKASGYT Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARPQGGSSWYRDY YYGMDVWGQGTTVTVSS Bertoglio Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display 17 et al., Library (Antibody, 2020 human, non- immune) C002 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 129 EVQLVESGGGVVQPGRSLRLSCAASGFT Human Patient FSIYGMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKEGRPSDIVVVVA FDYWGQGTLVTVSS C003 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 130 EVQLVESGGGLIQPGGSLRLSCAASGFT (weak) Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAGDTAVYYCARDYGDFYFDYWGQ GTLVTVSS C004 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 131 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPISGGTNYAQKFQGRVTMTRDTSISTA YMELSRLRSDDTAVYYCASPASRGYSGY DHGYYYYMDVWGKGTTVTVSS C005 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 132 QVQLVQSGPEVKKPGTSVKVSCKASGFT Human Patient FTSSAVQWVRQARGQRLEWIGWIVVG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPHCSGGSCLDAF DIWGQGTMVTVSS C006 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 133 QVQLVESGGGLVKPGGSLRLSCAASGFI (weak) Human Patient FSDYCMSWIRRAPGKGLEWLSYISNSGT TRYYADSVKGRFTISRDNGRNSLYLQMD SLSAEDTAVYYCARRGDGSSSIYYYNYM DVWGKGTTVTVSS C008 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 134 EVQLVESGGGVVQPGRSLRLSCAASGFT (weak) Human Patient FSSYGMHWVRQAPGKGLEWVTVISYD GRNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAREFGDPEWYFDY WGQGTLVTVSS C009 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 135 QVQLVQSGAEVKKPGASVKVSCMASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYAQKFQGRVTMTRDTSIST AYMELSRLRSDDTAVYYCARDSPFSALG ASNDYWGQGTLVTVSS C010 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 136 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSSYAMHWVRQAPAKGLEWVAVILYD GSGKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDGIVDTALVTW FDYWGQGTLVTVSS C013 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 137 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak) Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITADESTSTAYMEL SSLRSEDTAVYYCARGNRLLYCSSTSCYL DAVRQGYYYYYYMDVWGKGTTVTVSS C016 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 138 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSRYGMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKVTAPYCSGGSCY GGNFDYWGQGTLVTVSS C017 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 139 EVQLVESGGGLVQPGRSLRLSCAASGFT Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGTIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAFYYCAKAGVRGIAAAGP DLNFDHWGQGTLVTVSS C018 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 140 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSNYAIHWVRQAPGKGLEWVAVISYDG SNKYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDFDDSSFWAFDY WGQGTLVTVSS C019 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 141 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARVPREGTPGFD PWGQGTLVTVSS C021 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 142 QVQLQESGPGLVKPSQTLSLTCTVSGGSI SARS-CoV2 Human Patient SSGGYYWSWIRQHPGKGLEWIGYIYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARVWQYYDSSGSFDYW GQGTLVTVSS C022 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 143 QVQLQESGPGLVKPSETLSVTCTVSGGSI SARS-CoV2 Human Patient SSSRYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARHAAAYYDRSGYYFIEY FQHWGQGTLVTVSS C027 Ab SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 144 EVQLVESGGGVVQPGRSLRLSCAASGFT (weak), Human Patient FSSYGMHWVRQAPGKGLEWVAVISYD SARS-CoV2 GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKASGIYCSGGDCY SYYFDYWGQGTLVTVSS C029 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 145 QVQLQESGPGLVKPSQTLSLTCTVSGGSI SARS-CoV2 Human Patient SSGGYYWSWIRQHPGKGLEWIGYIYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARTMYYYDSSGSFDYW GQGTLVTVSS C030 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 146 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSSYGMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKASGIYCSGGNCY SYYFDYWGQGTLVTVSS C031 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 147 EVQLVESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSSYDMHWVRQATGKGLEWVSAIGTA GDTYYPGSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARVGYDSSGYSGWY FDLWGRGTLVTVSS C101 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 148 QVQLVESGGGLIQPGGSLRLSCAASGFI Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYTDSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCVRDYGDFYFDYWGQ GTLVTVSS C102 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 149 QVQLVESGGGLIQPGGSLRLSCAASGFI Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDYGDYYFDYWGQ GTLVTVSS C103 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 150 QVQLQQWGAGLLKPSETLSLTCAVSGG Human Patient SLSGFYWTWIRQPPGKGLEWIGETNHF GSTGYKPSLKSRVTISVDMSRNQFSLKVT SVTAADTAVYYCARKPLLYSDFSPGAFDI WGQGTMVTVSS C104 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 151 QVQLQQWGAGLLKPSETLSLSCAVYGG Human Patient SLSGYYWSWIRQPPGKGLEWIGEINHF GSTGYNPSLKSRVTISVDTSKSQFSVKLS SVTAADTAVYYCARKPLLYSNLSPGAFDI WGQGTMVTVSS C105 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 152 QVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARGEGWELPYDYWG QGTLVTVSS C106 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 153 QLQLQESGPGLVKPSETLSLTCTVSGASV SARS-CoV2 Human Patient SSGSYYWSWIRQPPGKGLEWIGYIYYSG STNYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARERPGGTYSNTWYTPT DTNWFDTWGQGTLVTVSS C107 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 154 QVQLVQSGAEVKKPGASVRVSCKASGY SARS-CoV2 Human Patient TFTSYGFSWVRQAPGQGLEWMGWISA YNGNTNFAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARGEAVAGTTGF FDYWGQGTLVTVSS C108 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 155 QVQLQESGPGLVKPSGTLSLTCAVSGGS (weak) Human Patient ISSTNWWSWVRQPPGKGLEWIGEIYHT GSTNYNPSLKSRVTISVDKSKNQFSLKLS SVTAADTAVYYCVRDGGRPGDAFDIWG QGTMVTVSS C109 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 156 EVQLVESGGGLVQPGGSLRLSCAASGFT Human Patient FSSYWMSWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKGRFTISGDNAKNSLYL HMNSLRAEDTAVYYCAIQLWLRGGYDY WGQGTLVTVSS C110 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 157 QVQLQQSGAEVKKPGESLKISCKGSGYS Human Patient FTSYWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYMQ WSSLKASDTAMYYCARSFRDDPRIAVA GPADAFDIWGQGTMVTVSS C111 Ab SARS-CoV2 S; RBD B-cells; SARS-CoV2 158 QLQLQESGPGLVKPSETLSLTCTVSGGSI Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARVEDWGYCSSTNCYSGAF DIWGQGTMVTVSS C112 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 159 QVQLVESGGGVVQPGRSLRLSCAASGF (weak) Human Patient TFSSHAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAREDYYDSSGSF DYWGQGTLVTVSS C113 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 160 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 Human Patient TFSNFGMHWVRQAPGKGLEWVAVIW YDGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARGVNPDDILTG VDAFDIWGQGTMVTVSS C114 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 161 QVQLVESGGGLIQPGGSLKLSCVVSGFT SARS-CoV2 Human Patient VSKNYISWVRQAPGKGLEWVSVIFAGG STFYADSVKGRFAISRDNSNNTLFLQMN SLRVEDTAIYYCARGDGELFFDQWGQG TLVTVSS C115 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 162 QVQLVESGGGLIKPGRSLRLSCTASGFTF (weak) Human Patient GDYAMTWFRQAPGKGLEWVGFIRSKA YGGTTGYAASVKYRFTISRDDSKSIAYLQ MDSLKTEDTAVYYCTRWDGWSQHDY WGQGTLVTVSS C116 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 163 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 Human Patient TYSTYAMHWVRQAPGKGLEWVAFISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDFYHNWFDPW GQGTLVTVSS C117 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 164 QVQLVESGGGVVQPGRSLRLSCAASGF (weak) Human Patient TFSTYAMHWVRQAPGEGLEWVAVISY DGSNTYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDPIWFGELLSP PFVHFDYWGQGTLVTVSS C118 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 165 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 (weak) Human Patient TFSNYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAIYYCASGYTGYDYFVRG DYYGLDVWGQGTTVTVSS C119 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 166 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKLQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARANHETTMDTY YYYYYMDVWGKGTTVTVSS C120 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 167 EVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMTWVRQAPGKGLEWVSLIYPG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAREGMGMAAAGTW GQGTLVTVSS C121 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 168 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWIS PVSGGTNYAQKFQGRVTMTRDTSISTAY MELSRLRSDDTAVYYCARAPLFPTGVLA GDYYYYGMDVWGQGTTVTVSS C122 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 169 EVQLVESGGGLIQPGGSLRLSCAASGLT Human Patient VSSNYMSWVRQAPGKGLEWVSVLYSG GSSFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARESGDTTMAFDYW GQGTLVTVSS C123 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 170 EVQLVESGGGLIQPGGSLRLSCAASGVT Human Patient VSRNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDLSAAFDIWGQG TMVTVSS C124 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 171 EVQLVESGGGLVQPGGSLRLSCAASGFT (weak) Human Patient FSGYSMNWVRQAPGKGPEWVSYISRSS STIYYADSVKGRFTISRDNAKNSLYLQMN SLRDEDTAVYYCAREGARVGATYDTYYF DYWGQGTLVTVSS C125 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 172 QVQLVQSGPEVKKPGTSVKVSCKASGFT Human Patient FTSSAVQWVRQARGQRLEWIGWIVVG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPYCSGGSCSDAF DIWGQGTMVTVSS C126 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 173 QVQLQESGPGLVKPSETLSLSCAVSGGSI SARS-CoV2 Human Patient GSYFWSWIRQPPGKGLEWIGYLHYSGS TNYNPSLKSRVTISVDTSKNQFSLKLSSV TAADTAVYYCARLQWLRGAFDIWGQGT MVTVSS C127 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 174 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYAQKFQGRVTMTRDTSIST AYMELSRLRSDDTAVYYCATAHPRRIQG VFFLGPGVWGQGTTVTVSS C128 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 175 EVQLLESGGGLVQPGGSLRLSCAASGFT Human Patient FSTYAMSWVRQAPGKGLEWVSTITGSG RDTYYADSVKGRFTISRDNSKNTLFLQLN SLRAEDAAVYSCANHPLASGDDYYHYY MDVWGKGTTVTVSS C130 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 176 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 Human Patient TFTNYYMHWVRQAPGQGLEWMGIINP SGGSTGYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARSRPTPDWYFD LWGRGTLVTVSS C131 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 177 QVQLVQSGSEVKKPGSSVKVSCKASGG Human Patient TFSSYAFSWVRQAPGQGLEWMGRIIPIL ALANYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCARVNQAVTTPFSMDV WGQGTTVTVSS C132 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 178 QVQLQESGPGLVKPSGTLSLTCAVSGGS (weak) Human Patient ISSNNWWSCVRQPPGKGLEWIGEIYHS GSTNYNPSLKSRVTISVDKSKNQFSLKLS SVTAADTAVYYCARGGDTAMGPEYFDY WGQGTLVTVSS C133 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 179 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVILY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDSDVDTSMVT WFDYWGQGTLVTVSS C134 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 180 EVQLLESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSNYAMSWVRQAPGKGLEWVSAISGS DGSTYYAGSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDPLITGPTYQYF HYWGQGTLVTVSS C135 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 181 QVQLVESGGGVVQPGRSLRLSCAASGF Human Patient TFSSYAMHWVRQAPGKGLEWVAVIPF DGRNKYYADSVTGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCASSSGYLFHSDY WGQGTLVTVSS C138 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 182 EVQLVESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSTYWMSWVRQPPGKGLEWVANIKQ DGSEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRADDTAVYYCAGGTWLRSSFDY WGQGTLVTVSS C139 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 183 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSSYAMHWVRQAPGKGLEWVAVISYD GSNKYSADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKGGAYSYYYYMD VWGKGTTVTVSS C140 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 184 EVQLVESGGGLVQPGGSLRLSCAASGVT Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG STFYADSVKGRFTISRDNSENTLYLQMN TLRAEDTAVYYCARDLYYYGMDVWGQ GTTVTVSS C141 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 185 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FSSYAMFWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARADLGYCTNGVC YVDYWGQGTLVTVSS C143 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 186 EVQLVESGGGLVQPGGSLRLSCAASGFS SARS-CoV2 Human Patient VSTKYMTWVRQAPGKGLEWVSVLYSG GSDYYADSVKGRFTISRDNSKNALYLQM NSLRVEDTGVYYCARDSSEVRDHPGHP GRSVGAFDIWGQGTMVTVSS C144 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 187 EVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSNNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDKSKNTLYLQM NRLRAEDTAVYYCAREGEVEGYNDFWS GYSRDRYYFDYWGQGTLVTVSS C145 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 188 EVQLVESGGGLIQPGGSLRLSCAASGFS Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAREGEVEGYYDFWS GYSRDRYYFDYWGQGTLVTVSS C146 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 189 EVQLVESGGGLVKPGGSLRLSCAASGLT SARS-CoV2 RBD Human Patient FTAYRMNWVRQAPGKGLEWLSSISNTN GDIYYADSVKGRFTISRDNAKNSLYLQM NSLRADDTAVYYCARDVASNYAYFDLW GQGTLVTVSS C147 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 190 EVQLVQSGAEVKKPGESLKISCKGSGYR SARS-CoV2 RBD Human Patient FTNYWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSITTAYLQW SSLKASDTAMYYCARLSDRWYSPFDPW GQGTLVTVSS C148 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 191 EVQLVESGGGLVQPGGSQRLSCAASGF SARS-CoV2 Human Patient TVSSNYMSWIRQAPGKGLEWVSVIYSG GSAYYVDSVKGRFTISRDNSKNTLYLQM NSLRPEDTAVYYCARIANYMDVWGKGT TVTVSS C150 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 192 EVQLVESGGGLVQPGGSLRLSCVASGFT SARS-CoV2 Human Patient FSSYWMHWVRQVPGKGPVWVSHINS EGSSTNYADSVRGRFTISRDNAKDTLYL QMNNLRAEDTAVYYCARPTAVAAAGN YFYYYGMDVWGQGTTVTVSS C151 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 193 EVQLVESGGGLVKPGGSLRLSCAASGFT (weak) Human Patient FSSYNMNWVRQAPGKGLEWVSCISSSS SYIYYADSVKGRFTISRDNAKNSLYLQMN SLRAEDTAVYYCARERGYDGGKTPPFLG GQGTLVTVSS C153 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 194 EVQLVESGGGLIQPGGSLRLSCAASGFT (weak) Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSGY STYYVDSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARVGGAHSGYDGSFDY WGQGTLVTVSS C154 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 195 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 (weak) Human Patient TFSRYGMHWVRQAPGKGLEWVAVMS YDGSSKYYADSVKGRFTISRDNSKNTLCL QMNSLRAEDTAVYYCAKQAGPYCSGGS CYSAPFDYWGQGTLVTVSS C155 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 196 EVQLVESGGGLIQPGGSLRLSCAASGFIV Human Patient SSNYMSWVRQAPGKGLEWVSVIYSGG STFYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDFGEFYFDYWGQG TLVTVSS C156 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 197 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 Human Patient TFSNYGMHWVRQAPGKGLEWVAVISY DGNNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKDPFPLAVAGT GYFDYWGQGTLVTVSS C164 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 198 EVQLVESGGGLVQPGGSLRLSCAASGFS (weak) Human Patient VSTKYMTWVRQAPGKGLEWVSVLYSG GSDYYADSVKGRFTISRDNSKNALYLQM NSLRVEDTGVYYCARDSSEVRDHPGHP GRSVGAFDIWGQGTMVTVSS C165 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 199 QVQLVQSGAEVKKPGSSVKVSCKASGG Human Patient TFSSYAINWVRQAPGQGLEWMGRIIPI VGIANYAQKFQGRVTITADKSSSTAYME LSSLRSEDTAVYYCARDLLDPQLDDAFDI WGQGTMVTVSS C201 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 200 EVQLVESGGGLVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCVKGVEYSSSSNFDY WGQGTLVTVSS C202 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 201 EVQLVESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG STYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDTLGRGGDYWGQ GTLVTVSS C204 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 202 EVQLLESGGGLEQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSTYAMSWVRQAPGKGLEWVSAISGSG AGTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARESDCGSTSCYQVG WFDPWGQGTLVTVSS C205 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 203 QVQLVQSGAEVKKPGASVKVSCKASGH SARS-CoV2 RBD Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARGPERGIVGAT DYFDYWGQGTLVTVSS C207 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 204 EVQLLESGGGLVQPGGSLRLSCAASGFT (weak) Human Patient FSSYAMSWVRQAPGKGLEWVSAISGSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKEPIGQPLLWWDY WGQGTLVTVSS C208 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 205 EVQLVQSGAEVKKPGESLKISCKGSGYSF SARS-CoV2 RBD Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLKWS SLKASDSAMYYCARGPNLQNWFDPWG QGTLVTVSS C210 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 206 EVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTFSRDNSKNTLYLQM NSLRAEDTAVYYCARDLMAYGMDVWG QGTTVTVSS C211 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 207 EVQLVESGGGLVQPGGSLRLSCAASEFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRPEDTAVYYCARDYGDFYFDFWGQ GTLVTVSS C212 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 208 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TVTGYYIHWVRQAPGQGLEWMGWISP NSGGTNYAQKFQGWVTMTRDMSITTA YMELSRLRSDDTAVYYCARERYFDLGG MDVWGQGTTVTVSS C214 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 209 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 Human Patient TFSSYGMHWVRQAPGKGLEWVAAIWY DGSNKHYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDVGRVTTWF DPWGQGTLVTVSS C215 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 210 EVQLLESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSSYAMSWVRQAPGKGLEWVSAITDSG DGTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCASEEDYSNYVGWFD PWGQGTLVTVSS C216 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 211 EVQLVESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 Human Patient FSSYDMHWVRQATGKGLEWVSAIGTA GDTYYPDSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARDRGSSGWYGWY FDLWGRGTLVTVSS CA1 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 212 EVQLVQSGAEVKKPGASVKVSCKASGYT Human Patient FTSYGISWVRQAPGQGLEWMGWISAY NGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCAREGYCSGGSCY SGYYYYYGMDVWGQGTTVTVSS CB6 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 213 EVQLVESGGGLVQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSMNTLFLQM NSLRAEDTAVYYCARVLPMYGDYLDYW GQGTLVTVSS CC12.1 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 214 EVQLVESGGGLIQPGGSLRLSCAASGLT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDLDVYGLDVWGQ GTTVTVSS CC12.10 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 215 QVQLVQSGAEVKKPGASVKVSCKASGYI Human Patient YSGYFMHWVRQAPGQGLEWMGWISP DSGGANYAQTFQGRVTMTRDTSTTTAH MELSRLRSDDTAVYYCARGPRYSGTHFD YWGQGTLVTVSS CC12.11 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 216 QVQLVQSGAEVKKPGASVKVSCKASGYI Human Patient FSGYYTHWVRQAPGQGLEWMGWISP DSGGTNYAQKFQGRVTMTRDTSITTAY VELSGLRSDDTAVYYCARGPRYSGTYFD YWGQGTLVTVSS CC12.12 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 217 QVQLVQSGAEVKKPGASVKVSCKASGYI Human Patient YSGYYMHWVRQAPGQGLEWMGWISP DSGGTNYAQRFQGRVTMTRDTSTTTAY MELSRLRSDDTAVYYCARGPRYSGTYFD YWGQGTLVTVSS CC12.13 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 218 EVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDPYGYSSIWDGQ GGHWGQGTLVTVSS CC12.14 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 219 QVQLVESGGGLVKPGGSLRLSCAASGFT Human Patient FNYYSMNWVRQAPGKGLEWISSISTSSS FVYYADSVKGRFTISRDNAKTSLYLQMN SLRAEDTAVYFCARGGYCSDGSCYVQDR LIYYYSGLDVWGQGTTVTVSS CC12.15 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 220 EVQLVESGGGLVQPGGSLRLSCAASGFT Human Patient FSTYEMNWVRQAPGKGLEWVSYISSSG STIYYADSVKGRFTISRDNAKNSLYLQMS SLRAEDTAIYYCARDRRRRYCTNGVCYR PEEIDYWGQGTLVTVSS CC12.16 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 221 QVQLVESGGGVVQPGRSLRLSCAASGF (weak) Human Patient TFSSYGMHWVRQAPGKGLEWVALIWY DGSNKNYADSVKGRFTISRDNSKNTLDL QMNSLRAEDTAVYYCARDPFPGAVAGT GYLQYWGQGTLVTVSS CC12.17 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 222 EVQLVESGGGVVQPGRSLRLSCAASGFT (weak) Human Patient FRNYGMHWVRQAPGKGLEGVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKSSGSYYYYYYGM DVWGQGTTVTVSS CC12.18 Ab SARS-CoV1, SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 223 EVQLVQSGAEVKKPGASVKVSCKASGYT SARS-CoV2 (weak) Human Patient FTSYYMHWVRQAPGQGLEWMGIINPS GGSTSYAQKFQGRVTMTRDTSTSTVYM ELSSLRSEDTAVYYCARLHCGGDCYLDY WGQGTLVTVSS CC12.19 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 224 EVQLLESGGGLVQPGGSLRLSCAASGFT (weak) Human Patient FSSYAMSWVRQAPGKGLEWVSAISGSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKGSGSGSYPNYYYY YGMDVWGQGTTVTVSS CC12.2 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 225 EVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVFYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDYGDLYFDYWGQ GTLVTVSS CC12.20 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1 S; non- B-cells; SARS-CoV2 226 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMSSLRGEDTAVYYCAKDQAYYDILTGY LNPPKNYYYYGMDVWGQGTTVTVSS CC12.21 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1 S; non- B-cells; SARS-CoV2 227 QVQLVQSGAEVKKPGASVKVSCKVSGY RBD Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MDLSSLRSEDTAVYYCATAFSIFGVVPPD YWGQGTLVTVS CC12.23 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 228 QVQLQESGPGLVKPSETLSLTCTVSGGSI (weak) RBD Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARQGDCSTTSCAYDYWG QGTLVTVSS CC12.24 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1 S; link B-cells; SARS-CoV2 229 EVQLVESGGGVVQPGRSLRLSCSASGFT Human Patient FSIYGMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDRTGNYYYGM DVWGQGTTVTVSS CC12.25 Ab SARS-CoV1, SARS-CoV1 S; non- B-cells; SARS-CoV2 230 QVQLVESGGGLVQPGGSLRLSCAASGF SARS-CoV2 RBD Human Patient TFSSYAMSWVRQAPGKGLEWVSAISGS GDSTYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDRYYEFWSGYS NWFDPWGQGTLVTISS CC12.26 Ab SARS-CoV2 SARS-CoV1 SARS-CoV1 S; non- B-cells; SARS-CoV2 231 EVQLVQSGAEVKKPGESLKISCKGSGYSF RBD Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTVSADKSISTAYLQW SSLKASDTAMYYCARVNYYDSSGYPSFH FDYWGQGTLVTVS CC12.27 Ab SARS-CoV1, SARS-CoV1 S; non- B-cells; SARS-CoV2 232 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TFIGYYMHWVRQAPGQGLEWMGWIN PNSGGTNYAQKFQGRVTMTRDTSISTV YMELSRLRSDDTAVYYCAREMPAAMGY YYYGMDVWGQGTTVTVSS CC12.28 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 233 EVQLLESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 and SARS- Human Patient FSNYAMTWVRQAPGKGLEWVSAISSGS CoV1 GSTYYADSVKGRFTISRDNSKNTVYLQM NSLRAEDTAIYYCAKANKYSSSEFDFWG QGTLVTISS CC12.3 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 234 QVQLVESGGGLIQPGGSLRLSCAASGFT Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKSTLYLQM NSLRVEDTAVYYCARDFGDFYFDYWGQ GTLVTVSS CC12.4 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 235 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWIS PNSGGTNYAQKFQGWVTMTRDTSVST AYMELSRLRFDDTAVYYCATESWVYGS GSYSSGAFDIWGQGTMVTVSS CC12.5 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 236 EVQLVQSGAEVKKPGASVKVSCKASGYI Human Patient YSGYYMHWVRQAPGQGLEWMGWISP DSGGTNYAQRFQGRVTMTRDTSTTTAY MELSRLRSDDTAMYYCARGPRYSGTYF DYWGQGTLVTVSS CC12.6 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 237 QVQLVQSGAEVKKPGASVKVSCKASGY! Human Patient FSGYYMHWVRQAPGQGLEWMGWISP DSGGTNYAQKFQGRVTMTRDTSITTGY MELSGLRSDDTAVYYCARGPRYSGTYFD YWGQGTLVTVSS CC12.7 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 238 EVQLVQSGAEVKKPGASVKVTCKTSGYI Human Patient FSGYYMHWVRQVPGQGLEWMGWISP DSGATNYAQKFQGRVTMTRDTSITTSYV ELTWLKSDDTAVYYCARGPRYSGTYFDF WGQGTLVTVSS CC12.8 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 239 QVQLVQSGAEVKKPGASVKVSCKASGYI Human Patient FSGYYTHWVRQAPGQGLEWMGWISP DSGGTNYAQKFQGRVTMTRDTSITTAY VELSGLRSDDTAVYYCARGPRYSGTYFD YWGQGTLVTVSS CC12.9 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 240 EVQLVQSGAEVKKPGASVKVSCKASGYI (weak) RBD Human Patient FSGYYMHWVRQAPGQGLEWMGWISP DSGGTNYAQNFQGRVTMTRDTSISTGY MELSRLRSDDTAMYYCARGPRYSGTYF DYWGQGVLVTVSS CC6.29 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 241 QVQLVQSGSELKKPGASVKVSCKASGYT Human Patient FATYALNWVRQAPGQGLEWMGWVNT NTGSPTYAQGFTGRFVFSFDTSVSTAYL QIRTLKAEDTAVYYCAVYYYDSGSPGWF DPWGQGTLVTVSS CC6.30 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 242 QVQLVQSGAEVKKPGSSVKVSCKASGG Human Patient TFSIYAITWVRQAPGQGLEWMGGIIPII GTANYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCARDFRYCSSTRCYFWF DPWGQGTLVTVSS CC6.31 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 243 EVQLVQSGAEVKKPGASVKVSCMASGY Human Patient TFTSYYMHWVRQAPGQGLEWMGIISP SGGGTSYAQKFQGRVTLTRDTSTSTVYM ELSSLRSEDTAVYYCARWYDSTGSIDYW GQGTLVTVSS CC6.32 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 244 EVQLVESGGGLVQPGRSLRLSCAASGFT SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIAFAGSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKDQGYSYGNYFD YWGQGTLVTVSS CC6.33 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 245 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 and SARS- Human Patient TFSSSAISWVRQAPGQGLEWMGGIIPIL CoV1 DITNYAQKFQGRVTITADKSTSTAFMELS SLRSEDTAVYYCALRNQWDLLVYWGQG TLVTVSS Clone11- Ab SARS-CoV2 S; RBD Immunised Mouse 246 QVQLQQPGAELVMPGASVKMSCKASG 9 YTFTDYWMHWVKQRPGQGLEWIGAE DTSDSYTSYNQKFKGKATLTVDESSSTAY MQLSSLTSEDSAVYYCARRGYGSSYTWF AYWGQGTLVTVSA CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; link B-cells; SARS-CoV2 247 QVQLVQSGAEVKKPGSSVKVSCKASGG B10 Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCARVSGYDSSGYWGDY WGQGTLVTVSS CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 248 QVQLVQSGAEVKKPGASVKVSCKASGY B4 Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARDGELLGWFD PWGQGTLVTVSS CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 249 EVQLVESGGGLVQPGRSLRLSCTASGFT D6 Human Patient FGDYAMSWFRQAPGKGLEWVGFIRSK AYGGTTEYAASVKGRFTISRDDSKSIAYL QMNSLKTEDTAVYYCTRVRRLWFGSYY YGMDVWGQGTTVTVSS CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 250 EVQLVESGGGLVQPGRSLRLSCTASGFT E12 Human Patient FGDYAMSWFRQAPGKGLEWVGFIRSK AYGGTTEYAASVKGRFTISRDDSKSIVYL QMNSLKTEDTAVYYCTRVRRLWFGSYY YGMDVWGQGTTVTVSS CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 251 QVQLVQSGAEVKNPGASVKVSCKASGY E8 Human Patient IFTNYYIHWVRQAPGQGLEWVGWIHSL SGGTSYAQKFQGRVTLTRDASIRTAYME LSRLGSDDTALYYCARASVSTITDFDYWG QGTLVAVSS CnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 252 QVQLVQSGAEVKKPGASVKVSCKASGYI G6 Human Patient FTNYYIHWVRQAPGQGLEWVGWIHSL SGGTSYAQKFQGRVTLTRDAPIRTAYME LSGLGSDDTAVYYCARASVATITDFDYW GQGTLVAVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 253 QVQLVESGGGVVQPGRSLRLSCAASGF 2006 SARS-CoV2 RBD Human Patient TFSYYAILWFRQAPGKGLEWVAIISYDGS NKYYADSVKGRFTISRDNSKNTLYLQMN SLRPEDTAVYYCARPQSGGYYAPLDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 254 QVQLVESGGGVVQPGRSLRLSCAASGF 2007 SARS-CoV2 Human Patient TFSRYGMHWVRQAPGKGLEWVGIISYD ASDKTYAESVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKVSATYYYYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 255 QVQLVESGGGVVQPGRSLRLSCAASGF 2009 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNPKNTLYL QMNSLRAEDTAVYYCARDTATYVLLWS GDFNLDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 256 QVQLVESGGGVVQPGRSLRLSCAASGF 2011 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLEWVTLISYD GGNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDAAVYFCARGHTGNYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 257 QVHLVESGGGVVQPGRSLRLSCAASGF 2013 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVISG DENNKFYANSVKGRFTISRDNSKNTLSL QMNSLRPEDTARYYCAKGGDSSGWAW DGDNPPTDYWGQGTLVIVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 258 EVQLVESGGGLVQPGRSLRLSCAASGFT 2015 SARS-CoV2 (weak) Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRTEDTALYYCAMGPFGELLPYYFD YWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 259 QVQLVQSGAEVKKPGASVKVSCKVSGY 2016 SARS-CoV2 Human Patient TLTELSIHWVRQAPGKGLEWMGGFDP EDAETIYAQNFQGRVTMTEDTSTDTAY MELSSLRSEDTALYYCAAAPAVMTAGW FDPWGQGTLVSVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 260 QVQLEESGPGLVKPSETLSLTCTVSGGSI 2017 SARS-CoV2 RBD Human Patient SSHYWSWIRQPPGKGLEWIGYIQDSGS TNYNPSLKSRVTISVDTSKNQFSLRLSSV TTADTAVYYCVRGAMAWFDPWGQGTL VTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 261 QVQLVQSGAEVKKPGASVKVSCKVSGY 2021 SARS-CoV2 Human Patient TLIELSIHWVRQAPGKGLEWMGGFDPE DVETIYAQKFQGRVTMTEDTSTDTAYM ELSSLTSEDRAVYYCATQPAAIGGTPPYY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 262 QVQLVQSGAEVKKPGASVKVSCKASGY 2022 SARS-CoV2 RBD Human Patient TFTSYVISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARDQGPTYYYGS GSPHYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 263 QVHLVESGGGVVQPGRSLRLSCAASGF 2025 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVISG DENNKFYANSVKGRFTISRDNSKNTLSL QMNSLRPEDTARYYCAKGGDSSGWAW DGDNPPTDYWGQGTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 264 QVQLVQSGAEVKKPGASVKVSCKVSGY 2026 SARS-CoV2 Human Patient TLTELSIHWVRQAPGKGLEWMGGFDP EDGETVYAQKFQGRVTMTEDTSSDTAY MELSSLRSEDTAVYYCATSFPIRGDPSYY YYYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 265 QVQLVESGGGVVQPGRSLRLSCAASGFI 2027 SARS-CoV2 RBD Human Patient FSTYGMHWVRQAPGKGLEWVAVISYD GSNKYNADSVKGRFTISRDNSKNTLYLQ MNSLRVEDTAVYYCAIYGYYYYGLDVW GQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 266 QVHLVESGGGVVQPGRSLRLSCAASGF 2028 SARS-CoV2 RBD Human Patient SFRNYGMHWVRQAPGKGLEWVAVISG DENNKFYANSVKGRFTISRDNSKNTLSL QMNSLRPEDTARYYCAKGGDSSGWAW DGDNPPTDYWGQGTLVIVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 267 QVQLQESGPGLVKPSGTLSLTCVVSGGS 2029 SARS-CoV2 RBD Human Patient ISSSNWGWVRQPPGKGLEWIGEIYLSG TTNYNPSLTSRVTISVDKSKNQFSLKLNS VTAADTAIYYCARPTAGAGGAFDIWGQ GTVVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 268 QVTLKESGPVLVKPTETLTLTCTVSGFSL 2031 SARS-CoV2 Human Patient SNARMGVSWIRQPPGKALEWLAHIFWN DENSYSTSLKTRLTISKDTSKSQVVLNMT NMDPVDTATYYCARTEWLLSDNWFDS WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 269 QVQLVQSGAEVKKPGASVKVSCKASGD 2032 SARS-CoV2 Human Patient TFSSYYLHWVRQAPGQGLQWMGISNP SGGSTTYAQKFQGRVTMTGDTSTSTVY MELSSLRSEDTAVYYCARGGLVPAARNA FDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 270 QVQLQESGPGLVKPSGTLSLTCVVSGGS 2033 SARS-CoV2 RBD Human Patient ISSSNWGWVRQPPGKGLEWIGEIYHSG TTNYNPSLRSRVTISVDKSKNQLSLKLNS VTAADTAIYYCARPTAGAGGAFDTWGQ GTMVTVSA COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 271 QVQLVQSGAEVKKPGASVKVSCKASGY 2034 SARS-CoV2 RBD Human Patient TFTTYGISWVRQAPGQGLEWMGWISA YNGNSNYGKKFQGRVTMTADTSTSTAY MELRSLRSDDTAVYYCARDLPIKVVVPA ADYNWFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 272 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2035 SARS-CoV2 RBD Human Patient NTNGVAVGWIRQPPGKALEWLALIYWD DDKRYSPSLKSRLTITKDTSKNQVVLTMT NMDPVDTATYYCAHRRGILTEDAFDIW GQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 273 EVQLVESGGGLVQPGESLRLSCAASGIT 2037 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFIISRHNSKNTLYLQM NSLRAEDTAVYYCARDLNEHGLDVWG QGTTVSVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 274 QVQLVQSGAEVKKPGASVKVSCKASGY 2039 SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SAGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARGTLIPAHRGAF DIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 275 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2041 SARS-CoV2 RBD Human Patient SSGTYYWSWIRQPAGKGLEWIGRFYTS GSTNYNPSLKSRVTISVDASKNQFSLKLS SVTAADTAVYYCARARPDYYYYYAMDV WGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 276 EVQLVESGGGLVQPGRSLRLSCAASGFT 2046 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIAYTDSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKAHSTGHQYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 277 QVQLVQSGAEVKKPGASVKVSCKASGY 2050 Human Patient TFTDYYMHWVRQAPGQGLEWMGWI NPNSRGTNYAQKFQGRVTMTRDTSIST VYMELSRLTSDDTAVYYCARVVVLGYGR PNNYYDGRNVWDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 278 QVTLRESGPALVKPTQTLSLTCTFSGFSL 2051 SARS-CoV2 Human Patient GTSGMCVSWIRQPPGKALEWLARIDW DDDKYYSTSLKTRLTISKDTSKNQVVLTM TNMDPVDTATYYCARGVVTYDYWGQG TLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 279 QVQLVQSGAEVKKPGSSVKVSCKASGD 2054 SARS-CoV2 RBD Human Patient TFSSYTINWVRQAPGQGLEWMGRIIPIL GIPNYAQKFQGRVTITADKSTSTAFMEL SSLRSEDTAVYYCARGRGYSNYGASYYM DVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 280 EVQLVESGGGLVQPGRSLRLSCAASGFT 2055 SARS-CoV2 Human Patient FDDYAMNWVRQPPGKGLEWVSGISW NSDSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAMYYCAKGRGAGYTSYM DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 281 QVQLAQSGAEVKKPGASVKVSCKAAGY 2064 Human Patient TFTSYDINWVRQATGQGLEWMGWMN SNSGNAGYAQKFQGRVTMTRDTSTSTA YMELSSLTSDDTAVYYCARMRTGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 282 EVQLVESGGGLVQPGGSLRLSCAASGFT 2068 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYPG GSAFYADSVKGRFTISRHNSNNTLCLQM NSLRTEDTAVYYCARSYDILTGYRDAFDI WGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 283 QVQLQQWGAGLLKPSETLSLTCAVSGG 2070 SARS-CoV2 Human Patient SFSAYYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLRSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARVGYSQGYYYYYMDV WGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 284 QMQLVQSGPEVKKPGTSVKVSCKTSGF 2072 Human Patient TFTSSAIQWVRQARGQRLEWIGWIVVG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPHCNRTSCYDAF DLWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 285 QVQLVQSGAEVKKPGSSVKVSCKASGG 2078 SARS-CoV2 Human Patient TFSSYSITWVRQAPGQGLEWMGRIIPVL GIANYAQKFQDRVTITADKSTSTAYMEL SSLRSEDTAVYYCARVGVSGFKSGSNWY FDLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 286 EVQLVESGGGLVQPGGSLRLSCAASGLT 2080 SARS-CoV2 Human Patient VRSNYMTWVRQTPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTVYLQM NSLRAEDTAVYYCARDLVTYGLDVWGQ GTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 287 EVQLVESGGGVVRPGGSLRLSCAASGFI 2082 SARS-CoV2 Human Patient FDDYDMTWVRQAPGKGLEWVSGISW NGGNTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCAVIMSPIPRYSGY DWAGGAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 288 QVQLVESGGGVVQPGRSLRLSCAASGF 2083 SARS-CoV2 Human Patient TFSNYGMHWVRQAPGKGLEWVAVMS YDGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKNLGPYCSGGT CYSLVGDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 289 EVQLVESGGGVVRPGGSLRLSCAASGFI 2094 SARS-CoV2 Human Patient FDDYDMTWVRQAPGKGLEWVSGISW NGGSTGYADSVKGRFTISRDNAKNSLYL QMSSLRAEDTALYHCAVIMSPIPRYSGY DWAGDAFDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 290 QVQLVQSGAEVKKPGASVKVSCKASGY 2096 Human Patient TFGSFDISWVRQATGQGLEWMGRMS SSSGSTAYAQKFQGRVTMTRDTSTSTA YMELSSLRSEDTAMYYCARMRSGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 291 EVQLVESGGGLVQPGRSLRLSCAASGFT 2097 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW SSGTIGYADSVKGRFIISRDSAKSSLYLQ MSSLRPEDTALYYCAKDIIRQGEDGMD VWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 292 EVQLLESGGGLIQPGGSLRLSCAASGFTF 2098 Human Patient SSYAMSWVRQAPGKGLEWVSGIISTSG GATYSADSVRGRFTTSRDSSKSILYLQM SSLRGEDTAVYYCVKGLFDWFPLWGQ GTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 293 EVQLVESGGGLVQPGGSLRLSCAASGFT 2103 SARS-CoV2 Human Patient FSRHWMTWVRQAPGKGLEWVASIKQ DGSEKYYVDSVKGRLTISRDSAKSSLYL QMSSLRAEDTAVYYCARLGFYYGGADY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 294 SVQLVESGGGLVQPGGSLRLSCAASGF 2108 SARS-CoV2 Human Patient TFHHYAMHWVRQAPGKGLEWVSGISG SSDYRAYADSLKGRFTISRDYAKSSLWL QMSSLTSEDTAFYYCAKGVDYGGKLAYF DSWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 295 QVQLVESGGGVVQPGRSLRLSCAASGF 2110 SARS-CoV2 Human Patient SFSSYVMSWVRQAPGKGqLEWVAVISY DGSSKYYADSVKGRFTISRDSSKSTLYLQ MSSLRAEDTAVYYCARDIDSGYDPTPVF DYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 296 EVQLVESGGGLVQPGGSLRLSCAASGFT 2111 SARS-CoV2 Human Patient FSSYDLHWVRQGTGKRLEWVSAIGTAG DTYYLGSVKGRFTISRESAKSSLYLQMS SLRAGDTAVYYCARVLYDSSGFYSWFDP WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 297 EVQLVESGGGLIQPGGSLRLSCAASEVT 2113 Human Patient VSSSYMSWVRQAPGKGLEWVSLIYSGG TTYYADSVKGRFTISRDSSKSTLYLQMS SLRAEDTAVYYCARDFLRWHDLWGQG TLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 298 QVQLVQSGAEVKKPGSSVKVSCKASGD 2114 SARS-CoV2 Human Patient TFSSYTINWVRQAPGQGLEWMGRIIPIL GIPNYAQKFQGRVTITADKSTSTAFMEL SSLRSEDTAVYYCARGRGYSNYGASYYM DVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 299 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2128 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGNGLEWIGSIYYSG STYYNPSLKGRVSISVDTSKNQFSLKLSS VTAADTAVYYCARILVIFTLNWFDPWGQ GTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 300 EVQLVESGGGLVKPGGSLRLSCAASGFT 2130 Human Patient FRDVWMSWVRQAPGKGLEWVGRIKS KIDGGTTDYAAPVKGRFTISRDDSKNTLY LQMNSLKTEDTAVYYCTTAGSYYYDTVG PGLPEGKFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 301 EVQLVESGGGLIQPGGSLRLSCAASEVT 2132 Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG TTYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDFLRWHDLWGQG TLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 302 QVQLQESGPGLVKPSETLSLTCTVSGGS 2137 SARS-CoV2 Human Patient VSSGSYYWSWIRQPPGKGLECIGYIYYSG SSNYNPSLKSRVTISVDTSKNQFSLKMSS VTAADTAVYYCAGSPVPPTIVGASYWG QGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 303 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2142 SARS-CoV2 RBD Human Patient TSYWIDWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSTSTAYLQW SSLKASDTAMYYCARRGEAAGIWYFDL WGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 304 EVQLVESGGGLVQPGGSLRLSCAASGFT 2143 SARS-CoV2 RBD Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSA GSTYYADSVKGRFSISRDKSKNTLYLQM NSLRAEDTAVYYCAKEGGSGSLRYYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 305 EVQLVESGGGLVQPGGSLRLSCEASGFT 2146 SARS-CoV2 Human Patient FSSSEINWVRQAPGKGLEWVSHISSSGSI IYYADSVKGRFTISRDNAKNSLYLQMNSL RAEDTAVYYCARRSYRSSWYYYYGMDV WGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 306 QVQLAESGGGVVQPGRSLRLSCAASGF 2147 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSTSGSYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 307 QVQLVESGGGVVQPGRSLRLSCAASGF 2150 SARS-CoV2 Human Patient TFSTYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMIGLRAEDTAVYYCARDWAPTYYDM PSAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 308 QVQLVQSGAEVRKPGSSVKVSCKASGG 2151 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPV FGTANYAQKFQGRVTITADKSTSTAFME LNSLRSEDTAVYYCARIGSYPEYFQHWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 309 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2158 SARS-CoV2 Human Patient SSGGYFWSWIRQHPGKGLEWIGSIYYS GSTYYNPSLRSRITISVDTSKNQFSLKLS SVTAADTAVYYCARGGSGSYSLFDYWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 310 QVQLAESGGGVVQPGRSLRLSCAASGF 2159 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSTSGSYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 311 QVQLAESGGGVVQPGRSLRLSCAASGF 2160 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSTSGSYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 312 EVQLVESGGGLVQPGGSLRLSCAASGLT 2165 Human Patient VRSNYMTWVRQTPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTVYLQM NSLRAEDTAVYYCARDLVTYGLDVWGQ GTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 313 QVQLVQSGAEVKKPGSSVKVSCKASGG 2166 SARS-CoV2 RBD Human Patient TFSSYAHWVRQAPGQGLEWMGGIIPIF GTTNYAQKFQGRVTITADESTSTAYVELS SLRSEDTAVYYCARIGHFDSSGYYLDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 314 EVQLVESGGGLVQPGGSLRLSCVASGFT 2171 SARS-CoV2 RBD Human Patient FSFYWMSWVRQAPGKGLEWVANIKQ DGGEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARLSGSSWDFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 315 EVQLVESGGGVVRPGGSLRLSCAASGFT 2173 SARS-CoV2 RBD Human Patient FDDYGMSWVRQAPGKGLEWVSAINW NGGSTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCARRRSSSRYSSG WYMYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 316 EVQLVESGGGLVQPGGSLRLSCVASGFT 2175 SARS-CoV2 RBD Human Patient FSFYWMSWVRQAPGKGLEWVANIKQ DGGEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARLSGSSWDFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 317 QITFKESGPTLVKPTETLTLTCTFSGFSV 2177 SARS-CoV2 RBD Human Patient STSGEGVGWIRQPPGKALEWLAVIYWD DDKRYSPSLKSRLTITRDTSKNQVVLTMT NMDPVDTATYYCAHRLWFRDAFDIWG QGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 318 EVQLVESGGGLVQPGGSLRLSCAASGFT 2178 SARS-CoV2 RBD Human Patient FSTYWMTWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKYRFTISRDNAKNSLYLQ MNSLRAEDTAVYYCARVGSSSWYFDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 319 QVQLVESGGGVVQPGRSLRLSCAASGF 2183 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAGISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARADTMVRGTYF EYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 320 QVQLVESGGGVVQPGRSLRLSCAASGF 2187 SARS-CoV2 RBD Human Patient TFSYYPMHWLWVRQAPGKGLEWVAVT SYDGTNKYYADSVKGRFTISRDNSKNTLY LQMNSLRAEDTAVYYCARGGATNFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 321 EAQLVESGGGLVQPGRSLRLSCAASGFT 2189 SARS-CoV2 RBD Human Patient FDDSAMHWVRQAPGKGLEWVSGISW NSGNVGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYYCTKASRYCSSTICY WNWFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 322 EVQLVESGGGLVQPGGSLRLSCAASGFT 2190 SARS-CoV2 Human Patient FSSYEMNWVRQAPGKGLEWVSYISSSG SAIYYADSVKGRFTISRDNAKNSLYLQM NSLRVEDTAVYYCAREARSRYFDWLPSY YFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 323 EVQLVESGGGVVRPGGSLRLSCAASGFT 2191 SARS-CoV2 RBD Human Patient FDDYGMSWVRQAPGKGLEWVSAINW NGGSTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCARRRSSSRYSSG WYMYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 324 QVHLVESGGGVVQPGRSLRLSCAASGF 2195 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVISN DEFNKFYANSVKGRFTISRDNSKNTVYL QLNSLRTEDTARYYCAKGGDGSGWAW DGDNPPTDYWGQGTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 325 QMQLVQSGPEVKKPGTSVKVSCKASGF 2196 Human Patient TFMSSAVQWVRQARGQRLEWIGWIVI GSGNTNYAQKFQERVTITRDMSTSTAY MELSSLRSEDTAVYYCAAPYCSSISCNDG FDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 326 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2197 SARS-CoV2 RBD Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARPDYSSGWFSYWYF DLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 327 QVQLVQSGAEVKKPGASVKVSCKVSGY 2199 SARS-CoV2 Human Patient TLTELSIHWVRQAPGKGLEWMGGFDP EDAETIYAQQFQGRVTMTEDTSTDTAY MELSSLKSEDTALYYCATGFAVFGRAAV PYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 328 QVQLVESGGGVVQPGRSLRLSCAASGF 2203 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLAWVALISYD GYNKYYADSVRGRFTISRINSKNTLSLQM NSLRAEDTAVYYCARGSAGNYYYGMDV WGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 329 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2207 SARS-CoV2 RBD Human Patient TSHWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAMYYCASALRERGVQLWSV WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 330 QVQLVESGGGVVQPGRSLRLSCAASGF 2210 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRVEDTAVYYCARDQEWFRELFL FDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 331 EVQLVESGGGLVKPGGSLRLSCAASGFT 2212 SARS-CoV2 Human Patient FSSYSMNWVRQAPGKGLEWVSSISNSN SFIYYADSMKGRFTISRDNAKNSLYLQM NSLRAEDTAVYYCARVNGNSNWNFGSY YYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 332 QVQLVQSGAEVKKPGSSVKVSCKASGG 2214 SARS-CoV2 RBD Human Patient TFSSYAIIWVRQAPGQGLEWMGGIIPIF GTTNYAQKFQGRVTITADESTSTAYVELS SLRSEDTAVYYCARIGHFDSSGYYLDYW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 333 EVQLVESGGGLVKPGGSLRLSCAASGFT 2215 SARS-CoV2 Human Patient FSGYSMNWVRQAPGKGLEWVSSISSSS SYIYYADSVKGRFTISRDNAKNSLYLQMN SLRAEDTAVYYCARWLQLRSDYYYFGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 334 QVQLVQSGAEVKKPGSSVKVSCKASGG 2216 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GAANYAQNFQGRVTITADESTSTGYMQ LSSLRFEDTAVYYCARTSHYDSSGSYFEY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 335 QVQLVESGGGVVQPGRSLRLSCAASGF 2218 SARS-CoV2 RBD Human Patient TFSSYALFWVRQAPGKGLEWVAVISYD GNNKYYADSVRGRFTISRDNSKNTLYLQ MNSLRPEDTAVYYCARPYTGSYKSYMD VWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 336 QVQLQESGPGLVKPSETLSLTCTVSGGSI 2222 SARS-CoV2 Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDMSKNQFSLKLRSVT AADTAVYYCARAPRERLQWGEYYFDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 337 QVQLVESGGGVVQPGRSLRLSCAASGF 2224 SARS-CoV2 RBD Human Patient TFSTYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAMYYCAKDGSIAAADY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 338 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2226 SARS-CoV2 RBD Human Patient TNSWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAIYYCATHRCSGGFCYLAYWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 339 QVQLVESGGGVVQPGRSLRLSCAASGF 2227 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGSKKDYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDQSQGAYILT GYRGYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 340 QVQLQQWGAGLLKPSETLSLTCAVYGG 2228 SARS-CoV2 Human Patient SFSGHYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARPPQAARIHYYYYMD VWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 341 EVQLVESGGGLVQPGRSLRLSCAASGFT 2231 SARS-CoV2 Human Patient FDDYAMNWVRQPPGKGLEWVSGISW NSDSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAMYYCAKGRGAGYTSYM DVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 342 EVQLVESGGGLIQPGGSLRLSCAASGFIV 2235 SARS-CoV2 RBD Human Patient SSNYMSWVRQAPGKGLEWVSVIYSGG STYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARESTQWGQGTLVTV SS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 343 QITLKESGPPLVEPKQTLTLTCTFSGFSL 2238 SARS-CoV2 RBD Human Patient TTSGEAVGWIRQPPGKALEWLALIYWDD DKHYSPSLRNRLTITRDTSKNQVVLTLTN VDPADTGTYYCAHRAVILNFDHWGQGF LVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 344 QVQLVESGGGVVQPGRSLRLSCAASGF 2239 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGINKYYADAVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARPRSGSYYAYFD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 345 EVQLVESGGGLVQPGRSLRLSCAASGFT 2240 SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKVGYTISRQWLV GEFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 346 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2241 SARS-CoV2 RBD Human Patient TSYWIDWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSTSTAYLQW SSLKASDTAMYYCARRGEAAGIWYFDL WGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 347 QLQLQESGPGLVKPSETLPLTCTVSGGSI 2243 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLQWIGNIYYS GSTYYNSSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARQSRGYSYAWSFDYW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 348 QVQLVESGGGVVQPGRSLRLSCAASGF 2245 SARS-CoV2 RBD Human Patient TFSNYGIHWVRQAPGQGLEWVAGIWY DGSNKYYVDSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAGSSGEGGLYYY YGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 349 QVQLVESGGGVVQPGRSLRLSCAASGF 2248 SARS-CoV2 RBD Human Patient TFDSYGVHWVRQAPGKGLEWVAVISYD GSNKHYADSVKGRFTISRDNSKNTLYVQ MNSLRTEDTAVYYCARDSGGNYGDSYF DYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 350 QVQLVESGGGVVQPGRSLRLSCAASGF 2250 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLAWVALISYD GYNKYYADSVRGRFTISRINSKNTLSLQM NSLRAEDTAVYYCARGSAGNYYYGMDV WGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 351 QVTLKESGPVLVKPTETLTLTCAVSGFSL 2251 SARS-CoV2 Human Patient SNAKMGVSWIRQPPGKALEWLAHIFSN DEKAYSTSLKTRLTISKDTSKSQVVLTVT NMDPVDTATYYCARIVLGASGTYPSPGFD PWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 352 EVQLVESGGGLVQPGGSLRLSCAASGFT 2253 SARS-CoV2 Human Patient FSSYWMHWVRQVPGKGLVWVSRINSD GSSTSYADSVKGRFTISRDNAKNTLYLE MNSLRAQDTAVYYCAGSPWLRGDIDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 353 QVQLVQSGSELTKPGASVKVSCKASGYT 2256 SARS-CoV2 Human Patient FTSYAMNWVRQAPGQGLEWMGWINT DTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARDPSYCSSTRCYT VGWFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 354 QVQLQESGPGLVKPSQTLSLTCTVSGDSI 2257 SARS-CoV2 Human Patient NSGNYYWSWIRQPAGKGLEWIGRMFT SGSTNYNPSLTSRVTMSIDTSKNQFSLNL NSVTAADTAMYYCARGHVAAWESCYY WGQGILVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 355 EVQLVESGGGVVRPGGSLRLSCAASGFT 2258 SARS-CoV2 Human Patient LDDYGLSWVRHAPGKGLEWVSGINWN GGRTAYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYHCARARGPSEQYYDLL TGYYDAFDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 356 EVQLLESGGGLVHPGGSLRLSCAASGFT 2260 SARS-CoV2 Human Patient FSSYALSWVRQAPGKGLEWVSAISGSG GSTYYADSVKGRFTISRDNSKNTLYLQM NRLRAEDTAVYYCAQMGPLGSTSSAAD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 357 QVQLVQSGAEVKKPGASVKVSCKASGY 2262 (weak) RBD Human Patient TFTSYDINWVRQATGQGLEWMGWMN PNSGNTGYAQKFQGRVTMTRNTSISTA YMELSSLRSEDTALYYCAREARYFDWIFE GSDYYYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 358 EVQLVESGGGLVQPGGSLRLSCEASGFT 2263 SARS-CoV2 Human Patient FSSSEINWVRQAPGKGLEWVSHISSSGSI IYYADSVKGRFTISRDNAKNSLYLQMNSL RAEDTAVYYCARRSYRSSWYYYYGMDV WGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 359 EVQLVESGGGLVQPGRSLRLSCTASGFIF 2266 SARS-CoV2 RBD Human Patient GDYAMGWVRQAPGKGLEWVGFIRGK AYDGTTEYAASVKGRFTISRDDSKYIAHL QMNSLKTEDTAVYYCIRDYDFWGGYYY HPLRAFDIWGRGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 360 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2268 Human Patient STSGVGVGWIRQPPGKALEWLALIYWD DDKRYSPSLKSRLSITKDTSKNQVVLTMT NMDPVDTGTYYCARHQIVVLFDMWG QGTRVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 361 QVQLVQSGAEVKKPGSSVKVSCKASGG 2270 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITADESTSTAYMEL SSLRSEDTAVYYCAITYYYDSSGYWWDD WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 362 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2273 SARS-CoV2 RBD Human Patient SSSSYYWGWIRQPPGKGLEWIGTIYYSG STYYNPSLKSRVTISVDTSKKQFSLKLSS VTAADTAVYYCAGEEVRGVKLYYYYAMD VWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 363 EVQLVESGGRLVLPGGSLRLSCAASGFTF 2274 SARS-CoV2 RBD Human Patient SVYEMNWVRQAPGKGLEWLSYIGTSGS PIYYADSVKGRFTVSRDNAKNSLYLQMN SLRVEDTALYYCARDRGWNYGLDYWG QGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 364 QVQLVESGGGVVQPGRSLRLSCAASGF 2277 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVALISSD GGNKFYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDVPTTVTAFTVF TYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 365 QVQLVESGGGVVQPGRSLRLSCAASGF 2281 SARS-CoV2 RBD Human Patient AFSNYAIHWVRQAPGKGLEWVAVISYD GNNKDYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARVPVMVRGVYF DYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 366 QVQLVQSGAEVKKPGASVKVSCKVSGY 2287 SARS-CoV2 Human Patient TFTSYDINWVRQATGQGLEWMGWMN PNSGHTGYAQKFQGRVTMTRNTSISTA YMELSSLRYEDTAVYYCARGYGLTYYMD VWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 367 QVQLAQSGAEVKKPGASVKVSCKAAGY 2290 (weak) Human Patient TFTSYDINWVRQATGQGLEWMGWMN PNSGNAGYAQKFQGRVTMTRDTSISTA YMELSSLRSEDTAVYYCARMRSGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 368 EVQLLQSGGGLVQPGGSLRLSCAASGFT 2293 SARS-CoV2 Human Patient FRNYAMSWVRQAPGKGLEWVSAISGS GGTTYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKNERITMLVVVTL FDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 369 EVQLVESGGGLVQPGGSLRLSCAASGFT 2296 SARS-CoV2 RBD Human Patient VSGNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSPRAEDTAVYYCARDPSAYYDILTGYSG DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 370 QVQLVESGGGVVQPGRSLRLSCAASGF 2299 SARS-CoV2 Human Patient SFSSYVMNWVRQAPGKGLEWVAVISY DGSSKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDIDSGYDPTPVF DYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 371 QVQLQESGPGLVKPSGTLSLTCAVSGGS 2300 SARS-CoV2 RBD Human Patient ISSSNWWTWVRQPPGKGLEWIGEIYHS GSTNYNPSLKSRVTISVDKSKNQFSLKLS SVTAADTAVYYCASRWGDYFDSSGAYDS WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 372 EVQLVESGGGLVKPGGSLRLSCAASGFT 2304 SARS-CoV2 Human Patient FSSYSMNWVRQAPGKGLEWVSCISSSS SFIYYADSVKGRFTISRDNAKNSLYLQMN SLRAEDTAVYYCARDPVWVDGELLSGGI PFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 373 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2305 SARS-CoV2 Human Patient RSSSYYWGWIRQPPGKGLEWIASIYYSG STYYNSSLKSRVTISVDTSKNQFSLKVNS MTAADTAVYYCAILWRGSSWADRHYYY YSMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 374 QVQLVESGGGVVQPGRSLRLSCTASGFT 2307 SARS-CoV2 Human Patient FSSYAMHWVRQAPGKGLEWVALISYD GNNKYYADSAKGRFTISRDNSKNTLYLQ MNSLRSEDTAVYYCARDLGRGLDPWG QGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 375 EVQLLESGGGLIQPGGSLRLSCAASGFTF 2308 Human Patient SNYAMSWVRQAPGKGLEWVSGIISSSG GATYNADSVRGRFTTSRDNSKNILYLQM NSLRGEDTAVYYCVKGLFDWFPLWGQ GTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 376 QVQLQESGPGLVKPSQTLSLTCAVSGAS 2310 SARS-CoV2 RBD Human Patient ISSGSYYWSWIRQPAGKGLEWIGRIYTS GNTNYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCATGYIGTYYYYMDVW GKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 377 EVQLVESGGGLVQPGRSLRLSCAASGFT 2313 SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKVSSITSLLGYYFD SWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 378 QVTLRESGPALVKPTQTLSLTCTFSGFSL 2318 SARS-CoV2 Human Patient GTSGMCVSWIRQPPGKALEWLARIDW DDDKYYSTSLKTRLTISKDTSKNQVVLTM TNMDPVDTATYYCARGVVTYDYWGQG TLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 379 QVQLVESGGGVVQPGRSLRLSCAASGF 2322 SARS-CoV2 RBD Human Patient TFSNYAMHWVRQAPGKGLDWVAVISY DGSNRYYAASVKGRFTISRDNSKNTLYL QMNSLRTEDTAVYFCARGDGYRSQFDP WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 380 QITFKESGPTLVKPTETLTLTCTFSGFSV 2325 SARS-CoV2 RBD Human Patient STSGEGVGWIRQPPGKALEWLAVIYWD DDKRYSPSLKSRLTITRDTSKNQVVLTMT NMDPVDTATYYCAHRLWFRDAFDIWG QGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 381 EVQLLESGGGLVQPGGSLRLSCAASGFT 2329 SARS-CoV2 Human Patient FNNYAMSWVRQAPGKGLEWVSAIGGS GGSTYYADSVKGRFTVSRDNSENTLYLQ MSSLRAEDTAVYYCARVEGDWLLGGPY YHYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 382 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2331 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGNGLEWIGSIYYSG STYYNPSLKGRVSISVDTSKNQFSLKLSS VTAADTAVYYCARILVIFTLNWFDPWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 383 EVQLVESGGGLVQPGGSLRLSCAASGFT 2333 SARS-CoV2 RBD Human Patient FSIYWMSWVRQAPGKGLQWVANIKQ DASEKYYVDSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAVYYCARLGGSSWHFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 384 QLQLQESGPGLVKPSETLSLTCTVSGGPI 2335 SARS-CoV2 Human Patient SSSRYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLNS VTAADTAVYYCARHDGSGEMDTITWGPI YYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 385 QITFKESGPTLVKPTETLTLTCTFSGFSV 2337 SARS-CoV2 RBD Human Patient STSGEGVGWIRQPPGKALEWLAVIYWD DDKRYSPSLKSRLTITRDTSKNQVVLTMT NMDPVDTATYYCAHRLWFRDAFDIWG QGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 386 QVQLVQSGAEVKKPGASVKVSCKASGY 2340 SARS-CoV2 RBD Human Patient TFTSYGMHWVRQAPGQRLEWMGWIN VGNGNTKYSQRFQGRVTITRDTSASTAY MELSSLRSEDTAVYYCAMGPSAFSWLD PWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 387 QVQLAESGGGVVQPGRSLRLSCAASGF 2341 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSTSGSYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 388 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2342 SARS-CoV2 Human Patient NTSGVGVGWIRQPPGKALEWLALIYWD DDKRYNPSLKSRLTITKDTSKNQVVLTM TNMDPVDTATYYCAHRPPSYHGWCYF DYWGQGNLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 389 QVQVVQSGAEVKKPGASVKVSCKASGY 2343 SARS-CoV2 RBD Human Patient TFKNYGISWVRQAPGQGLEWMGWISA YTGNTNYAQKFQGRMTMTTDTSTGTG YMELRSLRSDDTAVYYCARVQRRRLDY WGQGTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 390 QVQLQQWGAGLLKPSETLSLTCAVYGG 2346 SARS-CoV2 Human Patient SFSGHYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARPPQAARIHYYYYMD VWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 391 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2351 SARS-CoV2 Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTTYNPSFQGQVTISADKSLTTAFLHW SSLKASDTAIYYCARRFYGPSSFDYWGQ GTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 392 QVQLVQSGAEVKRPGASMNISCKASGY 2352 SARS-CoV2 Human Patient NFNNNYIYWVRQAPGQGLEWMGVVN PTGGGTAYAQGFQDRVTITSDTPRNTVY LGVTGLHSEDTAVYFCARGGEWRIVPG GRDYFDYWGQGTLVTVSA COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 393 EVQLVQSGAEVKKPGESLKISCKGFGYN 2353 Human Patient FTNYWIGWVRQMPGKGLEWMGIIYPG DSETRNSPSFQGQVTISADKSMSTAYLQ WSSLKASDTAMYYCARLGVSKYCSGGR CLSGGSNWFDPWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 394 EVHLVGSGGGLIQPGGSLRLSCAASGFT 2354 SARS-CoV2 Human Patient VSSNFMSWVRQAPGKGLEWVSIIHNG GDSYYTDSVKGRFTISRDNSKNTLYLQIV INNLRAEDTAVYYCASSSWLRGAFDIWG QGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 395 QMQLVQSGPEVKKPGTSVKVSCKTSGF 2355 Human Patient TFTSSAIQWVRQARGQRLEWIGWIVVG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPHCNRTSCYDAF DLWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 396 EVQLVESGGDLVKPGRSLRLSCSASGFTF 2357 SARS-CoV2 Human Patient GDYTMSWFRQAPGKGLEWVAFIRSKAY GGTTEYAASVIGRFTISRDDSKSIAYLQM NSLKSEDTAVYYCSRVRGSFYGSVGKNY GMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 397 QVQLVESGGGVVQPGRSLRLSCAASGF 2358 SARS-CoV2 Human Patient SFSSYVMNWVRQAPGKGLEWVAVISY DGSSKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDIDSGYDPTPVF DYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 398 QVQLVQSGAEVKKPGSSVKVSCKASGG 2367 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GAANYAQNFQGRVTITADESTSTGYMQ LSSLRFEDTAVYYCARTSHYDSSGSYFEY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 399 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2368 SARS-CoV2 RBD Human Patient TTYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARRRGGIGIEYGMDV WGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 400 QVQLVESGGGVVQPGRSLRLSCAASGF 2369 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVADISY DGSEKYYADSVKGRFTIYRDNSKNTLYLQ MNSLRAEDTAVYYCAKDFGGDNTAMV EYFFDFWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 401 QVQLQESGPGLVKPSETLSLTCTVSGGS 2370 SARS-CoV2 Human Patient VSSGSYYWSWIRQPPGKGLECIGYIYYSG SSNYNPSLKSRVTISVDTSKNQFSLKMSS VTAADTAVYYCAGSPVPPTIVGASYWG QGTLVTDSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 402 QVQLVESGGGVVQPGRSLRLSCAASGF 2371 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVISY DGTNKYYADSVKGRFTISRDNSKNTLYL QMNSLRADDTAVYYCAKGRGNYLTFFD SWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 403 EVQLVESGGGLVQPGGSLRLSCAASGLT 2373 SARS-CoV2 RBD Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISGDNSKNTLYLQM NSLRVDDTAVYYCARDPGSRYSGGWYD YYYAMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 404 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2378 SARS-CoV2 RBD Human Patient PTYWIGWVRQMPGKGLEWMGIIYPGD SDTRYGPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARRDTDFDYWGQGTL VTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 405 QMQLVQSGPEVKKPGTSVKVSCKASGF 2381 Human Patient TFTSSAVQWVRQARGQRLEWIGWIAV GSGNTNYAQKFQERVSITRDMSTSTAY MELSSLRSEDTAVYYCAAPYCSRTSCHD AFDIWGQGTKVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 406 QVQLVESGGGVVQPGRSLRLSCVASGF 2382 SARS-CoV2 Human Patient TFSSYGMHWVRQAPGKGLEWVAVISF DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVFYCAKDLPPYASGWY EGGFDYWGRGTQVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 407 QVQLVESGGGVVQPGRSLRLSCAASGF 2383 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVVSY DGSNKYYTDSVKGRFTISRDNSKNTLFLQ MIGLREEDTAVYYCAQGRGGYYSPFDD WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 408 QVTLKESGPVLVKPTETLTLTCTVSGFSL 2384 SARS-CoV2 Human Patient SNARMGVSWIRQPPGKALEWLAHIFSG DEKSYSTSLKSRLTISKDTSKSQVVLTMT NMDPLDTATYYCARTTWGTWIQAWYF DIWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 409 QVQLVESGGGVVQPGRSLRLSCAASGF 2386 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWF DGSNKHYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAREGDFWSGYYT GWFDPWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 410 QVQLVESGGGVVQPGRSLRLSCAASGF 2387 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKDLTIVVIPAAP NFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 411 EVQLLESGGGLVQPGGSLRLSCAASGFT 2388 SARS-CoV2 RBD Human Patient FSSYAMSWVRQAPGKGLEWVSFISGTG DSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKDQARVQDYIWGS YRSYGMDVWGLGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 412 EVQLVESGGGLVQPGRSLRLSCAASGFT 2389 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGTIGYADSVKGRFIISRDNAKNSLYLQ MNSLRPEDTALYYCAKDIIRQGEDGMD VWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 413 QVQLVQSGAEVKKPGASVKVSCKASGY 2391 Human Patient TFGSFDINWVRQATGQGLEWMGRMN SNSGNTAYAQKFQGRVTMTRDTSTNTA YMELSSLRSEDTAMYYCARMRSGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 414 EVQLVESGGGLVKPGGSLRLSCAASGFT 2394 SARS-CoV2 Human Patient FSGYSMNWVRQAPGKGLEWVSSISSSS SYIYYADSVKGRFTISRDNAKNSLYLQMN SLRAEDTAVYYCARWLQLRSDYYYFGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 415 EVQLVESGGGLVQPGGSLRLSCVASGFT 2397 SARS-CoV2 RBD Human Patient FSFYWMSWVRQAPGKGLEWVANIKQ DGGEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARLSGSSWDFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 416 EVQLVESGGGLVQPGGSLRLSCAASGFS 2399 SARS-CoV2 Human Patient VSTNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDYRDWIWGQGTL VTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 417 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2400 SARS-CoV2 RBD Human Patient STSGVGVGWIRQPPGKALEWLALIYWD DDKRYSPSLKSRLTITKDTSKNQVVLTMT NMDPVDTATYYCAHNRFQYCSSTTCYTL LPFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 418 QVQLVESGGGVVQPGRSLRLSCAASGF 2401 SARS-CoV2 RBD Human Patient TFSSYALFWVRQAPGKGLEWVAVISYD GNNKYYADSVRGRFTISRDNSKNTLYLQ MNSLRPEDTAVYYCARPYTGSYKSYMD VWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 419 QVQLVESGGGVVQPGRSLRLSCAASGF 2403 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMSSLRAEDTAVFYCARGDGDVYNFLL VRNWFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 420 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2405 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSFYYSG STYYNPSLKSRVTISVDTSKNQFSLNLSS VTAADTAVYSCASLWFGDLYSFDYWGQG TLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 421 EVQLVESGGGLVQPGGSLRLSCADSAFT 2406 SARS-CoV2 RBD Human Patient FSSFWMSWVRQAPGKGLEWVANIKQ DGSEKFYLDSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAVYYCARLGRSSWNFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 422 QVQLQESGPGLVKPSQTLSLTCTVSGDSI 2408 SARS-CoV2 RBD Human Patient SSGSYYWSWIRQPAGKGLEWIGRIYTSG STTYNPSLKSRVTISVNTSKNQFSLNLSS VTAADTAVYYCARVGGISPYYYYYYMDV WGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 423 QVQLVQSGAEVKKPGASVKVSCKASGY 2413 (weak) Human Patient TFTSYDINWVRQATGQGLEWMGWMN PNSGNAGYGQKFQGRVTMTRNTSISTA YMELSSLRSEDTAVYYCARMRSGWPTH GRPDDYWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 424 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2416 SARS-CoV2 Human Patient SSGGYYWSWIRQHPGKGLEWIGYIYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCASAKLVATISYFDYWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 425 QVQLQQWGAGLLKPSETLSLTCAVYGG 2417 SARS-CoV2 Human Patient SFSGYYWNWLRQPPGKGLEWIGEINHS GSTNYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARVGGYYYYYMDVWG KGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 426 EVRLLESGGGLVQPGGSLRLSCAASGFT 2418 SARS-CoV2 RBD Human Patient FSDYAMNWVRQAPGKGLEWVSAISAT GGSTFYADSVKGRFSISRDNSKNSLVLQ MNSLRAEDTAVYYCAKPYGMDVWGQ GTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 427 QGQLVQSGGDVVQPGKSLRLSCAASGF 2420 SARS-CoV2 RBD Human Patient TFTNYAMHWVRQAPGKGLEWVAVISN DGSNEKYVDSVKGRFSLSRDNSKNTVYL DMHSLRPEDTAIYYCARDRSNLERLVMT FGGIIAGAFDIWGQGARVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 428 QVQLVESGGGVVQPGRSLRLSCAASGF 2422 SARS-CoV2 RBD Human Patient TFSSYAMYWVRQAPGKGLEWVAVISYD GINKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARVNSGSYYSYFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 429 QVQLQESGPGLVKPSGTLSLTCAVSGGS 2427 SARS-CoV2 RBD Human Patient ISSSNWWSWVRQPPGKGLEWIGEIYHS GSTNYNPSLKSRVTISVDKSKNQFSLKLN SVTAADTAVYYCASRWGDYFDSSGAYD SWGQGTLLTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 430 QVQLVESGGGVVQPGKSLRLSCAASGF 2428 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGNNKFYVDSVKGRFTISRDNSKNTLY MEMNSLRAEDTAVYYCARKGPLWRFD YWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 431 EVQLVESGGGLIQPGGSLRLSCAASGFIV 2429 SARS-CoV2 RBD Human Patient SSNYMSWVRQAPGKGLEWVSVIYSGG STYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARESTQWGQGTLVTV SS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 432 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2430 SARS-CoV2 RBD Human Patient SSSSYYWGWIRQPPGKGLEWIGSVYYIG STYYNPSLKSRVTMSVDTSKNQFSLKLSS VTAADTAVYYCARAPFQLLDKYYFFYYM DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 433 EVQLVESGGDLIQPGGSLRLSCAASGLT 2434 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSIIYSGG STYYADSVKGRFSISRDNSNNTLYLQMN SLRAEDTAVYFCARHIPAWGYKWGQGT LVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 434 EVQLLESGGGLVQPGGSLRLSCAASGFT 2438 SARS-CoV2 Human Patient FTSYGMSWVRQAPGKGLEWVSAISISG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKLLGSGITLDNDAF DIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 435 QVQLVQSGAEVKKPGSSVKVSCKASGG 2441 SARS-CoV2 RBD Human Patient TFSSYAIIWVRQAPGQGLEWMGGIIPIF GTTNYAQKFQGRVTITADESTSTAYVELS SLRSEDTAVYYCARIGHFDSSGYYLDYW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 436 EVQLLESGGGLVQPGGSLRLSCAASGFT 2444 SARS-CoV2 Human Patient FTSYAMNWVRQAPGKGLEWVSAISVS GGSTYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDFGSGIVGATG FDFWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 437 EVQLVESGGGVVRPGGSLRLSCAASGFT 2445 SARS-CoV2 RBD Human Patient FDDYGMSWVRQAPGKGLEWVSAINW NGGSTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCARRRSSSRYSSG WYMYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 438 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2446 SARS-CoV2 RBD Human Patient TNSWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAIYYCATHRCSGGFCYLAYWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 439 QVQLVESGGGVVQPGRSLRLSCATSGFT 2449 SARS-CoV2 RBD Human Patient FSSFALHWVRQAPGKGLEWVTVISDDG NNKYYVDSVKGRFTISRDNSKNTLFLQM NSLRVEDTAIYYCARASYNSNWSIGEYFR DWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 440 QVQLVESGGGVVQPGRSLRLSCAASGF 2450 SARS-CoV2 Human Patient TFSTYGMHWVRQAPGKGLEWVAVILY DGSNRYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKQGGLYCSGTN CWGGYLDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 441 QITLKESGPTLVKPTQTLTLTCTVSGFSL 2451 SARS-CoV2 RBD Human Patient STSGVGVGCIRQPPGKALEWLALIYWDD DKRYSPSLKSRLTITRDTSKNQVVLTMTN MDPVDTGTYFCVHRHVSGAFDYWGQG TLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 442 QVQLVQSGSELKKPGASVKVSCKASGYT 2453 SARS-CoV2 RBD Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVNTAYL QISSLKAEDTAVYYCARARLLGYCSSTSC YTIGWGAFDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 443 QVQLVESGGGVVQPGRSLRLSCAASGF 2454 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAREGQGTYLDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 444 EVQLVESGGGLVQPGGSLRLSCAASGFT 2455 SARS-CoV2 Human Patient FSSYEMNWVRQAPGKGLEWVSYISSSG SAIYYADSVKGRFTISRDNAKNSLYLQM NSLRVEDTAVYYCAREARSRYFDWLPSY YFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 445 QVQLVESGGGVVQPGRSLRLSCAASGF 2458 SARS-CoV2 RBD Human Patient TFSRHAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFAISRDNSKNTLYL QMNSLRPEDTAVYYCARDPSPLVLITSID YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 446 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2459 SARS-CoV2 Human Patient SSGTYYCGWIRQPPGKGLEWIGSTYYG GSTLYNPSLRGRVTISVDTSKNQFSLKLS SVTAADTAVYYCARRGNYYDSKNWFDP WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 447 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2461 SARS-CoV2 Human Patient SSGGYFWSWIRQHPGKGLEWIGSIYYS GSTYYNPSLRSRITISVDTSKNQFSLKLS SVTAADTAVYYCARGGSGSYSLFDYWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 448 EVQLVESGGGLVQPGGSLRLSCAASGFT 2462 SARS-CoV2 Human Patient FSSSDLHWVRQATGKGLEWVSAIGTAG DTYYLGSVKGRFTISRENGKNSLYLQMN SLRAGDTAVYYCARVLYDSSGFYNWFDP WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 449 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2464 SARS-CoV2 Human Patient SSGGYYWSWIRQHPGKGLEWIGYISYS GSTYYNPSLKSRLTISVDTSKNQFSLKLS SVTAADTAVYYCARDLGDGYNLRVPAYF DLWGRGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 450 QVQLQESGPGLVKPSGTLSLTCAVSGGS 2465 SARS-CoV2 Human Patient ISSSNWWSWVRQPPGKGLEWIGEIYHG GSTDYNPSLKSRVTISVDKSKNQFSLKLT SVTAADTAVYYCARVDHVNVRDYWGPG TLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 451 EVQLVESGGGLVKPGGSLRLSCAASGFT 2466 SARS-CoV2 Human Patient FSSYSMNWVRQAPGKGLEWVSSISNSN SFIYYADSMKGRFTISRDNAKNSLYLQM NSLRAEDTAVYYCARVNGNSNWNFGSY YYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 452 QVQLVESGGGVVQPGRSLRLSCAASGF 2473 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVIYY DGSNKYYADSVKGRFTISRDNSKNTLYL QIHSLRAEDTAVYYCAREGQMAATTGID YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 453 EVQLVESGGGLVKPGGSLRLSCAASGFT 2474 SARS-CoV2 RBD Human Patient FSNAWMSWVRQAPGKGLEWVGRIKG KTDGGTTDYAAPVKGRFTISKDDSKNTL YLQMSSLNTEDTAVYWCTTLTYYYDSSA YLNDAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 454 EVQLVESGGGLVQPGRSLRLSCAASGFT 2478 SARS-CoV2 RBD Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSDNIGYADSVKGRFTISRDIAKNSLYLQ MNSLRAEDTALYYCAKGIYYDIFMPLLD WGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 455 QVQLVQSGAEVKKPGSSVKVSCKTSGD 2479 Human Patient TSSSYTVGWVRQAPGQGLEWMGRIIPI LGIAYSAQKFQGRLTITADKSTSTSYMEL SSLRSEDTAVYYCARGVVAATPGWFDP WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 456 QVQLVQSGAEVKKPGSSVKVSCKASGG 2481 SARS-CoV2 RBD Human Patient TFGSYVISWVRQAPGQGLQWMGGIIPI FGKPNYAQKFQGRVTITADESTSTAYME LSSLRSEDTAVYYCARGWFGELLKGTYW FDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 457 QVQLVQSGAEVKKPGSSVKVSCKASGG 2485 (weak) Human Patient TFSSYSITWVRQAPGQGLEWMGRIIPVL GIANYAQKFQDRVTITADKSTSTAYMEL SSLRSEDTAVYYCARVGVSGFKSGSNWY FDLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 458 EVQLVESGGGLVQPGGSLRLSCAVSGFT 2488 SARS-CoV2 RBD Human Patient FSSYWMHWVRQAPGKGLVWVSRINSD GSSTSYADSVKGRFTISRDNAKNTLYLQ MNSLRAEDTAVYYCAREVEQLAHMVDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; NTD B-cells; SARS-CoV2 459 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2489 (weak) Human Patient SSTTYYWGWIRQPPGKGLEWIASIYYSG STYYNPSLKSRLTVSVDTSKNQFSLKLSS VTAADTAVYYCARQWKWFGEAWYFDL WGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 460 EVQLVESGGGLVQPGGSLRLSCAASGFT 2490 SARS-CoV2 Human Patient FSSYWMNWVRQAPGKGLEWVANINQ DGGEKYYVDSVRGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARDPYDLYGDYG GTFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 461 QVQLVQSGAAVKKPGSSVKVSCKASGG 2495 SARS-CoV2 Human Patient TFSSYAISWVRQAPGQGLEWMGGIVPI FGTANYAQKFQGRVTITADESTTTAYME LNSLRSEDTAVYYCAREDYYGSGSLVDPY YYYRMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 462 QVQLVESGGGVVQPGRSLRLSCAASGF 2496 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVIW YDGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCVRDLALFEVVIQ QGVWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 463 QLQLQESGPGLVKPSETLSLTCTVSGGSV 2499 Human Patient SSRSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARHTVDCGGDCFPNDAF DIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 464 QVQLVQSGAEVKKPGASVKVSCKASGY 2504 Human Patient TFTDYYMHWVRQAPGQGLEWMGWI NPNSRGTNYAQKFQGRVTMTRDTSIST VYMELSRLTSDDTAVYYCARVVVLGYGR PNNYYDGRNVWDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 465 QVQLVESGGGVVQPGRSLRLSCAASGFI 2509 SARS-CoV2 RBD Human Patient FSTYAMHWVRQAPGKGLEWVAVISYD GDNKYYADSVKGRFTISRDNSKNTLYLE MNSLRAEDTAVYYCARPRGGSYQTCFD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 466 QVQLVQSGSELKKPGASVKVSCKASGYT 2510 SARS-CoV2 Human Patient FTSHTMNWVRQAPGQGLEWMGWIN TNTGNPMYAQGFTGRFVFSLDTSGSTA YLQISSLKAEDTAVYYCARWGPDYGDYA SNDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 467 EVQLVESGGGVVRPGGSLRLSCAASGFI 2514 SARS-CoV2 (weak) Human Patient FDDYDMTWVRQAPGKGLEWVSGINW NGGSTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCAVIMSPIPRYSGY DWAGDAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 468 QVQLVQSGSELKKPGASVKVSCKASGYT 2515 SARS-CoV2 RBD Human Patient FTTYAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQDFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARGLVGRIDPWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 469 QVQLVQSGAEVKKPGASVKVSCKASGY 2516 SARS-CoV2 Human Patient TFTNYYMHWVRQAPGQGLEWMGILN PGAGSTSYAQKFQGRVTMTSDTSTNTV YMQLSSLKSEDTAVYYCARDQQIVPHAD GFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 470 QVQLVQSGAEVRKPGSSVKVSCKASGG 2517 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPV FGTANYAQKFQGRVTITADKSTSTAFME LNSLRSEDTAVYYCARIGSYPEYFQHWG QGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 471 EVQLVESGGGLVQPGRSLRLSCAASGFT 2518 SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGTIGYADSVKGRFIISRDNAKNSLYLQ MNSLRPEDTALYYCAKDIIRQGEDGMD VWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 472 EVQLVESGGGLVQPGGSLRLSCAASGFT 2520 SARS-CoV2 RBD Human Patient FSSYWMSWVRQAPGKGLEWVANIKED GSEKYYVDSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAVYYCARDVGGYSGYDLG FDYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 473 QVQLVESGGGVVQPGRSLRLACAASGF 2521 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGNNKYYADSLKGRFTISRDDSKNTLYL QMNSLRAEDTAVYYCAKDRTAVFLFFGL GDAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 474 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2524 SARS-CoV2 RBD Human Patient TSHWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAMYYCASALRERGVQLWSV WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 475 EVRLLESGGGLVQPGGSLRLSCAASGFT 2525 SARS-CoV2 Human Patient FTSYAMSWVRQAPGKGLQWVSTISVSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKDPASGIVGPTHFD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 476 QVQLVQSGAEVKKPGASVKVSCKVSGY 2526 SARS-CoV2 Human Patient TLTELSIHWVRQAPGKGLEWMGGFDP EDAETIYAQQFQGRVTMTEDTSTDTAY MELSSLKSEDTALYYCATGFAVFGRAAV PYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 477 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2527 SARS-CoV2 Human Patient SSGDYYWSWIRQPPGKGLEWIGYIYYSG STYYNPSLKSRVTISVDTSKNQVSLKLSS VTAADTAVYYCARFRRSYGSGSYYNISFD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 478 QVQLVQSGSELKKPGASVKVSCKASGYT 2529 SARS-CoV2 RBD Human Patient FTRHAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQGFTGRFVFSLDTSVSTAY LQISSLKAEDTAVYYCVREYGSGHPLPIW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 479 QVQLQESGPGLVKPSETLSLTCSVSGGSI 2531 Human Patient RSYFWNWVRQPPGKGLEWIGYIYYSGS TNYKPSFKSRVTISLDTSKNQISLKLSSV TAADTAVYYCARATWLRDAFGIWGQGT MVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 480 QVQLVQSGAEVKKPGASVRVSCKAPGY 2532 SARS-CoV2 Human Patient TFTTYYIHWVRQAPGQGLEWMGIINPS AGSTTYAQKFQGRVTMTRDTSTSTVYM ELSSLRSEDTAVYYCARGFHVPAALRNW FDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 481 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2533 SARS-CoV2 Human Patient SSGGYYWSWIRQHPGKGLEWIGYIYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLT SVTAADTAVYYCAREANDSGSFYNGPFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 482 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2536 SARS-CoV2 RBD Human Patient SSGSYYWSWIRQPAGKGLEWIGRIFTSG STNYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARGGLLWFGGAGNYMD VWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 483 QVQLAQSGAEVKKPGASVKVSCKAGGY 2539 Human Patient TFTSYDINWVRQATGQGLEWMGWMN SNSGNAGYAQKFQGRVTMTRDTSISTA YMELSSLRSEDTAVYYCARMRTGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 484 QVQIQQWGAGVLKPSETLSLTCAVYGG 2545 SARS-CoV2 RBD Human Patient SFSGHYWSWIRQPPGKGLEWIGEINHS GSTKYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARGPPVTTFFVFSLLFD PWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 485 QVQLVESGGGVVQPGRSLRLSCAASGF 2546 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGRNKYYADSVKGRFTISRDNSKNTLYL QMSSLRAEDTAVYYCAKEGEWELRGNA LDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 486 QVQLVESGGGVVQPGRSLRLSCAASGF 2549 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPDKGLEWVAVIWY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAREGQWPNQAF DIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 487 QVQLQESGPGLVKPSETLSLTCTVSGGSI 2551 SARS-CoV2 RBD Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG SSYYSPSLKSRVTISADTSKNQFSLNLRS VTAADTAVYYCASGPPYMATFSYYFDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 488 QVQLVESGGGLVKPGGSLRLSCAASGFT 2552 SARS-CoV2 (weak) Human Patient FSDYYMSWIRQAPGKGLECVSYISSSGST IYYADSVKGRFTISRDNAKNSLYLQMNSL RAEDTAVYYCARDPIRDGVWGLNENDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 489 QVQLVESGGGVVQPGRSLRLSCAASGFI 2553 SARS-CoV2 RBD Human Patient FSSYAMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARSPPASYYNPSTG YFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 490 QVQLVQSGAEVKKPGASVKVSCKASGY 2554 SARS-CoV2 Human Patient TFTSHYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTSDTSTSTVY MELSSLRSEDTAMYYCARDVFWVPAAS SFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 491 QVQLVESGGGVVQPGRSLRLSCAASGF 2558 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRVEDTAVYYCARDQEWFRELFL FDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 492 QVQLAQSGAEVKKPGASVKVSCKAAGY 2562 Human Patient TFTSYDINWVRQATGQGLEWMGWMN SNSGNAGYAQKFQGRVTMTRDTSTSTA YMELSSLTSDDTAVYYCARMRTGWPTH GRPDDFWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 493 QVQLQQWGAGLLKPSETLSLTCAVYGG 2563 SARS-CoV2 Human Patient SFSGYYWSWIRQPPGKGLEWIGEINHS GSSNYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARGWGWGAVAGRAEY YFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 494 QVQLVESGGGVVQPGRSLRLSCAASGF 2564 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGYNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARAQGGNYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 495 QVQLQESGPGLVKPSQTLSLTCTVSGGSI 2565 SARS-CoV2 RBD Human Patient SSGSYYWSWIRQPAGKGLEWIGRVYIYS SGSTNYNPSLKSRVTISVDTSKNQFSLKL SSVTAADTAVYYCARGAASFDYWGQGTL VTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 496 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2570 SARS-CoV2 RBD Human Patient SSSSNYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARDPRVVVTARMYNWF DPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 497 QVQLQESGPGLVKPSETLSLTCTVSGGSL 2571 SARS-CoV2 Human Patient SSYYWSWIRQPPGKGLEWIGYIYDSGG ASRSTNYNPSLKSRVTISVDTSRNQLSLK LSSVTAADTAVYYCARDQRQFQLLGRFG WFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 498 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2574 SARS-CoV2 RBD Human Patient SSTTYYWGWIRQPPGKGLEWIASIYYSG STYYNPSLKSRLTVSVDTSKNQFSLKLSS VTAADTAVYYCARQWKWFGEAWYFDL WGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 499 QVQLVQSGSELKKPGASVKVSCKASGYT 2582 SARS-CoV2 RBD Human Patient FTTYAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQGFTGRFVFSLDTSVNTAF LHIGSLKAEDTAVYYCARDQDSGYPTYYY YYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 500 QVQLVQSGAEVKKPGASVKVSCKASGY 2583 SARS-CoV2 RBD Human Patient TFTSYDMNWVRQATGQGLEWMGWM NPNSGNTGYAQKFQGRVTMTRNTSIST AYMELSSLRSEDTAVYYCARGGIYYLVRG FIIGYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 501 EVALVESGGGLVKPGGSLRLSCAASGFIF 2584 SARS-CoV2 RBD Human Patient SNAWMTWVRQAPGKGLEWVGRIKSK SEGGTPEYAAPVKGRFIISRDDSTNSLHL QMNYLRIEDTAVYYCTTGGYSSYAASDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 502 EVQLVESGGGLVQPGGSLRLSCAASGFT 2585 SARS-CoV2 Human Patient FSSYSMNWVRQAPGKGLEWVSYISSRS STIKYADSVKGRFTISRDNAKNSLYLQM NSLRDEDTAVYYCARVDYYGSGSVYWYF DLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 503 EVQLVESGGGLVQPGRSLRLSCAASGFT 2586 SARS-CoV2 RBD Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIAYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYFCAKVGWELSIDAFDL WGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 504 QITFKESGPTLVKPTETLTLTCTFSGFSV 2587 SARS-CoV2 RBD Human Patient STSGEGVGWIRQPPGKALEWLAVIYWD DDKRYSPSLKSRLTITRDTSKNQVVLTMT NMDPVDTATYYCAHRLWFRDAFDIWG QGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 505 QVTLRESGPALVKPTQTLTLTCTFSGFSL 2589 (weak) Human Patient STSGMCVSWIRQPPGKALEWLARIDWD DDKYYSTSLETRLTISKDTSKNQVVLTMT NMDPVDTATYYCARIQYQLNGMDVW GQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 506 QVQLVQSGAEVKKPGASVKVSCKASGY 2590 SARS-CoV2 RBD Human Patient TFSSYDINWVRQATGQGLEWMGWVN PNSGHTGYAQKFQGRVTMTRNTSVSTA YMELSSLRSEDTAVFYCARGRVGYVGSG SRGYYYYYDMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 507 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2602 SARS-CoV2 RBD Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARPDYSSGWFSYWYF DLWGRGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 508 QVQLVQSGSALKKPGASVKVSCKASGYT 2610 SARS-CoV2 RBD Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARGRSYGLSLGYW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 509 QVQLVESGGGVVQPGRSLRVSCAASGF 2611 SARS-CoV2 RBD Human Patient TFSSHGMHWVRQAPGKGLEWVSVIWY DGSNKYYADSVKGRFTISRDNSKNTLSL QMNSLRAEDTAVYYCARESADISSRLDY WGRGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 510 QITFKESGPTLVKPTETLTLTCTFSGFSV 2614 SARS-CoV2 RBD Human Patient STSGEGVGWIRQPPGKALEWLAVIYWD DDKRYSPSLKSRLTITRDTSKNQVVLTMT NMDPVDTATYYCAHRLWFRDAFDIWG QGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 511 EVQLVESGGGLVQPGGSLRLSCAASGFI 2616 SARS-CoV2 RBD Human Patient LSDHYMDWVRQAPGKGLEWVGRTRN KANSYTTEYAASVKGRFTISRDDSKNSLY LQMNSLKTEDTAVYYCASVITFGGVIVRS YWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 512 QVQLVQSGAEVKKPGSSVKVSCKASGG 2617 SARS-CoV2 RBD Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPV FGTTNYAQKLQGRVTISADESTSTAYME VSSLRSEDTAVYYCARVSGYGDYGAYSD YWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 513 EVQLVESGGGLVQPGGSLRLSCVASEFT 2618 SARS-CoV2 Human Patient FSSYWMSWFRQAPGKGLEWVSGINW NGGSTGYADSVKGRFTISRDNAKNSLYL QMNSLKTEDTAVYYCASVITFGGVIVRSY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 514 EVQLLESGGGLVQPGGSLRLSCAASGFT 2619 SARS-CoV2 RBD Human Patient FNNYAMSWVRQAPGKGLEWVSAIGGS GGSTYYADSVKGRFTVSRDNSENTLYLQ MSSLRAEDTAVYYCARVEGDWLLGGPY YHYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 515 QVQLVESGGGVVQPGRSLRLSCAASGF 2620 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAGISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARADTMVRGTYF EYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 516 QVQLVESGGGVVQPGRSLRLSCAASGF 2621 SARS-CoV2 RBD Human Patient TFSSYLMHWVRQAPGKGLEWVAVIWA NGNRYYADSVKGRFTISRDISKNTLYLQ MNSLRAEDTAMYYCARDYCNGVTCNS NYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 517 QVQLQESGPGLVKPSGTLSLTCAVSGGS 2622 SARS-CoV2 Human Patient ISSSNWWSWVRQPPGKGLEWIGEIYHS GSTNYNPSLKSRVTISVDKSKNQFSLKLS SVTAADTAVYYCARGWYFDYWGQGTLV TVSA COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 518 QVQLVQSGAEVKKPGSSVKVSCKASGG 2624 SARS-CoV2 RBD Human Patient TFHNYAISWVRQAPGQGLEWMGGFIPI LGTTNYAQKFQGRVTITADESTSTAYME LSSLRSEDTAVYYCARVEGEGVDSYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 519 EVQLVESGGGLVQPGRSLRLSCAASGFT 2628 (weak) Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGTIGYADSVKGRFIISRDNAKNSLYLQ MNSLRPEDTALYYCAKDIIRQGEDGMD VWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 520 QLQVVQSGPGLVKPSETLSLTCTVSGDP 2631 SARS-CoV2 Human Patient VINTNYYWGWIRQPPGKGLEWIGTLSY SGGTHYNPSLSSRVTIAVDSSKKRFSLTL RSVTAADTAIYYCARHPVDGYNYGYSDL WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 521 QVQLVQSGAEVKKPGASVKVSCKASGY 2632 SARS-CoV2 Human Patient TFTDYYMHWVRQAPGQGLEWMGWI NPNSRGTNYAQKFQGRVTMTRDTSIST VYMELSRLTSDDTAVYYCARVVVLGYGR PNNYYDGRNVWDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 522 QVQLVESGGGVVQPGRSLRLSCAASGF 2639 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DEINKYYADSVKGRFTISRDNSKTTLDLQ MNSLRAEDTAVYYCARAGGGSYRGPFD YWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 523 QVQLVESGGGVVQPGRSLRLSCAASGF 2641 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLEWVTVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKSYNGNYYDAFDI WGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 524 QVQLVESGGGVVQPGRSLRLSCAASGF 2643 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARGSAGNYYYG MDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 525 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2656 SARS-CoV2 RBD Human Patient SDYWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAMYYCARLTFGGSGSYYFYYN GMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 526 EVQLVESGGGLVQPGGSLRLSCAASGFT 2660 SARS-CoV2 RBD Human Patient FSSYDMHWVRQATGKGLEWVSAIGTA GDTYYPGSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARADPYQLLGQHYYY GMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 527 QVHLVESGGGVVQPGRSLRLSCAASGF 2669 SARS-CoV2 RBD Human Patient TFSNYGMHWVRQAPGKGLEWVAVISN DEFNKFYANSVKGRFTISRDNSKNTVYL QLNSLRTEDTARYYCAKGGDGSGWAW DGDNPPTDYWGQGTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 528 QVTLKESGPVLVKPTETLTLTCAVSGFSL 2673 SARS-CoV2 Human Patient SNAKMGVSWIRQPPGKALEWLAHIFSN DEKAYSTSLKTRLTISKDTSKSQVVLTVT NMDPVDTATYYCARIVLGASGTYPSPGFD PWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 529 QVQLVESGGGVVQPGRSLRLSCAASGF 2675 SARS-CoV2 RBD Human Patient TFSIYGMHWVRQAPGKGLEWVAVISFD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDGSGSYYGWFD PWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 530 QVQLVQSGAEVKKPGSSVKVSCKASGG 2676 (weak) RBD Human Patient TFSSYAINWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTFTADESTSTAYME VSSLRSEDTAVYYCARSCGDCYSADLDF WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 531 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2677 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSMYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARLLWLRGHFDYWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 532 EVQLVESGGGVVRPGGSLRLSCAASGFI 2678 SARS-CoV2 Human Patient FDDYDMTWVRQAPGKGLEWVSGISW NGGNTGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYHCAVIMSPIPRYSGY DWAGGAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 533 QVQLVESGGGVVQPGRSLRLSCAASGF 2681 SARS-CoV2 RBD Human Patient TFSFYAIHWVRQAPGQGLEWAAAISSD GTYKYYADSVKGRFTISRDNSKNTSYLQ MNSLRAEDTAVYYCARALNKGFDPWG QGTLLTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 534 QMQLVQSGPEVKKPGTSVKVSCKTSGF 2684 (weak) Human Patient TFTSSAIQWVRQARGQRLEWIGWIVVG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPHCNRTSCYDAF DLWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 535 QVQLVQSGAEVKKPGASVQVSCEASGY 2685 SARS-CoV2 RBD Human Patient TFTTYYMHWVRQAPGQGLEWMGIINP SGGSTTYAQKFQGRVTMTRDTSTSTVY MDLSSLRSEDTAVYYCARDRLGDGSYLG GGYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 536 QVQLVQSGAEVKKPGASVKVSCQASGY 2693 (weak) Human Patient TFTSYDINWVRQATGQGLEWMGWMK SNSGNTGYAQKFQGRVTMTRNTSISTA YMELTSLRSEDTAVYYCARMRSGWPTH GRPDDLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 537 QVQLVQSGAEVKRPGSSVKVSCKASGG 2694 SARS-CoV2 Human Patient TFSSYTISWVRQAPGQGLEWMGRIIPIL AVANYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCARDHSGYYDSTSLMSP FFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 538 QVQLVQSGAEVKKPGASVKVSCKASGY 2697 SARS-CoV2 RBD Human Patient TFTSHYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTGDTSTSTVY MELSSLRSEDTAVYYCARDLAGVPAALG CWFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 539 QVQLVESGGGVVQPGRSLRLSCAASGF 2700 SARS-CoV2 RBD Human Patient TFSTYAMHWVRQAPGKGLEWVAVISY DGGNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKNLGPYCSGGT CYSLVGDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 540 EVQLVESGGGLVQPGGSLRLSCAASGFT 2703 SARS-CoV2 Human Patient FSSYDMHWVRQATGKGLEWVSAIGTA GDTYYPGSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARARGGYNWNFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 541 QVQLVESGGGVVQPGRSLRLSCAASGF 2705 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSYKYFADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDQGTVVTHFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 542 QVQLVESGGGVVQPGRSLRLSCAASGF 2709 SARS-CoV2 Human Patient TFSNYGMHWVRQAPGKGLEWVAVMS YDGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKNLGPYCSGGT CYSLVGDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 543 QVQLVQSGAEVKKPGASVKVSCKASGY 2710 SARS-CoV2 Human Patient TFTSYDINWVRQATGQGLEWMGWMS PNSGNTGYAQKFQGRVTMTRDTSISTA YMELNSLRSEDTAVYYCARMRSGWPTH GRPDDHWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 544 EVQLVESGGGVVQPGGSLRLSCAASGF 2713 SARS-CoV2 Human Patient TFDDYAMHWVRQAPGKGLEWVSLISG DGGNTYYADSVKGRFTISRDNSKNSLYL QMNSLRTEDTALYYCAKDEMAYPPSHH YYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 545 QVQLVQSGAEVKTPGASVKVSCKASGY 2717 SARS-CoV2 Human Patient TFTSYDINWVRQATGQGPEWMGWM NPNSGNTGYAHKFQGRVTMTRNTSIST AYMELSSLRSEDTAVYYCARGPSILTGFY NPLDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 546 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2718 SARS-CoV2 RBD Human Patient SSSNYYWGWIRQPPGKGLEWIGTIHYS GISYYNPSLKSRVTISVDTSNNKFSLELS SVTAADTAVYFCARRTYYDLWSAYSSTAY YCMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 547 QVRLVQSGAEVKKPGSSVKVSCKASGG 2722 SARS-CoV2 Human Patient TFSDYAISWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITADEFTITAYMEL SSLRSEDTAVYYCARLSGSGWLGYAMD VWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 548 QVQLVESGGGVVQPGRSLRLSCAASGF 2726 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISN DGRNKYYADSVKGRLTISRDNSKNTLYL QMNSLRAEDTAVYYCARPSNWYFDLW GRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 549 EVQLVESGGGLVQPGRSLTLSCAASGFT 2730 (weak) Human Patient FDDYTMHWVRQAPGKGLEWVSGIDW NGGTIGYADSVKGRFTISRDNAKNSLYL QMNSLRAEDTALYYCAKAGYYAYVWGS YRFEYFDNWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 550 EVQLVESGGGLVQPGGSLRLSCAASGVT 2733 Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG STFYADSVKGRFTISRHNSKNTLYLQMN SLRPEDTAVYYCARGPEPDAFDIWGQG TMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 551 QVQLQESGPGLVKPSETLSLTCTVSGGS 2734 SARS-CoV2 (weak) Human Patient VSSGSYYWSWIRQPPGKGLECIGYIYYSG SSNYNPSLKSRVTISVDTSKNQFSLKMSS VTAADTAVYYCAGSPVPPTIVGASYWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 552 QVQLVESGGGVVQPGRSLRLSCAASGF 2736 SARS-CoV2 Human Patient TFSDYAMHWVRQAPGKGLEWVADISF DGSNKYYADSVKGRFTISRDSSENTLYLQ MDSLRADDTAVYYCARDLSTTWYLEM WGPDAFDIWGQGTVVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 553 QVQLVESGGGVVQPGRSLRLSCAASGF 2740 SARS-CoV2 Human Patient TFRRYGMYWVRQAPGKGLEWVAVISY DGTDKYYTDSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKKGGPYCGGGN CYAGYFDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 554 QVQLQQWGAGLLKPSETLSLTCAVSGG 2749 SARS-CoV2 Human Patient SFSAYYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLRSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARVGYSQGYYYYYMDV WGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 555 EVQVVESGGGLVQPGRSLRLSCVSSGFI 2751 SARS-CoV2 Human Patient FDDYVMHWVRQRPGKGLEWVAGITYN GGILGYGDSVKGRFIIARDNVRGFLSLQ MGDLRTEDTALYYCARDYCSSTTCPAET YYYMDVWGKGTAVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 556 EVQLVESGGGLIQPGGSLRLSCAASEVT 2752 Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG TTYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDFLRWHDLWGQG TLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 557 EVQLVESGGGLVQPGGSLRLSCAASGFT 2753 SARS-CoV2 Human Patient FSSYDMHWVRQATGKGLEWVSTIGTA GDTYYPDSVKGRFTISRENAKNSLFLQM NSLRAGDTAVYYCARVDFDILTGYYSNW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 558 EAQLLESGGALVQPGGSLRLSCAASGFT 2756 SARS-CoV2 Human Patient FSCCAMGWVRQAPGRGLEWVSSIHDD GVGTFYAVSVKGRFSISRDNSKNTVYLQ MNGLRAEDTGVYYCAKWAGPIVMKYY LQYWGQGALVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 559 EVQLVESGGGLVQPGGSLRLSCAASGFT 2758 SARS-CoV2 Human Patient FSSYDMHWVRQATGKGLEWVSAIGTA GDTYYPDSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARGGDSGYDLGAWY FDLWGRGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 560 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2759 SARS-CoV2 Human Patient TNYWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLKASDTAMYYCARTPTLYNWFHPWG QGTPVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 561 QVTLRESGPALVKPTQTLTLTCTFSGFSL 2760 (weak) Human Patient STSGLCVSWIRQPPGKALEWLARIDWDD DKYYNTSLRTRLTISKDTSKNQVVLTMTN MDPVDTATYYCARATTFFYGMDVWGQ GTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 562 QLQLQESGPGLVKPSETLSLTCTVSGGSI 2762 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG ITYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARHQRYCSSSSCHVWDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 563 EVQLVESGGGLVQPGRSLRLSCAASGFT 2765 SARS-CoV2 Human Patient FDDYAMNWVRQPPGKGLEWVSGISW NSDSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAMYYCAKGRGAGYTSYM DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 564 EVQLVESGGGLVQPGGSLRLSCAASGFT 2767 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYPG GSAFYADSVKGRFTISRHNSNNTLCLQM NSLRTEDTAVYYCARSYDILTGYRDAFDI WGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 565 QVQLVESGGGVVQPGRSLRLSCAASGF 2768 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDDNSPQGSG WYFYYYYAMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 566 QVQLVESGGGVVQPGRSLRLSCAASGF 2769 SARS-CoV2 Human Patient TFSTYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMIGLRAEDTAVYYCARDWAPTYYDM PSAFDIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 567 EVQLVESGGGLVQPGGSLRLSCAASGFT 2774 SARS-CoV2 RBD Human Patient FSSYWMTWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKGRFTISRDNAKNSLSL QMNSLRVEDTAVYYCVRLGVSSWYFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 568 EVQLVESGGDLVQPGGSLRLTCAASGFT 2776 SARS-CoV2 RBD Human Patient FSSHWMTWVRQAPGKGLEWVANIKE DGREKYYVDSVKGRLTISRDNAKNSLYL QMNSLRAEDTAVYYCARVVVEVATNKG IHGVDYYYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 569 QVQLQQWGAGLLKPSETLSRTCAVYGA 2780 (weak) Human Patient SFSNYYWSWIRQPPGKGLEWIGEINHSE NTNYNPSLKSRVTISVDTSKNQFSLRLSS VTAADTAVYYCARLRYSSSGGHIFDYWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 570 QVQLVQSGAEVKKPGSSVKVSCKASGG 2783 SARS-CoV2 Human Patient TFSSYAISWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITADESTSTAYMEL SSLRSEDTAVYYCARGLTGSSAYKDEIYF DYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 571 QVQLQESGPGLVKPSETLSLTCTVSGGSI 2784 SARS-CoV2 RBD Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST KYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARDGGNAYSSGWYRYYYH MDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 572 EVQLVESGGGLVQPGGSLRLSCAASGFT 2786 SARS-CoV2 Human Patient FSSYDLHWVRQGTGKRLEWVSAIGTAG DTYYLGSVKGRFTISRENAKNSLYLQMN SLRAGDTAVYYCARVLYDSSGFYNWFDP WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 573 QVQLVQSGAEVKKPGASVRVSCKAPGY 2789 SARS-CoV2 Human Patient TFTTYYIHWVRQAPGQGLEWMGIINPS AGSTTYAQKFQGRVTMTRDTSTSTVYM ELSSLRSEDTAVYYCARGFHVPAALRNW FDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 574 EVQLVESGGGLVQPGGSLRLSCAASGFT 2790 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYPG GSAFYADSVKGRFTISRHNSNNTLCLQM NSLRTEDTAVYYCARSYDILTGYRDAFDI WGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 575 EAQLVESGGGLVQPGGSLRLSCEASGFI 2794 SARS-CoV2 Human Patient FSSYWMSWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARVNDGRPNPLE YYFDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 576 QVQLQESGPGLVKPSQTLSLTCTVSGDSI 2796 SARS-CoV2 Human Patient SSGRYYWSWIRQHPGKGLEWIGFVYYS GSTYYNPSLKSRVTISVDTSKNQFSLRLS SVTAADTAVYYCARETYSAYEMPPYFDY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 577 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2797 SARS-CoV2 Human Patient TSYWIGWVRQMPGKGLEWMGIIQPG DSDTRYSPSFQGQVTMSADKSTSTAYLQ WSSLKASDTAMYYCARDLIIESTIAARPG YYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 578 QVHLVQSGAEVKKPGASVKLSCKASGYT 2801 SARS-CoV2 Human Patient FTNYLLHWVRQAPGQGLEWMGNVNP SRGTATYPQKLDDRVTMTSDKSASTIYM ELSGLRSEDTAIYYCARERSGTYFFDYWG QGTLLTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 579 QVTLRESGPALVKPTQTLTLTCTFSGFSL 2807 Human Patient TTSGMCVSWIRQPPGKALEWLARIDWD DDKYYSTSLQTRLTISKDTSKNQVVLTMT NMDPVDTATYYCARETPVTAIDYWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 580 QVQLVQSGAEVKKPGSSVKVSCKASGFT 2808 SARS-CoV2 Human Patient FMSSAVQWVRQARGQRLEWIGWIVIG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPYCSSISCNDGF DIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 581 QVQLVQSGAEVKKPGASVKVSCKVSGY 2809 SARS-CoV2 Human Patient TFTGYVVHWVRQAPGQDLEWMGWIN TGYGNTKYSQKFQGRVTISWDTSATTAY MELSNLKSEDKAVYYCASMTRMSEQTY YGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 582 QVQLVESGGGVVQPGRSLRLSCAASGF 2811 SARS-CoV2 RBD Human Patient TFSSFAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAAYYCARELMSVGWGQ GTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 583 EVQLVESGGGLIQPGGSLRLSCAASGITV 2812 Human Patient SSNYMSWVRQAPGKGLEWVSVIYAGG STYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDALYYNGPGRDGM DVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 584 EVQLVESGGGLIQPGGSLRLSCAASGITV 2813 Human Patient SSNYMSWVRQAPGKGLEWVSVIYAGG STYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARDALYYNGPGRDGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 585 QVQLVESGGGVVQPGRSLRLSCAASGF 2814 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVISS DGSNKYYAGSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKDMVEPLFSHY YYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 586 QVQLQESGPGLVKPSETLSLTCTVSGGSI 2816 SARS-CoV2 Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDMSKNQFSLKLRSVT AADTAVYYCARAPRERLQWGEYYFDYW GQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 587 EVQLVESGGGLVQPGGSLRLSCAASGFT 2817 SARS-CoV2 Human Patient FRSYDMHWVRQVTGKGLEWVSTIGTA GDTYYPGSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARVFETKVIRGGRYY YYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 588 QVQLQQWGAGLLKPSETLSLTCAVYGG 2818 SARS-CoV2 RBD Human Patient SFSGYYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLKSRVTISVDTSKNHFSLKM NSVTAADTAVYYCARCRQMGNFYYYYM DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 589 QVQLQESGPGLVKPSQTLSLTCTVSGDSI 2819 Human Patient SSAGYYWSWIRQHPGKGLEWIGYIYYSG RTYYNPSLKSRVTMSVDTSKNQFSLRLRS VTAADTAVYYCARVVPTRGPVAWFDP WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 590 QVQLVESGGGVVQPGRSLRLSCAASGF 2820 SARS-CoV2 RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGSKKDYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDQSQGAYILT GYRGYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 591 QVQLVQSGAEVKKPGSSVKVSCKTAGG 2821 SARS-CoV2 Human Patient TSSSYAISWVRQAPGQGLEWMGRIIPIL GVAIYAQKFQGRVTITADKSTSTAYMEL NSLRSEDTAVYYCTTTQGGDYGDNLYYL DYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 592 EVQLVESGGGLVQPGGSLRLSCAASGVT 2822 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSLIYSGG STFYADSVKGRFTISRHNSKNTLYLQMN SLRPEDTAVYYCARGPEPDAFDIWGQG TMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 593 QVQLVQSGAEVKKPGASVKVSCKASGD 2826 SARS-CoV2 Human Patient TFTTYYIHWVRQAPGQGLEWMGIINPS GGSRSYAQKFQGRISMTSDTSTSTVYME LSSLRSEDTAVYYCARGYGFVPNVLYYFD YWGQGTLVTVST COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 594 EVQLVESGGGLVKPGGSLRLSCAASGFT 2828 SARS-CoV2 Human Patient FRDYSMNWVRQAPGKGLEWVSSISSG GSYIYYADSVKGRFTISRDNAKNSLYLQM NSLRAEDTAVYYCARGGSILWWLIDYW GQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; NTD B-cells; SARS-CoV2 595 EVQLLESGGGLVQPGGSLRLSCAASGFT 2830 SARS-CoV2 Human Patient FTSYAMSWVRQAPGKGLEWVSGISISG GSTYYAASVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKDSRSGIAGVDAFD IWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 596 EVQLVESGGGLVQPGGSLRLSCAASGLT 2832 Human Patient VSSNYMSWVRQAPGKGLECVSVIYAGG NTYYADSVKGRFTISRDNSKNTLYLQMN SLRAEDTAVYYCARGDGGYYSPFDYWG QGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 597 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2834 SARS-CoV2 Human Patient STSGVGVAWIRQPPGKALEWLALIYWDD DKRYSPSLKSRLTITKDTSKNQVVLTMTN MDPVDTATYYCAHRLPTPQLLPSFENW FDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 598 EVQLVESGGGLVQPGGSLRLSCAASGLT 2835 Human Patient VGSNYMNWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQLN SLRAEDTAVYYCAREVVGYFDCWGQGT LVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 599 QVQLQESGPGLVKPSETLSLTCTVSGGSI 2841 Human Patient SSYYWSWIRQPPGKGLEWIGHIYYTGSS YYNPSLKSRVTISLDTSKNQFSLKLNSVT AADTAVYYCARLRWLRGGIDFWGQGTLV IVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 600 QVQLVQSGAEVKKPGASVKVSCKASGD 2842 SARS-CoV2 Human Patient TFTTYYIHWVRQAPGQGLEWMGIINPS GGSRSYAQKFQGRISMTSDTSTSTVYME LSSLRSEDTAVYYCARGYGFVPNVLYYFD YWGQGILVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 601 QVELVESGGGVVQPGRSLRLSCAASGFI 2844 SARS-CoV2 RBD Human Patient FSSYAMHWVRQAPGKGLEWVAVISYD GGNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARAQGGNYYYGM DVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 602 QVQLVESGGGVVQPGRSLRLSCAASGF 2848 SARS-CoV2 (weak) Human Patient TFSRYAMYWVRQAPGKGLEWVALISYD GRNEYYADSVKGRFTISRDNSKNTLYLQ MNSLRAGDSAVYYCARDLAYHPYRDYG DDDYYYYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 603 QVQLVQSGAEVKKPGASVKVSCKASGY 2853 SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP GGGSTTYAQKFQGRVTMTSDTSTSTVY MELSSLRSEDTAMYYCARGAIPPNSRAE IDYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 604 QVQLVQSGAEVKKPGASVKVSCKASGY 2863 SARS-CoV2 Human Patient TFTSYYLHWVRQAPGQGLEWMGIINPS GGSTTYAQKFQGRVTMTRDTSTSAVYM ELRSLRSEDTAVYYCARENDYGDYVEPR DYYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 605 QVQLVESGGGVVQPGRSLRLSCAASGF 2872 SARS-CoV2 RBD Human Patient TFSTYGMHWVRQAPGKGLEWVAVIWY DGNKKYCADSVKGRCTISRDNSKNTLYL QMNSLRAEDTAVYYCAREGPFGDREAS GAFDVWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 606 QVQLVESGGGLVKPGGSLRLSCAASGFT 2873 SARS-CoV2 Human Patient FSDYYMSWIRQAPGKGLEWVSYISSSGI TIYYADSVKGRFTISRDNAKNSLYLQMNS LRAEDTAVYYCTGVVAAPAEYFQHWGQ GTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 607 EVQLVESGGGLVQPGGSLRLSCAASGFT 2878 SARS-CoV2 (weak) Human Patient FSRHWMTWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKGRLTISRDNAKNSLYL QMNSLRAEDTAVYYCARLGFYYGGADY WGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 608 QVQLVESGGGVVQPGRSLRLSCAASGF 2883 SARS-CoV2 RBD Human Patient TFSTYGMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAMYYCAKDGSIAAADY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 609 QVQLVQAGAEVKKPGASVKVSCKASGY 2891 SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARGAAVPAAGEF DYWGQGTLVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 610 QVQLVESGGGVVQSGGSLRLSCAASGF 2894 SARS-CoV2 Human Patient TFSTYGMHWVRQAPGKGLEWVAIISYD GINKYYADSVKGRFTISRDNSKNTVYLQ MNSLRTEDTAMYYCAKGDGSYLMDYF DYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 611 EVQLVESGGGLVQPGGSLRLSCAASGFT 2901 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYPG GSAFYADSVKGRFTISRHNSNNTLCLQM NSLRTEDTAVYYCARSYDILTGYRDAFDI WGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 612 QVQLQQWGAGLLKPSETLSLTCAVYGG 2904 SARS-CoV2 RBD Human Patient SFSGYYWSWIRQPPGKGLEWIGEINHS GSTNYNPSLKSRVTISVDTSKNHFSLKM NSVTAADTAVYYCARCRQMGNFYYYYM DVWGKGTTVTVSP COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 613 EVQLVQSGAEVKKPGESLKISCKGSGYSF 2906 SARS-CoV2 Human Patient TSYWVGWVRQMPGKGLEWMGIIYPG DSDTRDSPSFQGQVTISADKSISTAYLQ WSSLKASDTAMYYCARLGSESKIDYYYY GMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 614 QVQLVQSGAEVKKPGSSVKVSCKASGD 2909 SARS-CoV2 Human Patient TFSSYTINWVRQAPGQGLEWMGRIIPIL GIPNYAQKFQGRVTITADKSTSTAFMEL SSLRSEDTAVYYCARGRGYSNYGASYYM DVWGKGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 615 QLQLRESGPGLVKPSETLSLTCTVSGGSI 2911 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVFYCARMSRGYNYAYTFDIWG QGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 616 QVTLRESGPALVKPTQTLTLTCTFSGFSL 2919 Human Patient STSGMCLSWIRQPPGKALEWLARIDWD DDKYYSTSLETRLTISKDTSKNQVVLTMT NMDPVDTGTYYCARTMATINAFDIWG QGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 617 QVQLVESGGGVVQPGRSLRLSCAASGF 2933 SARS-CoV2 RBD Human Patient TFSYYPMHWLWVRQAPGKGLEWVAVT SYDGTNKYYADSVKGRFTISRDNSKNTLY LQMNSLRAEDTAVYYCARGGATNFDY WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 618 QVQLVQSGSELKKPGASVKVSCKASEYT 2934 SARS-CoV2 RBD Human Patient FTSYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARPGKAAAFDYWG QGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 619 QVQLVESGGGVVQPGRSLRLSCAASGF 2939 SARS-CoV2 Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGSNKYYAESVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARDLHQDWVVVV AANVYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 620 QMQLVQSGPEVKKPGTSVKVSCKASGF 2941 (weak) Human Patient TFMSSAVQWVRQARGQRLEWIGWIVI GSGNTNYAQKFQERVTITRDMSTSTAY MELSSLRSEDTAVYYCAAPYCSSISCNDG FDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 621 QVTLRESGPALVKPTQTLTLTCTFSGFSL 2942 SARS-CoV2 RBD Human Patient STSGLCVSWIRQPPGKALEWLARIDWDD DKYYNTSLRTRLTISKDTSKNQVVLTMTN MDPVDTATYYCARATTFFYGMDVWGQ GTTATVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 622 QVQLVESGGGVVQPGRSLRLSCAASGF 2944 SARS-CoV2 Human Patient TFRRYGMYWVRQAPGKGLEWVAVISY DGTDKYYTDSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKKGGPYCGGGN CYAGYFDYWGQGILVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 623 EVQVVESGGGLVQPGRSLRLSCAASGFT 2945 SARS-CoV2 Human Patient FEDYAMHWVRQAPGKGLEWVSGVSW NSGIIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKLDVGGYDFVSG HYYAFDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 624 QVQLVQSGSELKKPGASVKVSCKASGYT 2947 SARS-CoV2 RBD Human Patient FSDYAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQGFTGRFVFSLDTSVSTAY LQISSLKAEDTAVYYCARGLISLFRGAIF HYYYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 625 EVQLVESGGGLVQPGGSLRLSCAASGLT 2952 Human Patient VRSNYMTWVRQTPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTVYLQM NSLRAEDTAVYYCARDLVTYGLDVWGQ GTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 626 QITLKESGPTLVKPTQTLTLTCTFSGFSL 2953 SARS-CoV2 Human Patient STKRVGVGWIRQPPGKALEWLALIYWDD DQRYSPSLKSRLTITKDTSKNQVVLTMT NMDPVDTATYYCAHSGPPDLSPVLSQG WFDPWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 627 QVQLVESGGGVVQPGRSLRLSCAASGF 2955 Human Patient TFVTSGIHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKGGPNKEVLYFG ELLDYGMDVWGQGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 628 QVQVVQSGAEVKKPGASVKVSCKASGY 2960 SARS-CoV2 RBD Human Patient TFKNYGISWVRQAPGQGLEWMGWISA YTGNTNYAQKFQGRMTMTTDTSTGTG YMELRSLRSDDTAVYYCARVQRRRLDY WGQGTLVIVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 629 QMQLVQSGPEVKKPGTSVKVSCKASGF 2961 Human Patient TFMSSAVQWVRQARGQRLEWIGWIVI GSGNTNYAQKFQERVTITRDMSTSTAY MELSSLRSEDTAVYYCAAPYCSSISCNDG FDIWGQGTMVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 630 QVQLVQSGAEVKKPGASVKVSCKASGY 2997 SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP GGGSTTYAQKFQGRVTMTSDTSTSTVY MELSSLRSEDTAMYYCARGAIPPNSRAE IDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 631 QVQLVESGGGVVQPGRSLRLSCAASGF 3010 SARS-CoV2 Human Patient TFSDYAMHWVRQAPGKGLEWVADISF DGSNKYYADSVKGRFTISRDSSENTLYLQ MDSLRADDTAVYYCARDLSTTWYLEM WGPDAFDIWGQGTVVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 632 EVQLVESGGGLVQPGGSLRLSCAASGFT 3012 SARS-CoV2 Human Patient FSSYDLHWVRQGTGKRLEWVSAIGTAG DTYYLGSVKGRFTISRENAKNSLYLQMN SLRAGDTAVYYCARVLYDSSGFYNWFDP WGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 633 QVQLVESGGGVVQPGRSLRLSCAASGF 3013 SARS-CoV2 Human Patient TFSNYGMHWVRQAPGKGLEWVAVMS YDGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAKNLGPYCSGGT CYSLVGDYWGQGTLVTVSS COV2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 634 EVQLVQSGPEVKKPGTSVKVSCKASGFT 3025 Human Patient FMSSAVQWVRQARGQRLEWIGWIVIG SGNTNYAQKFQERVTITRDMSTSTAYM ELSSLRSEDTAVYYCAAPYCSSISCNDGF DIWGQGTMVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 635 EVQLVESGGGVVQPGGSLRLSCAASGF 3029 SARS-CoV2 Human Patient TFDDYAMHWVRQAPGKGLEWVSLISG DGGNTYYADSVKGRFTISRDNSKNSLYL QMNSLRTEDTALYYCAKDEMAYPPSHH YYYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 636 EVQLVESGGGLVQPGGSLRLSCAASGFT 3057 SARS-CoV2 RBD Human Patient FSSYWMSWVRQAPGKGLEWVANIKQ DGSEKYFVDSVKGRFTISRDNAKNSLYL QMNSLRAEDAAVYYCARLVTTVTTANG LYYYSYYYMDVWGKGTTVTVSS COV2- Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 637 EVQLVESGGGAVQPGRSLRLSCAASGFT 3058 SARS-CoV2 RBD Human Patient FSTYAMYWVRQAPGKGLEWVAVISYD GSNRYYADSVKGRFTISRDNSKNTLYLQ MNSLRPEDTAVYYCARDRSGNYRDAFD IWGQGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 638 HQHQVEQGPGGVEQSETLFLTCCVSGG 01 SARS-CoV2 RBD Human Patient FTISSCYKRGGIRQPPRKGEEWAVSSYYS SSTYYTPSLKSRVTISVDKSKNQFSLKMS SVTAADTAVYYCARVSSGYYFTPFDYWG QGTRGHRLF COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 639 EVQLVESGGGVVQPGRSLRLSCAASGFT 02 SARS-CoV2 RBD Human Patient FSIYAMHWVRQAPGKGLEWVAVISYD GSNQYYADSVRGRFTISRGNSKNTLYLQ MNSLRPEDTAVYYCARARGGSYNDAFD IWGQGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 link B-cells; SARS-CoV2 640 EVQLVESGGGVVQPGRSLRLSCAASGFT 03 Human Patient FSSYGMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDGQYYDFWSGY LGARTNPHYYYYMDVWGKGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 641 EVQLVQSGGGLVQPGRSLRLSCAASGFT 06 SARS-CoV2 RBD Human Patient FGEYAMHWVRQAPGKGLEWVSGISW NSGSIDYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKDMGEAVAGTHY GMDVWGQGTMVTASS COVA1- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 642 QVQLVESGAEVKKPGSSVKVSCKASGGT 07 SARS-CoV2 SARS-CoV2 RBD Human Patient LSSYAITWVRQAPGQGLEWVGGIIPIFG TANYAQKFQGRVTITADESTSTAYMELS SLRSEDTAVYYCARVGAYDSSGYSNDYW GQGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 643 EVQLVESGGGVVQPGGSLRLSCAASGF 08 SARS-CoV2 Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCAREDYYDSSGSF DYWGQGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 644 QLQLVESGPGLVKPSETLSLTCTVSGGSI 09 SARS-CoV2 RBD Human Patient SSYFWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARHSQGWLQQAVAFDIWG QGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 645 EVQLVESGGGLVQPGGSLRLSCAASGFT 10 SARS-CoV2 Human Patient VTSTYMTWVRRAPGKGLEWVSIIYNDD TTYYADSVKDRVTVSRDDSKNTLYLQM NSLRAEDTAIYYCARGGYYYDPSGYYSRS FSFDYWGQGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 646 EVQLVQSGTEVKKPGASVKVSCKASGYT 12 Human Patient FPGYYIHWVRQAPGQGLEWMGWINP NSGVAKSAQKFQGRVTMTRDSSISTVYL DVTSDDTAVYYCARDLVWATVSGTMD VWGQGTTVTVSS COVA1- Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 647 QVQLVQSGAEVKKPGASVKVSCKASGY 16 SARS-CoV2 SARS-CoV2 Human Patient TFTSYYMHWVRQAPGQGLEWMGIINS SGGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARPPRNYYDRSG YYQRAEYFQHWGQGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 648 EVQLVESGGGLVQPGGSLRLSCAASGFT 18 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARVEWAAAGTFYWG QGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 649 QVQLVESGGGLVKPGGSLRLSCAASGFT 19 SARS-CoV2 RBD Human Patient FSSYSMNWVRQAPGKGLEWVSSISSSSS FIYYADSVKGRFTISRDNAKNSLYLQMNS LRAEDTAVYYCARWKSDYYDSSGYYPAA FDIWGQRDKWSPSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 650 QVQLVESGGGLVKPGGSLRLSCAASGFT 20 SARS-CoV2 RBD Human Patient FSSYSMNWVRQAPGKGLEWVSSISSSSS YIYYADSVKGRFTISRDDAKNSLFLQMNS LRAEDTAVYYCAGDQNLYCSGDSCYYHY YGMDVWGQGTVVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 651 EVQLVESGGGVVQPGRSLRLSCAASGFT 21 RBD Human Patient FSSYAMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNTKNTLYLQ MNSLRAEDTAVYYCARDSEYYDILTGYL APTHYYYYYMDVWGKGTTVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 652 EVQLVESGAEVKKPGASVKVSCKASGYT 22 SARS-CoV2 RBD Human Patient FTSYGISWVRQAPGQGLEWMGWISAY NGYTNSAQKLQGRVTMTTDTSTSTAYM ELRSLRSDDTAVYYCARDLVDTAMVQTL DDYGMDVWGQGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 653 QVQLVQSGAEVKKPGESLKISCKGSGYR 23 SARS-CoV2 RBD Human Patient FTTYWIGWVRQMPGKGLEWMGIIYPG DSDTRYSPSFQGQVTISADKSISTAYLQW SSLTASDTAIYYCARYYYDSRGYTSIDFW GQGTLVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 654 EVQLVESGPGLVKPSETLSLTCTVSGGSI 25 SARS-CoV2 RBD Human Patient SSTSYYWGWIRQPPGKGLECIGSIYYSGS TYYNPSLKSRVTISVDTSKNQFSLKLSSV TAADTAVYYCARLNYDFWSGYYSYALYY MDVWGKGTMVTVSS COVA1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 655 QLQLQESGPGLVKPSQTLSLTCTVSGGSI 26 SARS-CoV2 RBD Human Patient SSGGYYWSWIRQLPGKGLEWIGYIYYSG STYYNPSLKSRVTISVDTSKNQFSLNLSS VTAADTAVYYCARQQLDYYDSSGCFDYW GQGTLVTVSS COVA1- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 656 EVQLVESGPGLVKPSETLSLTCTVSGGSI 27 SARS-CoV2 SARS-CoV2 RBD Human Patient SSYYWSWIRQPPGKRLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLNSVT AADTAAYYCARGFDYWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 657 EVQLVESGGGLVQPGGSLRLSCAASGFT 01 SARS-CoV2 Human Patient FSSYDMHWVRQTTGKGLQWVSAIGTA GDTYYPGSVKGRFTISRENAKNSLYLQM NSLRAGDTAVYYCARGGDRYPVGYFDL WGRGTLVTVSS COVA2- Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 658 VQLQQESGPGLVKPSETLSLTCTVSGGSI 02 SARS-CoV2 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG (weak) STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARRSTSRWGYYYMDVW GKGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 659 EVQLVESGGGLVQPGGSLRLSCAASGFT 03 SARS-CoV2 RBD Human Patient FSSYSMNWVRQAPGKGLEWVSYISSSSS TIYYADSVKGRFTISRDNAKNSLYLQMNS LRAEDTAVYYCAREANSDFWSGYLGYFD YWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 660 QVQLVETGGGLIQPGGSLRLSCAASGFT 04 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDLERAGGMDVW GQGTMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 661 EVQLLESGAEVKKPGESLKISCKGSGYSF 05 SARS-CoV2 Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARHMRPSIAARPGYQ YYMDVWGKGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 662 EVQLVETGGGLIQPGGSLRLSCAASGLT 07 Human Patient VSSNYMNWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAREAYGMDVWGQG TMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 663 EVQLLESGGGLVQPGGSLKLSCAASGFT 10 SARS-CoV2 RBD Human Patient FSSYAMSWVRQAPGKGLEWVSAISGSG SNTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKGLRGQQLVIPTEY FQHWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 664 EVQLVESGAEVKKPGSSVKVSCKASGGT 11 (weak) Human Patient LSSYAISWVRQAPGQGLEWMGGIIPIFG TANYAQKFQGRVTITTDESTSTAYMELSS LRSEDTAVYYCARGPRGCSSTSCYGSYFD YWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 665 EVQLVESGGGLVKPGGSLRLSCAASGFT 12 SARS-CoV2 RBD Human Patient FGSYSMSWVRQAPGKGLEWVSSISRSS SYIYNADSVRGRLTISRDNAKNSLYLQM NSLRVEDTAVYYCARDQPLPDILTGYYT GPLDYWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 666 QVQLVETGGGLIQPGGSLRLSCAASGFT 13 (weak) Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDLDTMGGMDVW GQGTRVTVSS COVA2- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 667 QVQLVQSGAEVKKPGSSVKVSCKASGG 14 SARS-CoV2 SARS-CoV2 RBD Human Patient TFSSYAIIWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITTDESTSTAYMEL SSLRSEDTAVYYCARVRYYDSSGYYEDY WGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 668 QVQLLESGGGLVQPGGSLRLSCAASGFT 15 Human Patient FSSYAMSWVRQAPGKGLEWASAISGSG GSTYYADSVEGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKDTGYCGDDCYIKLI RGGPDYWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 669 QVQLVQSGAEVKKPGATVKISCKVSGYT 16 SARS-CoV2 Human Patient FTDYYMHWVQQAPGKGLEWMGLVDP EDGETIYAEKFQGRVTITADTSTDTAYM ELSSLRSEDTAVYYCASSDSSGFVGSRGF DYWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 670 QVQLVESGAEVKKPGSSVKVSCKASGGT 17 SARS-CoV2 Human Patient FSSYGINWVRQAPGQGLEWMGGIIPIF GTANYAQKFQGRVTITTDESTSTAYMEL SSLRSEDTAVYYCASFGDDSGDEGVRW GQGTLVTVSS COVA2- Ab SARS-CoV1, SARS-CoV2 SARS-CoV1 S; non- B-cells; SARS-CoV2 671 EVQLVQSGAEVKKPGSSVKVSCKASGGT 18 SARS-CoV2 RBD Human Patient FSSYAISWVRQAPGQGLEWMGGIIPIFG TTNYAQKFQGRVTITTDESTSTAYMELSS LRSEDTAVYYCARVYSYDSSGYYLEYWG QGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 672 EVQLVESGGGLIQPGGSLRLSCAASGFT 20 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCASPLLLTPPDYYYYMD VWGKGTMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 673 EVQLVESGPGLVKPSETLSLTCTVSGGSI 22 SARS-CoV2 RBD Human Patient SSYYWSWIRQPAGKGLEWIGRIYTSGST NYNPSLKSRVTMSVDTSKNQFSLKLSSV TAADTAVYYCARWKYNDRFDYWGQGT RVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 674 EVQLVESGAEVKKPGSSVKVSCKASGGT 23 SARS-CoV2 Human Patient FSSYAISWVRQAPGQGLEWMGGIIPIFG TANYAQKFQGRVTITTDESTSTAYMELSS LRSEDTAVYYCARGPRYCSSTSCYAGVYF DYWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 675 EVQLVQSGAEVKKPGESLRISCKGSGYSF 24 SARS-CoV2 Human Patient TSYWISWVRQMPGKGLEWMGRIDPSD SYTNYSPSFQGHVTISADKSISTAYLQWS SLKASDTAMYYCARPNPAGGYDSSGWV DAFDIWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 676 EVQLVESGAEVKKPGASVKVSCKVSGYT 25 SARS-CoV2 RBD Human Patient LPELSMHWVRQTPGKGLEWMGGFDP EDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATGPTIAAAATN WFDPGGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 677 EVQLVESGGGLVKPGGSLRLSCAASGFT 26 SARS-CoV2 RBD Human Patient FSNAWMSWVRQAPGKGLEWVGRIKSK TDGGTTDYAAPVKGRFTISRDDSKNTLY LQMNSLKTEDTAVYYCTTDRGDSYGYYY CMDVWGKGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 678 EVQLVESGGGVVQPGRSLRLSCAASGFT 28 SARS-CoV2 RBD Human Patient FSSYGMHWVRQAPGKGLEWVAVIWY DGSNKYYADSVKGRFTISRDNSKNTLYL QMDSLRAEDTAMYYCAKDKAPPCSSG WYYFDYWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD B-cells; SARS-CoV2 679 EVQLVESGGGVVQPGRSLRLSCAASGFT 29 Human Patient FSSYTMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCASLPVVPAAIGPLP AFDIWGQGTMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 680 EVQLVESGPGLVKPSQTLSLTCTVSGGSI 30 SARS-CoV2 RBD Human Patient SSGDYYWSWIRQPPGKGLEWIGYIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARGVEDPVVPAAIPWCW FDPWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 681 EVQLVESGVEVKKPGASVKVSCKAFGYT 31 SARS-CoV2 Human Patient FTGQDMHWVRQAPGQGLEWMGWIN PSSAGTNYAQKFQGRVTMTRDTSISTAY MELSRLRSDDTSVYYCRKMLTIFGKVNQ TMLLISGAKGQWSPSLQWGQGTMVTV SS COVA2- Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 682 EVQLVESGAEVKKPGSSVKVSCKASGGT 32 SARS-CoV2 SARS-CoV2 Human Patient FSSYAISWVRQAPGQGLEWMGGIIPIFG TANYAQKFQGRATITTDESTSTAYMELSS LGSEDTAVYYCARTHSYDNSGQYFDYW GQGTMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 683 QVQLVQSGAEVKKPGESLRISCKGSGYS 33 SARS-CoV2 RBD Human Patient FTSHWISWVRQMPGKGLEWMGRIDPS DSYTNYSPSFQGHVTISADKSISTAYLQW SSLKASDTAMYYCARLKVITIFGVVRDDY GMDVWGQGTTVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 684 QVQLVESGGGVVQPGRSLRLSCAASGF 34 SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSASGSYYGAF DYWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 685 EVQLVESGAEVKKPGASVKVSCKVSGYT 37 SARS-CoV2 RBD Human Patient LPELSMHWVRQAPGKGLDWMGGFDP EDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATSPAVMSVGW VDPWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 686 QVQLQQSGPGLVKPSETLPLTCTVSGGS 38 SARS-CoV2 RBD Human Patient ISSSSYYWGWIRQPPGKGLEWIGSVFYS GSTYYNPSLKSRVTISVDTSKNQLSLKLS SVTAADTAVYYCARQVRQWLEDDAFDI WGQGTMVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 687 QVQLVETGGGLIQPGGSLRLSCAASGFT 39 SARS-CoV2 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYTG GTTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARAHVDTAMVESGA FDIWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 688 QVQLQESGPGLVKPSGTLSLTCAVSGGS 40 SARS-CoV2 RBD Human Patient ISSSNWWSWVRQPPGKGLEWIGEIYHS GSSNYNPSLKSRVTISVDKSKNQFSLKLN SVTAADTAVYYCAGRYCSGGRCGWFDP WGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 689 EVQLVESGGGLVKPGGSLRLSCSASGFT 41 SARS-CoV2 RBD Human Patient FSNYNMDWVRQAPGKGLEWVSSISSSS SYIYLADSVKGRFTISRDNAKNSLYLQMN SLRAEDTAVYYCARVQKDIVVVPVALAD YYYYGMDVWGQGTTVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 690 QVQLVQPGAEVKKPGASVKVSCKASGY 43 SARS-CoV2 RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGDTNYAQKLQGRVTMTTDTSTSTAY MELRSLKSDDTAVYYCARFDYGYPYSSW SVLSIDYWGQGTLVTVSS COVA2- Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 691 EVQLVESGGGVVQPGRSLRLSCAASGFT 44 SARS-CoV2 SARS-CoV2 Human Patient FSSYAMHWVRQAPGKGLEWVAVISYD GSYKYYADSVKGRFTISRDNSKNTLYLQ MNSLTAEDTAVYYCAREGSRQWLVIYF DYWGQGTLVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1, S; RBD B-cells; SARS-CoV2 692 EVQLLESGAEVKKPGASVKISCKASGYTF 45 SARS-CoV2 Human Patient TGYYMHWVRQAPGQGLEWMGWINP NSGGTNYAQKFQGRVTMTRDTSISTAY MELSRLRSDDTAVYYCARGDGDYYDSS GYYRPTLYNWLDPWGQGTRVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 693 QVQLQESGPGLVKPSETLSLTCTASGGSI 46 SARS-CoV2 Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARHPSGLYQLLNWGQGT LVTVSS COVA2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 694 EVQLVESGGGLVQPGRSLRLSCAASGFT 47 SARS-CoV2 RBD Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDSAKNSLYLQ MNSLRAEDTALYYCAKVATYYYDRSGYY YGGALDYWGQGTLVTVSS COVA3- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 695 EVQLVESGPGLVKPSETLSLTCTVSGGSI 01 SARS-CoV2 SARS-CoV2 RBD Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARGPAATYYYYMDVWGKG TRVTVSS COVA3- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 696 EVQLVESGGGLVQPGGSLRLSCAASGFT 03 SARS-CoV2 SARS-CoV2 RBD Human Patient FSSYAMSWVRQAPGKGLEWVSTISGSG GNTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCAKEIAVAGCFDYWG QGTLVTVSS COVA3- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 697 EVQLVESGGGVVQPGRSLRLSCAASGFT 04 SARS-CoV2 RBD Human Patient FSSYGMHWVRQAPGKGLEWVAVIWY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARVGSVKSTAGY DFWSGDPFDYWGQGTLVTVSS COVA3- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 698 QVQLVQSGAEVKKPGASVKVSCKVSGY 05 SARS-CoV2 Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATAYSVDTAMVR GVGYWGQGTLVTVSS COVA3- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 699 QVQLVESRAEVKKPGSSVKVSCKASGGT 06 SARS-CoV2 Human Patient FSSYAISWVRQAPGQGLEWMGRIIPILG ITNYAQKFQGRVTITADKSTSTAYMELSS LRSEDTAVYYCARDAPDYYDSSGPTYFD YWGQGTLVTVSS COVA3- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; non- B-cells; SARS-CoV2 700 QVQLVESGGGLVQPGRSLRLSCAASGFT 07 SARS-CoV2 RBD Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKAEPEVGGYDYY MDVWGKGTMVTVSS COVA3- Ab SARS-CoV1, SARS-CoV1, S; non- B-cells; SARS-CoV2 701 EVQLVESGPGLVKPSETLSLTCTVSGGSI 08 SARS-CoV2 SARS-CoV2 RBD Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLRLSSVT AADTAVYYCARGPAATYYYYMDVWGK GTMVTVSS COVA3- Ab SARS-CoV2 SARS-CoV1 SARS-CoV1, S; RBD B-cells; SARS-CoV2 702 EVQLVESGGGLVQPGRSLRLSCAASGFT 09 SARS-CoV2 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTALYYCAKMGPDPAHDYG RKNDAFDIWGQGTMVTVSS COVA3- Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV2 703 EVQLVESRAEMKKPGESLKISCKGSGYTF 10 SARS-CoV2 SARS-CoV2 Human Patient TNHWIAWVRQMPGKGLEWMGIIYPG DSDTRYSPSFEGQVTISADKSISTAYLQW SSLKASDTAMYYCARRGYTYGADFYGLD VWGQGTRVTVSS CR3022 Ab SARS-CoV1, SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV1 704 QMQLVQSGTEVKKPGESLKISCKGSGY SARS-CoV2 Human Patient GFITYWIGWVRQMPGKGLEWMGIIYP GDSETRYSPSFQGQVTISADKSINTAYLQ WSSLKASDTAIYYCAGGSGISTPMDVW GQGTTVTVSS CV-X1- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND 126 Human Patient CV-X2- Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND 106 Human Patient CV05-163 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-200 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-209 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-222 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-250 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-255 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-262 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-270 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-283 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-287 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV07-315 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV1 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 705 QVQLQESGPGLVKPSETLSLTCTVSGYSI SARS-CoV2 RBD Human Patient SSGYYWGWIRQPPGKGLEWIGSIYHSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARTPLSLRLRYNWYFDLW GRGTLVTVSS CV10 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 706 QVQLQESGPGLVKPSETLSLTCNVSGGSI SARS-CoV2 RBD Human Patient SSYYWSWIRQPPGKGLEWIGYIYYSGST NYNPSLKSRVTISVDTSKNQFSLKLSSVT AADTAVYYCARGFDYWGQGTLVTVSS CV11 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 707 QVQLQESGPGLVKPSQTLSLTCTVSGGSI SARS-CoV2 RBD Human Patient SSGGYYWSWIRQHPGKGLEWIGYIYYS GSTYYNPSLKSRVTISVDTSKNQFSLKLS SVTAADTAVYYCARETTGHFDYWGQGTL VTVSS CV12 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 708 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient NLSNYAMHWVRQASGKGLEWVSLISY DGSVKYYTDSVKGRFTVSGDNSKNTLFL QMNSLRPDDSALYYCVRGGVSGPNSFD MWGQGTTVTVSS CV13 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 709 QVQLVQSGSELKKPGASVKLSCQASGYS SARS-CoV2 RBD Human Patient FTNHAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQGFTGRFVFSLDTSVSTTYL HISSLKAEDTAVYYCARASARPGVATNL DFWGQGTLVVVSS CV15 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 710 EVQLVESGGGLVQPGGSLRLSCAASGFT RBD Human Patient FSSYWMSWVRQAPGKGLEWVANIKQ DGSEKYYVDSVKGRFTISRDNAKNSLYL QMNSLRAEDTAVYYCARDFNSYQLLWY YYYGMDVWGQGTTVTVSS CV16 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 711 EVQLVQSGAEVKKPGESLKISCKGSGYSF RBD Human Patient TSYWIGWVRQMPGKGLEWMGIIYPGD SDTRYSPSFQGQVTISADKSISTAYLQWS SLKASDTAMYYCARQSSFYSSGWYSYG MDVWGQGTTVTVSS CV17 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 712 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYAQKFQGRVTMTRDTSIST AYMELSRLRSDDTAVYYCARVDYGSGSY GWGWFDPWGQGTLVTVSS CV18 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 713 QVQLVQSGAEVKKPGASVKVSCKVSGY SARS-CoV2 RBD Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATTSPIVGAITWF DPWGQGTLVTVSS CV19 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 714 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYAQKFQGRVTMTRDTSIST AYMELSRLRSDDTAVYYCAREYYYDSSVY PYYYYAMDVWGQGTTVTVSS CV2 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 715 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARVRGSYYLFDY WGQGTLVTVSS CV21 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 716 EVQLVESGGGLVKPGGSLRLSCAASGFT RBD Human Patient FSNAWMSWVRQAPGKGLEWVGRIKSK TDGGTTDYAAPVKGRFTISRDDSKNTLY LQMNSLKTEDTAVYYCTTDRVYDYIWGS YRYLDYWGQGTLVTVSS CV22 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 717 EVQLVESGGGLVKPGGSLRLSCAASGFT SARS-CoV2 RBD Human Patient FSSYSMNWVRQAPGKGLEWVSSISSSSS YIYYADSVKGRFTISRDNAKNSLYLQMNS LRAEDTAVYYCARDRESYDILTGYSMEG CFDYWGQGTLVTVSS CV23 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 718 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTSYAMHWVRQAPGQRLEWMGWIN AGNGNTKYSQKFQGRVTITRDTSASTAY MELSSLRSEDTAVYYCARVWGYCSGGS CYVDAFDIWGQGTMVTVSS CV24 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 719 QVQLVQSGAEVKKPGASVKVSCKVSGY RBD Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATAPPYSPPSSWF DPWGQGTLVTVSS CV25 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 720 QVQLQESGPGLVKPSQTLSLTCTVSGGSI RBD Human Patient SSGDYYWSWIRQPPGKGLEWIGYIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARDHHYDFWSGYSSYYYY GMDVWGQGTTVTVSS CV26 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 721 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDEAYYDILTGY INAPKNYYYYGMDVWGQGTTVTVSS CV27 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 722 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYAMHWVRQAPGKGLEWVALISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCARSFGGSYYYGMD VWGQGTTVTVSS CV3 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 723 QVQLVQSGSELKKPGASVKLSCQASGYS SARS-CoV2 RBD Human Patient FTNHAMNWVRQAPGQGLEWMGWIN TNTGNPTYAQGFTGRFVFSLDTSVSTTYL HISSLKAEDTAVYYCARASARPGVATNL DFWGQGTLVVVSS CV30 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 724 EVQLVESGGGLIQPGGSLRLSCAASGVI Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDLDVSGGMDVW GQGTTVTVSS CV31 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 725 QVQLVQSGAEVKKPGASVKVSCKVSGY SARS-CoV2 RBD Human Patient TLTELSMHWVRQAPGKGLEWMGGFD PEDGETIYAQKFQGRVTMTEDTSTDTAY MELSSLRSEDTAVYYCATAPPYSPPSSWF DPWGQGTLVTVSS CV32 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 726 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSDVTNYAQKFQGRVTMTRDTSIST AYMELSRLRSDDTAVYYCAREARDYYGS GSLDYWGQGTLVTVSS CV33 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 727 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTSYDISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARDSVAGIYYYY GMDVWGQGTTVTVSS CV34 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 728 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSYGGSYYYGM DVWGQGTTVTVSS CV35 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 729 QVQLQESGPGLVKPSETLSLTCTVSGYSI RBD Human Patient SSGYYWGWIRQPPGKGLEWIGSIYHSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARTPLSLRLRYNWYFDLW GRGTLVTVSS CV36 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 730 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYVQKFQGRVTMTRDTSIST AYMELNRLRSDDTAVYFCARDLTTTAGT DYYYGMDVWGQGTTVTVSS CV37 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 731 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARARVAYDYIW GSYRYKAFDYWGQGTLVTVSS CV38 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 732 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARAQTAHYSSSF DYWGQGTLVTVSS CV38-113 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV38-139 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV38-142 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND SARS-CoV2 Human Patient CV38-183 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV38-221 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 ND Human Patient CV39 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 733 QVQLVESGGGVVQPGRSMRLSCAASG RBD Human Patient FNLSSYAMHWVRQASGKGLEWVSLISY DGSIKYYADSVKGRFTVSGDNSKNTLFL QMSSLRADDSALYYCVRGGVSGPNAFD IWGQGTTVTVSS CV4 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 734 QVQLVESGGGVVQPGRSLRLSCAASGF SARS-CoV2 RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSISGSYLGAFD YWGQGTLVTVSS CV40 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 735 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TFSSYGISWVRQDPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARVGLWWLGH PDAFDIWGQGTMVTVSS CV41 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 736 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARTKGGSYFAPF DYWGQGTLVTVSS CV42 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 737 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGNTNYAQKVQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARDRGYAATFG VFDYWGQGTLVTVSS CV43 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 738 QVQLVESGGGVVQPGRSLRLSCAASGF Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARVTVVHFDYW GQGTLVTVSS CV44 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 739 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTSYYMHWVRQAPGQGLEWMGIINP SGGSTSYAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARDLTSTSSSPYS YYYGMDVWGQGTTVTVSS CV45 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 740 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARVTVEAIFGVVI LPLKNWFDPWGQGTLVTVSS CV46 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 741 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient NLSNYAMHWVRQASGKGLEWVSLISY DGSIKYYTDSVKGRFTVSGDNSKNTLFLQ MNSLRPDDSALYYCVRGGVSGPNSFD MWGQGTTVTVSS CV47 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 742 QVQLVQSGAEVKKPGASVKVSCKASGY RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YSGNTNYAQKLQGRVTMTTDTSTSTAY MEVRSLRSDDTAVYYCARVGLWWLGH PDVFDIWGQGTMVTVSS CV48 Ab SARS-CoV2 SARS-CoV2 S; non- B-cells; SARS-CoV2 743 QVQLVQSGAEVKKPGSSVKVSCKASGG RBD Human Patient TFSSYTINWVRQAPGQGLEWMGRIIPIL GIADYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCARDLVEDTAMVTGAA AGTWGQGTLVTVSS CV5 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 744 QVQLVQSGAEVKKPGASVKVTCKASGY Human Patient TFTSYYLHWVRQAPGQGLEWMGIINPS GGTTSYAQKFQGRVTMTRDTSTSTVYM ELSSLRSEDTAVYYCARAGRRYSSSDDGA FDIWGQGTMVTVSS CV50 Ab SARS-CoV2 SARS-CoV2 S; non- B-cells; SARS-CoV2 745 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARDIMFGDDWL QKQPDYWGQGTLVTVSS CV7 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV2 746 QVQLVESGGGVVQPGRSLRLSCAASGF RBD Human Patient TFSSYAMHWVRQAPGKGLEWVAVISY DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARSISGSYLGAFD YWGQGTLVTVSS CV8 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 747 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 RBD Human Patient TFTSYGISWVRQAPGQGLEWMGWISA YNGNTNYAQKLQGRVTMTTDTSTSTAY MELRSLRSDDTAVYYCARLVPTWASYYD FWSGYPGGYGMDVWGQGTTVTVSS CV9 Ab SARS-CoV1, SARS-CoV2 S; non- B-cells; SARS-CoV2 748 QLQLQESGPGLVKPSETLSLTCTVSGGSI SARS-CoV2 RBD Human Patient SSSSYYWGWIRQPPGKGLEWIGSIYYSG STYYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCATHIVVVTATPNWYFDL WGRGTLVTVSS EY6A Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 749 EVQLVESGGGVVQPGRSLRLSCAASAFT Human Patient FSSYDMHWVRQAPGKGLEWVAVISYD GSNKYYADSVKGRFTISRDNSKNTLYLQ MNSLRAEDTAVYYCAKDGGKLWVYYFD YWGQGTLVTVSS Fab 2-4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 750 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGWI NPNSGGTNYTQMFQGRVTMTRDTSIST AYMEVSRLRSDDTAVYYCARDRSWAVV YYYMDVWGKGTTVTVSS FnC1t1p2_ Ab SARS-CoV2 SARS-CoV2 S; SInon- B-cells; SARS-CoV2 751 QVQLVQSGAEVKKPGASVKVSCKASGY A5 RBD Human Patient TFTSYDINWVRQATGQGLEWMGWMN PNSGNTGYAQKFQGRVTMTRNTSISTA YMELSSLRSEDTAVYYCARATTDCSSTSC WSLDFWSGYYTGGREKIFDWGQGTLVT VSS FnC1t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 752 QVQLVQSGSELKKPGASVKVSCKASGYT D4 Human Patient FLRFAMNWLRQAPGQGLEWMGWIDT NTGTPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARSLRGANLVPWG QGTLVTVSS FnC1t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 753 QVQLVQSGSELKKPGASVKVSCKASGYT G5 Human Patient FLRFAMNWLRQAPGQGLEWMGWIDT NTGTPTYAQGFTGRFVFSLDTSVSTAYL QISSLKAEDTAVYYCARSLRGANLVPWG QGTLVTVSS H014 Ab SARS-CoV1, SARS-CoV1, S; RBD Immunised ND SARS-CoV2 SARS-CoV2 Humanised (hACE2) Mouse H11-D4 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 754 QVQLVESGGGLMQAGGSLRLSCAVSGR Library (Nanobody, TFSTAAMGWFRQAPGKEREFVAAIRWS non-immune) GGSAYYADSVKGRFTISRDKAKNTVYLQ MNSLKYEDTAVYYCARTENVRSLLSDYA TWPYDYWGQGTQVTVSS H11-H4 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 755 QVQLVESGGGLMQAGGSLRLSCAVSGR Library (Nanobody, TFSTAAMGWFRQAPGKEREFVAAIRWS non-immune) GGSAYYADSVKGRFTISRDKAKNTVYLQ MNSLKYEDTAVYYCAQTHYVSYLLSDYA TWPYDYWGQGTQVTVSS H4 Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 756 QVQLVQSGAEVKKPGASVKVSCKASGY Human Patient TFTGYYMHWVRQAPGQGLEWMGRIN PNSGGTNYAQKFQGRVTMTRDTSISTA YMELSRLRSDDTAVYYCARVPYCSSTSCH RDWYFDLWGRGTLVTVSS HbnC2t1p2_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 757 QVQLVESGGGVVQPGRSLRLSCAASGF D9 Human Patient TFSSYGMHWVRQAPGKGLEWVAVIWY DGRNKYYVDSVKGRFTISRDNSKNTLYL QISSLRAEDTAVYYCARAARRPVVTDTM AYYMDVWGKGTTVTVSS HbnC3t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 758 QMQLVQSGPEVKKPGTSVKVSCKASGF C6 Human Patient TFTSSAVQWVRQARGQRLEWIGWIVV GSGNTNYAQKFQERVTITRDMSTSTAY MELSSLRSEDTAVYYCAAPHCSSTICYDG FDIWGQGTMVTVSS HbnC3t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 759 QVQLVESGGGVVQPGRSLRLSCAATGF F4 Human Patient TFRRYGMHWVRQAPGKGLEWVAGILF DGSNKYYVDSVKGRFTISRDSSRNTLYLQ LNSLRREDTAVYYCAKGGDYEWELLES WGQGTLVTVSS HbnC3t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 760 EVQLVESGGGLVQPGGSLRLSCAASGFT G4 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDFGDFFFDYWGQ GTLVTVSS HbnC3t1p2_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 761 EVQLVESGGGLVQPGGSLRLSCAASGFI B10 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCARDYGDYFFDYWGQ GTLVTVSS HbnC3t1p2_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 762 QMQLVQSGPEVKKPGTSVKVSCKASGF C6 Human Patient TFSSSAVQWVRQARGQRLEWIGWIVV GSGNTNYAQKFQGRVTITRDMSTRTAY MELSSLRSEDTAMYYCAAPYCSSTRCYD AFDIWGQGTMVTVSS HbnC4t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 763 EVQLVESGGGLVQPGRSLRLSCAASGFT D5 Human Patient FDDYAMHWVRQAPGKGLEWVSGISW NSGSIGYADSVKGRFTISRDNAKNSLYLQ MNSLRAEDTGLYYCAKDINYDSGGYHK NYFDYWGQGTLVTVSS Ju et al., Ab SARS-CoV2 SARS-CoV2 SARS-CoV2 S; Various B-cells; SARS-CoV2 205 2020 Human Patient Kim et Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 Various al., 2020 Human Patient LR1 Nb SARS-CoV2 S; RBD Phage Display 764 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR11 Nb SARS-CoV2 S; RBD Phage Display 765 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR15 Nb SARS-CoV2 S; RBD Phage Display 766 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR16 Nb SARS-CoV2 S; RBD Phage Display 767 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR2 Nb SARS-CoV2 S; RBD Phage Display 768 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR3 Nb SARS-CoV2 S; RBD Phage Display 769 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR5 Nb SARS-CoV2 S; RBD Phage Display 770 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR6 Nb SARS-CoV2 S; RBD Phage Display 771 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR7 Nb SARS-CoV2 S; RBD Phage Display 772 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS LR8 Nb SARS-CoV2 S; RBD Phage Display 773 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITDSG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-1 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 774 QVQLVESGGGSVQAGGSLRLSCAASGSI SARS-CoV2 NL63, OC43 Human Patient SSITYLGWFRQAPGKEREGVAALITDSG RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-10 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 775 QVQLVESGGGSVQAGGSLRLSCAASGSI SARS-CoV2 NL63, OC43 Human Patient SSITYLGWFRQAPGKEREGVAALITDSG RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-100 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 776 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-101 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 777 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-102 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 778 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-103 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 779 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-104 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 780 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-105 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 781 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-106 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 782 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-107 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 783 QVQLVESGGGSVQAGGSLRLSCAASGSI SARS-CoV2 NL63, OC43 Human Patient SSITYLGWFRQAPGKEREGVAALITDSG (weak) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-108 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 784 QVQLVESGGGSVQAGGSLRLSCAASGSI (weak) NL63, OC43, Human Patient SSITYLGWFRQAPGKEREGVAALITDSG SARS-CoV1 RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-109 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 785 QVQLVESGGGSVQAGGSLRLSCAASGSI SARS-CoV2 NL63, OC43 Human Patient SSITYLGWFRQAPGKEREGVAALITDSG (weak) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-11 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 786 QVQLVESGGGSVQAGGSLRLSCAASGSI SARS-CoV2 NL63, OC43 Human Patient SSITYLGWFRQAPGKEREGVAALITDSG RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAEWGYEWPLYYAS SWYWGQGTQVTVSS mAb-110 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 787 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 NL63, OC43 Human Patient FSSYGMHWVRQAPGKGLEWVAVIWY (weak) DGSNKYYADSVKGRFTISRDNSKNTLYL QMNSLRAEDTAVYYCARVGSGRVYWG QGTLVTVSS mAb-111 Ab 229E HKU1, S; Unk B-cells; SARS-CoV1 788 QVQLVESGPGLVRPSGTLSVTCAVSGDS (weak), NL63, OC43 Human Patient ISSDYWCTWVRQSPGKGLEWIGKISHS SARS-CoV1, GSLNYNPSLKSRVTMSVDKSKNHFSLKL SARS-CoV2 ASVTAADTAVYYCARVRIGASHHNFWS (weak) GYYTDAFDIWGQGTTVTVSS mAb-112 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 789 QVQLVQSGAEVKKPGESLKISCKASGYS (weak), Human Patient FTNYWVGWVRQMPAKGLEWMGIIWP HKU1 DDSDTRYRPSFQGQVTISVDKSISTAYLH (weak), WNSLKASDNGMYFCARAPLASCSGGRC NL63, SARS- PTYNRFDLWGQGTLVTVSS CoV1, SARS- CoV2 (weak) mAb-113 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 790 QVQLVQSGAEVKKPGSSMKVSCKASGV (weak), Human Patient NFRSYSFSWVRQAPGQGLEWMGGVIP NL63, SARS- YFPTANYADKFRDRVTITADESTGTVYLD CoV1, SARS- MSSLRSEDTAVYFCASEYFDGRSYHSFC CoV2 GLDVWGQGTTVTVSS (weak) mAb-114 Ab 229E, HKU1, OC43 S; Unk B-cells; SARS-CoV1 791 QVQLVESGGGLVQPGGSLRLSCAASGF NL63, SARS- Human Patient TFSNYAMTWVRQAPGKGLKWVSGINP CoV1, SARS- SGDATFYTDSVKGQFTISRDNSKNILYLQ CoV2 MNRLRADDTAIYYCAKGLSFYGSGSDAF (weak) DVWGQGTTVTVSS mAb-115 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 792 QVQLVQSGAEVKKPGASVKVSCKASGY (weak), Human Patient TFTDYYVHWVRQVPGQGLEWMGWIS NL63, SARS- PDSGDTIRAQNFQGRVTMTRDTSMNT CoV1, SARS- AYMEVNRLRTDDTAIYYCARDLISVIRGL CoV2 GGGMDVWGQGTTVTVSS (weak) mAb-116 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 793 QVQLVQSGAEVKKPGASVKVSCKTSGY (weak), Human Patient TFTGHYIHWVRQAPGQGLEWMGWIN HKU1 PASGDTNYAQKFQGRVTKTRDTSITTAY (weak), MELNRLRSDDTAVYYCARGGPLPWSDL NL63 DIVGTFDYWGQGTLVTVSS (weak), SARS-CoV1, SARS-CoV2 (weak) mAb-117 Ab 229E, HKU1, OC43 S; Unk B-cells; SARS-CoV1 794 EVQLVESGGGVVQPGKSLRLSCVPSGFS NL63, SARS- Human Patient FGTYGMHWVRQAPGKGPEWLAVMW CoV1, SARS- YDGITQYYADSVKGRFTISRDNSKETLYL CoV2 QMNSLTADDTGIYYCVKDQSSGDRLLYL (weak) GYFDLWGPGALVTVSS mAb-118 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 795 QVQLVQSGGGVVQPGKSLRLSCVASGF (weak), Human Patient SFGTYGMHWVRQAPGKGPEWLAVM NL63 WYDGITQYYADSVKGRFTISRDNSKETLY (weak), LQMNSLTADDTGVYYCVKDQSSGDRLL SARS-CoV1, YLGYFDLWGPGTLVTVSS SARS-CoV2 (weak) mAb-119 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 796 QVQLQESGPGLVKPSGTLSLTCAVSGAS (weak), Human Patient VSSDHWWSWVRQSPGKGLEWIGEVY NL63 HSGSTNYNPSLKSRVTISLDQSNNQFSLK (weak), LTSVTAADTAIYYCATMWGGLCTASNCY SARS-CoV1, GNPMDVWGQGTTVTVSS SARS-CoV2 (weak) mAb-12 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 797 QVQLVQSGAEVRKPGSSVKLSCKASGG SARS-CoV2 NL63, OC43 Human Patient TFSTHAISWVRQAPGQRPEWMGGIMP IFGESKDTQKFQGRVTFTADESTTTAYM ELRSLRSDDTAIYYCVRDSDPYTATVTSN HYWYAMDVWGQGTTVTVSS mAb-120 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 798 QVQLQQWGAGVLKPSETLSLTCAVYGG (weak), Human Patient SFRGFFWSWIRQPPGKGLEWIGQITHS HKU1 GSTNYNSSLKSRLTISVDTSKNQFSLNLS (weak), SVTAADTAIYYCARGQGGYDLRRVGYGLT NL63 SWFDPWGQGILVTVSS (weak), SARS-CoV1, SARS-CoV2 (weak) mAb-121 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 799 QVQLVQSGAEVKKPGASVKVSCKASGY (weak), Human Patient TFTSYYIHWVRQAPGQGLEWLGVIHPS NL63 GGSTTFAQKFQGRVTMTRDTSTSTVYM (weak), ELGSLRSDDTAVYYCARVLAGSSHEWQL SARS-CoV1, THDAFDIWGQGTTVTVSS SARS-CoV2 (weak) mAb-122 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 800 EVQLVESGAEVKKPGASVILSCKASGYTV (weak), Human Patient TNYYIHWVRQAPGQGLEWMGWIDPD HKU1 SGVTNFAEKFQGRVTMTRDTSISTAYME (weak), LRWLESDDTAVYYCAKDLITVIRGLGGG NL63 MDVWGQGTTVTVSS (weak), SARS-CoV1, SARS-CoV2 (weak) mAb-123 Ab 229E NL63, OC43 S; Unk B-cells; SARS-CoV1 801 EVQLLESGAEVKKPGSSVKVSCKASGGT (weak), Human Patient FSSDAISWVRQAPGQGLEWMGGIIPIF HKU1 GTTNYAQKFQGRVTITADESTNTAYMEL (weak), SSLRSEDTAVYYCARDGPYDSGGYHLNH SARS-CoV1, WGQGTLVTVSS SARS-CoV2 (weak) mAb-124 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 802 EVQLLESGGGVVNPGGSMRLSCAGSGF (weak), OC43 Human Patient TFSDHYMGWIRQAPGKGLEVISYISSSG SARS-CoV1, SFIRDADSVKGRFTISRDNAKNSVYLQM SARS-CoV2 NSLRAEDTAVYYCARMGPYGSGTFDYW (weak) GQGTLVTVSS mAb-125 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 803 EVQLVESGAEVRKPGSSVKVSCKATGGT (weak), Human Patient FSSYGITWVRQAPGQGLEWMGRIIPTL NL63 GRTNYAQKFQGRVTITADKSTSTAHMEL (weak), SSLRSEDTAVYYCARDLSTLQPDAIVNFD SARS-CoV1, YWGQGTLVTVSS SARS-CoV2 (weak) mAb-126 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 804 QVQLVQSGAEVKKPGSSVKVSCKTSGG (weak), OC43 Human Patient SFTSYVLSWVRQAPGQGLEWMGRIVP SARS-CoV1, NLGVANYAQKFQDRVTITADKSTTTAYL SARS-CoV2 ELRSLRSEDTAVYYCARDLYYDNGGYNY (weak) LDYWGPGTLVTVSS mAb-127 Ab 229E NL63, OC43 S; Unk B-cells; SARS-CoV1 805 QVQLVESGGGLVQPGGSLRLSCAASGF (weak), Human Patient TFSNYNMVWVRQAPGKGLEWISYISSSS HKU1 STIYYADSVKGRFIISRDNAKNSLHLQMN (weak), SLRDEDTAVYYCVRDYCNSVSCYTYYYIG SARS-CoV1, MDVWGQGTTVTVSS SARS-CoV2 (weak) mAb-128 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 806 EVQLVQSGAEVKKPGASVKVSCKASGYS (weak), Human Patient STNYGFSWVRQAPGQGLEWMGWISV HKU1, NL63 HSGNANFAQKFQGRITMTTDTSTTTAY (weak), MELRNLRSDDTATYYCATSASSYSRYYFG SARS-CoV1, LDVWGQGTTVTVSS SARS-CoV2 (weak) mAb-129 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 807 EVQLLESGPGLVKPSQTLSLTCTVSNGFI CoV1 OC43 Human Patient SSGEYYWSWIRQSPGKGLEWIGYISHSG (weak), STYYNRSLKSRVTISLDTSRNQFSLNLSS SARS-CoV2 VTAADTAVYYCARDLAKWSYGYYYSGMD (weak) VWGQGTTVTVSS mAb-13 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 808 QVQLVQSGAEVKKPGSSVKVSCKISGGT SARS-CoV2 NL63, OC43 Human Patient FKNSAFSWARQVPGQGFQWMGGIIP MFGVPHSVQMFQGRVTLTADESTSAVY MELSGLTSDDTAVYYCAREEYSGTVHNF FGMDVWGQGTTVTVSS mAb-130 Ab HKU1 229E, OC43 S; Unk B-cells; SARS-CoV1 809 EVQLVESGGGLVQPGRSLRLSCAASGFT (weak), Human Patient FDDYAMHWVRQVPGRGLEWVSGISW NL63 NSGTINYADSVMGRFTISRDNAKNSLYL (weak), QMNSLRAEDTALYYCAKDGRYCSGISCR SARS-CoV1 TGMDVWGQGTTVTVSS (weak), SARS-CoV2 (weak) mAb-131 Ab 229E NL63, OC43 S; Unk B-cells; SARS-CoV1 810 EVQLVESGGGLVQPGESLRLSCAASGFN (weak), Human Patient FSPYGMNWVRQAPGKGLEWIAYIISGS HKU1 GTIYYADSVKGRFTISRDNAQSSLYLQM (weak), NSLRAEDTAVYYCARGLLDYLHDAFDIW SARS-CoV1 GQGTMVTVSS (weak), SARS-CoV2 (weak) mAb-132 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 811 EVQLQESGPGLVKPSETLSLTCAVSGGS (weak), Human Patient VSSDTDYWGWIRQPPGKGLEWIGSIHD NL63 SERTYYDPSLKSRVTISVDTSKNQFSLRL (weak), SSVTAADTALYFCASRHLDLLPIGSFDVW SARS-CoV1 GRGTMVTVSS (weak), SARS-CoV2 (weak) mAb-133 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 812 QVQLLESGGGLVQPGRSLRLSCTASGFR (weak), OC43 Human Patient FGDYTMTWFRQAPGKGLEWVGFIRSIA SARS-CoV1 YGGTTEHAASVEGRFIISRDDSKSIAYLQ (weak), MNSLKAEDTGVYFCTRGSGMFYGSSSG SARS-CoV2 MDVWGQGTTVTVSS (weak) mAb-134 Ab 229E NL63, OC43 S; Unk B-cells; SARS-CoV1 813 EVQLLESGAEVKKPGSSVKVSCKTSGGT (weak), Human Patient FNSYTISWVRQAPGQGLEWMGGIIPIL HKU1 DTPHYAQKFRGRVTITADKSTSTAFMDL (weak), SSLTSEDTAVYYCAIRRDYSDYRDFDYW SARS-CoV1 GQGTLVTVSS (weak), SARS-CoV2 (weak) mAb-135 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 814 EVQLVESGPGLVKPSETLSLACTVSGGSI (weak), OC43 Human Patient SNYYWNWVRQPPGKGLEWIGNIYYSGS SARS-CoV1 TTFNPSLKSRVTISVDTSRNQFSLKLSSV (weak), TAADTAVYYCARQSSSWYNPYYFDQWG SARS-CoV2 QGTLVTVSS (weak) mAb-136 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 815 QVQLVQSGGGLVQPGESLRLSCAASGF CoV1 OC43 Human Patient NFSPYGMNWVRQAPGKGLEWIAYIISG (weak), SGTIYYADSVKGRFTISRDNAQSSLYLQM SARS-CoV2 NSLRAEDTAVYYCARGLLDYLHDAFDIW (weak) GQGTMVTVSS mAb-137 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 816 EVQLVESGAEVKNPGSSVKISCKSSGGTL CoV1 OC43 Human Patient GDYAISWVRQAPGLGLEWLGGIMPLH (weak), GTTGYSQRFRPRLTITADESARTAYMELT SARS-CoV2 ALSSEDSAIYYCARDPSILNTGNHHWYD (weak) LDLWGQGTEVTVSS mAb-138 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 817 EVQLLESGGGVVQPGRSLRLSCAASGFT (weak), OC43 Human Patient FNSYALFWVRQAPGKGLEWVAVVSYD SARS-CoV1 GNNKYYADSVKGRFTISRDNSKNTLYLQ (weak), MNSLKTEDTSVYYCARPRSGSYRQAIDY SARS-CoV2 WGLGTLVTVSS (weak) mAb-139 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 818 QVQLVQSGGGLVQPGGSLRLSCAASGFI (weak), Human Patient FSGHWMSWVRQAPGKGLEWVANIKQ NL63, SARS- DGREKHYVDSVKGRFTISRDNAKNSVSL CoV1 QMNSLRAEDTAVYYCVRQNVAIQYYYY (weak), AMDVWGQGTTVTVSS SARS-CoV2 (weak) mAb-14 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 819 EVQLVESGGGVVQPGRSLRLSCAASGFT SARS-CoV2 NL63, OC43 Human Patient FSGYPMHWVRQAPGKGLEWVALISFD GDSKYYTDSVKARFAISRDNSKNTLFLQ MNSLRVADTALYYCARAKGGSYSNAFD YWGQGTLVTVSS mAb-140 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 820 QVQLVESGAEVKKPGSSVKVSCKASGGT (weak), Human Patient LSDYAISWVRQAPGQGLEWMGGIMPI NL63, SARS- FGSPGYAEIFQGRVTITADESKSTVYMEL CoV1 TSLRSEDTAVYYCARDPSILDTGNHHWY (weak), DLDIWGQGTMVTVSS SARS-CoV2 (weak) mAb-141 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 821 QVQLVQSGAEVKKPGSSVKVSCKTSGAT (weak), Human Patient YKNSAFSWARQAPGQGFQWMGGIIPL NL63, SARS- FGVPHYVQMFQGRVTITADESTSAVYM CoV1 ELSGLTSDDTAVYYCAREEYSGTVHNFF (weak), GMDVWGQGTTVTVSS SARS-CoV2 (weak) mAb-142 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 822 EVQLVESGGGLVQPGGSLRLSCSASEFT (weak), Human Patient LRSHAMHWVRQAPGKGLEYVSGISTDG NL63, SARS- SGRFYADSVKGRFTISRDNSKNKLFLQM CoV1 SSLRPEDTAVYYCVRDWGSSTHYDVFDL (weak), WGQGTMVTVSS SARS-CoV2 (weak) mAb-143 Ab 229E, 229E S; Unk B-cells; SARS-CoV1 823 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), Human Patient TLADYAISWVRQAPGQGLEWMGGIKP HKU1 LHGAAGYSQHFRGRLSITADESASTAYM (weak), ELTGLRSEDTAMYYCARDPSILNTGNHH NL63 WYDLDLWGQGTMVTVSS (weak), OC43 (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-144 Ab 229E, HKU1, OC43 S; Unk B-cells; SARS-CoV1 824 QVQLVQSGAELKKPGSSVKVSCKASGG NL63, SARS- Human Patient TFYNSAFSWLRHAPGQGPEWMGGITP CoV1 SLGRVGYSERFLARLTITADESTSTVYME (weak), LTSLASEDTAVYYCARDASIVGTGNHLW SARS-CoV2 YGLDFWGHGTTVTVSS (weak) mAb-145 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 825 EVQLVESGGHVVLPGKSLRLSCAGSGFG (weak), Human Patient FPLYAMQWVRRAPGKGLEWVALVSYD NL63, SARS- SSNIRYADSVKGRFTISRDNSQNTLYLQ CoV1 MDSLRPEDTAMYYCARDNALQDGRPG (weak), YFDSWGQGTLVTVSS SARS-CoV2 (weak) mAb-146 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 826 EVQLVESGGGLVKPGGSLRLSCAASGFIF (weak), Human Patient SDYYMSWIRQAPGKGLEWVSYITGSGR NL63, SARS- TIHYADSVKGRFTISRDNAKNSVYLQMN CoV1 SLRAEDTAVYYCARGHRFLEFPLNYFDP (weak), WGQGTLVTVSS SARS-CoV2 (weak) mAb-147 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 827 EVQLLESGGHVVLPGKSLRLSCAGSGFG (weak), Human Patient FPLYAMQWVRRAPGKGLEWVALVSYD NL63 SSNIRYADSVKGRFTISRDNSQNTLYLQ (weak), MDSLRPEDTAMYYCARDNALQDGRPG SARS-CoV1 YFDSWGQGTLVTVSS (weak), SARS-CoV2 (weak) mAb-148 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 828 EVQLVESGGGVVQPGRSLRLSCAASGFT (weak), Human Patient FSKFAMHWVRQAPGKGLEWVAIISYDG NL63 SHKNYADSVKGRFTISRDNSKNTVYLQV (weak), DSLRAEDTAVYYCALLYGSGSYYNFVFFG SARS-CoV1 WKDGSDAWGPGTTVTVSS (weak), SARS-CoV2 (weak) mAb-149 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 829 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), Human Patient MFTDYAISWVRQAPGQRLEWMGGILP HKU1, NL63 AFAASGSPGYAPIFRGRATFSADVSTSTA (weak), YLELTNLKPEDTAVYYCARDPSILNTGNH SARS-CoV1 HWYDLDLWGQGTEVTVSS (weak), SARS-CoV2 (weak) mAb-15 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 830 QVQLVQSGAELKKPGSSVRVSCKAAGG SARS-CoV2 NL63, OC43 Human Patient TLTNYAISWVRQAPGQGFEWMGGIMP VSHTAGYAQKFQGRVTFTADESATTAY MDLTSLRPEDTAIYYCARDPSIHYTGNH HWYDLDIWGQGTMVTVSS mAb-150 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 831 QVQLVQSGAELKKPGSSVRVSCKAAGG (weak), Human Patient TLTNYAISWVRQAPGQGFEWMGGIMP HKU1 VSHTAGYAQKFQGRVTFTADESATTAY (weak), MDLTSLRPEDTAIYYCARDPSIHYTGNH NL63, SARS- HWYDLDIWGQGTMVTVSS CoV1 (weak), SARS-CoV2 (weak) mAb-151 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 832 QVQLVQSGAEVKKPGSSMRVSCRVSG (weak), Human Patient GTFITHAMSWVRQAPGQGPEWMGGI HKU1 VPLFGRASYAQPSQTRVQITADESTSTVY (weak), LEVPSLTSEDTAVYYCVRDSEPYTATRSQ NL63 NHYWYDMDVWGQGTTVTVSS (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-152 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 833 QVQLVQSGAELKKPGSSVRVSCKAAGG (weak), Human Patient TLTNYAISWVRQAPGQGFEWMGGIMP HKU1 VSHTAGYAQKFQGRVTFTADESATTAY (weak), MDLTSLRPEDTAIYYCARDPSIHYTGNH NL63 HWYDLDIWGQGTTVTVSS (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-153 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 834 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), Human Patient TLSHYAISWVRQAPGQGLEWMGGIMP HKU1 VSGTVGYAQKFQGRVKFTADEYASTAY (weak), MELTNLRSEDSAVYFCARDPSIVDSGPH NL63 HWYDLDIWGQGTMVTVSS (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-154 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 835 QVQLVESGAEVKRPGASVKVSCKASGY (weak), Human Patient AFSDYYMHWVRQAPGQGPEWMGWI HKU1 NPNSGDTGYPQKFRGWVTMTRDTSVS (weak), TAYMELKRLKSDDTAVYYCASGPNYFDY NL63 WGQGTLVTVSS (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-155 Ab 229E OC43 S; Unk B-cells; SARS-CoV1 836 EVQLLESGGGLVKPGGSLRLSCEASGFTF (weak), Human Patient SNYNMNWVRQAPGKGLEWVSSISGSS HKU1 SYISYADSVKGRFTISRDNAKNSLYLQMN (weak), SLRVEDTAVYYCARADRDYDFWSDPPLI NL63 DHWGQGTLVTVSS (weak), SARS-CoV1 (weak), SARS-CoV2 (weak) mAb-156 Ab 229E NL63, OC43 S; Unk B-cells; SARS-CoV1 837 EVQLVESGGGLIQPGGSLRLSCAASGFT (weak), Human Patient VTDNYMSWVRQAPGKGLEWVSVLYSG HKU1 GSTYYADAVQGRFSISRDNSKNALYLQM (weak), NSLRAEDTAVYYCARGFGNGWSYYFDY SARS-CoV1 WGQGTLVTVSS (weak), SARS-CoV2 (weak) mAb-157 Ab HKU1, SARS 229E, NL63, S; Unk B-cells; SARS-CoV1 838 EVQLVQSGGGLVQPGGSLRLSCAASGF CoV1 OC43 Human Patient TFSSYSMSWVRQAPGKGLEWVSYITRSS (weak), DNIYYAESVKGRFTISRDSAKNSLYLHMN SARS-CoV2 SLRDEDTAVYYCARDPGLEYSGNYFSYYY (weak) YAMDVWGQGTTVTVSS mAb-158 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 839 QVQLVQSGAEVKKPGSSVKVSCKASGG CoV1 OC43 Human Patient TFSTHAISWVRQAPGHGPEWMGGIIPL (weak), FGTSESAQRFQARVRFTADESTSTAYME SARS-CoV2 LSSLTSEDTAVYYCVRDSDPYTATSRNNH (weak) YWYDMDVWGQGTTVTVSS mAb-159 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 840 QVQLVQSGAEVKKPGSSVKVSCKVSGG CoV1 OC43 Human Patient RFSDYAISWLRQAPVKGLEWMGGIIPRL (weak), NRKGYSQDFQGRLTFTADESTSTAYMEL SARS-CoV2 SGLTSEDTAVYYCARDPTFLNSGNHFWY (weak) AVDIWGQGTTVTVSS mAb-16 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 841 EVQLVESGAEVRTPGSSVKLSCKASGGT SARS-CoV2 NL63, OC43 Human Patient FSTHAFSWVRQAPGQRPEWMGGIIPIF GESKDTQKFQGRVTFTADESTTTVYMEL RSLKSDDTAIYYCVRDSDPYTATYRNNHY WYAMDVWGQGTTVTVSS mAb-160 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 842 EVQLVESGGGVVKPGGSLRVSCVGSGF CoV1 OC43 Human Patient TFSDHYMSWIRQAPGKGLEIISYISTDGS (weak), YINDADSVKGRFINSRDNAKNSVYLQLN SARS-CoV2 SLRAEDTAVYYCARMGPSGSGSLDYWG (weak) QGSLVTVSS mAb-161 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 843 EVQLVESGPTLVKPTQTLTLTCTFSGFSL CoV1 OC43 Human Patient NTRELGVGWIRQPPGKALEWLALIYWD (weak), DDKRYSPSLKSRLSITKDTSKNQVVLTLT SARS-CoV2 NMDPGDTATYYCAHTSELPPRRPYAAF (weak) DFWGQGTLVTVSS mAb-162 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 844 EVQLVESGGGVVQPGGSLRLSCVASGF (weak), OC43 Human Patient PFGRYAMHWVRQAPGQGLEWLTLISF SARS-CoV1 DSSNIEYSDSVQGRFTISRDNSRNTLFLQ (weak), MTSLRPEDTAVYFCARDLPPLDYWGQG SARS-CoV2 TLVTVSS (weak) mAb-163 Ab HKU1 229E, OC43 S; Unk B-cells; SARS-CoV1 845 QVQLQQWGAGLLKPSETLSLTCAVNGG (weak), Human Patient SFNNYYWSWIRQPPGKGPEWIGEVVHS NL63 GSTTYNPSLKSRVTISIDMSKNQFALKLN (weak), SVTAADTAVYYCARGFTFTYSDFLTGQRI SARS-CoV1 FEYWGQGTLVTVSS (weak), SARS-CoV2 (weak) mAb-164 Ab HKU1 229E, OC43 S; Unk B-cells; SARS-CoV1 846 EVQLVESGGGVVQPGRSLRLSCAASGFT (weak), Human Patient FSSYAMHWVRQAPGKGLEWVALISYD NL63 GDKKYYPDSVRGRFTISRDNSKNTLHLQ (weak), MNSLRLEDTAVYYCARSYGGSYSTVGY SARS-CoV1 WGQGALVTVSS (weak), SARS-CoV2 (weak) mAb-165 Ab HKU1 229E, OC43 S; Unk B-cells; SARS-CoV1 847 QVQLVQSGGDSVNPGGSLRLSCAGSGF (weak), Human Patient SVRDVWMSWVRQAPGKGLEWIGRIKS NL63 EADGGSSDYRASLKDRFSIWRDASKNTL (weak), YLQVNGLQTEDTAIYFCSWNDVGWAFT SARS-CoV1 FWGQGTLVTVSS (weak), SARS-CoV2 (weak) mAb-166 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 848 QVQLVQSGAEVKKAGSSVKVSCKASGG (weak), OC43 Human Patient PFSSFAISWVRQAPGQGLEWLGGIMTV SARS-CoV1 FGPAHYAQKSRDRISITADESTSTSYLEL (weak), SSLTSDDTAVYYCAAEERSGTNHNYYGLD SARS-CoV2 VWGQGTTVTVSS (weak) mAb-167 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 849 EVQLVESGGGLIQPGGSLRLSCAASGFP (weak), OC43 Human Patient FSGTYMTWVRQAPGKGLEWVSIIYSGG SARS-CoV1 DTYYADSVKGRFTISRDNSKNTLFLQMN (weak), SLRVEDTAMYYCARDREMAIITERSYGL SARS-CoV2 DVWGQGTMVTVSS (weak) mAb-168 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 850 EVQLVESGGGLVQPGGSLRLSCGASGFT (weak), OC43 Human Patient FSDYAMSWVRQAPGKGLEWVSTISGSG SARS-CoV1 DKTYYADSLKGRFTNSRDNSKSTLYLQM (weak), TSLRAEDTAVYFCAKDRYCSGGSCFYDAF SARS-CoV2 DIWGQGTTVTVSS (weak) mAb-169 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 851 EVQLVESGGGVVQPGRSLRLSCEASGFT (weak), OC43 Human Patient FADYPMHWVRQAPGKGLEWVAVISSH SARS-CoV1 GRSQGYAASVKGRFTFSRDNSQSSLFLQ (weak), LNSLRVEDTAVYFCAREAQSSGRAGCLD SARS-CoV2 AWGQGTLVTVSS (weak) mAb-17 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 852 QVQLVQSGAELKKPGSSVRVSCKAAGG SARS-CoV2 NL63, OC43 Human Patient TLTNYAISWVRQAPGQGFEWMGGIMP VSHTAGYAQKFQGRVTFTADESATTAY MDLTSLRPEDTAIYYCARDPSIHYTGNH HWYDLDIWGQGTMVTVSS mAb-170 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 853 QVQLVQSGAEVREPGSSVKLSCKTSGGT (weak), OC43 Human Patient FSTHAISWVRQAPGQRPEWMGGIMPI SARS-CoV1 FGESKDTQKFQGRVTFTADESTTTAYME (weak), LRSLKSDDTAIYYCVRDSDPYTATVRSNH SARS-CoV2 YWYAMDVWGQGTTVTVSS (weak) mAb-171 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 854 EVQLVQSGAEVKKPGSSVKVSCKVSGG (weak), OC43 Human Patient RFSDYAISWLRQAPVKGLEWMGGIIPRL SARS-CoV1 NRKGYSQDFQGRLTFTADESTSTAYMEL (weak), SGLTSEDTAVYYCARDPTFLNSGNHFWY SARS-CoV2 AVDIWGQGTTVTVSS (weak) mAb-172 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 855 QVQLQESGRGLVKPSETLSLTCTVSGGSI (weak), OC43 Human Patient TSSRYYWGWIRQPPGRNLEWIGSIHYS SARS-CoV1 GTTSYNPSLWSRVAISVDTAQNQFSLRL (weak), NSVTAADTAVYYCAAPAPSNHESWSGT SARS-CoV2 DWFDPWGQGILVTVSS (weak) mAb-173 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 856 QVQLVQSGAEVKGPGASVKVSCKVSGY (weak), OC43 Human Patient SFITYDITWVRQAPGQGLEWMGWISTK SARS-CoV1 SGDTRYAQNVQGRVTMTTDTSTNTAY (weak), MELRNLKSDDTALYYCARTTPRGWEQ SARS-CoV2 WPVLEYWGQGTLVTVSS (weak) mAb-174 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 857 EVQLVESGGGLVQPGGSLRLSCEASGFN (weak), OC43 Human Patient FNSYSMSWVRQAPGKGLEWLSYISSRSS SARS-CoV1 TIKYASSVQGRFTVSRDNAKKSVYLQMN (weak), SLRDEDTAVYFCARELDSETYYNYNSLDV SARS-CoV2 WGQGTTVTVSS (weak) mAb-175 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 858 QVQLVESGGEVKKPGASVKVSCKASGY (weak), OC43 Human Patient TLSSYPISWVRQAPGHGLEWMGWINT SARS-CoV1 YNGRTNYEQMLQGRVTMTTDTSTSTAY (weak), MELRSLRSDDTAVYYCARVVFRHGQYD SARS-CoV2 DSSGRLAFDIWGQGTMVTVSS (weak) mAb-176 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 859 QVQLVQSGAELKKPGSSVRVSCKAAGG (weak), OC43 Human Patient TLTNYAISWVRQAPGQGFEWMGGIMP SARS-CoV1 VSHTAGYAQKFQGRVTFTADESATTAY (weak), MDLTSLRPEDTAIYYCARDPSIHYTGNH SARS-CoV2 HWYDLDIWGQGTMVTVSS (weak) mAb-177 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 860 EVQLLESGAEVKKPGSSVKVSCKTSGGT (weak), OC43 Human Patient FSTHAISWVRQAPGQGPEWMGGIIPLF SARS-CoV1 GTSEHAQRFQARVKFTADESTSTAYMEL (weak), SSLTPEDTAVYYCVRDSDPYTATSRNNH SARS-CoV2 YWYGMDVWGQGTTVTVSS (weak) mAb-178 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 861 EVQLLESGGGVVQPGTSLRLSCAVSGF (weak), NL63, OC43 Human Patient MFKNYAIHWVRQAPGKGLEWVAVISF SARS-CoV2 DGSDISYTESVQGRFTISRDNSENMLYL (weak) QMNSLRAEDTAMYYCAREPDGIGAAGI SGYWGQGTLVTVSS mAb-179 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 862 EVQLVESGGGLVKPGGSLRLSCVASGFT (weak), NL63, OC43 Human Patient FSDFYMSWIRQAPGKGLEWVSYISGSG SARS-CoV2 DTIYYADSVKGRFTVSRDNAKNSLFLQM (weak) SSLGAEDTAMYYCAREMATSFGYYFVLD VWGQGTTVTVSS mAb-18 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 863 QVQLQQWGAGLLKPSETLSLSCAVYGG SARS-CoV2 NL63, OC43 Human Patient SFSGFYWSWIRQPPGKGLEWIGEINHS GSANYNPSLMSRVTISMDTSKKQFSLQL RSVTAADTAVYYCARGQESPIVGVTGR WFDPWGQGTLVTVSS mAb-180 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 864 EVQLVESGGGVVQPGRSLRLSCAASEFT (weak), NL63, OC43 Human Patient FSTYAMHWVRQAPGKGLEWVALISYD SARS-CoV2 GINKYYADSVKGRFAISRDNSKNTLYLQV (weak) NSLRADDTAVYYCVRPYSGSYTNWFDL WGQGTLVTVSS mAb-181 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 865 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), NL63, OC43 Human Patient MLSDYAISWVRQAPGQRLEWMGGIM SARS-CoV2 PAFGSPGYAQIFRGRATISADVSTSTAYL (weak) ELTSLKPEDTAVYYCARDPSILNTGNHH WYDLDIWGQGTMVTVSS mAb-182 Ab 229E NL63, OC43, S; Unk B-cells; SARS-CoV1 866 QVQLVQSGAEVKMPGSSVKVSCKVSG (weak), SARS-CoV1 Human Patient GRFSDYAISWLRQAPLEGLEWMGGIVP HKU1 HLNRKGYSQKFQDRLTFTADDSTSTAYM (weak), ELSGLTSEDTAVYYCARDPTFLNTGNHF SARS-CoV2 WYAVDIWGQGTTVTVSS (weak) mAb-183 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 867 QVQLVQSGAEVKKPGSSVKVSCKASGG CoV2 OC43, SARS- Human Patient TFSTHAISWVRQAPGHGPEWLGGILPLF (weak) CoV1 GTSESAQRFQARVKITADESTSTAYMELS SLTSEDTAVYYCVRDSDPYTATSRNNHY WYAMDVWGQGTTVTVSS mAb-184 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 868 QVQLVQSGAEVKKPGSSVKVSCKVSGG (weak), OC43, SARS- Human Patient TFSNYAISWLRQAPGQGPEWMGGIIPA SARS-CoV2 CoV1 LSRVGYVRKFQARLTISADELTTTAYMDL (weak) SSLTSEDTAVYYCARDPSFLNTGNHFWY DFDLWGQGTTVTVSS mAb-185 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 869 QVQLQQWGAGLLKPSETLSLTCAVYGG (weak) NL63, OC43, Human Patient SFSGFYWTWIRQPPGKGLEWIGEINHS SARS-CoV1 GSSNYDLSLKSRVTMSVDTSKNQFSLKLS SVTAADTAVYYCARGMISPRIPRTTRQR WFDTWGQGTLVTVSS mAb-186 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 870 QVQLQQWGAGLLKPSETLSLTCGVYGG (weak) NL63, OC43, Human Patient SFSGYFWSWIRQSPGKGLEWIGEINHSR SARS-CoV1 SMSYNPSLKSRITMSVDTSKNQFSLNLN SVTAADTAVYFCARGKAHRNDFWSGYY PHWFDPWGQGILVTVSS mAb-187 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 871 QVQLVQSGAEVKKPGSSVKISCKISGDTF (weak) NL63, OC43, Human Patient STNAISWLRQAPGREPEWMGGIVPLVG SARS-CoV1 PASYAQRPQGRLTITADEFTNTAYLELNS LRSEDTATYYCARDSDPYTATRRHNHYW YAMDVWGQGTTVTVSS mAb-188 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 872 EVQLLESGPGLVKPSETLSLTCTVSGGSI (weak) NL63, OC43, Human Patient NSQYWNWIRQSPGKGLEWIGYVYYSGS SARS-CoV1 TNYNPSLKSRVTMSVDTSKNHFSLNLRS VTAADTAVYYCARGLVVRYFDGFPSGPII GAFDIWNQGTTVTVSS mAb-189 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 873 QVQLVQSGAEVKKPGSSVKVSCKVSGG (weak) NL63, OC43, Human Patient TFSSHAISWVRQAPGQRPEWMGGIMP SARS-CoV1 IFGESKDTQKFQGRVTFTVDESTNTAYM ELTSLKSEDTAIYYCVRDPDPYTATVRHN HYWHGMDVWGQGTTVTVSS mAb-19 Ab OC43, SARS- 229E, HKU1, S; Unk B-cells; SARS-CoV1 874 QVQLQQWGAGLLKPSETLSLTCAVYGG CoV1, SARS- NL63 Human Patient SFSGFHWSWIRQPPGKGLEWIGEVNHS CoV2 GSTKYNPSLKSRVTVSVDTSKNQFSLRLS SVTAADTAIYYCARGSLSREYDFLTAPQN GPWFDSWGQGALVTVSS mAb-190 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 875 EVQLLESGPGLVKPSETLSLTCTVSGGSI (weak) NL63, OC43, Human Patient SSNNLYWGWIRQPPGKGLEWIGSIYYSG SARS-CoV1 STYYNPSLKSRVIIPVDTSKDQFSLRLSS VTAADTAVYYCARHSQKDIVLIPAAQSPI FDYWGQGTLVTVSS mAb-191 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 876 EVQLVESGGGLVQPGGSLRLSCSASGFT (weak) NL63, OC43, Human Patient FSRYAMHWVRQAPGKGLEYVSAINLNG SARS-CoV1 DSTYYTDSVRGRFTISRDNSKNTLFLQMS NVRPEDTAFYYCVKDGGYYDSSGPGHW GQGTLVTVSS mAb-192 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 877 QVQLVQSGGGVVQPGGSLRLSCADSG (weak) NL63, OC43, Human Patient NAFIANPMHWVRQAPGKGLEWLALIST SARS-CoV1 DGNNRHYADSVKGRFTFSRDNSKNSLYL QMDSLRPEDTGVYYCARESRSSGRAGC FDSWGQGTLVTVSS mAb-193 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 878 QVQLVESGGGVVQPGTSLRLSCAATGF (weak) NL63, OC43, Human Patient TFTTYPMHWVRQAPGKGLEWVAVISY SARS-CoV1 DGMNQYYADFLKGRFTISRDNSKNTLYL QMNSLRADDTAVYYCARAYGGNYQNH FDHWGQGTLVTVSS mAb-194 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 879 EVQLVQWGAGLLKPSETLSLRCAVYGGS (weak) NL63, OC43, Human Patient FNGFYWTWIRQAPGQGLEWIAEINHSG SARS-CoV1 TTNYNPSLKSRVTISIDTSKKQFSLSLKS VTAADTAMYFCARGTISPIVGVPTPVVPR RGRSWFDPWGQGTLVTVSS mAb-195 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 880 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak) NL63, OC43, Human Patient TFSTHAISWVRQAPGHGPEWLGGIIPLF SARS-CoV1 GTSESAQRFQARVKITADESTSTAYMELS SLTSEDTAVYYCVRDSDPYTATSRNNHY WYAMDVWGQGTTVTVSS mAb-196 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 881 QVQLVQSGAEVREPGSSVKLSCKTSGGP (weak) NL63, OC43, Human Patient FSTHAFSWVRQAPGQRPEWMGGIMP SARS-CoV1 VFGESKDTQKFKGRVTFTADASTTTTYM ELRSLKSDDTAIYYCVRDSDPYTATSSHN HYWYAMDVWGQGTTVTVSS mAb-197 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 882 QVQLVESGGGLVKPGGSLRLSCAASGFT (weak) NL63, OC43, Human Patient FSDYYMIWIRQAPGKGLEWLSYISHTAS SARS-CoV1 TIYYADSVKGRFTISRDNAKNSLFLQMNS LTAEDTAVYYCARDRGSGVIDPWGQGT LVTVSS mAb-2 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 883 QVQLVESGGGLVQPGGSLRLSCSASGFT SARS-CoV2 NL63, OC43 Human Patient FSRFAMHWVRQAPGKGLEYVSAINLNG DSTYYTDSVRGRFTISRDNSKNTLYLQMS SVRPDDTAFYYCVKDGGYYDSSGPGHW GQGTLVTVSS mAb-20 Ab OC43, SARS- 229E, HKU1, S; Unk B-cells; SARS-CoV1 884 EVQLVESGPGLVKPSETLSLTCTVSGASV CoV1, SARS- NL63 Human Patient TAGSSYWGWIRQPPGKGLEWIGYMFSS CoV2 GNTKYNPSLKSRVTISADTSKNQFSLRLS SVTAADTAVYFCARVGWVRYFDWSKPY YYFDLWGRGTLVTVSS mAb-21 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 885 EVQLVESGGGLVQPGGSLRLSCAASGFT SARS-CoV2 NL63, OC43 Human Patient FSTSAMSWVRQAPGKGLEWVSRIGGG GGRTKYADSVKGRFTISRDNSKNTLYLQ MNSLRADDTAVYYCAKCDLVRYFDWLG EENNWFDPWGQGTLVTVSS mAb-22 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 886 QVQLVQSGAEVRKPGSSVKLSCKASGG SARS-CoV2 NL63, OC43 Human Patient TFSTHAISWVRQAPGQRPEWMGGIMP IFGESKDTQKFQGRVTFTADESTTTAYM ELRSLKSDDTAIYYCVRDSDPYTATVRNN HYWYALDVWGPGTMVTVSS mAb-23 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 887 EVQLVESGGGLSQPGGSLRLSCAASGFT SARS-CoV2 NL63, OC43 Human Patient VRTYCMNWVRQAPGKGLEWVSLVCG DNIDYYPDSVKGRFSISRDDSKNTLLLH MDSLRVEDTAVYYCARATPPGGGTGW PYFDFWGQGTLVTVSS mAb-24 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 888 QVQLVQSGAEMRKPGSSVKVSCKASGG (weak), NL63, OC43 Human Patient TFSRYCFSWVRQAPGQRLEWMGGIMS SARS-CoV2 ILGAHYAQKFOGRVTFTADESTNTAYME LISLTSEDTAVYYCAREEPSGTYHNYYGL DVWGQGTTVTVSS mAb-25 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 889 QVQLQESGPGLVKPSGTLSLTCAVSGGS SARS-CoV2 NL63, OC43 Human Patient ISSSDWCSWVRQPPGKGPEWIAEISHS GSTNYNPSLKSRVTMSVDRSKNQFSLNL NSVTAADTAVYYCAARIRGATHYDFWS GFWAGPFDIWGQGTTVTVSS mAb-26 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 890 EVQLQESGPGLVKPSGTLSLTCGVSGVSI SARS-CoV2 NL63, OC43 Human Patient SSSSWWSWVRQPPGRGLEWIGEISPSG STSYNPSFRSRLTMSVDKSRNQLSLKLSS VTAADTAVYYCARTQSNDFWSGYYTAA FDLWGQGTMVTVSS mAb-27 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 891 QVQLVQWGAGLLKPSETLSLTCAVYGG SARS-CoV2 NL63, OC43 Human Patient SFSGFHWSWIRQPPGKGLEWIGEINHS GSTKYNPSLKSRVTISVDTSKNQFSLRLR SVTAADTAIYYCARGSLSREYDFLTAPQN GPWFDSWGQGALVTVSS mAb-28 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 892 EVQLVESGPELKKPGSSVRVSCKASGGS SARS-CoV2 NL63, OC43 Human Patient FSNFAVSWVRQAPGQRLEWMGGVIPR FGRSEYVQKFQGRVTITVDEAASTAYME LSSLRSEDTAIYYCVLDTTSANPHNWYG MDVWGQGTTVTVSS mAb-29 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 893 QVQLVQSGGGVVNPGGSLRLSCVGSGF SARS-CoV2 NL63, OC43 Human Patient TFSDYYMGWIRQAPGKGLEVISYISSTGS YIRDADSVKGRFTISRDNAENSVYLQMN SLRGEDTAVYYCARMGPYGSGSFDYWG LGTLVTVSS mAb-3 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 894 QVQLQESGPGLVRPSETLSLTCTVSGDS SARS-CoV2 NL63, OC43 Human Patient VSSSDYHWGWIRQPPGKGLEWIGSIYY GGRSHFNPSLKSRVAIFVDTSNNQFSLRL NSVTASDTAVYFCAGRHQELLPMGSFD MWAQGTTVTVSS mAb-30 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 895 PGPACTVWAEVKKPGSSVKVSCKASGG NL63, OC43, Human Patient MFSDYAISWVRQAPGQRLEWMGGIM SARS-CoV1 PGLGSPGYAQIFRGRATISADVSTSTAYL ELTSLKPEDTAVYYCARDPSILNTGNHH WYDLDIWGQGTQVTVSS mAb-31 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 896 QVQLVQSGAEVKKPGSSVKVSCKASGG NL63, OC43, Human Patient TSSTHAISWVRQAPGQGLEWMGGIIPIF SARS-CoV1 GTTNYAQKFQDRVTITADESTSTAYMEL SSLRSEDTAVYFCVRDGAYDSSGYYSTQ WGQGTLVTVSS mAb-32 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 897 EVQLVQSGAEVKKPGSSVKVSCKVSGG SARS-CoV2 NL63, OC43 Human Patient RFSDYAISWLRQAPVKGLEWMGGIIPRL NRKGYSQDFQGRLTFTADESTSTAYMEL SGLTSEDTAVYYCARDPTFLNSGNHFWY AVDIWGQGTTVTVSS mAb-33 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 898 QVQLVQSGAEVKKPGSSVTVSCKVSGG SARS-CoV2 NL63, OC43 Human Patient RFSDYAISWLRQAPVEGLEWMGGIIPHL NKKGYSQKFQDRITFTADESTSTAYMEL SGLTSEDTAIYYCARDPTFLNTGNHFWY AVDIWGQGTTVTVSS mAb-34 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 899 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 NL63, OC43 Human Patient TFSLFHVHWVRQAPGQGLEWMGWIN PHNGDTTFAERFQGRVALTRDTSINTAY MELSRLTSDDTAVYFCARDFGVRYDDSR QLMKYCDSWGQGTLVTVSS mAb-35 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 900 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient TLADYAISWVRQAPGQGLEWMGGIKP LHGAAGYSQLFRGRLSITADESASTAYM ELTGLTSDDTAMYYCARDPSILNTGNHH WYDLDLWGQGTTVTVSS mAb-36 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 901 QVQLVQSGPELKKPGSSVRVSCKASGGS SARS-CoV2 NL63, OC43 Human Patient ISSYAISWVRQAPGQRLEWMGGVLPM MGRESPVQKFKDRVTIAADESTSTAYM ELRSLSAEDTAVYYCVVDTTMADPHNW YGLDVWGQGTTVTVSS mAb-37 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 902 QVQLVQSGPGLVRPSGTLSLTCAVSGDS SARS-CoV2 NL63, OC43 Human Patient ISGDYWCTWVRQTPGKGLEWIGKISHS GSINYNPSLKSRITMSVDKSKNQFSLKLN SVTAADTAMYYCARVRVGASHHNFWS GYYTDAFDIWGQGTTVTVSS mAb-38 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 903 QVQLVQSGAEVKKPGSSVKVSCKVSGG SARS-CoV2 NL63, OC43 Human Patient TFSNYAISWLRQAPGQGPEWMGGIIPA LSRVGYARKFQARLTISADELTTTAYMDL SSLTSEDTAVYYCARDPSFLNTGNHFWY DFDMWGQGTTVTVSS mAb-39 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 904 EVQLQQSGAEVKKPGSSVKVSCKASGG NL63, OC43, Human Patient TSSTHAISWVRQAPGQGLEWMGGIIPIF SARS-CoV1 GTTNYAQKFQDRVTITADESTSTAYMEL SSLRSEDTAVYFCVRDGAYDSSGYYSTQ WGQGTLVTVSS mAb-4 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 905 EVQLVESGGGLVKPGGSLRLSCAASGFT SARS-CoV2 NL63, OC43 Human Patient FSDYYMNWVRQAPGKGLEWVSSISSSS YMYYADSMKGRFTISRDNAQNSLYLQM SSLRAEDTAVYYCARDFPGDTAVAGTGF NYWGQGTLVTVSS mAb-40 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 906 QVQLVESGGDLVKPGRSLRLSCTASGFTI NL63, OC43, Human Patient GDYAMTWFRQAPGKGLECVAVIRSRAF SARS-CoV1 GGTTEYAASVKGRFIVSRDDSNSVAFLQ MNSLKTEDTAVYYCSRDLRRGYYDSNG HQQFDLWGQGTLVTVSS mAb-41 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 907 QVQLVESGGGVVQPGRSLRLSCAASGF NL63, OC43, Human Patient TFSRYGMHWVRQAPGKGLEWVAVIYS SARS-CoV1 DGRNEYYADSVKGRFTISRDNSKNTLHL QMNSLGAADTAVYYCARDPGPITFFDW SPDKSRKSYYDYNGMDVWGQGTTVTV SS mAb-42 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 908 EVQLLESGGGVVQPGTSLRLSCVASGFT NL63, OC43, Human Patient FSTFAMHWVRQAPGKGLEWVALISFDS SARS-CoV1 TNIRYANSVRGRFTISRDNSKNTLYLEVD SLRIEDTGVYYCARDLPPLDYWGQGTLV TVSS mAb-43 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 909 QVQLVQSGAEVRKPGSSVKLSCKASGG SARS-CoV2 NL63, OC43 Human Patient TFSTHAISWVRQAPGQRPEWMGGIIPIF GESKDTQKFQGRVTFTADESTTTAYMEL RSLRSDDTAIYYCVRDSDPYTTTFSHNHY WYAMDVWGQGTTVTVSS mAb-44 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 910 QVQLVQSGGGLVQPGGSLRVSCSASGF SARS-CoV2 NL63, OC43 Human Patient TFSSFAMHWVRQAPGKGLEYVAGISDN GHTTMYADSVKGRFTISRDNSKNTLYLQ LSSLRPEDTAVYFCVKDNVILPGAIVRPQ FDYWGQGTLVTVSS mAb-45 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 911 QVQLVQSGAEVKKPGSSVKVSCKVSGG NL63, OC43, Human Patient MFSDYAISWVRQAPGQRLEWMGGIM SARS-CoV1 PGLGSPAYAQIFRGRVTISADISTSTAYL EVTSLRPEDTAVYYCARDPSILNTGNHHW YDLDMWGQGTTVTVSS mAb-46 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 912 EVQLVESGGGVVQPGRSLRLSCVASGFT SARS-CoV2 NL63, OC43 Human Patient LAPYGMQWVRQAPGKGLEWVAFLSH DGSHLGYVDSVKGRFTISRDNSKNTLYLE MNSLRAEDTATYYCARDNVVQQNADN VGYFDFWGQGSLVTVSS mAb-47 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 913 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient MFRDYAISWLRQAPGQRLEWMGGIM PAFGAPGYAQIFRGRATISADVSTTTAYL ELTSLMPDDTAVYYCARDPSILNTGNHH WYDLDLWGQGTTVTVSS mAb-48 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 914 QVTLKESGAEVKKPGSSVKVSCKTSGGT SARS-CoV2 NL63, OC43 Human Patient FSTHAISWVRQAPGQGPEWMGGIIPLF GTSQHAQRFQARVKFTADESTNTAYME LSSLTPEDTAVYYCVRDSDPYTATSRNNH YWYGMDVWGHGTTVTVSS mAb-49 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 915 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient MFSDYAISWVRQAPGQRLEWMGGIM PGLGSPAYAQSFGGRVTISADISTSTAYL EVTSLRPEDTAVYYCARDPSILNTGNHH WYDLDMWGQGTMVTVSS mAb-5 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 916 EVQLVESGGGLVQPGRSLRLSCSASGFS SARS-CoV2 NL63, OC43 Human Patient FGDYAMSWFRQAPGKGLQWVGLIKTR AYGAATDYAASVQGRFIISRDDSKSIAYL QMNSLKTEDTAVYFCAREGTSLGYYYYY AMDVWGHGTTVTVSS mAb-50 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 917 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient MFSDYAISWVRQAPGQRLEWMGGIM PGLGSPAYAQIFRGRVTISADISTSTAYL EVTSLRPEDTAVYYCARDPSILNTGNHHW YDLDMWGQGTTVTVSS mAb-51 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 918 EVQLVESGGGLVQPGGSLRLSCLTSGFS SARS-CoV2 NL63, OC43 Human Patient FSSYWMIWVRQAPGKGLEWVANIEPD GNEEYYVDSVKGRFTISRDNAKNSLYLQ MNSLRAEDTAVYYCARGPIRHFGLDAFD IWGQGTTVTVSS mAb-52 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 919 QVQLVQSGDEMKKPGSSVKVSCKASGD NL63, OC43, Human Patient TFSTHAISWVRQAPGQGPEWMGGIIPL SARS-CoV1 FGTASYAQTSQSRVKITADESTSTAYMEL SSLTSEDTAVYYCVRDSDPYTATSRNNHY WYGMDVWGQGTTVTVSS mAb-53 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 920 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient MFSDYAISWVRQAPGQRLEWMGGIM PGLGSPAYAQSFGGRVTISADISTSTAYL EVTSLRPEDTAVYYCARDPSILNTGNHH WYDLDMWGQGTMVTVSS mAb-54 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 921 EVQLVESGGGLVQPGGSLRLSCSASGFT SARS-CoV2 NL63, OC43 Human Patient FSNYAMYWVRQAPGKRPEYVSGISSNG GITYYADSVEGRFTVSRDNSKKSLYLQM SSLRPEDTAVYYCVKDLGATVTYDVFDV WGQGTMVTVSS mAb-55 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 922 EVQLVESGGGLVQPGGSLRLSCAASGFT NL63, OC43, Human Patient FSSYSMSWVRQAPGKGLEWVSGHDGG SARS-CoV1 TTHYADSVKGRFTISRDDSMNTLSLQM NSLRAEDTAVYYCAKERDLPGRGGYFDH WGQGTLVTVSS mAb-56 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 923 QVQLQQWGAGLLKPSETLSLTCAVYGG NL63, OC43, Human Patient SFRGFYWTWIRQPPGKGLEWIGEVSHS SARS-CoV1 GETNYNPSLKSRVTISVDTSKNQFSLNLI SVTAADTSVYYCARGYTAPIIREVPITFR PRWFDPWGQGTPVTVSS mAb-57 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 924 QVQLVQSGGGVVNPGGSMRLSCAGSG SARS-CoV2 NL63, OC43 Human Patient FTFSDHYMGWIRQAPGKGLEVISYISSS GSFIRDADSVKGRFTISRDNAKNSVYLQ MNSLRAEDTAVYYCARMGPYGSGTFDY WGQGTLVTVSS mAb-58 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 925 QVQLVQSGGNVVQPGGSLRLSCVGSEF SARS-CoV2 NL63, OC43 Human Patient SITFFAMQWVRRTPGKGLEWVALVSHD GSNIRYSDSVKGRFIISRDNAKNTLYLQL DSLTPEDTGIYYCARDHALQNGRPGYFD SWGQGSQVTVSS mAb-59 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 926 QVQLVQSGGGLVQPGGSLRLSCSASGF SARS-CoV2 NL63, OC43 Human Patient TFNTYAMHWVRQAPGKRLEYVSSITRD GAGKFYADSVKGRFTISRDNSKNTLYQQ MSSLRPEDTAVYYCVREGQQWLGLYFD HWGQGALVTVSS mAb-6 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 927 QVQLVQSGAEVKKPGASVKVSCRASGY SARS-CoV2 NL63, OC43 Human Patient TFSGYDINWVRQATGQGLEWMGWM NPNSGDTGYAHKFQGRVTMTRNSSIST AYMELSSLTSEDTAVYFCAREKKSFGPQY YYGSGEDWGQGTLVTVSS mAb-60 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 928 EVQLVQSGAEMKKPGESLKISCKGSGYS SARS-CoV2 NL63, OC43 Human Patient FPNYWIGWVRQMPGKGLEWMAIMW PSDSDTRYSPSFQGQVTISADTSTSTVYL QWGSLKASDTAMYYCVRQRYCSGGSCF LFEDAFEIWGQGTMVTVSS mAb-61 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 929 EVQLVESGGGLVQPGGSLRLSCAASGFI NL63, OC43, Human Patient FKNEPMNWIRQFPGKGLEWISNIRDNG SARS-CoV1 NDVYYADSVKGRFTVSRDNAKNSLYLQ MNSLRDDDTALYYCVRDTDWAFDSWG QGTLVTVSS mAb-62 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 930 EVQLVESGPTLVKPTQTLTLTCTFSGFSLT NL63, OC43, Human Patient TRRQGVGWLRRPPGKALEWLALIYWD SARS-CoV1 DDKRYSPSLKSRLTITKDTSKNHVVLSLT NVGPADTATYYCAHTSELPPRRPYAAFD FWGQGTLVTVSS mAb-63 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 931 EVQLLESGGGLVQPGGSLRLSCAASGFP NL63, OC43, Human Patient FSTDAMNWVRQAPGEGLEWVSTISDS SARS-CoV1 GRDTYYAASVRGRFTISRDNSKNTVYLQ MNSLRVEDTAVYYCANTNFLDYWGQG TLVTVSS mAb-64 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 932 EVQLQESGPGLLKPSETLSLTCTVSGSPIA SARS-CoV2 NL63, OC43 Human Patient SNYWSWVRQPAGKGLEWIGRIDTSPTT DYNPSLKSRVIMSVDTSTSQFSLKMSSVT AADTAVYYCTRSFISFDSSGHPYYYYAMD VWGQGTTVTVSS mAb-65 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 933 QVQLVQSGAEVRKPGSSVKLSCRASGG SARS-CoV2 NL63, OC43 Human Patient TFHTYTVNWVRQAPGQGLEWLGGIIPIF GTPTYAQRFQGKVSITADSSTNTVFMEL TSLTSEDTAVYYCTRETGTDEFDFWGQG ALVTVSS mAb-66 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 934 EVQLVESGPGLVKPSGTLSLTCAVSGAS NL63, OC43, Human Patient VSSDHWWSWVRQSPGKGLEWIGEVY SARS-CoV1 HSGSTNYNPSLKSRVTISLDQSNNQFSLK LTSVTAADTAIYYCATMWGGLCTASNCY GNPMDVWGQGTTVTVSS mAb-67 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 935 EVQLVESGPGLVKPSGTLSLTCAVTGAS NL63, OC43, Human Patient VSSDHWWSWVRQSPGKGLEWIGEVY SARS-CoV1 HSGSTNYNPSLKSRVTISLDQSNNQFSLK LTSVTAADTAIYYCATMWGGLCTASNCY GNPMDVWGQGTTVTVSS mAb-68 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 936 QVQLQESGPGLVKPSGTLSLTCAVSGAS SARS-CoV2 NL63, OC43 Human Patient VSSDHWWSWVRQSPGKGLEWIGEVY HSGSTNYNPSLKSRVTISLDQSNNQFSLK LTSVTAADTAIYYCATMWGGLCTASNCY GNPMDVWGQGTTVTVSS mAb-69 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 937 QVQLQESGGGLVQPGGSLRLSCEASGF SARS-CoV2 NL63, OC43 Human Patient SFSDFVMHWVRQVPGKGLEWVSRISH DGSITSYVDSVKGRFTVSRDNGKKTLYL QMNSPRTEDTAVYYCARDLAWTFFDY WGHGTLVTVSS mAb-7 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 938 EVQLLESGGGLSRPGGSLRLSCAASGFIA SARS-CoV2 NL63, OC43 Human Patient SRNCMQWVRQAPGKGLEWVSIICGDEI TYIRDSVKGRFTISRDDSKNTLHLEMNSL RADDTAVYYCARATPPGGTTGWPYIDL WGQGTLVTVSS mAb-70 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 939 EVQLLESGGGLVQPGGSLRLSCAASGFP (weak), Human Patient FSTDAMNWVRQAPGEGLEWVSTISDT NL63, SARS- GRDTYYAASVKGRFTISRDNSKNTVYLQ CoV1 MNSLRAEDTAVYYCANTNFLDYWGQG (weak), TLVTVSS SARS-CoV2 mAb-71 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 940 EVQLVESGGGLVQPGRSLRLSCAASGFIL NL63, OC43, Human Patient DDYAVHWVRLAPGKGLEWVSGITWNS SARS-CoV1 GYLGYADSVKGRFTISRDNAKNSLYLQM NSLRPEDTALYYCAKLGTDHPIGVDVW GQGTTVTVSS mAb-72 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 941 QVQLVQSGGGLVQPGGSLRLSCSASGF NL63, OC43, Human Patient TFNTYTMHWVRQAPGKGLEYVSAISSN SARS-CoV1 GVVTYYADSVKGRFTISRDNSKNTLYLQ MSSLRAEDTAVYYCVKALYSSSWCPFDY WGQGALVTVSS mAb-73 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 942 QVQLQQSGGGLVQPGGSLRLSCEASGF NL63, OC43, Human Patient NFNSYSMSWVRQAPGKGLEWLSYISSR SARS-CoV1 SSTIKYASSVQGRFTVSRDNAKKSVFLQ MNSLRDEDTAVYYCARELDSETYYNYNS LDVWGQGTTVTVSS mAb-74 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 943 QVQLQESGPGLVRPSETLSLTCTVSRGSI NL63, OC43, Human Patient SSSYWSWIRQPPGKGLEWIGFMYYSGS SARS-CoV1 TNYNPSLKSRVTISLDTSKNQFSLKLSSVT AADTAVYYCAKAQGIYYRGWSYWFDP WGQGTLVTVSS mAb-75 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 944 EVQLVQSGAEVKKPGASVKISCKASGYA (weak), Human Patient FRNNYINWIRQAPGQGLEWMGIINPSA NL63, SARS- GTSTYAQKFQGRVTMTRDTSTNTVYME CoV1 ITSLRSEDTATYFCAREARRQVTQWFGE (weak), FWGPYNWFDPWGQGTLVTVSS SARS-CoV2 mAb-76 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 945 QVQLQQWGAGLLKPSETLSLTCGVYGV SARS-CoV2 NL63, OC43 Human Patient SFSDYYWSWIRQPPGKGLEWIGEINHS GITNYNPSLKSRVTISVDTSKNQFSLKLSS VTAADTAVYYCARGLISYTLWLRESYFDY WGQGTLVTVSS mAb-77 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 946 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient SLRDYAISWVRQAPGQGPEWMGGIMP IFGTAGYAQKFQGRVKFTADESATTAYM ELTGLRSEDSAVYFCARDPSILNTGNHH WYDLDIWGQGTTVTVSS mAb-78 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 947 QVQLVQSGAEVKKPGASVKVSCKASGY NL63, OC43, Human Patient TFTNDGFVWVRQAPGQVPEWMGWIS SARS-CoV1 VHTGDTIYAQRFQGRVTMTTDTSTRTSY MELMSLRSDDTAVYYCARDYGDGPPD HWGQGTLVTVSS mAb-79 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 948 QVQLVQSGPEVKKPGSSVRVSCKVSGG SARS-CoV2 NL63, OC43 Human Patient PFSSYGVSWARQAPEKGLEWMGGVLPI FGTVGYVHKFQGRVTITADESTSTVYMA LSSLRSEDTAVYYCVLDTTMSHPHNWY GMDVWGHGTTVTVSS mAb-8 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 949 QVQLVQSGAEVKKPGSSMKLSCKASGI SARS-CoV2 NL63, OC43 Human Patient NFRSYSFSWVRQAPGQGLEWMGGVIP YFPTANYAEKFRGRVTATADESTGTVYLE MSSLRSEDTAVYYCASEYFDGRSYHSFC GLDVWGQGTLVTVSS mAb-80 Ab 229E, HKU1 OC43 S; Unk B-cells; SARS-CoV1 950 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), Human Patient TLSDYAISWVRQAPGQGLEWMGGIMP NL63, SARS- VFGSPGYAEIFQGRLTITADESRSTAYME CoV1 LTSLRSEDTAVYYCARDPSILNTGPHHW (weak), YDLDIWGPGTTVTVSS SARS-CoV2 mAb-81 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 951 EVQLVQSGAEVKKPGSSMRVSCRVSGG NL63, OC43, Human Patient TFITHAMSWVRQAPGQGPEWMGGIV SARS-CoV1 PLFGRASYAQPSQTRVQITADESTSTVYL EVPSLTSEDTAVYYCVRDSEPYTATRSQN HYWYDMDVWGQGTTVTVSS mAb-82 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 952 EVQLVESGPGLVKPSATLSLTCTVSGGSI CoV1, SARS- OC43 Human Patient NNYYWTWVRQSAGKGLEWIGRINTSG CoV2 STNYNASLKSRVTMSIDTSKNEFSLRLSS VTAADTAVYYCAREFGVRFLDRSLFGAM DVWGHGATVTVSS mAb-83 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 953 QVQLVESGGGVVQPGRSLRLSCAASGF NL63, OC43, Human Patient TFSAFAMHWVRQAPGKGLEWVTIISYD SARS-CoV1 GSNEYYADSVQGRFSISRDNSKNTLFLQ MSSLRTEDTAIYYCARAGGYLSAFDIWG QGTTVTVSS mAb-84 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 954 EVQLVQSGAEVKKPGSSVKVSCKVSGGT SARS-CoV2 NL63, OC43 Human Patient FSNYAISWLRQAPGQGPEWMGGIIPAL SKVGYAGKFQARLTFSADELKTTVYMDL SSLTSEDTAVYYCARDPSFLNAGNHFYYD FDVWGQGTMVTVSS mAb-85 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 955 QVQLQESGPGLVKPSGTLSLTCAVSGGS NL63, OC43, Human Patient ITSRDWWSWVRQPPGKGLEWIGEVYH SARS-CoV1 SGSTSYNPSLKSRVTISVDKSKNEFSLKLS SVTAADTAVYYCARAGNIVVMPAAQYY FDYWGQGTLVTVSS mAb-86 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 956 EVQLVESGGSVVQPGTSLKLSCAGSAGL SARS-CoV2 NL63, OC43 Human Patient TITRYAMHWVRQAPGKGLEWVALVSH DGIHIGYSDSVRGRFTISRDNSRNTLYLQ MDGLRPEDTAVYYCVRDDVLQHSRPSG PGYFVSWGQGTLVTVSS mAb-87 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 957 QVQLQESGPGLVKPSETLSLTCTVSGGS NL63, OC43, Human Patient MNHYYWSWIRQPPGKGLEGIGYTYYSG SARS-CoV1 STNYNPSLKSRVTISVDASKNQFSLRLSSV TAADTAVYYCARGSQIDLRGGLGATFFD YWGQGTLVTVSS mAb-88 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 958 QVQLVESGAEVKKPGSSVKISCKISGDTF NL63, OC43, Human Patient STNAISWLRQAPGREPEWMGGIVPLVG SARS-CoV1 PASYAQRPQGRLTITADEFTNTAYLELNS LRSEDTATYYCARDSDPYTATRRHNHYW YAMDVWGQGTTVTVSS mAb-89 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 959 EVQLLESGGGLVQPGGSLRLSCAASGFIF SARS-CoV2 NL63, OC43 Human Patient KNEPMNWIRQFPGKGLEWISNIRDNG NDVYYADSVKGRFTVSRDNAKNSLYLQ MNSLRDDDTALYYCVRDTDWAFDSWG QGTLVTVSS mAb-9 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 960 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 NL63, OC43 Human Patient TFSSYDINWVRQATGQGLEWMGWMS PNTGDTGYAHKFQGRVRMTSNTSISTA YMELNSLTSEDTAVYYCARRGNNFGYYY YYTVDVWGQGTTVTVSS mAb-90 Ab HKU1, SARS- 229E, NL63, S; Unk B-cells; SARS-CoV1 961 QVQLVQSGADVKKPGASVKVSCKASGY CoV1, SARS- OC43 Human Patient TFTSYYMHWVRQAPGQGLEWLGVIHP CoV2 SGGSTTFAQKFQGRVTMTRDTSTSTVY MELSSLRSEDTAVYYCARVLAGSSHEW QLTHDAFDIWGQGTTVTVSS mAb-91 Ab HKU1 229E, NL63, S; Unk B-cells; SARS-CoV1 962 EVQLLESGGGLVQPGGSLRLSCAASGFT (weak), OC43 Human Patient FSSYAMSWVRQAPGKGLEWVSGIDGG SARS-CoV1 GGSSYYADSVRGRFTVSRDNSKNMLHL (weak), QMNSLRADDTAVYFCAKGDWIRYFDW SARS-CoV2 SLPISFFDYWGQGALVTVSS mAb-92 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 963 EVQLLESGPGLLKPSETLSLTCTVSGDSV SARS-CoV2 NL63, OC43 Human Patient SSGNFYWSWVRRPPGKALEWIAYSHYT GGTNSDPSFMGRVTMSIDPSRNQFSLR LTSVAAADTAVYYCARTTSPLTYSGHWP LFDYWGQGSLVTVSS mAb-93 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 964 QVQLVQSGDEMKKPGSSVKVSCKASGD SARS-CoV2 NL63, OC43 Human Patient TFSTHAISWVRQAPGQGPEWMGGIIPL FGTASYAQTSQSRVKITADESTSTAYMEL SSLTSEDTAVYYCVRDSDPYTATSRNNHY WYGMDVWGQGTTVTVSS mAb-94 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 965 QVQLVQSGAEVKKPGSSVKVSCKASGG NL63, OC43, Human Patient MFTDYAISWVRQAPGQRLEWMGGIM SARS-CoV1 PGLGSPAYAQIFRDRATISADVSTSTAYL ELTSLKPEDTAVYYCARDPSILNTGNHH WYDLDIWGQGTTVTVSS mAb-95 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 966 QVQLVQSGAEVKKPGSSVKVSCKASGG SARS-CoV2 NL63, OC43 Human Patient MFTDYAISWVRQAPGQRPEWMGGIM PGLGSPAYAQIFRGRATISADLSTSTAYLE LTSLKPEDTAVYYCARDPSILNTGNHHW YDLDIWGQGTMVTVSS mAb-96 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 967 QVTLKESGGGLVQPGGSLRLSCAASGFT NL63, OC43, Human Patient VNSYGMSWVRQAPGKGLEWVSGFKSR SARS-CoV1 SDRPDYAESVKGRFTISRDTSKNTVYLE MIGLRAEDTATYYCVRMDWMEWMKY YFDSWGQGALVTVSS mAb-97 Ab SARS-CoV1 229E, HKU1, S; Unk B-cells; SARS-CoV1 968 QVQLVQSGAEVKKPGSSVKVSCKASGG (weak), NL63, OC43 Human Patient MISDYAISWVRQAPGQRLEWMGGIMP SARS-CoV2 AFGSPGYAQIFRGRATISADVSTNTAYLE LTSLNPDDTAVYYCARDPSILNTGNHHW YDLDMWGQGTMVTVSS mAb-98 Ab SARS-CoV1, 229E, HKU1, S; Unk B-cells; SARS-CoV1 969 QVQLVESGGSVVQPGTSLKLSCAGSAGL SARS-CoV2 NL63, OC43 Human Patient TITRYAMHWVRQAPGKGLEWVALVSH (weak) DGIHIGYSDSVRGRFTISRDNSRNTLYLQ MDGLRPEDTAVYYCVRDDVLQHSRPSG PGYFVSWGQGTLVTVSS mAb-99 Ab SARS-CoV2 229E, HKU1, S; Unk B-cells; SARS-CoV1 970 QVQLQESGPGLVKPSGTLSLTCAVSGAS (weak) NL63, OC43, Human Patient VSSDHWWSWVRQSPGKGLEWIGEVY SARS-CoV1 HSGSTNYNPSLKSRVTISLDQSNNQFSLK LTSVTAADTAIYYCATMWGGLCTASNCY GNPMDVWGQGTTVTVSS mBG17 Ab SARS-CoV1, 229E N Immunised Mouse 971 EVKLEESGGGLVQPGGSMKFSCVASGF SARS-CoV2, TFSDYWMNWVRQSPDKGLEWVAEIRL NL63 KSNNYATHYAASVKGRFTISRDDSKSSVY (weak) LQMNNLRAEDSGIYYCTRSAMDYWGQ GTSVTVSS mBG21 Ab SARS-CoV1, 229E N Immunised Mouse 972 QIQLVQSGPELKKPGETVKISCKASGYTF SARS-CoV2, TDYSMHWVKQAPGKGSKWMGWINTE NL63 TGEPTYADDFKGRFAFSLETSASTAYLQI (weak) NNLKNEDTATYFCALRRWGQGTLVTVS S mBG22 Ab SARS-CoV1, 229E N Immunised Mouse 973 QIQLVQSGPELKKPGETVKISCKASGYTF SARS-CoV2, TDYSMHWVKQAPGKGSKWMGWINTE NL63 TGEPTYADDFKGRFAFSLETSASTAYLQI (weak) NNLKNEDTATYFCALRRWGQGTLVTVS A mBG57 Ab SARS-CoV1, 229E N Immunised Mouse 974 QIQLVQSGPELKKPGETVKISCKASGYTF SARS-CoV2, TDYSMHWVKQAPGKGSKWMGWINTE NL63 TGEPTYADDFKGRFAFSLETSASTAYLQI (weak) NNLKNEDTATYFCALRRWGQGTLVTVS A mBG67 Ab SARS-CoV1, 229E N Immunised Mouse 975 EVQLVESGGGLVQPGGSLKLSCAASGFT SARS-CoV2, FSNYGMSWVRQTPDKRLELVATINRNG NL63 GSTYYLDSVKVRFTISRDNAKSTLFLQLSS (weak) LKSDDTAMYYCARIYDFDEDYFDVWGA GTTVTVSS MD17 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND (weak) Library (Antibody, human, immune - CoV2) MD29 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND (weak) Library (Antibody, human, immune - CoV2) MD45 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND Library (Antibody, human, immune - CoV2) MD47 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND (weak) Library (Antibody, human, immune - CoV2) MD62 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND Library (Antibody, human, immune - CoV2) MD63 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND Library (Antibody, human, immune - CoV2) MD65 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND Library (Antibody, human, immune - CoV2) MD67 Ab SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND Library (Antibody, human, immune - CoV2) mNb6 Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) mNb6-tri Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) MnCit3p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 976 EVQLLESGGGLVQPGGSLRLSCAASGFT G9 Human Patient FRNYAMTWVRQAPGKGLEWVSGISDS GDRTYNADSVKGRFSISRDNSKNTLHLQ MNSLRAEDTAVYYCALASGSYFGGANY WGQGTLVTVSS MnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 977 EVQLVESGGGLVQPGGSLRLSCAASGFT A3 Human Patient VSSNYMSWVRQAPGRGLEWVSVIYSG GSTFYADSVKGRFTISRDNSKNTLYLQM NSLRPEDTAVYYCATGARFGESPFDYW GQGTLVTVSS MnC2t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 978 EVQLVESGGGLVQPGGSLRLSCAASGFT C5 Human Patient VSSNYMSWVRQAPGKGLEWVSVIYSG GSTYYADSVKGRFTISRDNSKNTLYLQM NSLRAEDTAVYYCATGARFGESPFDYW GQGTLVTVSS MnC2t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-COV2 979 QVQLVQSGAEVKKPGSSVKVSCKASGG C11 Human Patient TFSRYTIIWVRQAPGQGLEWMGRIIPIL DIANYAQKFQGRVTITADKSTSTAYMEL SSLRSEDTAVYYCAREGGLDYFGSRNSG WTYTWFDPWGQGTLVTVSS MnC4t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 980 QLQVQESGPGLVKPSETLSLTCTVSGASI A10 Human Patient SSNHYFWGWIRQPPGKGLAWIGSMHY SGSTYYNPSLKSRVTISVDTSKNQLSLKLS SVTAADTAVYYCARGVNYYDRNGYYRN DGFDIRGQGTMVTVSS MnC4t1p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 981 EVQLVESGGGLVQPGGSLRLSCAASGFT A11 Human Patient FSSYSMNWVRQAPGKGLEWVSYISSSS NTRYYTDSVMGRFTISRDNAKNSLFLQ MNSLRAEDTAVYYCASSKGFCSGGSCSD YWGQGTLVTVSS MnC4t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 982 EVQLVESGGHLVQPGRSLRLSCAASGFT B3 Human Patient FDDYAMHWVRQVPGKGLEWVSGISW NGGILDYADSVKGRFTISRDNAKNSLYL HMRSLRTDDTALYYCAKDLRRQDYYAD WYFDLWGRGTLVTVSS MnC4t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 983 QLQVQESGPGLVKPSETLSLTCTVSGASI D10 Human Patient SSNHYFWGWIRQPPGKGLAWIGSMHY SGSTYYNPSLKSRVTISVDTSKNQLSLKLS SVTAADTAVYYCARGVNYYDRNGYYRN DGFDIRGQGTMVTVSS MnC4t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 984 EVQLVESGGHLVQPGRSLRLSCAASGFT E6 Human Patient FDDYAMHWVRQVPGKGLEWVSGISW NGGILGYADSVKGRFTISRDNAKNSLYL QMRSLRTDDTALYYCAKDLRRQDYYAD WYFDLWGRGTLVTVSS MnC4t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 985 QLQVQESGPGLVKPSETLSLTCTVSGASI F5 Human Patient SSNHYFWGWIRQPPGKGLAWIGSMHY SGSTYYNPSLKSRVTISVDTSKNQLSLKLS SVTAADTAVYYCARGVNYYDRNGYYRN DGFDIRGQGTMVTVSS MnC4t2p2_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 986 QVQLVQSGSELKKPGASVKISCKASGYIF A4 Human Patient INYAMNWVRQAPGQGLEWMGWINT NTGNPTYAQDFTGRFVFSLDTSLSTAYL QISSLEAEDTAVYYCAKIGSRNSLGVWG QGTLVTVSA MnC5t2p1_ Ab SARS-CoV2 SARS-CoV2 S; RBD B-cells; SARS-CoV2 987 QMQLVQSGPEVKKPGTSVKVSCKASGF G1 Human Patient TFTSSAVQWVRQARGQRLEWIGWIVV GSGNTDYAQKFQERVTITRDVSTSTAYM ELSSLRSEDTAVYYCAAPRCSGGSCYDGF DIWGQGTMVTVSS MR10 Nb SARS-CoV2 S; RBD Phage Display 988 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVANTWMEWYRQAPGKEREWVAAITS non-immune) YGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGATTKVY DYWGQGTQVTVSS MR14 Nb SARS-CoV2 S; RBD Phage Display 989 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVMYTHMHWYRQAPGKEREWVAAIV non-immune) SLGEYTTYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGAANKY YDYWGQGTQVTVSS MR17 Nb SARS-CoV2 S; RBD Phage Display 990 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEVWRMEWYRQAPGKEREGVAAIES non-immune) YGHGTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDDGQLAYHY DYWGQGTQVTVSS MR17_K56W Nb SARS-CoV2 S; RBD Derived from MR17 991 QVQLVESGGGLVQAGGSLRLSCAASGF PVEVWRMEWYRQAPGKEREGVAAIES YGWGTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDDGQLAYHY DYWGQGTQVTVSS MR17_K99W Nb SARS-CoV2 S; RBD Derived from MR17 992 QVQLVESGGGLVQAGGSLRLSCAASGF PVEVWRMEWYRQAPGKEREGVAAIES YGHGTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVWDDGQLAYH YDYWGQGTQVTVSS MR17_K99Y Nb SARS-CoV2 S; RBD Derived from MR17 993 QVQLVESGGGLVQAGGSLRLSCAASGF PVEVWRMEWYRQAPGKEREGVAAIES YGHGTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVYDDGQLAYHY DYWGQGTQVTVSS MR2 Nb SARS-CoV2 S; RBD Phage Display 994 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYFSYMAWYRQAPGKEREWVAAINSE non-immune) GDSTTYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDYGWYNSQY DYWGQGTQVTVSS MR3 Nb SARS-CoV2 S; RBD Phage Display 995 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNAHFMYWYRQAPGKEREWVAAIYS non-immune) YGRTLYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDYGAASWEYD YWGQGTQVTVSS MR4 Nb SARS-CoV2 S; RBD Phage Display 996 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PMYAWEMAWYRQAPGKEREWVAAIR non-immune) SMGVHTHYSDSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDFGGHQA YYDYWGQGTQVTVSS MR6 Nb SARS-CoV2 S; RBD Phage Display 997 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEDTWMEWYRQAPGKEREWVAAITS non-immune) WGFKTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGDTSASY DYWGQGTQVTVSS MR7 Nb SARS-CoV2 S; RBD Phage Display 998 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNSWMEWYRQAPGKEREWVAAITSY non-immune) GYKTYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDEGYFSDEYDY WGQGTQVTVSS MR8 Nb SARS-CoV2 S; RBD Phage Display 999 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEWAHMHWYRQAPGKEREWVAAIV non-immune) SAGHYTVYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDWGSSNQ YYDYWGQGTQVTVSS Nb11 Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) Nb11-59 Nb SARS-CoV1, SARS-CoV1, S; RBD Phage Display ND SARS-CoV2 SARS-CoV2 (Immunised Camel) Nb3 Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) Nb3-bi Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) Nb3-tri Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) Nb4-43 Nb SARS-CoV2 SARS-CoV1 SARS-CoV2 SARS-CoV1 S; RBD Phage Display ND (Immunised Camel) Nb6 Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) Nb6-tri Nb SARS-CoV2 SARS-CoV2 S; RBD Yeast Display ND Library (scFv, human) NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1000 DVQLQESGGDLVQPGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 101 GSTYYADSVKGRFTSSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYNGSYYY TCHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1001 DVQLQESGGGLVQPGGSLRLSCAVSGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 102 GSTYYADSVKGRFTSSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGTYYY NCHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1002 DVQLQESGGGLVQPGGSLRLSCAASGL CoVnb- TLDYYTIGWFRQAPGKEREGVSCISSSD 103 DSTYYADSVKGRFTISRDNAKNTVYLQM NSLKPEDTAVYYCATAPGTYYKGSYYPM CHYYGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1003 DVQLQESGGGLVQPGGSLRLSCAVSGF CoVnb- TLDYYAIGWFRQAPGKEREGVACISSSD 104 GTTYYADSVKGRFTISRDNAKNTVYLQM NSLKPEDTAVYYCATRPLTYYSGSYYTTCS DYGMDYWGKGTLVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1004 DVQLQESGGGLVQPGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISNSD 105 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGSYYYT CHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1005 DVQLQESGGGLVQSGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISNSD 106 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGSYYYT CHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1006 DVQLQESGGGLVQPGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISNSD 107 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGSYYYT CHPGGMDYWGKGTLVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1007 DVQLQESGGGLVQPGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISNSG 108 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGSYYYT CHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1008 DVQLQESGGGLVQSGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCITNSD 109 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCASFPSTYYSGSYYYT CHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1009 DVQLQESGGGLVQPGGSLRLSCAASGF CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 110 GSTYYADSVKGRFTISRDNAKNTVYLQM NSLKPDDTAVYYCAAALSEGGYTIDGSS WCYHSVYGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1010 DVQLQESGGGSVEAGGSLRLSCAASGV CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 111 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTADYYCAAVPSTYYSGTYYY NCHPGAMHYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1011 DVQLQESGGGLVQPGGSLRLSCAASGL CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 112 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGTYYY TCHPGGMDYWGKGTQVTVSS NIH- Nb SARS-CoV2 S; RBD Immunised Llama 1012 DVQLQESGGGLVQPGGSLRLSCAASGL CoVnb- TLDYYAIGWFRQAPGKEREGVSCISSSD 113 GSTYYADSVKGRFTTSRDNAKNTVYLQ MNSLKPEDTAVYYCAAVPSTYYSGTYYY TCHPGGMDYWGKGTLVTVSS P2B-2F6 Ab SARS-CoV2 SARS-CoV1 SARS-CoV2 S; RBD B-cells; SARS-CoV2 1013 QVQLQESGPGLVKPSETLSLTCTVSGYSI Human Patient SSGYYWGWIRQPPGKGLEWIGSIYHSG STYYNPSLKTRVTISVDTSKNQFSLKLSSV TAADTAVYYCARAVVGIVVVPAAGRRAF DIWGQGTMVTVSS S110 Ab SARS-CoV1, SARS-CoV1 S; B-cells; SARS-CoV1 ND SARS-CoV2 RBD + non- Human Patient S124 Ab SARS-CoV1, SARS-CoV1 S; RBD B-cells; SARS-CoV1 ND SARS-CoV2 Human Patient S303 Ab SARS-CoV1, SARS-CoV1 S; RBD B-cells; SARS-CoV1 ND SARS-CoV2 Human Patient S304 Ab SARS-CoV1, SARS-CoV1, S; RBD B-cells; SARS-CoV1 ND SARS-CoV2 SARS-CoV2 Human Patient S306 Ab SARS-CoV1, SARS-CoV1 SARS-CoV2 S; non- B-cells; SARS-CoV1 ND SARS-CoV2 RBD Human Patient S309 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV1 1014 QVQLVQSGAEVKKPGASVKVSCKASGY SARS-CoV2 and SARS- Human Patient PFTSYGISWVRQAPGQGLEWMGWIST CoV1 YNGNTNYAQKFQGRVTMTTDTSTTTGY MELRRLRSDDTAVYYCARDYTRGAWFG ESLIGGFDNWGQGTLVTVSS S310 Ab SARS-CoV1, SARS-CoV1 S; non- B-cells; SARS-CoV1 ND SARS-CoV2 RBD Human Patient S315 Ab SARS-CoV1, SARS-CoV2 S; RBD B-cells; SARS-CoV1 ND SARS-CoV2 and SARS- Human Patient CoV1 Sb#1 Nb SARS-CoV2 S; RBD Phage Display 1015 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVRKANMHWYRQAPGKEREWVAAIM non-immune) SKGEQTVYADSVEGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCRVFVGWHYFG QGTQVTVS Sb#10 Nb SARS-CoV2 S; RBD Phage Display 1016 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQSHYMRWYRQAPGKEREWVAAIES non-immune) TGHHTAYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCTVYVGYEYHGQG TQVTVS Sb#11 Nb SARS-CoV2 S; RBD Phage Display 1017 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVETENMHWYRQAPGKEREWVAAIYS non-immune) HGMWTAYADSVKGRFTISRDNTKNTVY LQMNSLKPEDTAVYYCEVEVGKWYFGQ GTQVTVS Sb#12 Nb SARS-CoV2 S; RBD Phage Display 1018 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKASRMYWYRQAPGKEREWVAAIQS non-immune) FGEVTWYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVWVGQEYWG QGTQVTVS Sb#13 Nb SARS-CoV2 S; RBD Phage Display 1019 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYASNMHWYRQAPGKEREWVAAIES non-immune) QGYMTAYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCWVIVGEYYVGQ GTQVTVS Sb#14 Nb SARS-CoV2 S; RBD Phage Display 1020 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQAREMEWYRQAPGKEREWVAAIKS non-immune) TGTYTAYAYSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGSSYIGQGTQ VTVS Sb#15 Nb SARS-CoV2 S; RBD Phage Display 1021 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKNFEMEWYRKAPGKEREWVAAIQS non-immune) GGVETYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCFVYVGRSYIGQGT QVTVS Sb#16 Nb SARS-CoV2 S; RBD Phage Display 1022 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAYKTMWWYRQAPGKEREWVAAIES non-immune) YGIKWTRYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCIVWVGAQYHG QGTQVTVS Sb#17 Nb SARS-CoV2 S; RBD Phage Display 1023 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAGRNMWWYRQAPGKEREWVAAIY non-immune) SSGTYTEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCHVWVGSLYKGQ GTQVTVS Sb#18 Nb SARS-CoV2 S; RBD Phage Display 1024 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKHARMWWYRQAPGKEREWVAAID non-immune) SHGDTTWYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCYVYVGASYWG QGTQVTVS Sb#19 Nb SARS-CoV2 S; RBD Phage Display 1025 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNSHEMTWYRQAPGKEREWVAAIQS non-immune) TGTVTEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGSSYLGQG TQVTVS Sb#2 Nb SARS-CoV2 S; RBD Phage Display 1026 QVQLVESGGGLVQAGGSLRLSCATSGF Library (Nanobody, PVYQANMHWYRQAPGKEREWVAAIQ non-immune) SYGDGTHYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCRAVYVGMHYFG QGTQVTVS Sb#20 Nb SARS-CoV2 S; RBD Phage Display 1027 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEQREMEWYRQAPGKEREWVAAIDS non-immune) NGNYTFYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGKSYIGQGT QVTVS Sb#21 Nb SARS-CoV2 S; RBD Phage Display 1028 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKHHWMFWYRQAPGKEREWVAAIK non-immune) SYGYGTEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCFVGVGTHYAGQ GTQVTVS Sb#22 Nb SARS-CoV2 S; RBD Phage Display 1029 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYAAEMEWYRQAPGKEREWVAAISS non-immune) QGTITYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCFVYVGKSYIGQGTQ VSVS Sb#23 Nb SARS-CoV2 S; RBD Phage Display 1030 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYAAEMEWYRQAPGKEREWVAAISS non-immune) QGTITYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCFVYVGKSYIGQGTQ VSVS Sb#25 Nb SARS-CoV2 S; RBD Phage Display 1031 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVHAWEMAWYRQAPGKEREWVAAIR non-immune) SFGSSTHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDFGTHHYAY DYWGQGTQVTVS Sb#26 Nb SARS-CoV2 S; RBD Phage Display 1032 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNTWWMHWYRQAPGKEREWVAAIT non-immune) SWGFRTYYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDKGMAVQ WYDYWGQGTQVTVS Sb#27 Nb SARS-CoV2 S; RBD Phage Display 1033 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYNTWMEWYRQAPGKEREWVAAITS non-immune) HGYKTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGDMFTA YDYWGQGTQVTVS Sb#28 Nb SARS-CoV2 S; RBD Phage Display 1034 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYHSTMFWYRQAPGKEREWVAAIYSS non-immune) GQHTYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDSGQWRQEY DYWGQGTQVTVS Sb#29 Nb SARS-CoV2 S; RBD Phage Display 1035 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEHEMAWYRQAPGKEREWVAAIRS non-immune) MGRKTLYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDFGYTWHEY DYWGQGTQVTVS Sb#3 Nb SARS-CoV2 S; RBD Phage Display 1036 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNYKTMWWYRQAPGKEREWVAAIW non-immune) SYGHTTHYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCVVWVGHNYEG QGTQVTVS Sb#30 Nb SARS-CoV2 S; RBD Phage Display 1037 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVTMAWMWWYRQAPGKEREWVAAI non-immune) RSEGVRTYYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDYGQAHA YYDYWGQGTQVTVS Sb#31 Nb SARS-CoV2 S; RBD Phage Display 1038 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNSHFMEWYRQAPGKEREWVAAIQH non-immune) SSGFHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDTGTTEDYD YWGQGTQVTVS Sb#32 Nb SARS-CoV2 S; RBD Phage Display 1039 QVQLDESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYHAWMEWYRQAPGKEREWVAAITS non-immune) SGRHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDAGRVYNSY DYWGQGTQVTVS Sb#33 Nb SARS-CoV2 S; RBD Phage Display 1040 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAHAWMEWYRQAPGKEREWVAAIT non-immune) SYGYKTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDTGTYRFYY DYWGQGTQVTVS Sb#34 Nb SARS-CoV2 S; RBD Phage Display 1041 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWNQTMVWYRQAPGKEREWVAAI non-immune) WSMGHTYYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDAGVYNR YYDYWGQGTQVTVS Sb#35 Nb SARS-CoV2 S; RBD Phage Display 1042 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEHYWMEWYRQAPGKEREWVAAITS non-immune) FGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGFASHA YDYWGQGIQVTVS Sb#36 Nb SARS-CoV2 S; RBD Phage Display 1043 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PEIAWEMAWYRQAPGKEREWVAAIRS non-immune) FGERTLYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDFGWQHQE YDYWGQGTQVTVS Sb#37 Nb SARS-CoV2 S; RBD Phage Display 1044 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYHAYMEWYRQAPGKEREWVAAIYS non-immune) NGEHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDSGSFNQAY DYWGQGTQVTVS Sb#38 Nb SARS-CoV2 S; RBD Phage Display 1045 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEWSHMHWYRQAPGKEREWVAAIV non-immune) SKGGYTLYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDYGVHFKRY DYWGQGTQVTVI Sb#39 Nb SARS-CoV2 S; RBD Phage Display 1046 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVFHVWMEWYRQAPGKEREWVAAID non-immune) SAGWHTYYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDAGNTTS AYDYWGQGTQVTVS Sb#4 Nb SARS-CoV2 S; RBD Phage Display 1047 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYAQNMHWYRQAPGKEREWVAAIYS non-immune) HGYWTLYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCEVQVGAWYTGQ GTQVTVS Sb#40 Nb SARS-CoV2 S; RBD Phage Display 1048 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYYNWMEWYRQAPGKEREWVAAIH non-immune) SNGDETFYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDIDAEAYAY DYWGQGTQVTVS Sb#41 Nb SARS-CoV2 S; RBD Phage Display 1049 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYHVWMEWYRQAPGKEREWVAAITS non-immune) SGSHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDSGQWRVQ YDYWGQGTQVTVS Sb#42 Nb SARS-CoV2 S; RBD Phage Display 1050 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYWHHMHWYRQAPGKEREWVAAIIS non-immune) WGWYTTYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDHGAQNQ MYDYWGQGTQVTVS Sb#45 Nb SARS-CoV2 S; RBD Phage Display 1051 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYRDRMAWYRQAPGKEREWVAAIYS non-immune) AGQQTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDVGHHYEYY DYWGQGTQVTVS Sb#46 Nb SARS-CoV2 S; RBD Phage Display 1052 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVDNGYMHWYRQAPGKEREWVAAID non-immune) SYGWHTIYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDKGQMRA AYDYWGQGTQVTVS Sb#47 Nb SARS-CoV2 S; RBD Phage Display 1053 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVSWHSMYWYRQAPGKEREWVAAIFS non-immune) EGDWTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDYGSSYYKY DYWGQGTQVTVS Sb#48 Nb SARS-CoV2 S; RBD Phage Display 1054 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVSQSVMAWYRQAPGKEREWVAAIYS non-immune) KGQYTHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDAGSSYWD YDYWGQGTQVTVS Sb#49 Nb SARS-CoV2 S; RBD Phage Display 1055 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, GQIEYLGWFRQAPGKEREGVAALNTW non-immune) TGRTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRTKPLNT YYYSYWGQGTPVTVS Sb#5 Nb SARS-CoV2 S; RBD Phage Display 1056 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVFSGHMHWYRQAPGKEREWVAAILS non-immune) NGDSTHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCRVHVGAHYFGQ GTQVTVS Sb#50 Nb SARS-CoV2 S; RBD Phage Display 1057 QVQLVESGGGSVQAGGSLRLSCAASGYI Library (Nanobody, DKIVYLGWFRQAPGKEREGVAALYTLSG non-immune) HTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAATEGHAHALYRLH YYWGQGTQVTVS Sb#51 Nb SARS-CoV2 S; RBD Phage Display 1058 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYQGEMHWYRQAPGKEREWVAAIRS non-immune) TGVQTWYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCRVWVGTHYFG QGTQVTVS Sb#52 Nb SARS-CoV2 S; RBD Phage Display 1059 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, IQRIYYLGWFRQAPGKEREGVAALMTYT non-immune) GHTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAAYVGAENPLPYS MYGYWGQGTQVTVS Sb#53 Nb SARS-CoV2 S; RBD Phage Display 1060 QVQLVESGGGSVQAGGSLRLSCAASGQ Library (Nanobody, ISHIKYLGWFRQAPGKEREGVAALITRW non-immune) GQTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAADYGASDPLWFI HYLYWGQGTQVTVS Sb#55 Nb SARS-CoV2 S; RBD Phage Display 1061 QVQLVESGGGSVQAGGSLRLSCAASGKI Library (Nanobody, WTIKYLGWFRQAPGKEREGVAALMTR non-immune) WGYTYYADSVKGRFTVSLDNAKNTVYL QMNSLKPEDTALYYCAAANYGSNFPLAE EDYWYWGQGTQVTVS Sb#56 Nb SARS-CoV2 S; RBD Phage Display 1062 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, ISQIHYLGWFRQAPGKEREGVAALNTDY non-immune) GYTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAAYYFGDDIPLW WEAYSYWGQGTQVTVS Sb#58 Nb SARS-CoV2 S; RBD Phage Display 1063 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, ISTIEYLGWFRQAPGKEREGVAALYTWH non-immune) GQTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRHMPLS ATEYSYWGQGTQVTVS Sb#59 Nb SARS-CoV2 S; RBD Phage Display 1064 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, IESIYYLGWFRQAPGKEREGVAALWTG non-immune) DGETYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAAAWGNSAPLTT YRYYYWGQGTQVTVS Sb#6 Nb SARS-CoV2 S; RBD Phage Display 1065 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEQGRMYWYRQAPGKEREWVAAIIS non-immune) HGTVTVYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGAQYWGQ GTQVTVS Sb#61 Nb SARS-CoV2 S; RBD Phage Display 1066 QVQLVESGGGSVQAGGSLRLSCAASGFI Library (Nanobody, YGITYLGWFRQAPGKEREGVAALVTWN non-immune) GQTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAADWGYDWPLW DEWYWYWGQGTQVTVS Sb#62 Nb SARS-CoV2 S; RBD Phage Display 1067 QVQLVESGGGSVQAGGSLRLSCAASGTI Library (Nanobody, ADIKYLGWFRQAPGKEREGVAALMTR non-immune) WGSTYYADSVKGRFTVSLDNAKNTVYL QMNSLKPEDTALYYCAAANYGANYPLYS QQYSYWGQGTQVTVS Sb#63 Nb SARS-CoV2 S; RBD Phage Display 1068 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSIKYLGWFRQAPGKEREGVAALMTRW non-immune) GMTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAANYGANEPLQY THYNYWGQGTQVTVS Sb#64 Nb SARS-CoV2 S; RBD Phage Display 1069 QVQLVESGGGSVQAGGSLRLSCAASGFI Library (Nanobody, ESIFYLGWFRQAPGKEREGVAALYTYVG non-immune) QTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAASYGAAHPLSIMR YYYWGQGTQVTVS Sb#65 Nb SARS-CoV2 S; RBD Phage Display 1070 QVQLVESGGGSVQAGGSLRLSCAASGTI Library (Nanobody, AHIKYLGWFRQAPGKEREGVAALMTK non-immune) WGQTYYADSVKGRFTVSLDNAKNTVYL QMNSLKPEDTALYYCAAASYGANFPLKA SDYSYWGQGTQVTVS Sb#66 Nb SARS-CoV2 S; RBD Phage Display 1071 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, QAITYLGWFRQAPGKEREGVAALVTW non-immune) NGQTYYADSVKGRFTVSLDNAKNTVYL QMNSLKPEDTALYYCAAADWGYDWPL WDEWYWYWGQGTQVTVS Sb#67 Nb SARS-CoV2 S; RBD Phage Display 1072 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALVTYSG non-immune) NTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAATWGHSWPLYND EYWYWGQGSQVTVS Sb#68 Nb SARS-CoV2 S; RBD Phage Display 1073 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALITVNG non-immune) HTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAAAWGYAWPLHQ DDYWYWGQGTQVTVS Sb#69 Nb SARS-CoV2 S; RBD Phage Display 1074 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALNTFNG non-immune) TTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAATWGYSWPLIAEY NWYWGQGTQVTVS Sb#7 Nb SARS-CoV2 S; RBD Phage Display 1075 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVLFTYMHWYRQAPGKEREWVAAIWS non-immune) SGNSTWYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCFVKVGNWYAGQ GTQVTVS Sb#71 Nb SARS-CoV2 S; RBD Phage Display 1076 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALKTQAG non-immune) FTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAANWGYSWPLYEA DDWYWGQGTQVTVS Sb#8 Nb SARS-CoV2 S; RBD Phage Display 1077 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNAGNMHWYRQAPGKEREWVAAIQ non-immune) SYGRTTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCRVFVGMHYFGQ GTQVTVS Sb#9 Nb SARS-CoV2 S; RBD Phage Display 1078 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVSSSTMTWYRQAPGKEREWVAAINSY non-immune) GWETHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGGSYIGQG TQVTVS Sb100 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1079 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALVTSDG non-immune) RTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAANWGYSWPLYQT EYWYWGQGTQVTVSS Sb12 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1080 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQLYWMEWYRQAPGKEREWVAAITS non-immune) DGDYTEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVKVGEWYYGQ GTQVTVSS Sb13 Nb SARS-CoV2 S; RBD Phage Display 1081 QVQLVESGGGLVQAGGSLRLSCAASGF (weak) Library (Nanobody, PVENYYMRWYRQAPGKEREWVAAIES non-immune) SGAETRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVVVGWGYAGQ GTQVTVSS Sb15 Nb SARS-CoV2 S; RBD Phage Display 1082 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYEHYMRWYRQAPGKEREWVAAIQS non-immune) HGNHTAYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCFVVVGNGYTGQ GTQVTVSS Sb16 Nb SARS-CoV2 S; RBD Phage Display 1083 QVQLVESGGGLVRAGGSLRLSCAASGF Library (Nanobody, PVASQEMTWYRQAPGKEREWVAAISSS non-immune) GRQTEYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGGSYIGQGT QVTVSS Sb17 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1084 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKASEMEWYRQAPGKEREWVAAIASI non-immune) GYNTYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCLVYVGATYIGQGTQ VTVSS Sb2 Nb SARS-CoV2 S; RBD Phage Display 1085 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVSNEEMTWYRQAPGKEREWVAAIAS non-immune) NGNQTEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGASYIGQG TQVTVSS Sb21 Nb SARS-CoV2 S; RBD Phage Display 1086 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKESEMTWYRQARGKEREWVAAINS non-immune) HGMTTHYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCYVYVGGSYIGQ GTQVTVSS Sb22 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1087 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNHYEMEWYRQAPGREREWVAAIM non-immune) DSTGYETAYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCYVYVGASYIGQ GTQVTVSS Sb23 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1088 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVESENMHWYRQAPGKEREWVAAIYS non-immune) TGGWTLYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCAVQVGYWYEGQ GTQVTVSS Sb25 Nb SARS-CoV2 S; RBD Phage Display 1089 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVESTEMTWYRQAPGKEREWVAAIESE non-immune) GHGTEYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGAGYIGQGT QVTVSS Sb27 Nb SARS-CoV2 S; RBD Phage Display 1090 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKASEMVWYRQAPGKEREWVAAILS non-immune) QGHATEYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVWVGRSYIGQG TQVTVSS Sb28 Nb SARS-CoV2 S; RBD Phage Display 1091 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYSAEMEWYRQAPGKEREWVAAISSY non-immune) GTNTYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGSSYIGQGTQ VTVSS Sb30 Nb SARS-CoV2 S; RBD Phage Display 1092 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWYKEMEWYRQAPGKEREWVAAITS non-immune) AGHHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGESYIGQGT QVTVSS Sb32 Nb SARS-CoV2 S; RBD Phage Display 1093 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAHKSMWWYRQAPGKEREWVAAIES non-immune) TGDTTRYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCVVWVGEVYRGQ GTQVTVSS Sb37 Nb SARS-CoV2 S; RBD Phage Display 1094 QVQLVESGGGLVQAGGSLRLSCAASGF (weak) Library (Nanobody, PVYNTWMEWYRQAPGKEREWVAAITS non-immune) YGFHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGNTTAYY DYWGQGTQVTVSS Sb38 Nb SARS-CoV2 S; RBD Phage Display 1095 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYWAHMTWYRQAPGKEREWVAAIV non-immune) SSGAYTAYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDFGTQEHYY DYWGQGTQVTVSS Sb39 Nb SARS-CoV2 S; RBD Phage Display 1096 QVQLVESGGGPVQAGGSLRLSCAASGF Library (Nanobody, PVMWSHMHWYRQAPGKEREWVAAIV non-immune) SYGAYTIYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDFGGYRYYY DYWGQGTQVTVSS Sb40 Nb SARS-CoV2 S; RBD Phage Display 1097 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQGTWMEWYRQAPGKEREWVAAIT non-immune) SVGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGAIAKNY DYWGQGTQVTVSS Sb42 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1098 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYNTWMEWYRQAPGKEREWVAAITS non-immune) WGFKTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGYTGYYY DYWGQGTQVTVSS Sb43 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1099 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEWTHMHWYRQAPGKEREWVAAIA non-immune) SSGAYTVYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGSQDRY YDYWGQGTQVTVSS Sb45 Nb SARS-CoV2 S; RBD Phage Display 1100 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAGTWMEWYRQAPGKEREWVAAITS non-immune) YGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGKSSQVY DYWGQGTQVTVSS Sb46 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1101 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNYTIMFWYRKAPGKEREWVAAIKSH non-immune) GATTLYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDVGNDQKSYD YWGQGTQVTVSS Sb47 Nb SARS-CoV2 S; RBD Phage Display 1102 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVVWAHMHWYRQAPGKEREWVAAIT non-immune) SEGAHTIYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGTYSTYY DYWGQGTQVTVSS Sb5 Nb SARS-CoV2 S; RBD Phage Display 1103 QVQLVESGGGLVQAGGSLRLSCAASGF (weak) Library (Nanobody, PVAQQEMTWYRQAPGKEREWVAAISS non-immune) IGSITHYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGASYIGQGT QVTVSS Sb50 Nb SARS-CoV2 S; RBD Phage Display 1104 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQYEHMHWYRQAPGKEREWVAAIVS non-immune) EGAYTHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGWLAQY YDYWGQGTQVTVSS Sb52 Nb SARS-CoV2 S; RBD Phage Display 1105 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNYNWMEWYRQAPGKEREWVAAIT non-immune) SWGYKTYYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDEGMWQ HYYDYWGQGTQVTVSS Sb54 Nb SARS-CoV2 S; RBD Phage Display 1106 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWNTWMEWYRQAPGKEREWVAAIT non-immune) SYGFKTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDEGNSQSHY DYWGQGTQVTVSS Sb56 Nb SARS-CoV2 S; RBD Phage Display 1107 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEMWSMEWYRQAPGKEREWVAAI non-immune) MSFGYQTWYADSVKGRFTISRDNAKNT VYLQMNSLKPEDTAVYYCNVKDAGNSK ALYDYWGQGTQVTVSS Sb57 Nb SARS-CoV2 S; RBD Phage Display 1108 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEHDHMHWYRQAPGKEREWVAAIVS non-immune) QGAYTVYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGRAGAR YDYWGQGTQVTVSS Sb58 Nb SARS-CoV2 S; RBD Phage Display 1109 QVQLVESGGGLVQAGGSLRLSCAASGF (weak) Library (Nanobody, PVDAAWMEWYRQAPGKEREWVAAIT non-immune) SYGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDMDRWRTT YDYWGQGTQVTVSS Sb6 Nb SARS-CoV2 S; RBD Phage Display 1110 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNHTRMYWYRQAPGKEREWVAAIQS non-immune) HGQNTFYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVWVGNQYWG QGTQVTVSS Sb60 Nb SARS-CoV2 S; RBD Phage Display 1111 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVVAWQMTWYRQAPGKEREWVAAIR non-immune) SFGVSTHYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGYEYEG YDYWGQGTQVTVSS Sb61 Nb SARS-CoV2 S; RBD Phage Display 1112 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVQHEWMEWYRQAPGKEREWVAAIT non-immune) SYGYRTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDTGTYQAW YDYWGQGTQVTVSS Sb62 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1113 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVEQEHMYWYRQASGKEREWVAAIVS non-immune) EGAYTAYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCNVKDWGGYQW YYDYWGQGTQVTVSS Sb63 Nb SARS-CoV2 S; RBD Phage Display 1114 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNAEIMFWYRQAPGKEREWVAAIKSA non-immune) GTTTLYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCNVKDYGAQAHYYD YWGQGTQVTVSS Sb67 Nb SARS-CoV2 S; RBD Phage Display 1115 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVMWAHMAWYRQAPGKEREWVAAI non-immune) VSAGAYTHYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDWGTYNS YYDYWGQGTQVTVSS Sb7 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1116 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNAEEMEWYRQAPGKEREWVAAISS non-immune) SGDWTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCLVYVGSTYIGQGT QVTVSS Sb71 Nb SARS-CoV2 S; RBD Phage Display 1117 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, IQHIKYLGWFRQAPGREREGVAALMTR non-immune) YGQTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAAHYGDNFPLAY QAYLYWGQGTQVTVSS Sb75 Nb SARS-CoV2 S; RBD Phage Display 1118 QVQLVESGGGSVQAGGSLRLSCAASGYI Library (Nanobody, NQIYYLGWFRQAPGKEREGVAALNTYQ non-immune) GQTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRDEPLYH YYYSYWGQGTQVTVSS Sb76 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display 1119 QVQLVESGGGLVQAGGSLRLSCAASSFP Library (Nanobody, VDTYHMAWYRQAPGKEREWVAAIVS non-immune) WGWRTYYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCNVKDIGAQEVH YDYWGQGTQVTVSS Sb78 Nb SARS-CoV2 S; RBD Phage Display 1120 QVQLVESGGGSVQAGGSLRLSCAASGYI Library (Nanobody, KSIKYLGWFRQAPGKEREGVAALMTRY non-immune) GETYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAANYGNNWPLTG VNYWYWGQGTQVTVSS Sb8 Nb SARS-CoV2 S; RBD Phage Display 1121 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVKSYEMEWYRQAPGKEREWVAAISSY non-immune) GEYTEYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVWVGDSYLGQGT QVTVSS Sb83 Nb SARS-CoV2 S; RBD Phage Display 1122 QVQLVESGGGSVQAGGSLRLSCAASGG Library (Nanobody, ITHIVYLGWFRQAPGKEREGVAALMTR non-immune) WGTTYYADSVKGRFTVSLDNAKNTVYL QMNSLKPEDTALYYCAAAKYGQNFPLSY HAYRYWGQGTQVTVSS Sb84 Nb SARS-CoV2 S; RBD Phage Display 1123 QVQLVESGGGSVQAGGSLRLSCAASGYI Library (Nanobody, KHIEYLGWFRQAPGKEREGVAALKTSSG non-immune) STYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAARYGRSDPLHYHE YSYWGQGTQVTVSS Sb85 Nb SARS-CoV2 S; RBD Phage Display 1124 QVQLVESGGGSVQAGGSLRLSCAASGSI Library (Nanobody, SSITYLGWFRQAPGKEREGVAALVTSRG non-immune) KTYYADSVKGRFTVSLDNAKNTVYLQM NSLKPEDTALYYCAAASWGYTWPLYTYD YWYWGQGTQVTVSS Sb88 Nb SARS-CoV2 S; RBD Phage Display 1125 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWAHHMLWYRQAPGKEREWVAAIA non-immune) SWGANTAYADSVKGRFTISRDNAKNTV YLQMNSLKPEDTAVYYCNVKDSGQYRE NYDYWGQGTQVTVSS Sb9 Nb SARS-CoV2 S; RBD Phage Display 1126 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVGQQHMYWYRQAPGKEREWVAAIYS non-immune) YGHITKYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCWVYVGDYYEGQG TQVTVSS Sb90 Nb SARS-CoV2 S; RBD Phage Display 1127 QVQLVESGGGSVQAGGSLRLSCAASGA Library (Nanobody, INQIYYLGWFRQAPGKEREGVAALSTKY non-immune) GETYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRQYPLTF VYYSYWGQGTQVTVSS Sb93 Nb SARS-CoV2 S; RBD Phage Display 1128 QVQLVESGGGSVQAGGSLRLSCAASGH Library (Nanobody, IAQIEYLGWFRQAPGKEREGVAALSTNQ non-immune) GYTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRTYPLSY MAYTYWGQGTQVTVSS Sb94 Nb SARS-CoV2 S; RBD Phage Display 1129 QVQLVESGGGSVQAGGSLRLSCAASGYI Library (Nanobody, TMIEYLGWFRQAPGKEREGVAALNTHT non-immune) GGTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARWGRYEPLHY AYYSYWGQGTQVTVSS Sb95 Nb SARS-CoV2 S; RBD Phage Display 1130 QVQLVESGGGSVQAGGSLRLSCAASGN Library (Nanobody, IYNIKYLGWFRQAPGKEREGVAALMTRY non-immune) GETYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAASYGANWPLVS AAYTYWGQGTQVTVSS Sb97 Nb SARS-CoV2 S; RBD Phage Display 1131 QVQLVESGGGSVQAGGSLRLSCAASGA Library (Nanobody, ISTIEYLGWFRQAPGREREGVAALYTER non-immune) GYTYYADSVKGRFTVSLDNAKNTVYLQ MNSLKPEDTALYYCAAARYGHAQAPLH YFWYGYWGQGTQVTVSS SR1 Nb SARS-CoV2 S; RBD Phage Display 1132 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVAAYEMEWYRQAPGKEREWVAAINS non-immune) MGDQTYYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCYVYVGFSYIGQG TQVTVSS SR13 Nb SARS-CoV2 S; RBD Phage Display 1133 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVDYMEMEWFRQAPGKEREWVAAITS non-immune) NGRETYYADSVKGRFTVSRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGSSYIGQGT QVTVSS SR18 Nb SARS-CoV2 S; RBD Phage Display 1134 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWFQEMEWYRQAPGKEREWVAAISS non-immune) QGTHTYYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCYVYVGASYLGQG TQVTVSS SR31 Nb SARS-CoV2 S; RBD Phage Display 1135 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWQGEMAWYRQAPGKEREWVAAIS non-immune) SMGYKTYYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCAVMVGFWYAG QGTQVTVSS SR34 Nb SARS-CoV2 S; RBD Phage Display 1136 QVQLVESGGGLVQAGGSLRLSCAAGGF Library (Nanobody, PVKDHEMEWYRQAPGKEREWVAAITS non-immune) SGWGTNTYYADSVKGRFTISRDNAKNT VYLQMNSLKPEDTAVYYCYVYVGSSYIG QGTQVTVSS SR38 Nb SARS-CoV2 S; RBD Phage Display 1137 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVNQEEMEWYRQAPGKEREWVAAIKS non-immune) WGTLTAYADSVKGRFTISRDNAKNTVYL QMNSLKPEDTAVYYCAVHVGQTYIGQG TQVTVSS SR4 Nb SARS-CoV2 S; RBD Phage Display 1138 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVYSWNMWWYRQAPGKEREWVAAIE non-immune) SHGDSTRYADSVKGRFTISRDNAKNTVY LQMNSLKPEDTAVYYCYVWVGHTYYG QGTQVTVSS SR5 Nb SARS-CoV2 S; RBD Phage Display 1139 QVQLVESGGGLVQAGGSLRLRCAASGF Library (Nanobody, PVETTEMEWYRQAPGKEREWVAAISSY non-immune) GSETYYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGTSYLGQGT QVTVSS SR7 Nb SARS-CoV2 S; RBD Phage Display 1140 QVQLVESGGGLVQAGGSLRLSCAASGF Library (Nanobody, PVWSNEMEWYRQAPGKEREWVAAITS non-immune) YGTTEYADSVKGRFTISRDNAKNTVYLQ MNSLKPEDTAVYYCYVYVGYSYIGQGTQ VTVSS Ty1 Nb SARS-CoV2 SARS-CoV2 S; RBD Immunised Alpaca 1141 QVQLVETGGGLVQPGGSLRLSCAASGF TFSSVYMNWVRQAPGKGPEWVSRISP NSGNIGYTDSVKGRFTISRDNAKNTLYL QMNNLKPEDTALYYCAIGLNLSSSSVRG QGTQVTVSS VH-Fc- Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND B01 (Human) VH2-A01- Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND B01 (Human) VH2-A01- Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND B02 (Human) VH3-B01 Nb SARS-CoV2 SARS-CoV2 S; RBD Phage Display ND (Human) VHH-72 Nb SARS-CoV1, SARS-CoV2 S; RBD Immunised Llama 1142 QVQLQESGGGLVQAGGSLRLSCAASGR SARS-CoV2 and SARS- TFSEYAMGWFRQAPGKEREFVATISWS CoV1 GGSTYYTDSVKGRFTISRDNAKNTVYLQ MNSLKPDDTAVYYCAAAGLGTVVSEW DYDYDYWGQGTQVTVSS W23UACh Nb SARS-CoV2 S; RBD Immunised Alpaca 1143 QVQLVESGGGLVQPGESLRLSCAASGNI FGIAAVHWFRKAPGKEREFTAGFGSDG STNYANSVKGRFTISRDNAKNTTYLQMN SLKPEDTAVYYCHALIKNELGFLDYWGP GTQVTVSS W25UACh Nb SARS-CoV2 S; RBD Immunised Alpaca 1144 QVQLVESGGGLVQPGESLRLSCAASGSI FGIYAVHWFRMAPGKEREFTAGFGSHG STNYAASVKGRFTMSRDNAKNTTYLQM NSLKPADTAVYYCHALIKNELGFLDYWG PGTQVTVSS SEQ SEQ ID Heavy V Heavy J Light V Light J ID Name NO.: VL Gene Gene Gene Gene NO.: CDRH3 0304-2F8 1145 EIVMTQSHTLLPVTPGEPASITCRSSQS IGHV5-51 IGHJ6 IGKV2-28 IGKJ3 2057 ARRGDGLYYY LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) GMDV GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPQTFGQGT KVDIK 0304-3H3 1146 DIVMTQSPATLSVSPEERATLSCRASQ IGHV4-59 IGHJ2 IGKV3-15 IGKJ1 2058 ARDRIAPVGK SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) FFGWYFDL RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNKWPPWTFGQGTKV DIK 0304- 1147 EIVLTQSPDSLAVSLGERATINCRSSQS IGHV3-64 IGHJ4 IGKV4-1 IGKJ3 2059 ARSSSRGFDY 4A10 VLYSSNNKNYLAWYQQKPGQPPKVLI (Human) (Human) (Human) (Human) YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSSPYAFGPGT KVDIK 0304-4A2 1148 EIVLTQSPDSLAVSLGERATINCKSSQS IGHV4-39 IGHJ4 IGKV4-1 IGKJ1 2060 ARELFTAVAG VLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) KGGIDY YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCHQYYNTPRTFGQG TKVEIK 0317-A1 1149 DIVMTQSPATLSLSPGERATLSCRASQ IGHV3-30 IGHJ6 IGKV3-11 IGKJ3 2061 AKDFKGGSSS SVSSYLAWYQQKPGQAPRLLIYDASN (Human) (Human) (Human) (Human) WYTPEIEYG RATGIPARFSGSGSGADFTLTISSLEPE MDV DFAVYYCRQRSNWPPTFGGGTKVDIK 0317-A2 1150 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV7-4- IGHJ6 IGKV1-39 IGKJ3 2062 ARLIRHEAHT SISSYLNWYQQEPGKAPKLLIYAASSLQ 1 (Human) (Human) (Human) YCSGGSCYSP SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) DYYYGMDV ATYYCQQSYSTPPTFGQGTKVDIK 0317-A3 1151 DIQMTHSLILLSASVGDRVTITCRASQS IGHV3-48 IGHJ3 IGKV1-39 IGKJ1 2063 ASNPPLGEPY ISSYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) FDI GVPSRFSGSGSGADFTLTISSLQPEDFA TYYCQQTYRPPWTFGQGTKVDIK 0317-A7 1152 EIVVTQSLLSLPVTPGEPASISCRSSQS IGHV3- IGHJ6 IGKV2-28 IGKJ1 2064 ARWGGGMQ LLHSNGYNYLDWYLQKPGQSPQVLIYL 303 (Human) (Human) (Human) YLDV GSNRASGVPDRFSGSGSGTDFTLKISR (Human) VEAEDVGVYYCMQTLQTPYTFGQGTK VEIK 0317-A8 1153 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV7-4- IGHJ4 IGKV1-33 IGKJ4 2065 ARAGPNYDF DISNYLNWYQQKPGKAPKLLIYDASNL 1 (Human) (Human) (Human) WSGYYQTFD ETGVPSRFSGSGSGTDFTFTISSLQPED (Human) Y IATYYCQQYDNLPLTFGGGTKVEIK 0317-A9 1154 EIVMTQSPLSSPVTLGQPASISCRSSQS IGHV1-24 IGHJ6 IGKV2-24 IGKJ3 2066 ATATAMDGY LVHSDGNTYLSWLQQRPGQPPRLLIY (Human) (Human) (Human) (Human) YYYYGMDV KISNRFSGVPDRFSGSGAGTDFTLKISR VEAEDVGVYYCMQATQFPYTFGQGT KVDIK 0317-B1 1155 DIVMTHSLRLLAVSLGERATINCKSSQS IGHV5-51 IGHJ3 IGKV4-1 IGKJ3 2067 ASAGSSWYG VLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) DAFDI YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTYGSFGGG TKVDIK 0317-C4 1156 QAVVTQPPSVSAAPGQKVTISCSGSSS IGHV1-24 IGHJ5 IGLV1-51 IGU3 2068 ATATIFGVAN NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) NWFDP KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSSLSVVVFGGGTKL TVL 0317-C9 1157 QAVVTQPPSASGTPGQRVTISCSGSSS IGHV3-30 IGHJ6 IGLV1-44 IGU3 2069 AKDLGYYDILT NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) GQLGGYYYYY QRPSGVPDRFSGSKSGTSASLAISGLQ GMDV SEDEADYYCAAWDDSLNGVVFGGGT KLTVL 10C10 1158 DIQLTQSPSSLSASVRNRVTITCRASQG IGHV3-7 IGHJ3 IGKV1-17 IGKJ4 2070 ARDWDYDILT IKNDLCWYQQKPGKAPKRLIYAASSLQ (Human) (Human) (Human) (Human) GSWFGAFDI SGVPSRFSGSGSGTEFTLTISSLQPEDF ATYYCLQHNNYPLTFGGGTNEEIK 1A09 1159 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ4 IGLV1 IGU1 2071 ARKDYYYGSS AVTTSNYANWVQEKPDHLFTGLIGGT 1 (Mouse) (Mouse) (Mouse) YAMDY NNRAPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDEAIYFCALWYSNHWVFGGGTKL TVL 1A10 1160 DIQMTQSPSSLSASLGDRVTISCRASQ IGHV1-76 IGHJ2 IGKV10-96 IGKJ2 2072 ARDYGSSYVD DISNYLNWYQQKPDGTVKLLIFYTSRL (Mouse) (Mouse) (Mouse) (Mouse) YFDY HSGVPSRFSGSGSGTDYSLTISNLEQE DIATYFCQQGNTLPYTFGGGTKLEIK 1A12 1161 DIKMTQSPSSMYASLGERVTITCKASQ IGHV14-4 IGHJ4 IGKV14- IGKJ1 2073 STGGYGNYV DINSFLSWFQQKPGKSPKTLIYRANRL (Mouse) (Mouse) 111 (Mouse) DAMDY VDGVPSRFSGSGSGQDYSLTISSLDYE (Mouse) DMGIYYCLQYDEFRTFGGGTKLEIK 1B07 1162 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ4 IGLV1 IGU3 2074 ARKDYYGSSS AVTTSNYANWVQEKPDHLITGLIGGT 1 (Mouse) (Mouse) (Mouse) NVMDY NNRVPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDEAIYFCALWYSNQFIFGSGTKVT VL 1610 1163 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ4 IGLV1 IGU1 2075 ARKDYYGSSL AVTTSNYANWVQEKPDHLFTGLIGGT 1 (Mouse) (Mouse) (Mouse) AMDY NNRAPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDEAIYFCALWYSNHWVFGGGTKL TVL 1C05 1164 DIVLTQSPASLAVSLGQRATISCRASES IGHV1-42 IGHJ4 IGKV3-10 IGKJ5 2076 ARRNYDLYYY VDSYGTSFMHWYQQKPGQPPKLLIYL (Mouse) (Mouse) (Mouse) (Mouse) AMDY ASNLESGVPARFSGSGSRTDFTLTIDPV EADDAATYYCQQNNEDPLTFGAGTKL ELK 1C06 1165 DVVMTQTPLSLPVSLGDQASISCRSSQ IGHV1-7 IGHJ4 IGKV1-117 IGKJ1 2077 ARSDYYGSSY SIVHSNGNTYLEWYLQKPGQSPKLLIY (Mouse) (Mouse) (Mouse) (Mouse) VGYAMDY KVSNRFSGVPDRFSGSGSGTDFTLKIS RVEAEDLGVYYCFQGSHVPPTFGGGT KLEIK 1C07 1166 DIVLTQSPASLAVSLGQRATISCRASEG IGHV1-42 IGHJ4 IGKV3-10 IGKJ5 2078 ARRNYDLYYY VDSYGSSFMHWYQQKPGQPPKLLIYL (Mouse) (Mouse) (Mouse) (Mouse) AMDY ASNLESGVPARFSGSGSGTDFTLTIDP VEADDAATYYCQQNNEDPLTFGAGTK LELK 1D04 1167 DIKMTQSPSSMYASLGERVTITCKASQ IGHV14-4 IGHJ4 IGKV14- IGKJ1 2079 STGGYGNYV DINSFLSWFQQKPGKSPKTLIYRANRL (Mouse) (Mouse) 111 (Mouse) DAMDY VDGVPSRFSGSGSGQDYSLTISSLEYED (Mouse) MGIYYCLQYDEFRTFGGGTKLEIK 1D05 1168 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ4 IGLV1 IGU3 2080 ARKDYYGSSS AVTTSNYANWVQEKPDHLITGLIGGT 1 (Mouse) (Mouse) (Mouse) NVMDY NNRVPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDKAIYFCALWYSNQFIFGSGTKVT VL 1E02 1169 DIVLTQSPASLAVSLGQRATISCRASEG IGHV1-42 IGHJ4 IGKV3-10 IGKJ5 2081 SRRNYDLYYY VDSYGSSFMHWYQQKPGQAPKLLIYL (Mouse) (Mouse) (Mouse) (Mouse) AMDY ASNLESGVPARFSGSGSRTDFTLTIDPV EADDAAIYYCQQNNEDPLTFGAGTKL EIK 1E07 1170 DIVLTQSPASLAVSLGQRATISCRASES IGHV1-42 IGHJ3 IGKV3-1 IGKJ1 2082 ARGAGAY VEYYGTSLMQWFQQKPGQPPKLLIFA (Mouse) (Mouse) (Mouse) (Mouse) ASNVESGVPARFGGSGSGTDFSLNIHP VEEDDIAMYFCQQSRKVPWTFGGGT KLEIK 1E10 1171 QIVLTQSPAIMSASPGEKVTMTCSASS IGHV1-82 IGHJ3 IGKV4-59 IGKJ2 2083 ARDHGPA SVSYMHWYQQKSGTSPKRWIYDTSKL (Mouse) (Mouse) (Mouse) (Mouse) ASGVPARFSGSGSGTSYSLTISSMEAE DAATYYCQQWSSNPPTFGSGTKLEIK 1H06 1172 DIVLTQSPASLAVSLGQRATISCRASES IGHV1-42 IGHJ3 IGKV3-1 IGKJ1 2084 ARGAGAY VEYYGTSLMQWFQQKPGQPPKLLIFA (Mouse) (Mouse) (Mouse) (Mouse) ASNVESGVPARFGGSGSGTDFSLNIHP VEEDDIATYFCQQSRKVPWTFGGGTK LEIK 1H10 1173 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ2 IGLV1 IGU1 2085 ARISYYDYEG AVTTSNYANWVQEKPDHLFTGLIGGT 1 (Mouse) (Mouse) (Mouse) VDY NNRAPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDEAIYFCALWYSNHWVFGGGTKL TVL 1M-1D2 1174 QAVVTQPPSASGTPGQRVTISCSGSSS IGHV3-64 IGHJ4 IGLV1-47 IGU3 2086 ARGAEYYDF NIGSNYVYWYQQLPGTAPKLLIYNNN (Human) (Human) (Human) (Human) WSGYYSAYFD QRPSGVPDRFSGSKSGTSASLAISGLRS Y EDEADYYCAAWDDSLIYVLFGGGTKLT VL 2B04 1175 QAVVTQESALTTSPGETVTLTCRSSTG IGHV2-9- IGHJ4 IGLV1 IGU1 2087 ARKDYYGRYY AVTTSNYANWVQEKPDHLFTGLIGGT 1 (Mouse) (Mouse) (Mouse) GMDY NNRAPGVPARFSGSLIGDKAALTITGA (Mouse) QTEDEAIYFCALWYNNHWVFGGGTK LTVL 2C02 1176 QIVLTQSPAIMSASPGEKVTMTCSASS IGHV1-74 IGHJ1 IGKV4-55 IGKJ5 2088 AILDSYWYFD SVSYMYWYQQKPGSSPRLLIYDTSNLA (Mouse) (Mouse) (Mouse) (Mouse) V SGVPIRFSGSGSGTSYSLTISRMEAEDA ATYYCQQWSSYPLTFGAGTKLELK 2C03 1177 DVVMTQTPLSLPVSLGDQASISCRSSQ IGHV1-82 IGHJ1 IGKV1-117 IGKJ2 2089 ARKSYGYWH SIVYSNGNTYLEWYLQKPGQSPKLLIYK (Mouse) (Mouse) (Mouse) (Mouse) FDV VSNRFSGVPDRFSGSGSGTDFTLKISG VEAEDLGVYYCFQGSHVPYTFGGGTK LEIK 2C04 1178 DIVLTQSQASLAVSLGQRATISCRASES IGHV1-26 IGHJ2 IGKV3-1 IGKJ1 2090 AAGKGDY VEYYGTSLMQWYQQKPGQPPKLLIYA (Mouse) (Mouse) (Mouse) (Mouse) ASNVESGVPARFSGSGSGTDFSLNIHP VEEDDIAMYFCQQSRKVPWTFGGGT KLEIK 2D01 1179 QIVLTQSPAIMSASPGEKVTMTCSASS IGHV1-74 IGHJ1 IGKV4-55 IGKJ5 2091 AILDSYWYFD SVSYMYWYQQKPGSSPRLLIYDTSNLA (Mouse) (Mouse) (Mouse) (Mouse) V SGVPIRFSGSGSGTSYSLTISRMEAEDA ATYYCQQWSSYPLTFGAGTKLELK 2D08 1180 DIVLTQSQASLAVSLGQRATISCRASES IGHV1-26 IGHJ2 IGKV3-1 IGKJ1 2092 AAGKGDY VEYYGTSLMQWYQQKPGQPPKLLIYA (Mouse) (Mouse) (Mouse) (Mouse) ASNVESGVPARFSGSGSGTDFSLNIHP VEEDDIAMYFCQQSRKVPWTFGGGT KLEIK 2D11 1181 DIVLTQSPASLAVSLGQRATISCRASES IGHV1-26 IGHJ3 IGKV3-2 IGKJ1 2093 ARKGDGYYG VDNYGISFMNWFQQKPGQPPKLLIYA (Mouse) (Mouse) (Mouse) (Mouse) GFAY ASNQGSGVPARFSGSGSGTDFSLNIHP MEEDDTAMYFFQQSKEVPWTFGGGT KLEIK 2E06 1182 DIVLTQSPASLTVSLGQRATISCKASQS IGHV14-3 IGHJ4 IGKV3-4 IGKJ2 2094 ATYGSYYLYYY VDYGGDRYMNWYQQKPGQPPKLLIF (Mouse) (Mouse) (Mouse) (Mouse) AMNY AASNLESGIPARFSGSGSGTDFTLNIHP VEEEDAATYYCQQSNEDPYTFGGGTK LEIK 2E10 1183 DIVLTQSPASLAVSLGQRATMSCRASE IGHV1-76 IGHJ4 IGKV3-4 IGKJ5 2095 ARYDGNLYYY SVDSYGNGFMHWYQQKPGQPPKLLI (Mouse) (Mouse) (Mouse) (Mouse) AMDY YLASNLESGVPARFSGSGSRTDFSLTID PVEADDAAIYYCQQNNEDPLTFGAGT KLELK 2F04 1184 DIVLTQSPAILSVSPGERVSFSCRASQN IGHV1-55 IGHJ2 IGKV5-48 IGKJ5 2096 ARWDFYGSR IGTIIHWYQQRTNGSPRLLIKYASESVS (Mouse) (Mouse) (Mouse) (Mouse) TFDY GIPSRFSGSGSGTDFTLSINSVESEDIA DYYCQQSSSWPLTFGAGTKLELK 2H04 1185 DIVLTQSPAILSVSPGERVSFSCRASQN IGKV5-48 IGKJ5 IGHV1-55 IGHJ2 2097 ARWDFYGSR IGTIIHWYQQRTNGSPRLLIKYASESVS (Mouse) (Mouse) (Mouse) (Mouse) TFDY GIPSRFSGSGSGTDFTLSINSVESEDIA DYYCQQSSSWPLTFGAGTKLELK 2M- 1186 QSALTQPHSVSESPGKTVTISCTGSSGS IGHV3-66 IGHJ6 IGLV6-57 IGU3 2098 ARATWLRGV 10B11 IASNYVQWYQQRPGSAPTTVIYEDNQ (Human) (Human) (Human) (Human) MDVW RPSGVPDRFSGSIDSSSNSASLTISGLK TEDEADYYCQSYDSSNHWVFGGGTKLT VL 2M-12D7 1187 AIRMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ3 IGKV1-39 IGKJ3 2099 AKDVRYCSST SITGYLNWYQQKPGKAPKLLISAASSL (Human) (Human) (Human) (Human) SCYFSAFDI QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPRTFGPGTKVEIK 2M-13A3 1188 AIRMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ3 IGKV4-1 IGKJ5 2100 ARGGGSYYY SVLYSPNNKNYLAWYQQKPGQPPKLL (Human) (Human) (Human) (Human) WFDP IYWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPFTFGQGT RLEIK 2M- 1189 EIVMTQSPGTLSLSPGERATLSCRASQ IGHV4-34 IGHJ3 IGKV3-20 IGKJ1 2101 ARAGYSSSWY 13D11 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) GVRGVDP RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSRSWTFGQGTKVEI K 2M-14B2 1190 AIRMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ5 IGKV1-39 IGKJ3 2102 AKGSDIVWP SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) VGNWFDP SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTFTLYTFGQGTKVDIK 2M-14E4 1191 DIVMTQSPSSLSASVGDRVSITCRASQ IGHV4-61 IGHJ4 IGKV1-39 IGKJ3 2103 ARVQRYYPDS NISNYLNWYQQKPGEAPKLLISAASSL (Human) (Human) (Human) (Human) SGFYGRRFDI QSGVPSRFGGSGSGTGFTLTINSLQPE DFATYYCQQSHSFPFTFGPGTKVDIK 2M-14E5 1192 AIRMTQSPSFLSVSVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-9 IGKJ4 2104 ARSGGGSYR GISSYLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) GPFDY QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCQQLNSYVTFGGGTKVEIK 2M-2D1 1193 QSVLTQLPSASGTPGQTVTISCSGNVF IGHV4-39 IGHJ3 IGLV1-47 IGU3 2105 ARGDRIQLW KEKSNYVYWYQQLPGTAPKLLIYRNN (Human) (Human) (Human) (Human) LLDAFDI HRPSGVPDRFSGSKSGTSPSLAISGLRS EDEADYYCAARDDSLSGWVFSGRTKL TVL 2M-2D4 1194 EIVMTQSPATLSLSPGERATLSCRASQS IGHV3-23 IGHJ4 IGKV3-11 IGKJ3 2106 AKIGLGLGGL VSTSLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) LRRYFDY ATGVPARFSGSGSGTDFTLTISSLEPDD FAVYYCQQRTNWPLFGPGTKVEIK 2M-2G12 1195 DIQMTQSPSSLSVSAGERATLSCRASQ IGHV3-11 IGHJ6 IGKV1-39 IGKJ1 2107 GTRIMITWYS SVSSYLIWCHQKPGKAPKLLIYDASTLQ (Human) (Human) (Human) (Human) RRGMDG TGVPSRFIGGGSGTNFTLTIISLQPEDF AAYYCQQNYSTWTIGQGSRVEMK 2M-4G4 1196 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV1-46 IGHJ6 IGLV2-23 IGU3 2108 ARERGDSSGY VGMYNLVSWYQQHPGQAPKLMIYE (Human) (Human) (Human) (Human) YEIITTANRRF GSKRPSGVSNRFSGSKSGNTASLTISGL GMDV QAEDEAYYYCCSYAVSSTWVFGGGTK LTVL 2M-7E9 1197 DIVMTQSPATLSLSPGERATLSCRASQ IGHV1-69 IGHJ6 IGKV3-11 IGKJ3 2109 ARIPGWDRG SVSNFLAWYQQKPGQAPRLLIYDASN (Human) (Human) (Human) (Human) TDRNWNDD RATGIPARFSGSGSGTDFTLTISSLEPE DFAVYYCQQRSNWPPAFTFGPGTKVE IK 2M-8E7 1198 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ5 2110 ARTYSFDSSG VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYYDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPKITFGQGTRLEIK 2M-8H10 1199 DIQMTQSPDSLAVSLGERATIKCKSSQ IGHV3-30 IGHJ5 IGKV4-1 IGKJ1 2111 ARAFYDSNW SVLHSSNNKNYLAWYQQKAGQPPSLL (Human) (Human) (Human) (Human) SVGSYFDS LYWASTRESGVPDRFSGSGSGTDFTLT ISSLQAEDVAVYYCQQYYNNQWTFGQ GTKVDIK 2M-9F10 1200 AIRMTQSPSSLSASVGDRVTISCRATQ IGHV3-9 IGHJ4 IGKV1-39 IGKJ3 2112 AKDSVRREYT NINYFLNWYQQKPGRAPKLLIYAASGL (Human) (Human) (Human) (Human) HARVPFDN QSGVPSRFSGSGTGRVFTLTINSLQPD DFATYYCQQSFVSPRTFGQGTKVDIK 2M-9H1 1201 DIVMTQSPSSLSAFVGDRVTITCRASR IGHV3-30 IGHJ4 IGKV1-17 IGKJ4 2113 AKSSKIFYLGE DIGGDLSWFQQKPGKAPERLIYAASSL (Human) (Human) (Human) (Human) SREVDY ESGVPSRFSGSGSATEFALTITSLQPED FATYYCLQHKSYPLTFGGGTKVDIK 31B5 ND ND ND ND ND 2114 ARVEYYYGSG SYMPWYFDL 31B9 ND ND ND ND ND 2115 ATYYYDSSGYS YGMDV 32D4 ND ND ND ND ND 2116 TEEGSGSEGP IEFDY 413-2 ND ND ND ND ND 2117 ARDNNYRNY YYYMDVW 414-1 ND ND ND ND ND 2118 ARGALGCSST SCYPNNFDY W 47D11 ND ND ND ND ND 2119 ND 4A8 1202 EIVMTQSPLSSPVTLGQPASISCRSSQS IGHV1-24 IGHJ6 IGKV2-24 IGKJ3 2120 ATSTAVAGTP LVHSDGNTYLSWLQQRPGQPPRLLIY (Human) (Human) (Human) (Human) DLFDYYYGM KISNRFSGVPDRFSGSGAGTDFTLKISR DV VEAEDVGVYYCTQATQFPYTFGQGTK VDIK 505-3 ND ND ND ND ND 2121 ARDFISRPRG YRW 505-5 ND ND ND ND ND 2122 ARDFISRPRG YRW 505-8 ND ND ND ND ND 2123 ARGQDDFWS MNWFDPW 515-1 ND ND ND ND ND 2124 ARDFISRPRG YRW 515-5 ND ND ND ND ND 2125 TRGSQWATI NDARFDYW 553-15 ND ND ND ND ND 2126 ARVWYYYGP RDYW 553-49 ND ND ND ND ND 2127 AKDSSSWYNY YGMDVW 553-60 ND ND ND ND ND 2128 ARVFRGSQY WFDPW 553-63 ND ND ND ND ND 2129 ARMEAPKLTL DPW 8D2 1203 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-7 IGHJ3 IGKV1-17 IGKJ4 2130 ARDWDYDILT GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) GSWFGAFDI QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPLTFGGGTKVEIK 8D9 1204 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU3 2131 ARPTIGYSYGS DKYACWYRQKPGQSPVLVIYQDSKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTGVFGGGTKLTVL 9A1 1205 DIVMTQSPATLSASPGERVTLSCRASQ IGHV3-30 IGHJ6 IGKV3-15 IGKJ3 2132 AKVSAIFWLG NIRNNLAWYQQKPGQAPRLLIHGAST (Human) (Human) (Human) (Human) QGLSPIDV RAAGAPARFSGSGSDTQFTLTVSSLQS EDFAVYYCHQYSKWPVTFGGGTKVDI K Ab_510A ND IGHV2-70 IGHJ4 IGKV2-28 IGKJ1 2133 ARVQVAAAG (Human) (Human) (Human) (Human) SPYDY Ab_510A5 ND IGHV3-9 IGHJ4 IGKV1-39 IGKJ2 2134 AKDRGYEILTP (Human) (Human) (Human) (Human) ASFDY Ab_510D7 ND IGHV1-69 IGHJ4 IGKV3-20 IGKJ2 2135 ATGRYTYGYG (Human) (Human) (Human) (Human) YYFDY Ab_510G ND IGHV4-31 IGHJ4 IGKV1-33 IGKJ4 2136 ARDYGGNSN (Human) (Human) (Human) (Human) YFHY Ab_510H10 ND IGHV2-70 IGHJ4 IGKV1-39 IGKJ2 2137 ARIQRGIAAD (Human) (Human) (Human) (Human) Y Ab_510H2 ND IGHV3-66 IGHJ4 IGKV1-9 IGKJ4 2138 ARDKWEGTF (Human) (Human) (Human) (Human) DY Ab_510H ND IGHV3-66 IGHJ6 IGKV3-11 IGKJ1 2139 AETGWDGM (Human) (Human) (Human) (Human) DV Ab_510H7 ND IGHV4-59 IGHJ5 IGKV1D-13 IGKJ4 2140 ARHCPWQQL (Human) (Human) (Human) (Human) VSNWFDP Ab_511A1 ND IGHV4-31 IGHJ6 IGKV3-15 IGKJ1 2141 AREKIRSIAAA (Human) (Human) (Human) (Human) GTVYYYGMD V Ab_511A5 ND IGHV4-31 IGHJ2 IGLV3-21 IGU1 2142 ARIYRGTMVV (Human) (Human) (Human) (Human) VFSDLHWYFD L Ab_511B11 ND IGHV3-7 IGHJ4 IGLV1-40 IGU1 2143 AGLFWYGGY (Human) (Human) (Human) (Human) FDY Ab_511B ND IGHV4-59 IGHJ5 IGKV1D-12 IGKJ4 2144 ASTYWDSSGY (Human) (Human) (Human) (Human) YYGVDY Ab_511D11 ND IGHV1-18 IGHJ6 IGKV3-20 IGKJ2 2145 AVLDYCSGGS (Human) (Human) (Human) (Human) SSSGYYNYGM DV Ab_511E5 ND IGHV1-2 IGHJ2 IGLV1-40 IGU2 2146 ARDSLFSRVD (Human) (Human) (Human) (Human) WYFDL Ab_511E7 ND IGHV5-51 IGHJ4 IGKV1-33 IGKJ3 2147 ALAVGRGIPT (Human) (Human) (Human) (Human) SYFDY Ab_511E9 ND IGHV1-18 IGHJ4 IGKV6-21 IGKJ2 2148 AREGAGLIIAY (Human) (Human) (Human) (Human) DY Ab_511G5 ND IGHV1-46 IGHJ4 IGLV1-47 IGU3 2149 ARDGALYSNS (Human) (Human) (Human) (Human) PTEFDY Ab_511G7 ND IGHV3-33 IGHJ4 IGKV1-33 IGKJ4 2150 AKGGNYGDY (Human) (Human) (Human) (Human) LRGFDY Ab_511H11 ND IGHV3-33 IGHJ6 IGKV1-39 IGKJ1 2151 VRGDHSSGW (Human) (Human) (Human) (Human) YGTYYYYMDV Ab_511H7 ND IGHV3-23 IGHJ6 IGLV1-47 IGU3 2152 ARGLQYYYDT (Human) (Human) (Human) (Human) SGYYKDSYYY GVDV Ab_51A1 ND IGHV3-66 IGHJ3 IGKV1-9 IGKJ5 2153 ARDLNIAGGF (Human) (Human) (Human) (Human) DI Ab_51A3 ND IGHV1-18 IGHJ4 IGKV3-11 IGKJ5 2154 ARDLAWFGE (Human) (Human) (Human) (Human) LSESPIEY Ab_51D2 ND IGHV2-5 IGHJ3 IGKV1-39 IGKJ4 2155 AHRLAPDYDF (Human) (Human) (Human) (Human) LTGYYNGDD AFDV Ab_51D3 ND IGHV3-66 IGHJ6 IGKV1-33 IGKJ2 2156 AREGLLVGPT (Human) (Human) (Human) (Human) GRGLGMDV Ab_51D4 ND IGHV2-70 IGHJ4 IGKV1-39 IGKJ2 2157 ARMVVRGV (Human) (Human) (Human) (Human) MLDY Ab_51D7 ND IGHV5-51 IGHJ3 IGKV1-39 IGKJ2 2158 ATRTGWTND (Human) (Human) (Human) (Human) AFDI Ab_51E10 ND IGHV1-18 IGHJ2 IGKV4-1 IGKJ4 2159 ARARQLVLN (Human) (Human) (Human) (Human) WYFDL Ab_51E12 ND IGHV3-7 IGHJ4 IGKV1-8 IGKJ2 2160 ARLMYYYGNF (Human) (Human) (Human) (Human) DY Ab_51E7 ND IGHV3-13 IGHJ2 IGKV1-39 IGKJ1 2161 ARVGYYGSGS (Human) (Human) (Human) (Human) YPLYWYFDL Ab_51F11 ND IGHV1-69 IGHJ4 IGKV3-20 IGKJ2 2162 ATGRYTYGYG (Human) (Human) (Human) (Human) YYFDY Ab_52C1 ND IGHV3-66 IGHJ4 IGLV1-40 IGU3 2163 ARLASDGSGS (Human) (Human) (Human) (Human) YLDYFDY Ab_52C6 ND IGHV1-69 IGHJ6 IGLV8-61 IGU2 2164 ATDGGGGSY (Human) (Human) (Human) (Human) YYAHYYYGM Ab_52F7 ND IGHV3-9 IGHJ6 IGKV2D-30 IGKJ2 2165 AKDIGVMVP (Human) (Human) (Human) (Human) GVTPYGMDV Ab_52G9 ND IGHV3-66 IGHJ6 IGKV1-33 IGKJ1 2166 ARDPMRPG (Human) (Human) (Human) (Human) MDV Ab_53C10 ND IGHV3-43 IGHJ4 IGLV3-21 IGU1 2167 ARESPKLTGY (Human) (Human) (Human) (Human) FDY Ab_53C5 ND IGHV1-69 IGHJ4 IGKV1-5 IGKJ2 2168 ARGRYTYGTE (Human) (Human) (Human) (Human) GYFDN Ab_53F12 ND IGHV3-66 IGHJ6 IGKV3-15 IGKJ2 2169 ARDAVGSYYY (Human) (Human) (Human) (Human) GMEV Ab_53F9 ND IGHV3-53 IGHJ4 IGKV2D-30 IGKJ2 2170 AREGLVGTTL (Human) (Human) (Human) (Human) TFDY Ab_53H3 ND IGHV3-66 IGHJ3 IGKV1-33 IGKJ3 2171 ARYYGPQGR (Human) (Human) (Human) (Human) AFDI Ab_55A8 ND IGHV1-69 IGHJ4 IGKV1-5 IGKJ2 2172 ARGTEYGDYD (Human) (Human) (Human) (Human) VSHD Ab_55C9 ND IGHV3-53 IGHJ4 IGKV1-39 IGKJ2 2173 AREGLVGTAL (Human) (Human) (Human) (Human) AFDY Ab_56C12 ND IGHV3-30 IGHJ5 IGKV1-39 IGKJ1 2174 AKDPTSLYCS (Human) (Human) (Human) (Human) GGSCYNNWF Ab_56D7 ND IGHV3-66 IGHJ6 IGKV1-9 IGKJ5 2175 ARDLDYYGM (Human) (Human) (Human) (Human) DV Ab_56E1 ND IGHV3-30 IGHJ3 IGLV1-44 IGU3 2176 AGGGVLVTS (Human) (Human) (Human) (Human) DPDAFDI Ab_56H11 ND IGHV4-4 IGHJ4 IGLV1-44 IGU3 2177 AGEQHIVTTII (Human) (Human) (Human) (Human) DY Ab_56H3 ND IGHV3-66 IGHJ4 IGKV3-20 IGKJ1 2178 ARDYGDYYFD (Human) (Human) (Human) (Human) Y Ab_57A6 ND IGHV5-51 IGHJ4 IGLV3-19 IGU3 2179 ARQESGWSF (Human) (Human) (Human) (Human) DY Ab_57A8 ND IGHV3-23 IGHJ4 IGKV1-5 IGKJ4 2180 AKGQRGSPD (Human) (Human) (Human) (Human) FFDY Ab_57A9 ND IGHV1-3 IGHJ4 IGKV4-1 IGKJ1 2181 ARAGWELNY (Human) (Human) (Human) (Human) Ab_57B8 ND IGHV3-53 IGHJ4 IGKV1-9 IGKJ5 2182 ARDLVTWGL (Human) (Human) (Human) (Human) DY Ab_57C4 ND IGHV3-15 IGHJ5 IGKV1-39 IGKJ4 2183 STTNDYGDYS (Human) (Human) (Human) (Human) ANY Ab_57E11 ND IGHV1-8 IGHJ5 IGLV1-44 IGU3 2184 ARGLWFGDL (Human) (Human) (Human) (Human) TRTKYNWFD P Ab_57F7 ND IGHV4-34 IGHJ6 IGLV1-44 IGU3 2185 ARDDSSSSGV (Human) (Human) (Human) (Human) GTGMDV Ab_57G9 ND IGHV2-70 IGHJ4 IGKV1-39 IGKJ2 2186 ARITPHLVYDY (Human) (Human) (Human) (Human) Ab_58A4 ND IGHV4-59 IGHJ5 IGKV3-20 IGKJ1 2187 ARTLGAYYDIL (Human) (Human) (Human) (Human) TGFRTPGGW FAP Ab_58D2 ND IGHV3-11 IGHJ2 IGKV3-11 IGKJ2 2188 ASPLLSHNYG (Human) (Human) (Human) (Human) SGSYYNVYWY FEL Ab_58G1 ND IGHV3-53 IGHJ6 IGKV1D-12 IGKJ4 2189 ARDLENGGL (Human) (Human) (Human) (Human) DV Ab_58G6 ND IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2190 AAPNCNSTTC (Human) (Human) (Human) (Human) HDGFDI Ab_59A2 ND IGHV3-66 IGHJ4 IGKV1-33 IGKJ3 2191 ARDLPLHGDY (Human) (Human) (Human) (Human) FDY Ab_59D6 ND IGHV4-34 IGHJ4 IGLV1-40 IGU2 2192 ARHRRDYITM (Human) (Human) (Human) (Human) IVRPTRLWAF DY Ab_81A11 ND IGHV1-69 IGHJ2 IGLV1-40 IGU2 2193 AREAGTTDW (Human) (Human) (Human) (Human) YFDL Ab_81C3 ND IGHV4-39 IGHJ4 IGLV2-14 IGU1 2194 ARHPRFSWR (Human) (Human) (Human) (Human) GNDSGYFDY Ab_81C7 ND IGHV2-5 IGHJ4 IGLV1-36 IGU3 2195 AHSMVRGVL (Human) (Human) (Human) (Human) FGADFDY Ab_81C8 ND IGHV3-33 IGHJ4 IGKV1-39 IGKJ1 2196 ARDGVDFGM (Human) (Human) (Human) (Human) VTLFDY Ab_81E1 ND IGHV1-24 IGHJ4 IGLV1-47 IGU2 2197 AITSVARGLR (Human) (Human) (Human) (Human) GYFDT Ab_81E10 ND IGHV1-24 IGHJ4 IGLV1-47 IGU2 2198 AITSLARGLKG (Human) (Human) (Human) (Human) YFDS Ab_81F2 ND IGHV4-34 IGHJ5 IGKV2-28 IGKJ4 2199 ARGWTVPPL (Human) (Human) (Human) (Human) WVLNWFDP Ab_82B6 ND IGHV4-61 IGHJ5 IGKV2-30 IGKJ1 2200 AMTYYDYIW (Human) (Human) (Human) (Human) GRVDPQFDP Ab_82C6 ND IGHV4-39 IGHJ4 IGKV2-30 IGKJ2 2201 ARFITDGYSS (Human) (Human) (Human) (Human) GSDS Ab_82F6 ND IGHV3-30 IGHJ4 IGKV1-33 IGKJ4 2202 AKQASPYCSG (Human) (Human) (Human) (Human) GSCYSGNFDY Acharya Various Various Various Various Various Various et al., 2020 B38 1206 DIVMTQSPSFLSASVGDRVTITCRASQ IGHV3-53 IGHJ6 IGKV1-9 IGKJ2 2203 AREAYGMDV GISSYLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCQQLNSYPPYTFGQGTKLEIK BD-236 ND IGHV3-53 IGHJ6 ND ND 2204 ARDLGEAGG (Human) (Human) MDV BD-368-2 ND ND ND ND ND ND BD-494 ND IGHV3-53 IGHJ6 IGKV1-9 IGKJ3 2205 ARDLVVYGM (Human) (Human) (Human) (Human) DV BD-498 ND IGHV3-66 IGHJ6 IGKV1-9 IGKJ5 2206 ARDLVVYGM (Human) (Human) (Human) (Human) DV BD-500 ND IGHV3-53 IGHJ6 IGKV1-39 IGKJ5 2207 ARDAMSYG (Human) (Human) (Human) (Human) MDV BD-503 ND IGHV3-53 IGHJ6 IGKV1-39 IGKJ3 2208 ARDAAVYGID (Human) (Human) (Human) (Human) V BD-504 ND IGHV3-66 IGHJ6 IGKV1-9 IGKJ3 2209 ARDLISRGMD (Human) (Human) (Human) (Human) V BD-505 ND IGHV3-53 IGHJ6 IGKV1-33 IGKJ5 2210 ARDRVVYGM (Human) (Human) (Human) (Human) DV BD-506 ND IGHV3-53 IGHJ6 IGKV1-9 IGKJ4 2211 ARDLVSYGM (Human) (Human) (Human) (Human) DV BD-507 ND IGHV3-53 IGHJ6 IGKV1-9 IGKJ3 2212 ARDLVVYGM (Human) (Human) (Human) (Human) DV BD-508 ND IGHV3-53 IGHJ6 IGKV1-39 IGKJ2 2213 ARDAQNYG (Human) (Human) (Human) (Human) MDV BD-515 ND IGHV3-66 IGHJ4 IGKV1-39 IGKJ5 ND (Human) (Human) (Human) (Human) BD-604 ND IGHV3-53 IGHJ6 IGKV1-9 IGKJ2 2214 ARDLGPYGM (Human) (Human) (Human) (Human) DV BD-629 ND IGHV3-53 IGHJ4 IGKV3-20 IGKJ1 2215 ARDYGDYYFD (Human) (Human) (Human) (Human) Y BD23 1207 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV7-4- IGHJ6 IGKV1-5 IGKJ2 2216 ARPQGGSSW SISSWLAWYQQKPGKAPKLLIYKASSL 1 (Human) (Human) (Human) YRDYYYGMD ESGVPSRFSGSGSGTEFTLTISSLQPDD (Human) V FATYYCQQYNSYPYTFGQGTKLEIK Bertoglio 17 Various Various Various Various Various et al., 2020 C002 1208 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-30 IGHJ4 IGKV1-39 IGKJ1 2217 AKEGRPSDIV ISSYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) VWAFDY GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPRTFGQGTKVEIK C003 1209 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ4 IGKV3-20 IGKJ2 2218 ARDYGDFYFD VSSTYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) Y ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPRTFGQGTKLEIK C004 1210 AIRMTQSPSSLSASVGDRVTITCQASQ IGHV1-2 IGHJ6 IGKV1-33 IGKJ5 2219 ASPASRGYSG DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) YDHGYYYYM ETGVPSRFSGSGSGTDFTFTISSLQPED DV IATYYCQQYDNLPITFGQGTRLEIK C005 1211 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2220 AAPHCSGGSC VRSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) LDAFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK C006 1212 QSVLTQPPSASGTPGQRVTVSCSGSSS IGHV3-11 IGHJ6 IGLV1-44 IGU3 2221 ARRGDGSSSI NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) YYYNYMDV QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYFCAAWDDSLNGPVFGGGT KLTVL C008 1213 DIQMTQSPSTLSASVGDRVTITCRANQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ1 2222 AREFGDPEW SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) YFDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYWTFGQGTKVEIK C009 1214 QSALTQPPSASGSPGQSVTISCTGTSS IGHV1-2 IGHJ4 IGLV2-8 IGU3 2223 ARDSPFSALG DVGGYNYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) ASNDY VSKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEAEYYCSSDAGSNNVVFGGGT KLTVL C010 1215 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-30 IGHJ4 IGKV1-39 IGKJ1 2224 ARDGIVDTAL ISTYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) VTWFDY GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPPWTFGQGTKVEIK C013 1216 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ6 IGKV3-11 IGKJ4 2225 ARGNRLLYCS VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) STSCYLDAVR ATGIPARFSGSGSGTDFTLTISSLEPED QGYYYYYYM FAVYYCQQRSNWPLTFGGGTKVEIK DV C016 1217 AIRMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ4 2226 AKVTAPYCSG DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GSCYGGNFDY ETGVPSRFSGSGSGTDFTFTINSLQPED IATYYCQQYDNLPPTFGGGTKVEIK C017 1218 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-9 IGHJ4 IGKV3-11 IGKJ5 2227 AKAGVRGIAA VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) AGPDLNFDH ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRITFGQGTRLEIK C018 1219 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-30 IGHJ4 IGKV1-39 IGKJ2 2228 ARDFDDSSF IRSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) WAFDY SGVPSRFSGSGSGTDFTLTISSLQPDDF ATYYCQQSYSTPPATFGQGTKLEIK C019 1220 SYELTQPPSVSVAPGKTARITCGENNI IGHV1-46 IGHJ5 IGLV3-21 IGU3 2229 ARVPREGTPG GSKSVHWYQQKPGQAPVLVIYYDSDR (Human) (Human) (Human) (Human) FDP PSGIPERFSGSNSGNTATLTINRVEAG DEADYYCQVWDSSSDHVVFGGGTKL TVL C021 1221 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV4-31 IGHJ4 IGKV2-28 IGKJ3 2230 ARVWQYYDS LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) SGSFDY GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPFTFGPGTK VDIK C022 1222 DIQMTQSPSTLSASVGDSVTITCRASQ IGHV4-39 IGHJ1 IGKV1-5 IGKJ2 2231 ARHAAAYYDR SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) SGYYFIEYFQH ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNNYRYTFGQGTKLEIK C027 1223 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ1 2232 AKASGIYCSG SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) GDCYSYYFDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSTFGQGTKVEIK C029 1224 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV4-31 IGHJ4 IGKV2-28 IGKJ4 2233 ARTMYYYDSS LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) GSFDY GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPHTFGGGT KVEIK C030 1225 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ1 2234 AKASGIYCSG SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) GNCYSYYFDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSTFGQGTKVEIK C031 1226 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ2 IGKV1-39 IGKJ4 2235 ARVGYDSSGY SISSYLNWYQQKPGKAPKVLIYAASSL (Human) (Human) (Human) (Human) SGWYFDL QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPPLTFGGGTKVEIK C101 1227 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ4 IGKV3-20 IGKJ1 2236 VRDYGDFYFD VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) Y ATGIPDRFSGGGSETDFTLTISRLEPED CAVYYCQQYGSSPRTFGQGTKVEIK C102 1228 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ4 IGKV3-20 IGKJ1 2237 ARDYGDYYFD VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) Y ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPRTFGQGTKVEIK C103 1229 EIVLTQSPGTLSLSPGERATLSCRASQT IGHV4-34 IGHJ3 IGKV3-20 IGKJ4 2238 ARKPLLYSDFS VTANYLAWYQQKPGQAPRLLIYGASK (Human) (Human) (Human) (Human) PGAFDI RATGIPDRFSGSGSGTDFTLSISRLEPE DFAVYYCQQYTTTPRTFGGGTKVEIK C104 1230 EIVLTQSPGTVSLSPGERATLSCWASQ IGHV4-34 IGHJ3 IGKV3-20 IGKJ4 2239 ARKPLLYSNLS SVSASYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) PGAFDI RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGTTPRTFGGGTKVEIK C105 1231 QSALTQPPSASGSPGQSVTISCTGTSS IGHV3-53 IGHJ4 IGLV2-8 IGU3 2240 ARGEGWELP DVGGYKYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) YDY VSKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEADYYCSSYEGSNNFVVFGGG TKLTVL C106 1232 SYELTQPPSVSVAPGKTARITCGGNNI IGHV4-61 IGHJ4 IGLV3-21 IGU3 2241 ARERPGGTYS GSKSVHWYQQKPGQAPVLVIYFDSDR (Human) (Human) (Human) (Human) NTWYTPTDT PSGIPERFSGSNSGNTATLTISRVEAGD NWFDT EADYYCQVWDSSRDHVVFGGGTKLT VL C107 1233 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV1-18 IGHJ4 IGLV1-47 IGU3 2242 ARGEAVAGTT NIGSNYVYWYQQLPGTAPKLLIYRNN (Human) (Human) (Human) (Human) GFFDY QRPSGVPDRFSGSKSGTSASLAISGLRS EDEADYYCAAWDDSLSGFVVFGGGTK LTVL C108 1234 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ3 IGLV2-14 IGU1 2243 VRDGGRPGD VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) AFDI SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCNSYTSSSTRVFGTGTKV TVL C109 1235 QSALTQPPSASGSPGQSVTISCTGTSS IGHV3-7 IGHJ4 IGLV2-8 IGU3 2244 AIQLWLRGGY DVGGYNYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) DY VTKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEADYYCSSYAGSNNYVVFGGG TKLTVL C110 1236 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV5-51 IGHJ3 IGKV1-5 IGKJ2 2245 ARSFRDDPRI SISYWLAWYQQKPGKAPKLLIYQASSL (Human) (Human) (Human) (Human) AVAGPADAF ESGVPSRFSGSESGTEFTLTISSLQPDD DI FATYYCQQYNSYPYTFGQGTKLEIK C111 1237 QSVLTQPPSVSEAPRQRVTISCSGSSS IGHV4-59 IGHJ3 IGLV1-36 IGU3 2246 ARVEDWGYC NIGNNAVNWYQQVPGKAPKLLIYYDD (Human) (Human) (Human) (Human) SSTNCYSGAF LLPSGVSDRFSGSKSGTSASLAISGLQS DI EDEADYYCAAWDDSLNGAWVFGGG TKLTVL C112 1238 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ4 IGLV2-14 IGU3 2247 AREDYYDSSG VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) SFDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTWVFGGGTKL TVL C113 1239 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-33 IGHJ3 IGKV1-5 IGKJ4 2248 ARGVNPDDIL SMSSWLAWYQQKPGNAPKLLIYKASS (Human) (Human) (Human) (Human) TGVDAFDI LESGVPSRFSGSGSGTEFTLTISSLQPD DFATYYCQQHNSSPLTFGGGTKVEIK C114 1240 QSVLTQPPSVSGAPGQRVTISCTGTSS IGHV3-53 IGHJ4 IGLV1-40 IGU3 2249 ARGDGELFFD NIGAGYDVHWYQQLPGRAPKVLISGN (Human) (Human) (Human) (Human) Q NIRPSEVPDRFSGSRSGTSASLAITSLQ PEDEAQYYCQSYDSSLYAVFGGGTKLT VL C115 1241 DIVMTQSPLSLSVTPGEPASISCRSSQS IGHV3-49 IGHJ4 IGKV2-28 IGKJ2 2250 TRWDGWSQ LLHSNGNNYFDWYLQKPGQSPQLLIY (Human) (Human) (Human) (Human) HDY LGSNRASGVPDRFSGSGSGTDFTLKIS RVEAEDVGVYYCMQVLQIPYTFGQGT KLEIK C116 1242 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-30 IGHJ5 IGLV6-57 IGU3 2251 ARDFYHNWF SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DP QRPSGVPDRFSGSIDRSSNSASLTISGL KTEDEADYYCQSYDSGNHWVVFGGG TRLTVL C117 1243 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV3-30 IGHJ4 IGLV1-51 IGU1 2252 ARDPIWFGEL NIGNNLVSWYQQLPGTAPKLLIYENN (Human) (Human) (Human) (Human) LSPPFVHFDY KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGAWDSSLSAGGVYVFGT GTKVTVL C118 1244 QPVLTQSPSASASLGASVKLTCTLSSGH IGHV3-30 IGHJ6 IGLV4-69 IGU3 2253 ASGYTGYDYF SSYAIAWHQQQPEKGPRYLMKLNTD (Human) (Human) (Human) (Human) VRGDYYGLD GSHSKGDGIPDRFSGSSSGAERYLTISS V LQSEDEADYYCQTWGTGILVFGGGTK LTVL C119 1245 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-46 IGHJ6 IGLV2-14 IGU3 2254 ARANHETTM VGGYKYVSWYQRHPGKAPKLMIYDV (Human) (Human) (Human) (Human) DTYYYYYYMD SNRPSGVSNRFSGSKSGNTASLTISGL V QAEDEADYYCSSYTSSSTSVVFGGGTQ LTVL C120 1246 AIRMTQSPSSLSASVGDTVTITCQASQ IGHV3-53 IGHJ4 IGKV1-33 IGKJ4 2255 AREGMGMA DISKYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) AAGT ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLPQTFGGGTKVEIK C121 1247 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ6 IGLV2-23 IGU3 2256 ARAPLFPTGV VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) LAGDYYYYG KRPSGVSNRFSGSKSGNTASLTISGLQ MDV AEDEADYYCCSYAGSSTLVFGGGTKLT VL C122 1248 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-53 IGHJ4 IGKV1-9 IGKJ2 2257 ARESGDTTM ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) AFDY GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSDSYTFGQGTKLEIK C123 1249 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-53 IGHJ3 IGKV1-9 IGKJ5 2258 ARDLSAAFDI ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPPAFGQGTRLEIK C124 1250 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-48 IGHJ4 IGKV3-11 IGKJ1 2259 AREGARVGA FSSYLAWYQQKPGQAPRLLIYDASNRA (Human) (Human) (Human) (Human) TYDTYYFDY TGIPARFSGSGSGTDFTLTISSLEPEDF AVYYCQQRNNWPPEWTFGQGTKVEIK C125 1251 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2260 AAPYCSGGSC VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) SDAFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK C126 1252 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV4-59 IGHJ3 IGLV6-57 IGU3 2261 ARLQWLRGA SIASNYVQWYQQRPGSAPTTVINEDN (Human) (Human) (Human) (Human) FDI QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNLVFGGGTKLT VL C127 1253 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV1-2 IGHJ6 IGLV1-44 IGU3 2262 ATAHPRRIQG NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) VFFLGPGV QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGVVFGGGT KLTVL C128 1254 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-23 IGHJ6 IGKV3-20 IGKJ4 2263 ANHPLASGD VNSRQLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) DYYHYYMDV RATGIPERFSGSGSGTDFTLTISRLESE DFAVYHCQQYGSSRALTFGGGTKVEIK C130 1255 SYELTQPPSVSVAPGKTARITCGGNNI IGHV1-46 IGHJ2 IGLV3-21 IGU3 2264 ARSRPTPDW GSKSVHWYQQKPGQAPVLVIYYDSDR (Human) (Human) (Human) (Human) YFDL PSGIPERFSGSNSGNTATLTISRVEAGD EADYYCQVWDSSSDHPGVVFGGGTK LTVL C131 1256 EIVMTQSPATLSVSPGERATLSCRASQ IGHV1-69 IGHJ6 IGKV3-15 IGKJ5 2265 ARVNQAVTT SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) PFSMDV RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPITFGQGTRLEIK C132 1257 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ4 IGLV2-14 IGU3 2266 ARGGDTAMG VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) PEYFDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTLLFGGGTKLT VL C133 1258 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ1 2267 ARDSDVDTS SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) MVTWFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPPWTFGQGTKVEIK C134 1259 SYELTQPPSVSVAPGKTARITCGGNNI IGHV3-23 IGHJ4 IGLV3-21 IGU3 2268 AKDPLITGPTY GSKSVHWYQQKPGQAPVLVIYYDSDR (Human) (Human) (Human) (Human) QYFHY PSGIPERFSGSNSGNTATLTISRVEAGD EAEYHCQVWDSSSDRPGVVFGGGTK LTVL C135 1260 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ1 2269 ASSSGYLFHS SISNWLAWFQQKPGKAPKLLIYEASSL (Human) (Human) (Human) (Human) DY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYPWTFGQGTKVEIK C138 1261 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-7 IGHJ4 IGLV6-57 IGU3 2270 AGGTWLRSSF SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNWVFGGGTKL TVL C139 1262 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3- IGHJ6 IGKV1-33 IGKJ4 2271 AKGGAYSYYY DISNYLNWYQQKPGKAPKLLIYDASNL 303 (Human) (Human) (Human) YMDV ETGVPSRFSGSGSGTDFTFTISSLQPED (Human) IATYYCQQYDNLPLTFGGGTKVEIK C140 1263 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-66 IGHJ6 IGKV1-9 IGKJ2 2272 ARDLYYYGM ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) DV GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYSYTFGQGTKLEIK C141 1264 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-30 IGHJ4 IGLV6-57 IGU3 2273 ARADLGYCTN SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) GVCYVDY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNWVFGGGTKL TVL C143 1265 QSALTQPASVSGSPGQSITISCTGTSND IGHV3-66 IGHJ3 IGLV2-23 IGU3 2274 ARDSSEVRDH VGSYTLVSWYQQYPGKAPKLLIFEGTK (Human) (Human) (Human) (Human) PGHPGRSVG RSSGISNRFSGSKSGNTASLTISGLQGE AFDI DEADYYCCSYAGASTFVFGGGTKLTVL C144 1266 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-53 IGHJ4 IGLV2-14 IGU1 2275 AREGEVEGY VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) NDFWSGYSR SNRPSGVSNRFSGSKSGNTASLTISGL DRYYFDY QAEDEADYYCSSYTSSSTRVFGTGTKV TVL C145 1267 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-53 IGHJ4 IGLV2-14 IGU1 2276 AREGEVEGYY VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) DFWSGYSRD SNRPSGVSNRFSGSKSGNTASLTISGL RYYFDY QAEDEADYYCSSYTSSTTRVFGTGTRV TVL C146 1268 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-21 IGHJ4 IGLV2-14 IGU1 2277 ARDVASNYAY IGVYNYISWSQQHPGKAPKVMIYDVT (Human) (Human) (Human) (Human) FDL NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYRGSSTPYVFGTGTKV TVL C147 1269 QAVVTQEPSLTVSPGGTVTLTCGSSTG IGHV5-51 IGHJ5 IGLV7-46 IGU3 2278 ARLSDRWYSP AVTSGHYPYWFQQKSGQAPRTLIYETS (Human) (Human) (Human) (Human) FDP IKHSWTPARFSGSLLGGKAALTLSGAQ PEDEADYYCLLSYSGARPVFGGGTKLT VL C148 1270 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-66 IGHJ6 IGKV3-15 IGKJ4 2279 ARIANYMDV SVSSHLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) RATGIPTRFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPPLTFGGGTKVEIK C150 1271 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-74 IGHJ6 IGLV2-14 IGU3 2280 ARPTAVAAA VGYYNFVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) GNYFYYYGM NRPSGVSNRFSGSKSGNTASLIISGLQA DV EDEADYYCSSYRSSSTLVFGGGTKLTVL C151 1272 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-21 IGHJ4 IGLV6-57 IGU3 2281 ARERGYDGG SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) KTPP QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNYWVFGGGTK LTVL C153 1273 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-53 IGHJ4 IGLV2-23 IGU3 2282 ARVGGAHSG VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) YDGSFDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSSTWVFGGGTKL TVL C154 1274 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ5 2283 AKQAGPYCS GISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GGSCYSAPFD ETGVPSRFSGSGSGTDFTFTISSLQPED Y IATYYCQQYDNLPITFGQGTRLEIK C155 1275 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-53 IGHJ4 IGKV3-15 IGKJ1 2284 ARDFGEFYFD SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) Y RATAIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPRTFGQGTKVEIK C156 1276 SYELTQPPSVSVAPGQTARISCGGNNI IGHV3-30 IGHJ4 IGLV3-21 IGU3 2285 AKDPFPLAVA GSKNVHWYQQKPGQAPVLVVYDDS (Human) (Human) (Human) (Human) GTGYFDY DRPSGIPERFSGSNSGNTATLTISRVEA GDEADYYCQVWDSSSDPWVFGGGTK LTVL C164 1277 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-66 IGHJ3 IGLV2-23 IGU3 2286 ARDSSEVRDH VGSYTLVSWYQQYPGKAPKLLIFEVTK (Human) (Human) (Human) (Human) PGHPGRSVG RSSGISNRFSGSKSGNTASLTISGLQGE AFDI DEADYYCCSYAGASTFVFGGGTKLTVL C165 1278 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-69 IGHJ3 IGKV3-20 IGKJ1 2287 ARDLLDPQLD VSSTYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DAFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK C201 1279 IRMTQSPSSVSASVGDRVTITCRASQG IGHV3-9 IGHJ4 IGKV1-12 IGKJ4 2288 VKGVEYSSSS ISSWLAWYQQKPGKAPKLLIYVESSLQ (Human) (Human) (Human) (Human) NFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQANSFPLTFGGGTKVEIK C202 1280 DIQLTQSPSSLSASVGDRVTITCQASQ IGHV3-66 IGHJ4 IGKV1-33 IGKJ2 2289 ARDTLGRGG DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) DY ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLPRSFGQGTKLEIK C204 1281 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-23 IGHJ5 IGKV1-39 IGKJ1 2290 ARESDCGSTS ISSYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) CYQVGWFDP GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPPWTFGQGTKVEIK C205 1282 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-46 IGHJ4 IGKV3-20 IGKJ1 2291 ARGPERGIVG VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) ATDYFDY ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYVSSPWTFGQGTKVEIK C207 1283 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-23 IGHJ4 IGKV3-11 IGKJ1 2292 AKEPIGQPLL VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) WWDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPRGFGQGTKVEIK C208 1284 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV5-51 IGHJ5 IGKV3-20 IGKJ4 2293 ARGPNLQNW VSGSYLAWYQQRPGQAPRLLIYGASS (Human) (Human) (Human) (Human) FDP RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSLTFGGGTKVEIK C210 1285 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-53 IGHJ6 IGKV1-9 IGKJ4 2294 ARDLMAYGM ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) DV GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPQGTFGGGTKVEIK C211 1286 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-66 IGHJ4 IGKV3-15 IGKJ1 2295 ARDYGDFYFD SVSSNLAWYQQKPGQGPRLLIYGAST (Human) (Human) (Human) (Human) F RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPRTFGQGTKVEIK C212 1287 LTQPASVSGSPGQSITISCTGTSSDVGS IGHV1-2 IGHJ6 IGLV2-23 IGU3 2296 ARERYFDLGG YNLVSWYQQHPGKAPKLMIYEDSKRP (Human) (Human) (Human) (Human) MDV SGVSNRFSGSKSGNTASLTISGLQAED EADYYCCSYAGSSTRLFGGGTKLTVL C214 1288 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-33 IGHJ5 IGKV1-39 IGKJ1 2297 ARDVGRVTT ISSYLTWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) WFDP GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPPWTFGQGTKVEIK C215 1289 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-23 IGHJ5 IGKV1-39 IGKJ1 2298 ASEEDYSNYV ISSYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) GWFDP GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPPWTFGQGTKVEIK C216 1290 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-13 IGHJ2 IGKV1-39 IGKJ5 2299 ARDRGSSGW ISSYLNWYQQKPGKAPKLLIYVASSLQS (Human) (Human) (Human) (Human) YGWYFDL GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSTPPITFGQGTRLEIK CA1 1291 DIVMTQTPATLSLSPGERATLSCRASQ IGHV1-18 IGHJ6 IGKV3-11 IGKJ3 2300 AREGYCSGGS SVSSYLAWYQQKPGQAPRLLIYDASN (Human) (Human) (Human) (Human) CYSGYYYYYG RATGIPARFSGSGSGTDFTLTISSLEPE MDV DFAVYYCQQRRNWGTFGPGTKVDIK CB6 1292 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3-66 IGHJ4 IGKV1-39 IGKJ2 2301 ARVLPMYGD SISRYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) YLDY QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPPEYTFGQGTKLEIK CC12.1 1293 DIVMTQSPSFLSASVGDRVTITCRASQ IGHV3-53 IGHJ6 IGKV1-9 IGKJ3 2302 ARDLDVYGLD GISSYLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) V QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCQQLNSYPPKFTFGPGTKVEIK CC12.10 1294 QSALTQPASVSGSPGQSLTISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2303 ARGPRYSGTH VGGYNYVSWYQQHPDKAPKLMIYDV (Human) (Human) (Human) (Human) FDY NNRPSGVSNRFSGSKSGSTASLTISGL QAEDEADYYCSSYAGSSTQVFGGGTK LTVL CC12.11 1295 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2304 ARGPRYSGTY VGGYNYVSWYQQHPGKVPKLMIYDV (Human) (Human) (Human) (Human) FDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSAQLFGGGTKL TVL CC12.12 1296 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2305 ARGPRYSGTY VGGYNYVSWYQQHPDKAPKLMIYDV (Human) (Human) (Human) (Human) FDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSGSTQVFGGGTKL TVL CC12.13 1297 DVVMTQSPSSLSASVGDRVTITCQAS IGHV3-53 IGHJ4 IGKV1-33 IGKJ5 2306 ARDPYGYSSI QDISNYLNWYQQKPGKAPKLLIYDAS (Human) (Human) (Human) (Human) WDGQGGH NFATGVPSRFSGTGSGTDFTFTISSLQP EDIATYYCQQYDNLPITFGQGTRLEIK CC12.14 1298 DVVMTQSPLSLPVTLGQPASISCRSSQ IGHV3-21 IGHJ6 IGKV2-30 IGKJ3 2307 ARGGYCSDGS SLVYSDGNTYLNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) CYVQDRLIYYY YKVSNRDSGVPDRFSGSGSGTDFTLKI SGLDV SRVEAEDVGVFYCMQGTHWPPTFGQ GTKVDIK CC12.15 1299 QAVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-48 IGHJ4 IGLV1-40 IGU3 2308 ARDRRRRYCT NIEAGYDVHWYQQLPGTAPKLLIYVN (Human) (Human) (Human) (Human) NGVCYRPEEI SNRPSGVPDRFSGSKSGTSASLAITGL DY QAEDEADYYCQSYDSSLSGVVFGGGT KLIVL CC12.16 1300 SYELTQPPSVSVAPGQTARITCGGNNI IGHV3-33 IGHJ4 IGLV3-21 IGU3 2309 ARDPFPGAV GSKSVHWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) AGTGYLQY RPSGIPERFSGSNSGNTATLTISRVEAG DEADYYCQVWDSSSDPWVFGGGTKL TVL CC12.17 1301 SYELTQPPSVSVAPGKTARITCGGNNI IGHV3-30 IGHJ6 IGLV3-21 IGU3 2310 AKSSGSYYYYY GSKSVHWYQQKPGQAPVLVVYDDTD (Human) (Human) (Human) (Human) YGMDV RPSGIPERFSGSSSGNTATLTISRVEAG DEADYYCQVWDSSSDHPVVFGGGTK LTVL CC12.18 1302 NFMLTQPHSVSESPGKTVTISCTRSSG IGHV1-46 IGHJ4 IGLV6-57 IGU3 2311 ARLHCGGDC SIANNYVKWYQQRPGSSPTTVIYEDN (Human) (Human) (Human) (Human) YLDY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNHEEIWVFGG GTKLIVL CC12.19 1303 SYELTQSPSVSVAPGQTARITCGGNNI IGHV3-23 IGHJ6 IGLV3-21 IGU3 2312 AKGSGSGSYP GSKSVHWYQRKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) NYYYYYGMD RPSGIPERFSGSNSGNTATLTISRVEAG V DEADYYCQVWDNNSDHLVFGGGTKL TVL CC12.2 1304 EIVMTQSPGTLSLSPGERATLSCRASQ IGHV3-53 IGHJ4 IGKV3-20 IGKJ2 2313 ARDYGDLYFD SVSSSYLAWYQQKPGQAPRLLIYGVSS (Human) (Human) (Human) (Human) Y RATGIPDRFSGSGSETDFTLTISRLEPE EFAVYYCQQYGSSPRTFGQGTKLEIK CC12.20 1305 QSVLTQPPSASSTPGQRVTISCSGSSSN IGHV3-30 IGHJ6 IGLV1-47 IGU3 2314 AKDQAYYDIL IGSNYVYWYQQLPGTAPKLLIYTNNQR (Human) (Human) (Human) (Human) TGYLNPPKNY PSGVPDRFSGSKSGTSASLAISGLRSED YYYGMDV EADYYCAAWDDSLSGRVVFGGGTKLT VL CC12.21 1306 QAVVTQPPSASGTPGQRVTISCSGSSS IGHV1-24 IGHJ4 IGLV1-44 IGU3 2315 ATAFSIFGVVP NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) PDY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGPVFGGGT KLTVL CC12.23 1307 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-39 IGHJ4 IGLV3-25 IGU3 2316 ARQGDCSTTS KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) CAYDY SGIPERFSGSSSGTTATLTISGVQAEDE ADYYCQSADSSGTYLVVFGGGTKLAV CC12.24 1308 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-30 IGHJ6 IGKV1-39 IGKJ1 2317 AKDRTGNYYY ISSYLNWYQQKPGKAPKLLIYAASNLQ (Human) (Human) (Human) (Human) GMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPWTFGQGTKVEIK CC12.25 1309 QSALTQPPSASGTPGQRVTISCSGSSS IGHV3-23 IGHJ5 IGLV1-44 IGU3 2318 AKDRYYEFWS NIGSNTVNWYQQLPGTAPKVLVYSND (Human) (Human) (Human) (Human) GYSNWFDP QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGPVFGGGT KLTVL CC12.26 1310 QTVVTQEPSLTVSPGGTVTLTCVSSTG IGHV5-51 IGHJ4 IGLV7-43 IGU3 2319 ARVNYYDSSG AVTSGYYPNWFQQKPGQAPRALIYST (Human) (Human) (Human) (Human) YPSFHFDY SKKHSWTPARFSGSLLGGKAALTLSGV QPEDEAEYYCLLYYGGAQRWVFGGG TKLTVL CC12.27 1311 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ6 IGLV3-23 IGU1 2320 AREMPAAM VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) GYYYYGMDV KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCYSYAGSSTFVFVFGTGTK VIVL CC12.28 1312 QSALTQPPSASGTPGQRVTISCSGSSS IGHV3-23 IGHJ4 IGLV1-47 IGU3 2321 AKANKYSSSE NIGSNYVYWYQQLPGAAPKLLIYRND (Human) (Human) (Human) (Human) FDF QRPSGVPDRFSGSKSGTSVSLAISGLRS EDEADYYCAAWDDSLSGWVFGGGTK LTVL CC12.3 1313 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ4 IGKV3-20 IGKJ2 2322 ARDFGDFYFD VSSYLAWYQQKPGQAPRLLIYGASSRA (Human) (Human) (Human) (Human) Y TGIPDRFSGSGSGTDFTLTISRLEPEDF AVYYCQQYGSSPRTFGQGTKLEIK CC12.4 1314 QSVLTQPPSASGSPGQSVTISCTGTSS IGHV1-2 IGHJ3 IGLV2-8 IGU3 2323 ATESWVYGS DVGGYDYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) GSYSSGAFDI VSKRPSGVPDRFSGSKSGNTASLTVPG LQAEDEADYYCTSYAGSNNFVFGGGT KLIVL CC12.5 1315 QTVVTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2324 ARGPRYSGTY VGGYNYVSWYQQHPDKAPKLIIYDVS (Human) (Human) (Human) (Human) FDY NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEAAYYCSSYTSSSTQVFGGGTKLT VL CC12.6 1316 QSALTQPTSVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2325 ARGPRYSGTY VGGYNYVSWYQQHPGKAPKLIIYDVS (Human) (Human) (Human) (Human) FDY NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTVSSTQVFGGGTKLT VL CC12.7 1317 QPVLTQPASVSGSPGQSLTISCTGTSS IGHV1-2 IGHJ4 IGLV2-14 IGU3 2326 ARGPRYSGTY DIGGFNYVSWYQQHPGKAPKLMIFD (Human) (Human) (Human) (Human) FDY VSKRPSGVPNRFSGSKSGNTASLTISGL QAEDEGDYYCSSYTISSAQVFGGGTKL TVL CC12.8 1318 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2327 ARGPRYSGTY VGGYNHVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) FDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSAQLFGGGTKL TVL CC12.9 1319 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ4 IGLV2-14 IGU3 2328 ARGPRYSGTY VGGYNYVSWYQQHPGKVPKLMIYDV (Human) (Human) (Human) (Human) FDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSAQVFGGGTKL TVL CC6.29 1320 DIQLTQSPSSLSASVGDRVTITCRASQT IGHV7-4- IGHJ5 IGKV1-39 IGKJ3 2329 AVYYYDSGSP ASSYLNWYQQKPGKAPNLLIYAASSLQ 1 (Human) (Human) (Human) GWFDP SGVPSRFSGSGSVTDFTLTISSLQPEDF (Human) ATYYCQQSYSTPPTFGQGTKVDIK CC6.30 1321 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-69 IGHJ5 IGKV1-39 IGKJ3 2330 ARDFRYCSST NISSYLNWYQQEAGKAPKLLIYAASSL (Human) (Human) (Human) (Human) RCYFWFDP QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPRTFGQGTKVDIK CC6.31 1322 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-46 IGHJ4 IGKV1-17 IGKJ4 2331 ARWYDSTGSI GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) DY QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPILTFGGGTKLEIK CC6.32 1323 QLVLTQPPSVSVAPGKTARITCGGNNI IGHV3-9 IGHJ4 IGLV3-21 IGU6 2332 AKDQGYSYG GSKSVYWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) NYFDY RPSGIPERFSGSNSGNTATLTISRVEAG DEADYYCQVWDSSSDHPYVFGSGTKV TVL CC6.33 1324 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-20 IGKJ1 2333 ALRNQWDLL VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) VY ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQHYGSSLWTFGQGTKLEIK Clone11- 1325 DVLMTQTPLSLPVSLGDQASISCRSSQ IGHV1-69 IGHJ3 IGKV1-117 IGKJ5 2334 ARRGYGSSYT 9 SIVHSNGNTYLEWYLQKPGQSPKLLIY (Mouse) (Mouse) (Mouse) (Mouse) WFAY KVSNRFSGVPDRFSGSGSGTDFTLKIS RVEAEDLGVYYCFQGSHVPLTFGAGT KLELK CnC2t1p1_ 1326 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2335 ARVSGYDSSG B10 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YWGDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPALTFGGGTKVEIK CnC2t1p1_ 1327 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-18 IGHJ5 IGLV2-23 IGU3 2336 ARDGELLGW B4 VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) FDP KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSSTWVFGGGTKL TVL CnC2t1p1_ 1328 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-49 IGHJ6 IGKV2-28 IGKJ3 2337 TRVRRLWFGS D6 LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) YYYGMDV GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPGTFGPGT KVDIK CnC2t1p1_ 1329 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-49 IGHJ6 IGKV2-28 IGKJ3 2338 TRVRRLWFGS E12 LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) YYYGMDV GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPGTFGPGT KVDIK CnC2t1p1_ 1330 QSALTQPASVSGSPGQSITISCTGTSGD IGHV1-2 IGHJ4 IGLV2-23 IGU3 2339 ARASVSTITDF E8 VGSYNLVSWYQQHPGKAPKLVIYEAT (Human) (Human) (Human) (Human) DY KRPSGVSNRFFASKSGNTASLTISGLQ AEDEADYYCCSYAGVRTVVFGGGTKL TVL CnC2t1p1_ 1331 QSALTQPASVSGSPGQSITISCTGTSGD IGHV1-2 IGHJ4 IGLV2-23 IGU3 2340 ARASVATITDF G6 IGSYNLVSWYQQYPGKAPKLIIYEASKR (Human) (Human) (Human) (Human) DY PSGVSNRFFASKSGNTASLTISGLQAE DEADYYCCSYAGVRTVVFGGGTKLTVL COV2- 1332 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3- IGHJ4 IGKV3-20 IGKJ1 2341 ARPQSGGYYA 2006 VSSSYLAWYQQKPGQAPRLLIYGASSR 303 (Human) (Human) (Human) PLDY ATGIPDRFSGSGSGTDFTLTISRLEPED (Human) FAVYYCQQYGSSPWTFGQGTKVEIK COV2- 1333 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ6 IGKV1-33 IGKJ3 2342 AKVSATYYYYY 2007 DISTYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) YGMDV ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLLFTFGPGTKVDVK COV2- 1334 QSALTQPASVSGSPGQSITISCTGTSGD IGHV3-30 IGHJ4 IGLV2-14 IGU3 2343 ARDTATYVLL 2009 VGAYNYVSWYQQHPVKAPKLMIYDV (Human) (Human) (Human) (Human) WSGDFNLDY SKRPSGVSNRFSGSKSGNTASLTISGLQ TEDEADYYCSSYTSSSTLWVFGGGTKL TVL COV2- 1335 ITCRASQSISSYLNWYQQKPGKAPKLLI IGHV3- IGHJ6 IGKV1-39 IGKJ3 2344 ARGHTGNYYY 2011 YAASSLQSGVPSRFGGSASGTDFTLTIS 303 (Human) (Human) (Human) GMDV SLQPEDFATYYCQQSYSTFTFGPGTKV (Human) DIK COV2- 1336 DIVMTQSPDFLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ4 2345 AKGGDSSGW 2013 SVLHTPKNKNYLAWYKQKPGQPPKVL (Human) (Human) (Human) (Human) AWDGDNPPT IYWASTRESGVPERFSGSGSGTDFTLII DY SSLQAEDAAVYYCQQYYTAPLTFGGG1 KVEIK COV2- 1337 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-9 IGHJ4 IGKV3-11 IGKJ2 2346 AMGPFGELLP 2015 VSSYLAWYQQKPGQAPRLLIYDTSNR (Human) (Human) (Human) (Human) YYFDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPYTFGQGTKLEIK COV2- 1338 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-24 IGHJ5 IGLV2-14 IGU3 2347 AAAPAVMTA 2016 VGGYHYVSWYQHHPGKAPKLIIYDVIK (Human) (Human) (Human) (Human) GWFDP RPSGVSNRFSGSKSGNTASLTISGLQA EDEAYYYCSSYTSSTTWVFGGGTRLTV L COV2- 1339 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV4-59 IGHJ5 IGLV1-40 IGU1 2348 VRGAMAWF 2017 NIGAGYNVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) DP NNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSFDSSLSGSDVFGTGT KVSVL COV2- 1340 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV1-24 IGHJ4 IGLV1-47 IGU2 2349 ATQPAAIGGT 2021 NIGSNYVYWYQQLPGTAPKLLIYRNN (Human) (Human) (Human) (Human) PPYY QRPSGVPDRFSGSKSGTSASLAISGLRS EDEADYYCAAWDASLSGHVVFGGGT KLTVL COV2- 1341 DIVMAQTPLSLPVTPGEPASISCRSSQS IGHV1-18 IGHJ6 IGKV2-40 IGKJ2 2350 ARDQGPTYYY 2022 LLDSDDGNTYFDWYLQKPGQSPQLLI (Human) (Human) (Human) (Human) GSGSPHYGM YTLSYRASGVPDRFSGSGSGTDFTLKIN DV RVEAEDVGVYYCMQRIEFPWTFGQG TKLEIK COV2- 1342 DIVMTQSPDFLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ4 2351 AKGGDSSGW 2025 SVLHTPKNKNYLAWYKQKPGQPPKVL (Human) (Human) (Human) (Human) AWDGDNPPT IYWASTRESGVPERFSGSGSGTDFTLII DY SSLQAEDAAVYYCQQYYTAPLTFGGG1 KVEIK COV2- 1343 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-24 IGHJ6 IGKV1-16 IGKJ1 2352 ATSFPIRGDPS 2026 GITNYLAWFQQKPGKAPKSLIYAVSSL (Human) (Human) (Human) (Human) YYYYYYGMDV QSGVPSKFSGSGSGTDFTLTISSLQPED FATYYCQQYNSYPWTFGQGTKVEIK COV2- 1344 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-30 IGHJ6 IGLV3-25 IGU3 2353 AIYGYYYYGLD 2027 KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) V SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTYFWVFGGGTKLTV L COV2- 1345 DIVMTQSPDFLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ4 2354 AKGGDSSGW 2028 SVLHTPKNKNYLAWYKQKPGQPPKVL (Human) (Human) (Human) (Human) AWDGDNPPT IYWASTRESGVPERFSGSGSGTDFTLII DY SSLQAEDAAVYYCQQYYTAPLTFGGG1 KVEIK COV2- 1346 QSVLTQPPSVSGTPGQRVTISCSGSNS IGHV4-4 IGHJ3 IGLV1-44 IGU3 2355 ARPTAGAGG 2029 KIGSYSVNWYQQLPGTAPKLLIYRNNQ (Human) (Human) (Human) (Human) AFDI RPSGVPDRFFGSKSGTSASLAISGLQSE DEADYYCSVWDDSLNGPLFGGGTKLT FV COV2- 1347 SYELTQPPSVSVSPGQTARITCSGDAW IGHV2-26 IGHJ5 IGLV3-25 IGU3 2356 ARTEWLLSDN 2031 PNQYAYWYQQKPGQAPVLVIYKDTER (Human) (Human) (Human) (Human) WFDS PSGIPERFSGSSSGTTVTLTISGVQAED EADYFCQSSDSSGVVFGGGTKLTVL COV2- 1348 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV1-46 IGHJ3 IGKV1-5 IGKJ1 2357 ARGGLVPAA 2032 SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) RNAFDI ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSWTFGQGTKVEIK COV2- 1349 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV4-4 IGHJ3 IGLV1-44 IGU3 2358 ARPTAGAGG 2033 KIGSYSVNWYQQLPGTAPKLLIYRNNQ (Human) (Human) (Human) (Human) AFDT RPSGVPDRFSGSKSGTSASLAISGLQSE DEADYYCSVWDDSLNGPLFGGGTKLT FL COV2- 1350 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-18 IGHJ5 IGKV1-39 IGKJ4 2359 ARDLPIKVVV 2034 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) PAADYNWFD SGVPSRFSGSGSGTDFTLTISSLQPEDF P ATYYCQQSYSTPPTFGGGTKVQIK COV2- 1351 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-5 IGHJ3 IGKV1-39 IGKJ1 2360 AHRRGILTED 2035 SISSYLNWYQQRPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) AFDI SGVPSRFSGSGYGTDFTLTISSLQPEDF ATYYCQQSYNTPRTFGQGTKVEIK COV2- 1352 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3-53 IGHJ6 IGKV1-12 IGKJ5 2361 ARDLNEHGL 2037 GISSWLAWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) DV QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQTNSFPTFGQGTRLEIR COV2- 1353 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-46 IGHJ3 IGKV3-20 IGKJ3 2362 ARGTLIPAHR 2039 VSSSFLAWYQQKPGQAPRLLIYGASN (Human) (Human) (Human) (Human) GAFDI RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGNSPQFGPGTKVDIK COV2- 1354 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-61 IGHJ6 IGKV1-5 IGKJ1 2363 ARARPDYYYY 2041 SISNWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) YAMDV ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSTWTFGQGTKVEIK COV2- 1355 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ6 IGKV1-39 IGKJ2 2364 AKAHSTGHQ 2046 SISSFLNWYQQKPGKAPKLLIYAAFNL (Human) (Human) (Human) (Human) YYYGMDV QSGVPSRFSGSGSGTDFTLTISSLQSED FATYYCQQSYNTPYTFGQGTKLEIK COV2- 1356 QSVLTQPPSASGTPGQRVIISCSGSSSN IGHV1-2 IGHJ4 IGLV1-44 IGU2 2365 ARVVVLGYGR 2050 IGSNTVKWYHQLPGTAPKLLICSNNQR (Human) (Human) (Human) (Human) PNNYYDGRN PSGVPDRFSGSKSDTSASLAISGLQSED VWDY EADYYCAAWDDSLNALVFGGGTKLTV L COV2- 1357 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-70 IGHJ4 IGKV1-39 IGKJ5 2366 ARGVVTYDY 2051 SIAGYLNWYQQKPGKAPKLLIYGTTSL (Human) (Human) (Human) (Human) QSGVPVRFSGSGSGTDFTLTISSLQPE DFATYYCQQSYSTPGTFGQGTRLEIK COV2- 1358 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV1-69 IGHJ6 IGKV1-33 IGKJ2 2367 ARGRGYSNY 2054 DINHYLNWYQQKPGKAPKLLIYDASN (Human) (Human) (Human) (Human) GASYYMDV LETGVPSRFSGSGSGTDFTFTITSLQPE DVATYYCQQSDNLPMYTFGQGTKLEI K COV2- 1359 SYVLTQPPSVSVAPGKTARITCEGNNI IGHV3-9 IGHJ6 IGLV3-21 IGU2 2368 AKGRGAGYTS 2055 GSKSVHWYQQKPGQAPVLVVYDDSG (Human) (Human) (Human) (Human) YMDV RPSGIPERFSGSNSGNTATLTISRVEAG DEADYFCQVWDSSSDHHVVFGGGTK LTVL COV2- 1360 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2369 ARMRTGWPT 2064 NIGSYTVNWYQQFPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDF QRTSGVPDRFSGSKSGTSASLAISGLQ SEDEANYYCLVWDDSLNGLVFGGGTK LTVL COV2- 1361 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-53 IGHJ3 IGLV1-40 IGU2 2370 ARSYDILTGYR 2068 NIGSGSDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) DAFDI TNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSRLSGFVVFGGG TKLTVL COV2- 1362 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-34 IGHJ6 IGKV1-39 IGKJ4 2371 ARVGYSQGYY 2070 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) YYYMDV QSGVPSRFSGSGSGTDFSLTISSLQPED FATYSCQQSYTTLLTFGGGTKVEIK COV2- 1363 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2372 AAPHCSRTSC 2072 VSSSYLGWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YDAFDL ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK COV2- 1364 QSVLTQPPSVSGAPGQRVTLSCTGSSS IGHV1-69 IGHJ2 IGLV1-40 IGU3 2373 ARVGVSGFKS 2078 SIGAGYDVHWYQQLPGTAPKLLIYGS (Human) (Human) (Human) (Human) GSSWYFDL SSRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSDSVFGGGT KVTVL COV2- 1365 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-66 IGHJ6 IGKV1-9 IGKJ5 2374 ARDLVTYGLD 2080 ISSYLAWYQQKPGTAPSLLIYAASTLQ (Human) (Human) (Human) (Human) V SGVPSRFSGSGSGTEFTLTISSLQPEDF ATYYCQLLSSHPLTFGQGTRLEIK COV2- 1366 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-20 IGHJ3 IGLV3-19 IGU3 2375 AVIMSPIPRYS 2082 RSYYASWYQQKPGQVPILVIYDKSSR (Human) (Human) (Human) (Human) GYDWAGGAF PSGIPDRFSGSSSGSTASLTITGAQAED DI EADYYCSSRDSSGSAVVFGGGTKLTV L COV2- 1367 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ3 2376 AKSLGPYCSG 2083 DISSYLSWYQQKPGKAPKLLIYDASSL (Human) (Human) (Human) (Human) GTCYSLVGDY ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYASLPFTFGPGTKVDIK COV2- 1368 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-20 IGHJ3 IGLV3-19 IGU2 2377 AVIMSPIPRYS 2094 RSYYASWYQQKPGQVPILVIYDKSSR (Human) (Human) (Human) (Human) GYDWAGDAF PSGIPDRFSGSSSGSTASLTITGAQAED DI EADYYCSSRDSSGSAVVFGGGTKLTV L COV2- 1369 QSVLTQAPSASGTPGQRVTISCSGSSS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2378 ARMRSGWPT 2096 SIGSYTISWYQQLPGTAPKLLIYGSDQ (Human) (Human) (Human) (Human) HGRPDDF RTSGVPDRFSGSKFGTSASLAISGLQSE DESSYYCAVWDDSLSGLVFGGGTKL TVL COV2- 1370 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ6 IGKV1-39 IGKJ1 2379 AKDIIRQGED 2097 SIASYLSWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) GMDV QSGVPSRFSGSGSGTDFTLTISSLQPEE FATYYCQQSYSTPWTFGQGTKVEIK COV2- 1371 DIVMTQSPATLSVSPGERAILSCRASQ IGHV3-23 IGHJ3 IGKV3-15 IGKJ1 2380 VKGLFDWFPL 2098 SVRSSLAWYQQKPGQAPRLLISGAST (Human) (Human) (Human) (Human) RATAIPARFSGSGSGTEFTLTITSLQSE DCAVYYCHQYSSWPQTFGQGTKVEIK COV2- 1372 SFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-7 IGHJ4 IGLV6-57 IGU3 2381 ARLGFYYGGA 2103 SIASSYVQWYQQRPGSAPTTVISEDS (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSIDSSSSSASLTISGL KTEDEADYYCQSYDGISRAWVFGGGT KLTVL COV2- 1373 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-9 IGHJ4 IGKV2-28 IGKJ5 2382 AKGVDYGGK 2108 LLHSLGYSSLSWYLQKPGQSPHLLIYL (Human) (Human) (Human) (Human) LAYFDS GSSRASGVPDRFSGSGSATDFTLKISR LEAEDVGVYYCMQALQTPLTFGQGTR LEIK COV2- 1374 DIQMTQSPSSLSACVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-39 IGKJ5 2383 ARDIDSGYDP 2110 SISSYLSWYQQKPGKGPKLLIYAASSLQ 303 (Human) (Human) (Human) TPVFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYSSLSITFGQGTRLEIK COV2- 1375 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ5 IGKV1-39 IGKJ1 2384 ARVLYDSSGF 2111 SISSYLSWYQQKPGKAPKLLIYAASSLE (Human) (Human) (Human) (Human) YSWFDP SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYEIPPWTFGQGTKVEIK COV2- 1376 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ5 IGKV1-33 IGKJ4 2385 ARDFLRWHD 2113 DISSYLSWYQQKPGKAPKLLIYDASS (Human) (Human) (Human) (Human) L LETGVPLRFSGSGSGTDFIFTISSLQPE DIATYYCQQYDSLPPVFGGGTKVEIK COV2- 1377 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-69 IGHJ6 IGLV1-40 IGU2 2386 ARGRGYSNY 2114 NIGAGYDVHWYQQLPETAPKLLIYAN (Human) (Human) (Human) (Human) GASYYMDV SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGSVFGGGT KLTVL COV2- 1378 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV4-39 IGHJ5 IGLV6-57 IGU2 2387 ARILVIFTLNW 2128 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) FDP QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSGNPIFGGGTKLT VL COV2- 1379 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-15 IGHJ4 IGKV4-1 IGKJ4 2388 TTAGSYYYDT 2130 SVLYSSNNKNYLAWYQQKPGQPPKLL (Human) (Human) (Human) (Human) VGPGLPEGKF MYWASTRESGVPDRFSGSGSGAEFTL DY TISSLQAEDVAIYYCQQYYSTLTFGGGT KVEIK COV2- 1380 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ5 IGKV1-33 IGKJ4 2389 ARDFLRWHD 2132 DINNYLNWYQQKPGKAPKLLIYDASN (Human) (Human) (Human) (Human) L LETGVPLRFSGSGSGTDFTFTISSLQPE DIATYYCQQYDNLPPVFGGGTKVEIK COV2- 1381 NFMLTQPHSVSESPGKTVTFSCTGSSG IGHV4-61 IGHJ4 IGLV6-57 IGU2 2390 AGSPVPPTIV 2137 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) GASY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDGINRWLVFGGGT KLTVL COV2- 1382 QPVLTQPPSASASLGASVTLTCTLSSGY IGHV5-51 IGHJ2 IGLV9-49 IGU2 2391 ARRGEAAGI 2142 SNYKVDWYQQRPGKGPRFVMRVGT (Human) (Human) (Human) (Human) WYFDL GGIVGSKGDGIPDRFSVLGSGLNRYLTI KNIQEEDESDYHCGADHGSGSNFEYV VFGGGTKLTVL COV2- 1383 QSVVTQPPSASGTPGQRVTISCSGSSS IGHV3-66 IGHJ6 IGLV1-44 IGU1 2392 AKEGGSGSLR 2143 NIGYNIVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) YYYYGMDV QRPSGVPDRFSGSKSGTSASLSISGLQS EDEADYYCAAWDDSLNGYVFGTGTK VTVL COV2- 1384 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-48 IGHJ6 IGKV1-9 IGKJ1 2393 ARRSYRSSWY 2146 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) YYYGMDV GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPVTFGQGTKVEIK COV2- 1385 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ6 IGLV2-14 IGU1 2394 ARSTSGSYYY 2147 VGDYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) GMDV SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEAEYYCSSYTSSSTLLYVFGTGTK VTVL COV2- 1386 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3- IGHJ3 IGLV3-21 IGU3 2395 ARDWAPTYY 2150 GNKGVHWYQQKPGQAPVLVVDDDS 303 (Human) (Human) (Human) DMPSAFDI DRPSGIPERFSGSNSGNTATLIISSVEV (Human) GDEADFYCQVWDSSSDHPGVFGGGT KLTVL COV2- 1387 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ1 IGKV3-11 IGKJ4 2396 ARIGSYPEYFQ 2151 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCHYRSNWPPVLTFGGGTKVEIE COV2- 1388 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV4-31 IGHJ4 IGKV1-33 IGKJ2 2397 ARGGSGSYSL 2158 DITNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) FDY ETGVPSRFSGSGSGTDFTFTISSLQPED FATYYCQQYDNLYSVHFGQGTKLEIK COV2- 1389 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ6 IGLV2-14 IGU1 2398 ARSTSGSYYY 2159 VGDYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) GMDV SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEAEYYCSSYTSSSTLLYVFGTGTK VTVL COV2- 1390 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ6 IGLV2-14 IGU1 2399 ARSTSGSYYY 2160 VGDYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) GMDV SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEAEYYCSSYTSSSTLLYVFGTGTK VTVL COV2- 1391 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-66 IGHJ6 IGKV1-9 IGKJ5 2400 ARDLVTYGLD 2165 ISNYLAWYQQKPGTAPNLLIYAASTLQ (Human) (Human) (Human) (Human) V SGVPSRFSGSGSGTEFTLTISSLQPEDF ATYYCQLLNSHPLTFGQGTRLEIK COV2- 1392 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ3 2401 ARIGHFDSSG 2166 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYLDY PTGIPARFTGSGSGTDFTLTISSLEPED FAVYYCQHRTNWPPLFTFGPGTKVDIK COV2- 1393 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU1 2402 ARLSGSSWDF 2171 DKYACWYQQRPGQSPVLVIYQDSKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTGVFGTGTKVTVL COV2- 1394 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-20 IGHJ6 IGKV1-5 IGKJ1 2403 ARRRSSSRYSS 2173 SVSTWLAWYQQKPGKAPNLLIYEASSL (Human) (Human) (Human) (Human) GWYMYYYY ESGVPSRFSGSGSGTEFTLTISSLQPDD MDV FATYYCQQYNTYSGTFGQGTKVEIK COV2- 1395 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU1 2404 ARLSGSSWDF 2175 DKYACWYQQRPGQSPVLVIYQDSKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTGVFGTGTKVTVL COV2- 1396 DIQMTQSPSSLSASVGDRVTITCRARQ IGHV2-5 IGHJ3 IGKV1-39 IGKJ1 2405 AHRLWFRDA 2177 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDI HSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQTYSTFWTFGQGTNVEIK COV2- 1397 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU2 2406 ARVGSSSWYF 2178 DKYACWYQQKPGQSPVVVIYQDSKR (Human) (Human) (Human) (Human) DY PSGIPERFSGSNSGNTATLTISGTQAM DEADYYCQAWDSSTAVFGGGTKLTVL COV2- 1398 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ4 IGLV2-14 IGU2 2407 ARADTMVRG 2183 VGGYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) TYFEY SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEADYCCSSYTSSRAVLFGGGTKL TVL COV2- 1399 SYVLTQPPSVSVAPGKTANITCGGNNI IGHV3- IGHJ4 IGLV3-21 IGU3 2408 ARGGATNFD 2187 GRKSVHWYQQKSGQAPVLVVYDDSD 303 (Human) (Human) (Human) Y RPSGIPERFSGSNSGNTATLTISRVEAG (Human) DEADYYCQVWDSSSDHPEWVFGGGT KLTVL COV2- 1400 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ5 IGKV1-39 IGKJ4 2409 TKASRYCSSTI 2189 SISSYLNWYQQKPGKAPKLLIYGASSLQ (Human) (Human) (Human) (Human) CYWNWFDP TGVPSRFSGSGSGTDFTLTIRSLQPEDF ASYYCQQSYSTPTFGGGTKVEIK COV2- 1401 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-48 IGHJ4 IGLV2-14 IGU2 2410 AREARSRYFD 2190 IGGYNYVSWYQQHPGKAPKLLIYDVS (Human) (Human) (Human) (Human) WLPSYYFDY NRPSGVSTRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSSSTHVVFGGGTKL TVL COV2- 1402 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-20 IGHJ6 IGKV1-5 IGKJ1 2411 ARRRSSSRYSS 2191 SVSTWLAWYQQKPGKAPNLLIYEASSL (Human) (Human) (Human) (Human) GWYMYYYY ESGVPSRFSGSGSGTEFTLTISSLQPDD MDV FATYYCQQYNTYSGTFGQGTKVEIK COV2- 1403 DIVMTQSPDFLAVSLGERATISCKSSQS IGHV3-30 IGHJ4 IGKV4-1 IGKJ4 2412 AKGGDGSG 2195 VLYTPKNKNYLAWYKQKPGQPPKVLIY (Human) (Human) (Human) (Human) WAWDGDNP WASTRESGVPDRFSGSGSGTDFTLIISS PTDY LQAEDAAVYYCQQYYTAPLTFGGGTR VEIK COV2- 1404 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2413 AAPYCSSISCN 2196 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DGFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQHYGSSRGWTFGQGTKVEIK COV2- 1405 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV5-51 IGHJ2 IGKV3-20 IGKJ5 2414 ARPDYSSGW 2197 VSSNFLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) FSYWYFDL RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGRSPITFGQGTRLEIK COV2- 1406 SYELTQPPSVSVSPGQTASITCFGDKLG IGHV1-24 IGHJ4 IGLV3-1 IGU2 2415 ATGFAVFGRA 2199 DKYACWFQQKPGQSPVLIIYQGAKRP (Human) (Human) (Human) (Human) AVPY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTVVFGGGTKLTVL COV2- 1407 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ6 IGKV1-39 IGKJ2 2416 ARGSAGNYYY 2203 TITNYLNWYQLKSGRAPKLLIYAASSLQ (Human) (Human) (Human) (Human) GMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYTFGQGTKLEIK COV2- 1408 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV5-51 IGHJ4 IGLV1-40 IGU3 2417 ASALRERGVQ 2207 NIGAGYDVHWYQQLPGTAPKLLIFINS (Human) (Human) (Human) (Human) LWSV NRPSGVPDRFSGSKSGTSASLAITGLQ AEDEADYYCQSYDSSLGALFGGGTKLT VL COV2- 1409 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-12 IGKJ3 2418 ARDQEWFRE 2210 GISSWLAWYQQKPGKAPKLLIYDASSL 303 (Human) (Human) (Human) LFLFDY QSGVPSRFSGSGSGTDFTLTISSLQPED (Human) FATYYCQQANSFPPTFGPGTKVDIK COV2- 1410 EIVLTQSPAILSLSPGERATLSCRASQS IGHV3-21 IGHJ6 IGKV3-11 IGKJ1 2419 ARVNGNSN 2212 VSSYLAWYQQKPGQAPRLLIYDTSNRAT (Human) (Human) (Human) (Human) WNFGSYYYYY GIPARFSGSGSGTDFTLTISSLEPEDFA MDV FYYCQQRGNWWTFAQGTKVEIK COV2- 1411 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ3 2420 ARIGHFDSSG 2214 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYLDY PTGIPARFTGSGSGTDFTLTISSLEPED FAVYYCQHRTNWPPLFTFGPGTKVDIK COV2- 1412 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-21 IGHJ6 IGKV3-15 IGKJ1 2421 ARWLQLRSD 2215 SVSNNLAWYQHKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) YYYFGMDV RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYFCQQCYNWPPWTFGQGTKVE IK COV2- 1413 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2422 ARTSHYDSSG 2216 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) SYFEY ATGIPARFSGSGSGTDFTLTISSLDPED FAVYYCHKRSNWPPSLTFGGGTKVEIK COV2- 1414 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ6 IGKV4-1 IGKJ1 2423 ARPYTGSYKS 2218 SVLYSSNNKNSLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YMDV YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSISWTFGQG TKVEIK COV2- 1415 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-59 IGHJ4 IGLV2-23 IGU2 2424 ARAPRERLQ 2222 VGSYNLVSWYQQHAGKAPKLMIYEVI (Human) (Human) (Human) (Human) WGEYYFDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAVSTTYVIFGGGTKLT VL COV2- 1416 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ1 2425 AKDGSIAAAD 2224 SVLHSSNNKDSLVWYQQKPGQPPKLL (Human) (Human) (Human) (Human) Y IYWASSRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPWTFGQG TKVEIK COV2- 1417 QPVLTQPPSASASLGASVTLTCTLSSGY IGHV5-51 IGHJ4 IGLV9-49 IGU2 2426 ATHRCSGGFC 2226 SNYKVDWYQQRPGKGPRFVMRVGT (Human) (Human) (Human) (Human) YLAY GGIVGSKGDGIPDRFSVLGSGLNRYLTI KNIQEEDESDYHCGADHGSGSNFVFV VFGGGTKLTVL COV2- 1418 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-33 IGHJ6 IGKV2-28 IGKJ3 2427 ARDQSQGAYI 2227 LLHSNGYNYLDWYLQKPGQSPQFLIYL (Human) (Human) (Human) (Human) LTGYRGYGM GSNRASGVPDRFSGSGSGTDFILKISR DV VEAEDVGVYYCMQALQTPFTFGPGTK VDIK COV2- 1419 EIVMTQSPATLSVSPGERATLSCRASQ IGHV4-34 IGHJ6 IGKV3-15 IGKJ4 2428 ARPPQAARIH 2228 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) YYYYMDV RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNYWPPLTFGGGTKVEI K COV2- 1420 SYVLTQPPSVSVAPGKTARITCEGNNI IGHV3-9 IGHJ6 IGLV3-21 IGU2 2429 AKGRGAGYTS 2231 GSKSVHWYQQKPGQAPVLVVYDDSG (Human) (Human) (Human) (Human) YMDV RPSGIPERFSGSNSGNTATLTISRVEAG DEADYFCQVWDSSSDHHVVFGGGTK LTVL COV2- 1421 DIQMTQSPSTLSASVGDRVTITCRASH IGHV3-53 IGHJ4 IGKV1-5 IGKJ1 2430 ARESTQ 2235 SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNTYSQTFGQGTKVEIK COV2- 1422 FYELTQPPSVSVSPGQTAGITCSGDKL IGHV2-5 IGHJ4 IGLV3-1 IGU3 2431 AHRAVILNFD 2238 GHKYAYWYQQKPGQSPILLIYQDDKR (Human) (Human) (Human) (Human) PSGIPERFSGSNSGTIATLTISGTQPVD EADYYCQAWDNDAGVVFGGGTKLTV L COV2- 1423 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-16 IGKJ4 2432 ARPRSGSYYA 2239 GISNYLAWFQQKPGKAPKSLIYAASSL 303 (Human) (Human) (Human) YFDY QSGVPSKFSGSGSGTDFTLTISSLQPED (Human) VATYYCQQYNSHPPTFGGGTKVEIK COV2- 1424 QSALTQPPSASGSPGQSVTISCTGTSS IGHV3-9 IGHJ4 IGLV2-8 IGU2 2433 AKVGYTISRQ 2240 DVGTYNYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) WLVGEFDY VSKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEAEYYCSAYAGSNNLVFGGGT KLTVL COV2- 1425 QPVLTQPPSASASLGASVTLTCTLSSGY IGHV5-51 IGHJ2 IGLV9-49 IGU2 2434 ARRGEAAGI 2241 SNYKVDWYQQRPGKGPRFVMRVGT (Human) (Human) (Human) (Human) WYFDL GGIVGSKGDGIPDRFSVLGSGLNRYLTI KNIQEEDESDYHCGADHGSGSNFEYV VFGGGTKLTVL COV2- 1426 QSALTQPASVSGSHGQSITISCTGTSSD IGHV4-39 IGHJ4 IGLV2-23 IGU2 2435 ARQSRGYSYA 2243 VGSYNLVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) WSFDY KRPSGVSNRFSGSTSGNTASLTISGLQ AEDEADYYCCSYAGIVLFGGGTKVTVL COV2- 1427 SYELTQPPSVSVSPGQTTRITCSGDALP IGHV3-33 IGHJ6 IGLV3-25 IGU3 2436 AGSSGEGGLY 2245 KQYGYWYQQKAGQAPILVIYKDSERP (Human) (Human) (Human) (Human) YYYGMDV SGIPERFSGSSSGTTVTLTISGVQAEDE AHYYCQSGDSSGTYVVFGGGTKLTVL COV2- 1428 SYELTQPPSVSVSPGQTARITCSGDALS IGHV3-30 IGHJ4 IGLV3-25 IGU3 2437 ARDSGGNYG 2248 KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) DSYFDY SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSVDRSGTYFNWVFGGGTKLT VL COV2- 1429 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ6 IGKV1-39 IGKJ2 2438 ARGSAGNYYY 2250 TITNYLNWYQLKSGRAPKLLIYAASSLQ (Human) (Human) (Human) (Human) GMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYTFGQGTKLEIK COV2- 1430 QTVVTQEPSLTVSPGGTVTLTCASSAG IGHV2-26 IGHJ5 IGLV7-43 IGU3 2439 ARIVLGASGT 2251 AVTSGYYPNWFQQKPGQAPRALIYST (Human) (Human) (Human) (Human) YPSPGFDP ANKHSWTLARFSGSLLGGKAALTLSG VQPEDEAEYYCLLYYGGAWVFGGGTK LTVL COV2- 1431 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-74 IGHJ4 IGLV6-57 IGU2 2440 AGSPWLRGDI 2253 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSIDSSSNSASLTISGL MTEDEADYYCQSYDGSNHAVVFGGG TKLTVL COV2- 1432 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV7-4- IGHJ5 IGLV3-21 IGU2 2441 ARDPSYCSST 2256 GSKNVHWYQQKPGQAPVVVVYDDS 1 (Human) (Human) (Human) RCYTVGWFD DRPSGIPERFSGSNSGNTATLTISRVEA (Human) P GDEADYYCQVWDSSSDPVVFGGGTK LTVL COV2- 1433 NIVMTQSPLSLPVTPGEPASISCRSSQS IGHV4-61 IGHJ4 IGKV2-28 IGKJ1 2442 ARGHVAAWE 2257 LLNSNGLTYLDWYLQKPGQSPQLLIYF (Human) (Human) (Human) (Human) SCYY VSNRASGVSDRFSGSGSGADFTLTISR VEAEDVGVYYCMQALQTPQTFGQGT KVEIK COV2- 1434 EIVLTQSPGTLSLSPGERATLSCGASQS IGHV3-20 IGHJ3 IGKV3-20 IGKJ4 2443 ARARGPSEQY 2258 ISSSYLAWYQQKPGQAPRLLIYGASSRA (Human) (Human) (Human) (Human) YDLLTGYYDA AGIPDRFSGSGSGTDFTLTISRLEPEDF FDI AVYFCQQYGGSLTFGGGTKVEIK COV2- 1435 SYELTQPPSVSVSPGQTASITCSGDKM IGHV3-23 IGHJ4 IGLV3-1 IGU2 2444 AQMGPLGST 2260 GDKYACWYQQKPGQSPVVVIYEDNK (Human) (Human) (Human) (Human) SSAADY RPSGIPERFSGSNSGNTATLTISGTQA MDEADYYCQAWDSSLVVFGGGTKLT VL COV2- 1436 QSALTQPPSVSGSPGQSVTISCTGTSS IGHV1-8 IGHJ6 IGLV2-18 IGU3 2445 AREARYFDWI 2262 DVGSYNRVSWYQQPPGTAPKLMIYE (Human) (Human) (Human) (Human) FEGSDYYYYG VSNRPSGVPDRFSGSKSGNTASLTISG MDV LQAEDEADYYCSSYTSSSLRVFGGGTK LTVL COV2- 1437 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-48 IGHJ6 IGKV1-9 IGKJ1 2446 ARRSYRSSWY 2263 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) YYYGMDV GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPVTFGQGTKVEIK COV2- 1438 QSALTQPRSVSGSPGQSVTISCTGTSS IGHV3-49 IGHJ3 IGLV2-11 IGU1 2447 IRDYDFWGG 2266 DVGGYNYVSWYQQHPGKAPKLMIYD (Human) (Human) (Human) (Human) YYYHPLRAFDI VTKRPSGVPERFSGSKSGNTASLTISGL QAEDEADYSCCSYAGSYTYVFGTGTKV TVL COV2- 1439 QSALTQPASVSGSPGQSITISCTGTGSD IGHV2-5 IGHJ3 IGLV2-14 IGU2 2448 ARHQIVVLFD 2268 VGGSNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) M SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTLVLFGGGTKL SVL COV2- 1440 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ2 2449 AITYYYDSSGY 2270 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) WWDD ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPSYTFGQGTKLEIK COV2- 1441 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ6 IGLV2-14 IGU3 2450 AGEEVRGVKL 2273 IGGYNYVSWYQQHPGKAPKLMIYDVS (Human) (Human) (Human) (Human) YYYYAMDV NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSISTWVFGGGTKVT VL COV2- 1442 SYELTQPSSVSVSPGQTARITCSGDALP IGHV3-48 IGHJ4 IGLV3-10 IGU2 2451 ARDRGWNYG 2274 KRYAYWYRQKSGQAPVLVIHEDSKRP (Human) (Human) (Human) (Human) LDY SGIPERFSGSTSGTMATLTITGAQLEDE ADYYCFSMDSSGDLRVFGGGTKLTVL COV2- 1443 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ4 2452 ARDVPTTVTA 2277 SISTYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) FTVFTY SGVPSRFSGSGSGTDFTLTISSLQPEDY ATYYCQQSYSTPGLTFGGGTKVEIK COV2- 1444 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ4 IGLV2-14 IGU2 2453 ARVPVMVRG 2281 VVGYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) VYFDY RNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEADYFCISYTSSRTLVFGGGTKLT VL COV2- 1445 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV1-8 IGHJ6 IGLV3-21 IGU2 2454 ARGYGLTYY 2287 GSKNVHWYQQKPGQAPVLVVYDDS (Human) (Human) (Human) (Human) MDV DRPSGIPERFSGSNSGNTATLTISRVEA GDEADYYCQVWDSSYYHPVVFGGGT KLTVL COV2- 1446 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2455 ARMRSGWPT 2290 NIGSYTVNWYQQFPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDF QRTSGVPDRFSGSKSGTSASLAISGLQ SEDEANYYCLVWDDSLNGLVFGGGTK LTVL COV2- 1447 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV3-23 IGHJ4 IGLV1-51 IGU2 2456 AKNERITMLV 2293 NIGNNYISWYQQLPGTAPKLLIYDNNK (Human) (Human) (Human) (Human) VVTLFDY RPSGIPDRFSGSKSGTSATLGITGLQTG DEADYYCGTWDSSLSAVVFGGGTKLT VL COV2- 1448 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-66 IGHJ6 IGKV1-5 IGKJ1 2457 ARDPSAYYDIL 2296 SINSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) TGYSGDV ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYSIYSWTFGQGTKVEIK COV2- 1449 DIQMTQSPSSLSACVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-39 IGKJ1 2458 ARDIDSGYDP 2299 SISSYLNWYQQKPGKGPKLLIYAASSLQ 303 (Human) (Human) (Human) TPVFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYSTPWTFGQGTKVEIK COV2- 1450 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV4-4 IGHJ4 IGKV1-12 IGKJ4 2459 ASRWGDYFD 2300 GISSWLAWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) SSGAYDS QRGVPSRFSGSGSGTDFTLTISSLQPE DFATYYCQQANSLPLTFGGGTKVEVK COV2- 1451 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV3-21 IGHJ4 IGLV1-44 IGU2 2460 ARDPVWVDG 2304 NIESNSVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) ELLSGGIPFDY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGVVFGGGT KLTVL COV2- 1452 QSVLTQPPSASGTPGQRVTISCSGSTS IGHV4-39 IGHJ6 IGLV1-44 IGU3 2461 AILWRGSSW 2305 NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) ADRHYYYYSM QRPSGVPDRFSGSKSGPSASLAISGLQ DV SVDEADYYCAAWDDSLNGWVFGGG TKLTVL COV2- 1453 SYELTQSPSVSVSPGQTASITCSGDKLG IGHV3- IGHJ5 IGLV3-1 IGU3 2462 ARDLGRGLDP 2307 DKYACWYQQRPGQSPVLVIYQDSQR 303 (Human) (Human) (Human) PSGIPERFSGSNSGNTATLTISGTQAM (Human) DEADYYCQAWDSSTAVFGGGTKLTVL COV2- 1454 DIVMTQSPATLSVSPGERAILSCRASQ IGHV3-23 IGHJ3 IGKV3-15 IGKJ1 2463 VKGLFDWFPL 2308 SVRSNLAWYQQKPGQAPRLLISGAST (Human) (Human) (Human) (Human) RATAIPARFSGSGSGTEFTLTITSLQSE DCAVYYCHQYNNWPQTFGQGTKVEIK COV2- 1455 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-61 IGHJ6 IGKV1-39 IGKJ4 2464 ATGYIGTYYYY 2310 SISTYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) MDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYHCQQSYSTLTFGGGTKVEIK COV2- 1456 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-9 IGHJ4 IGKV3-11 IGKJ4 2465 AKVSSITSLLG 2313 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYFDS ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQHRSNWPPRLTFGGGTKVEIK COV2- 1457 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-70 IGHJ4 IGKV1-39 IGKJ5 2466 ARGVVTYDY 2318 SIAGYLNWYQQKPGKAPKLLIYGTTSL (Human) (Human) (Human) (Human) QSGVPVRFSGSGSGTDFTLTISSLQPE DFATYYCQQSYSTPGTFGQGTRLEIK COV2- 1458 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-30 IGHJ5 IGKV3-20 IGKJ2 2467 ARGDGYRSQ 2322 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) FDP ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSYTFGQGTKLEIK COV2- 1459 DIQMTQSPSSLSASVGDRVTITCRARQ IGHV2-5 IGHJ3 IGKV1-39 IGKJ1 2468 AHRLWFRDA 2325 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDI HSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQTYSTFWTFGQGTNVEIK COV2- 1460 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV3-23 IGHJ6 IGLV1-47 IGU3 2469 ARVEGDWLL 2329 NIGSNYVYWYQQLPGTAPKLLISRNN (Human) (Human) (Human) (Human) GGPYYHYYG QRPSGVPDRFSGSKSGTSASLAISGLRS MDV EDEADYYCAAWDDSLSSWVFGGGTK LTVL COV2- 1461 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV4-39 IGHJ5 IGLV6-57 IGU2 2470 ARILVIFTLNW 2331 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) FDP QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSGNPIFGGGTKLT VL COV2- 1462 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU3 2471 ARLGGSSWH 2333 DKYSSWYQQKPGQSPVLVIYEDTKRPS (Human) (Human) (Human) (Human) FDY GIPERFSGSNSGNTATLTISGTQAMDE ADYYCQAWSSSTAVFGGGTKLTVL COV2- 1463 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ6 IGLV2-14 IGU2 2472 ARHDGSGEM 2335 VGGYNYVSWYQQHPGKAPKLMIYYV (Human) (Human) (Human) (Human) DTITWGPIYYY SNRPSGVSNRFSGSKSGNTASLTISGL MDV QAEDEADYYCSSYTSSTLNVLFGGGTK LTVL COV2- 1464 DIQMTQSPSSLSASVGDRVTITCRARQ IGHV2-5 IGHJ3 IGKV1-39 IGKJ5 2473 AHRLWFRDA 2337 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDI HSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPGTFGQGTRLEIK COV2- 1465 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-3 IGHJ5 IGLV1-40 IGU1 2474 AMGPSAFSW 2340 NIGAGYDVHWYQHLPGTAPKLLIYGN (Human) (Human) (Human) (Human) LDP SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGWSVFGTG TKVTVL COV2- 1466 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ6 IGLV2-14 IGU1 2475 ARSTSGSYYY 2341 VGDYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) GMDV SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEAEYYCSSYTSSSTLLYVFGTGTK VTVL COV2- 1467 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-5 IGHJ4 IGKV1-39 IGKJ2 2476 AHRPPSYHG 2342 SISIYLNWYQQKPGKAPKLLIYAASTLQ (Human) (Human) (Human) (Human) WCYFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTHMSTFGQGTKLEIK COV2- 1468 DIVVTQTPLSLSVTPGQPASISCKSSET IGHV1-18 IGHJ4 IGKV2D-29 IGKJ5 2477 ARVQRRRLDY 2343 LLHSDGKTYLSWYLQKPGQPPQLLIYEV (Human) (Human) (Human) (Human) SNRFSGVPDRFSGSGSGTDFTLKIGRV EAEDVGLYYCMQSIQLAFGQGTRLEIE COV2- 1469 EIVMTQSPATLSVSPGERATLSCRASQ IGHV4-34 IGHJ6 IGKV3-15 IGKJ4 2478 ARPPQAARIH 2346 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) YYYYMDV RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNYWPPLTFGGGTKVEI K COV2- 1470 SSELTQDPAVSVALGQTVTITCQGDSL IGHV5-51 IGHJ4 IGLV3-19 IGU2 2479 ARRFYGPSSF 2351 RSHYASWYKVKPGQAPLLVIYGRNNR (Human) (Human) (Human) (Human) DY PSGIPDRFSGSRSGNTASLTITGAQVD DEADYYCSSGDSSTDHHVVFAGGTKL AW COV2- 1471 DMEVTQFPSSLSASIGDRVTITCRATQ IGHV1-46 IGHJ4 IGKV1-39 IGKJ4 2480 ARGGEWRIV 2352 SISTYLNWYQQKPGKAPNLLIYSASHL (Human) (Human) (Human) (Human) PGGRDYFDY QRGVPARFSGSGSGTEFTLTITTLQPE DVGTYYCHQSYGVPITFGGGTKVDIK COV2- 1472 EIVMTQSPATLSVSPGERATLSCRASQ IGHV5-51 IGHJ5 IGKV3-15 IGKJ2 2481 ARLGVSKYCS 2353 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) GGRCLSGGS RATGIPARFSGSGSGTEFTLTISSLQSE NWFDP DFAVYYCQQYNNWPPMYTFGQGTKL EIK COV2- 1473 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-53 IGHJ3 IGLV6-57 IGU2 2482 ASSSWLRGAF 2354 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DI QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSKYVVFGGGTKL TVL COV2- 1474 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2483 AAPHCNRTSC 2355 VSSSYLGWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YDAFDL ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK COV2- 1475 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-49 IGHJ6 IGKV2-28 IGKJ2 2484 SRVRGSFYGS 2357 LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) VGKNYGMDV GSTRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPLYTFGQGT KLEIK COV2- 1476 DIQMTQSPSSLSACVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-39 IGKJ5 2485 ARDIDSGYDP 2358 SISSYLNWYQQKPGKGPKLLIYAASSLQ 303 (Human) (Human) (Human) TPVFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYSSLSITFGQGTRLEIK COV2- 1477 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2486 ARTSHYDSSG 2367 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) SYFEY ATGIPARFSGSGSGTDFTLTISSLDPED FAVYYCHKRSNWPPSLTFGGGTKVEIK COV2- 1478 SNELTQPPSVSVSPGQTARITCSGDAL IGHV5-51 IGHJ6 IGLV3-25 IGU2 2487 ARRRGGIGIE 2368 PKQYAYWYQQKPGQAPVLVIYKDTER (Human) (Human) (Human) (Human) YGMDV PSGIPERFSGSSSGTTVTLTISGVQAED EADYYCQSTASSGTYVVFGGGTKLTVL COV2- 1479 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ1 2488 AKDFGGDNT 2369 SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) AMVEYFFDF ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSPTFGQGTKVEIK COV2- 1480 NFMLTQPHSVSESPGKTVTFSCTGSSG IGHV4-61 IGHJ4 IGLV6-57 IGU2 2489 AGSPVPPTIV 2370 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) GASY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDGINRWLVFGGGT KLTVL COV2- 1481 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-15 IGKJ1 2490 AKGRGNYLTF 2371 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) FDS RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPGTFGQGTKVEI K COV2- 1482 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-66 IGHJ6 IGKV3-20 IGKJ2 2491 ARDPGSRYSG 2373 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) GWYDYYYAM ATGIPDRFSGSGSGTDFTLTISRLEPED DV FAVYYCQQYGSSPPYTFGQGTKLEIK COV2- 1483 QPVLTQPPSASASLGASVTLTCTLSSGY IGHV5-51 IGHJ4 IGLV9-49 IGU2 2492 ARRDTDFDY 2378 SNYKVDWFQQRPGKGPRFVMRVGT (Human) (Human) (Human) (Human) GGIVGSKGDGIPDRFSVLGSGLNRYLTI KNIQEEDESDYHCGADHGSGSNFVYV VFGGGTKLTVL COV2- 1484 EVVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2493 AAPYCSRTSC 2381 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) HDAFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYHCQHFGSSSQWTFGQGTKVEIK COV2- 1485 QTVVTQEPSLTVSPGGTVTLTCASSTG IGHV3-30 IGHJ4 IGLV7-43 IGU3 2494 AKDLPPYASG 2382 AVTSGYFPNWFQQKPGQAPRALIFST (Human) (Human) (Human) (Human) WYEGGFDY NNRHSWTPARFSGSLLGDKAALTLSG VQPEDEAEYYCLLYYGGPWVFGGGTK LTVL COV2- 1486 EIVMTQSPGTLSVSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-15 IGKJ1 2495 AQGRGGYYS 2383 TLSSNLAWYQQKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) PFDD ATGIPARFSGSGSGTEFTLTISSLQSED FAVYHCQQYNNWPLAFGQGTKVEIK COV2- 1487 QSALTQPASVSGSPGQSITISCTGTSSD IGHV2-26 IGHJ2 IGLV2-23 IGU2 2496 ARTTWGTWI 2384 IGSYNLVSWYQQYPGKAPKLMIYEVSK (Human) (Human) (Human) (Human) QAWYFDI RPSGVSNRFSGSKSGNTASLTISGLQA EDEADYYCCSYAGGNTFVVFGGGTKL TVL COV2- 1488 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-33 IGHJ5 IGKV3-15 IGKJ1 2497 AREGDFWSG 2386 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) YYTGWFDP RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPRTFGQGNRVEI N COV2- 1489 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ4 IGLV2-14 IGU2 2498 AKDLTIVVIPA 2387 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) APNFDY SNRPSGVSNRFSGSRSGNTASLTISGL QAEDEADYYCSSYTSSSTPVVFGGGTK LTVL COV2- 1490 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-23 IGHJ6 IGKV2-28 IGKJ1 2499 AKDQARVQD 2388 LLHSNGYNYLDWYLQKPGQSPHLLIYL (Human) (Human) (Human) (Human) YIWGSYRSYG GSNRASGVPDRFSGSGSGTDFTLKISR MDV VEAEDVGVYYCMQALQTPRTFGQGT KVEIK COV2- 1491 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ6 IGKV1-39 IGKJ1 2500 AKDIIRQGED 2389 NIASYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) GMDV QSGVPSRFSGSGSGTDFTLTISSLQPEE FATYYCQQSYSTPWTFGQGTKVEIK COV2- 1492 QSVLTQAPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2501 ARMRSGWPT 2391 NIGSYTINWYQQLPGTAPKLLIYGNDQ (Human) (Human) (Human) (Human) HGRPDDF RTSGVPDRFSGSKFGTSASLAISGLQSE DENNYYCAVWDDSLNGLVFGGGTKL TVL COV2- 1493 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-21 IGHJ6 IGKV3-15 IGKJ1 2502 ARWLQLRSD 2394 SVSNNLAWYQHKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) YYYFGMDV RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYFCQQCYNWPPWTFGQGTKVE IK COV2- 1494 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU1 2503 ARLSGSSWDF 2397 DKYACWYQQRPGQSPVLVIYQDSKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTGVFGTGTKVTVL COV2- 1495 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-66 IGHJ4 IGKV1-33 IGKJ1 2504 ARDYRDWI 2399 DISKYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) ERGVPSRFSGSGSGTDFTFTISSLQAED IATYYCQQYHNLPRTFGQGTKVEIK COV2- 1496 DIQLTQSPSFLSASVRDRVTITCRASQG IGHV2-5 IGHJ4 IGKV1-9 IGKJ3 2505 AHNRFQYCSS 2400 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) TTCYTLLPFDY GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPFTFGPGTKVDIK COV2- 1497 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ6 IGKV4-1 IGKJ1 2506 ARPYTGSYKS 2401 SVLYSSNNKNSLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YMDV YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSISWTFGQG TKVEIK COV2- 1498 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ5 IGLV2-14 IGU1 2507 ARGDGDVYN 2403 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) FLLVRNWFDP GNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTLYVFGTGTKV TVL COV2- 1499 DIQMTQSPSSLSASVGDRVTFTCRASQ IGHV4-39 IGHJ4 IGKV1-27 IGKJ1 2508 ASLWFGDLYS 2405 GISNYLAWYQQKPGKVPKLLIYAASTL (Human) (Human) (Human) (Human) FDY QSGVPSRFSGIGSGTDFTLTISSLQPED VATYYCQKYNSAPWTFGQGTKVEIK COV2- 1500 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU2 2509 ARLGRSSWN 2406 DKFVCWYQQKPGQSPVLVIYQDNKR (Human) (Human) (Human) (Human) FDY PSGIPERFSGSNSGNTATLTISGTQALD EADYYCQAWDSSTGVFGGGTKLTVL COV2- 1501 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV4-61 IGHJ6 IGKV1-9 IGKJ5 2510 ARVGGISPYY 2408 ISSYLAWYQQKPGKAPKLLMYAASTL (Human) (Human) (Human) (Human) YYYYMDV QSGVPSRFSGSGSGTEFTLTINTLQPE DFATYYCQQLNSYPITFGQGTRLEIK COV2- 1502 QSVLTQPPSASGTPGQRVTFSCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU3 2511 ARMRSGWPT 2413 NIGSYTVNWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAVWDDSLNGLVFGGGT KLTVL COV2- 1503 QSVLTQPPSVSEAPRQRVTISCSGSSS IGHV4-31 IGHJ4 IGLV1-36 IGU2 2512 ASAKLVATISY 2416 NIGNNAVNWYQQLPGKAPKLLIYYDD (Human) (Human) (Human) (Human) FDY LLPSGVSDRFSGSKSGTSASLAISGLQS EDEADYYCAAWDDSLNGVVFGGGTK LTVL COV2- 1504 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-34 IGHJ6 IGKV1-39 IGKJ4 2513 ARVGGYYYYY 2417 SITSYLNWYQQRPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) MDV SGVPSRFSGSGSGTDFTLSISSLQPEDF ATYYCQQSYTTLLTFGGGTKVEIK COV2- 1505 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-23 IGHJ6 IGLV2-14 IGU3 2514 AKPYGMDV 2418 VGGYNFVSWHQQHPGKAPKNMIYD (Human) (Human) (Human) (Human) VSKRPSGVSNRFSGSKSGNTASLTISGL HTEDEADYYCSSYTSTSTPWVFGGGTK LTVL COV2- 1506 EIVMTQSPGTLSVSPGERATLSCRASQ IGHV3-30 IGHJ3 IGKV3-15 IGKJ5 2515 ARDRSNLERL 2420 SLSSHLAWYQQKPGQAPRLLIYGVSTR (Human) (Human) (Human) (Human) VMTFGGIIAG ATGIPARFSGSGSGTEFTLAISSLQSED AFDI SAVYYCQQYHVWPPITFGQGTRLEIK COV2- 1507 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ1 2516 ARVNSGSYYS 2422 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YFDY YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPLTFGQGT KVEIK COV2- 1508 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV4-4 IGHJ4 IGKV1-12 IGKJ4 2517 ASRWGDYFD 2427 GISSWLAWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) SSGAYDS QSGVPSRFSGSGSGTDFTLTITSLQPED FATYYCQQGNSFPLTFGGGTKVEIK COV2- 1509 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-33 IGHJ4 IGLV1-40 IGU3 2518 ARKGPLWRF 2428 NIGAGYDVHWYQQIPGTAPKLLFYGN (Human) (Human) (Human) (Human) DY NNRPSGVPDRFSDSKSGTSASLAITGL QAEDEADYYCQSYDSSLSAWVFGGGT KLTVL COV2- 1510 DIQMTQSPSTLSASVGDRVTITCRASH IGHV3-53 IGHJ4 IGKV1-5 IGKJ1 2519 ARESTQ 2429 SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNTYSQTFGQGTKVEIK COV2- 1511 EIVLTQSPATLSLSPGERATLSCRASQS IGHV4-39 IGHJ6 IGKV3-11 IGKJ5 2520 ARAPFQLLDK 2430 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYFFYYMDV ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPGVTFGQGTRLEIK COV2- 1512 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ4 IGKV1-33 IGKJ2 2521 ARHIPAWGY 2434 DIRNYLNWYQQKPGKAPELLIYDASNL (Human) (Human) (Human) (Human) K ETGVPSRFSGSGSGTDFIFTISSLQPED IATYYCHQYDYLPYTFGQGTKLDIK COV2- 1513 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-23 IGHJ3 IGKV1-39 IGKJ2 2522 AKLLGSGITLD 2438 SISSYLNWYQQKPGKAPKLLIYAATSLQ (Human) (Human) (Human) (Human) NDAFDI SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQTYSTPLYTFGQGTKLEIK COV2- 1514 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ3 2523 ARIGHFDSSG 2441 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYLDY PTGIPARFTGSGSGTDFTLTISSLEPED FAVYYCQHRTNWPPLFTFGPGTKVDIK COV2- 1515 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-23 IGHJ4 IGLV3-25 IGU2 2524 AKDFGSGIVG 2444 NQYAYWYQQKPGQAPVLVMCKDSE (Human) (Human) (Human) (Human) ATGFDF RPSGIPERFSGSSSGTTVTLTISGVQAE DEADYYCQSADSSGTYVVFGGGTKLT VL COV2- 1516 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-20 IGHJ6 IGKV1-5 IGKJ1 2525 ARRRSSSRYSS 2445 SVSTWLAWYQQKPGKAPNLLIYEASSL (Human) (Human) (Human) (Human) GWYMYYYY ESGVPSRFSGSGSGTEFTLTISSLQPDD MDV FATYYCQQYNTYSQTFGQGTKVEIK COV2- 1517 QPVLTQPPSASASLGASVTLTCTLSSGY IGHV5-51 IGHJ4 IGLV9-49 IGU2 2526 ATHRCSGGFC 2446 SNYKVDWYQQRPGKGPRFVMRVGT (Human) (Human) (Human) (Human) YLAY GGIVGSKGDGIPDRFSVLGSGLNRYLTI KNIQEEDESDYHCGADHGSGSNFVFV VFGGGTKLTVL COV2- 1518 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ1 IGKV4-1 IGKJ1 2527 ARASYNSNW 2449 SLLYTSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) SIGEYFRD YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSPPWTFGQG TKVEIK COV2- 1519 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ5 2528 AKQGGLYCSG 2450 DISNYLHWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) TNCWGGYLD ETGVPSRFSGSGSGTDFTFTISSLQPED Y IATYYCQQYHNLPPITFGQGTRLEIK COV2- 1520 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV2-5 IGHJ4 IGLV3-1 IGU1 2529 VHRHVSGAF 2451 ETYVSWYQQKPGQSPVLVIYEDSKRPS (Human) (Human) (Human) (Human) DY GIPERFSGSNSGNTATLTISGTQAMDE ADYYCQAWDSSTGGVFGTGTKVTVL COV2- 1521 DIQMTQSPSSLSASVGDRVTITCQASL IGHV7-4- IGHJ3 IGKV1-33 IGKJ5 2530 ARARLLGYCS 2453 DISKYLNWYQHKPGKAPNLLIYDAFNL 1 (Human) (Human) (Human) STSCYTIGWG ERGVPSRFSGSGSGTDFTFTISSLQPED (Human) AFDI IATYYCQQYDNLPPGVSTTFGQGTRLE IK COV2- 1522 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-33 IGHJ4 IGLV3-10 IGU3 2531 AREGQGTYLD 2454 KKYAHWYQQKSGQAPVLVIYEDSKRP (Human) (Human) (Human) (Human) Y SGIPERFSGSSSGTMATLTISGAQVED EADYYCCSTDSSGNQRVFGGGTKLTVL COV2- 1523 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-48 IGHJ4 IGLV2-14 IGU2 2532 AREARSRYFD 2455 IGGYNYVSWYQQHPGKAPKLLIYDVS (Human) (Human) (Human) (Human) WLPSYYFDY NRPSGVSTRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSSSTHVVFGGGTKL TVL COV2- 1524 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-30 IGHJ4 IGLV3-25 IGU2 2533 ARDPSPLVLIT 2458 RQYTYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) SIDY SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADTIGTYWVFGGGTKLTVL COV2- 1525 EIVMTQSPATVSVSPGERATLSCRASQ IGHV4-39 IGHJ5 IGKV3-15 IGKJ2 2534 ARRGNYYDSK 2459 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) NWFDP RATGIPARFSASGSGTEFTLTISSLQSE DFAVYYCQQYNNWPPMYTFGQGTKVE IK COV2- 1526 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV4-31 IGHJ4 IGKV1-33 IGKJ2 2535 ARGGSGSYSL 2461 DITNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) FDY ETGVPSRFSGSGSGTDFTFTISSLQPED FATYYCQQYDNLYSVHFGQGTKLEIK COV2- 1527 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ5 IGKV1-39 IGKJ1 2536 ARVLYDSSGF 2462 SISSYLNWYQQKPGKAPKLLIYAASSLK (Human) (Human) (Human) (Human) YNWFDP SGVPSRFGGSGSGTDFTLTISSLQPEDF ATYYCQQSYEMPPWTFGQGTKVEIE COV2- 1528 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-31 IGHJ2 IGLV3-25 IGU1 2537 ARDLGDGYN 2464 NQYAYWYHQKPGQAPVVVIYKDSER (Human) (Human) (Human) (Human) LRVPAYFDL PSGIPQRFSGSSSGTTVTLTISGVQAED EADYYCQSADSSGYVFGTGTKVTVL COV2- 1529 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ4 IGLV2-14 IGU1 2538 ARVDHVNVR 2465 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) DY SKRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSSSIPYVFGTGTKVT VL COV2- 1530 EIVLTQSPAILSLSPGERATLSCRASQS IGHV3-21 IGHJ6 IGKV3-11 IGKJ1 2539 ARVNGNSN 2466 VSSYLAWYQQKPGQAPRLLIYDTSNRAT (Human) (Human) (Human) (Human) WNFGSYYYYY GIPARFSGSGSGTDFTLTISSLEPEDFA MDV FYYCQQRGNWWTFAQGTKVEIK COV2- 1531 SYELTQPPSVSVSPRQTARITCSGDALP IGHV3-33 IGHJ4 IGLV3-10 IGU3 2540 AREGQMAAT 2473 KKYAYWYQQKSGQAPVLVIYEDSKRP (Human) (Human) (Human) (Human) TGIDY SGIPERFSGSSSGTMATLTISGAQVED EADYYCYSTDTSGNHWVFGGGTKLTV L COV2- 1532 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-15 IGHJ3 IGLV3-10 IGU3 2541 TTLTYYYDSSA 2474 KKYAYWYQQKSGQAPVLVISEDSKRP (Human) (Human) (Human) (Human) YLNDAFDI SGIPERFSGSSSGTVATLTISGAQVEDE ADYYCYSTDSSGNHRVFGGGTKLTVL COV2- 1533 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-9 IGHJ4 IGKV3-20 IGKJ2 2542 AKGIYYDIFM 2478 VSSTFLAWYQQKPGQAPRLLIFGASSR (Human) (Human) (Human) (Human) PLLD ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCHQYGTSPYTFGQGTKLEIK COV2- 1534 EIVMTQSPATLSVSPGERVTLSCRASQ IGHV1-69 IGHJ5 IGKV3-15 IGKJ4 2543 ARGVVAATP 2479 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) GWFDP RATGIPARFSGGGSGTEFTLTISSLQSE DFAVYYCQQYNNFLTFGGGTKVEIK COV2- 1535 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV1-69 IGHJ5 IGKV4-1 IGKJ2 2544 ARGWFGELL 2481 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) KGTYWFDP YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPGFGQGT KLEIK COV2- 1536 QSVLTQPPSVSGAPGQRVTLSCTGSNS IGHV1-69 IGHJ2 IGLV1-40 IGU3 2545 ARVGVSGFKS 2485 NIGAGYDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) GSNWYFDL SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSDSVFGGGT KVTVL COV2- 1537 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-74 IGHJ4 IGLV3-25 IGU3 2546 AREVEQLAH 2488 NQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) MVDY SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTSWVFGGGTKLTVL COV2- 1538 EIVLTQSPGTLSLSPGERASLSCRASQS IGHV4-39 IGHJ2 IGKV3-20 IGKJ4 2547 ARQWKWFG 2489 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) EAWYFDL ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPFTFGGGTKVEIK COV2- 1539 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-7 IGHJ4 IGKV1-5 IGKJ4 2548 ARDPYDLYGD 2490 SISSWLAWYQQKPRKAPKLLIYKASTLE (Human) (Human) (Human) (Human) YGGTFDY SGVPSRFSGSGSGTEFTLTISSLQPDDF ATYYCQQYNSYSLTFGGGTKVEIK COV2- 1540 EIVLTQSPATLSVSPGERATLSCRASQS IGHV1-69 IGHJ6 IGKV3-15 IGKJ1 2549 AREDYYGSGS 2495 VSSNLAWYQQKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) LVDPYYYYRM ATGIPARFSGSGSGTDFTLTISSLQSED DV FALYYCQQYNNWWRTFGQGTKVEIN COV2- 1541 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-33 IGHJ4 IGLV3-10 IGU3 2550 VRDLALFEVVI 2496 KKYAYWYQQKSGQAPVLVIYEDSKRP (Human) (Human) (Human) (Human) QQGV SGIPERFSGSSSGTMATLTISGAQVED EADYYCYSTDSSGNHWVFGGGTKLTV L COV2- 1542 SSELTQDPAVSVALGQTVRITCQGDSL IGHV4-39 IGHJ3 IGLV3-19 IGU2 2551 ARHTVDCGG 2499 RSYYASWYQQKPGQAPLLVIYGKNNR (Human) (Human) (Human) (Human) DCFPNDAFDI PSGIPDRFSGSSSGNTPSLTITGAQAED EADYYCNFRDSSGHHPVFGEGTKLTVL COV2- 1543 QSVLTQPPSASGTPGQRVIISCSGSSSN IGHV1-2 IGHJ4 IGLV1-44 IGU2 2552 ARVVVLGYGR 2504 IGSNTVKWYHQLPGTAPKLLICSNNQR (Human) (Human) (Human) (Human) PNNYYDGRN PSGVPDRFSGSKSDTSASLAISGLQSED VWDY EADYYCAAWDDSLNALVFGGGTKLTV L COV2- 1544 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3- IGHJ4 IGKV3-15 IGKJ1 2553 ARPRGGSYQT 2509 SVSSNLAWYQQKPGQAPRLLIYGAST 303 (Human) (Human) (Human) CFDY RATGIPARFSGSGSGTEFTLTISSLQSE (Human) DFAVYYCQQYNNWPGTFGQGTKVEI K COV2- 1545 SYELTQPSSVSVSPGQTARITCSGDVLA IGHV7-4- IGHJ4 IGLV3-27 IGU2 2554 ARWGPDYGD 2510 KNYARWFQQKPGQAPVLVIYKDSERP 1 (Human) (Human) (Human) YASNDY SGIPKRFSGSSSGTTVTLTISGAQVEDE (Human) ADYYCYSAADNNRVFGGGTKLTVL COV2- 1546 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-20 IGHJ3 IGLV3-19 IGU2 2555 AVIMSPIPRYS 2514 RSYYASWYQQKPGQVPILVIYDKNNR (Human) (Human) (Human) (Human) GYDWAGDAF PSGIPDRFSGSSSGNTASLTITGAQAED DI EADYYCNSRDSSGNAVVFGGGTKLTV L COV2- 1547 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV7-4- IGHJ5 IGKV1-33 IGKJ3 2556 ARGLVGRIDP 2515 DISNSLSWYQQKPGKAPKLLIYDASNL 1 (Human) (Human) (Human) KTGVPSRFSGSGSGTDFTFTISSLQPED (Human) IATYYCQQYDNLLLFTFGPGTKVDIK COV2- 1548 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-46 IGHJ3 IGKV3-11 IGKJ1 2557 ARDQQIVPH 2516 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) ADGFDI ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPRTWTFGQGTKVE IK COV2- 1549 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ1 IGKV3-11 IGKJ4 2558 ARIGSYPEYFQ 2517 VSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCHYRSNWPPVLTFGGGTKVEIE COV2- 1550 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-9 IGHJ6 IGLV3-19 IGU2 2559 AKDIIRQGED 2518 RSYYASWYQQKPGQVPILVIYDKNNR (Human) (Human) (Human) (Human) GMDV PSGIPDRFSGSSSGNTASLTITGAQAED EADYYCNSRDSSGNAVVFGGGTKLTV COV2- 1551 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-7 IGHJ6 IGLV3-19 IGU3 2560 ARDVGGYSG 2520 RSYYANWYQQKPGQAPVVVIFGKNN (Human) (Human) (Human) (Human) YDLGFDYYYY RPSGIPDRFSGSNSGNTASLTITGAQA MDV EDEADYYCNSRDSSGYIWGWMFGGG TKLTVL COV2- 1552 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3-30 IGHJ3 IGLV3-21 IGU3 2561 AKDRTAVFLF 2521 GSKSVHWYQQKPGQAPVVVVYDDSD (Human) (Human) (Human) (Human) FGLGDAFDI RPSGLPERFSGSNSGNTATLTISRVEA GDEADYYCQVWDSSSDHWVFGGGT KLTVL COV2- 1553 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV5-51 IGHJ4 IGLV1-40 IGU3 2562 ASALRERGVQ 2524 NIGAGYDVHWYQQLPGTAPKLLIFINS (Human) (Human) (Human) (Human) LWSV NRPSGVPDRFSGSKSGTSASLAITGLQ AEDEADYYCQSYDSSLGALFGGGTKLT VL COV2- 1554 QLVLTQSPSASASLGASVKLTCTLSSGH IGHV3-23 IGHJ4 IGLV4-69 IGU3 2563 AKDPASGIVG 2525 TTYAIAWHQQQPEKGPRYLMKLNSD (Human) (Human) (Human) (Human) PTHFDY GSHTRGDGIPDRFSGSSSGAERYLTISS LQSEDEADYYCQSWDTGIGVFGGGTK LTVL COV2- 1555 SYELTQPPSVSVSPGQTASITCFGDKLG IGHV1-24 IGHJ4 IGLV3-1 IGU2 2564 ATGFAVFGRA 2526 DKYACWFQQKPGQSPVLIIYQGAKRP (Human) (Human) (Human) (Human) AVPY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWDSSTVVFGGGTKLTVL COV2- 1556 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-30 IGHJ4 IGLV2-23 IGU2 2565 ARFRRSYGSG 2527 VGSYNLVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) SYYNISFDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYVGSSTYVVFGGGTKL TVL COV2- 1557 SYELTQPPSVSVSPGQTARITCSADALS IGHV7-4- IGHJ4 IGLV3-25 IGU3 2566 VREYGSGHPL 2529 KQYAYWYQQKPGQAPVVVIYKDSERP 1 (Human) (Human) (Human) PI SGIPERFSGSSSGTTVTLTISGVQAEDE (Human) ADYYCQSADSSSHWVFGGGTKLTVL COV2- 1558 NFMLTQPHSVSESPGKTVTISCTGNSG IGHV4-59 IGHJ3 IGLV6-57 IGU2 2567 ARATWLRDA 2531 SIASNYVQWYQQRPGSAPTTVIYEDS (Human) (Human) (Human) (Human) FGI QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSFDSGNVVFGGGTKL TVL COV2- 1559 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV1-46 IGHJ5 IGLV1-44 IGU2 2568 ARGFHVPAAL 2532 NIGSNTVNWYQQLPGTAPKLLIYNNN (Human) (Human) (Human) (Human) RNWFDP QRPSGVPDRLSGSKSGTSASLAISGLQ SEDEADYYCVAWDDSRNGLVFGGGT KLTVL COV2- 1560 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV4-31 IGHJ4 IGKV4-1 IGKJ2 2569 AREANDSGSF 2533 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YNGPFDY YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTRTFGQGT KLEIK COV2- 1561 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV4-61 IGHJ6 IGKV4-1 IGKJ2 2570 ARGGLLWFG 2536 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) GAGNYMDV YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPPYTFGQG TKVEIK COV2- 1562 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU3 2571 ARMRTGWPT 2539 NIGSYTVNWYQQFPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDF QRTSGVPDRFSGSKSGTSASLAISGLQ SEDEASYYCLAWDDSLNGLVFGGGTK LTVL COV2- 1563 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV4-34 IGHJ5 IGLV1-47 IGU3 2572 ARGPPVTTFF 2545 NIGSNYVYWYQQLPGTAPKLLIYSSNQ (Human) (Human) (Human) (Human) VFSLLFDP RPSGVPDRFSGSKSGTSASLAISGLRSE DEADYYCAAWDASLSGWVFGGGTKL TVL COV2- 1564 SYELTQPPSVSVSPGQTARITCSADALP IGHV3-30 IGHJ3 IGLV3-25 IGU3 2573 AKEGEWELR 2546 KHYAYWYQQRPGQAPVLVIYKDIERP (Human) (Human) (Human) (Human) GNALDI SGIPERFSGSSSGTTVTLTITGAQAEDE ADYYCQSVDGSGSSVVFGGGTKLAVL COV2- 1565 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-33 IGHJ3 IGLV3-1 IGU2 2574 AREGQWPN 2549 DKYACWYQQKPGQSPVLVIHQDSQR (Human) (Human) (Human) (Human) QAFDI PSGIPERFSGSNSGNTATLTISGTQAM DEADYYCQAWDSSTHVVFGGGTKLT VL COV2- 1566 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ4 IGLV2-14 IGU1 2575 ASGPPYMATF 2551 VGGYNYVSWFQHHPDKAPRLMIYDV (Human) (Human) (Human) (Human) SYYFDY SKRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSSSTPFVFGTGTKVT VL COV2- 1567 QPVLTQSSSASASLGSSVKLTCTLSSGH IGHV3-11 IGHJ4 IGLV4-60 IGU3 2576 ARDPIRDGV 2552 SSYIIAWHQQQPGKAPRYLMKLEGSG (Human) (Human) (Human) (Human) WGLNENDY SYNKGSGVPDRFSGSSSGADCYLTISN LQSEDEADYYCETWDSNTRVFAGGTK LTVL COV2- 1568 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ2 2577 ARSPPASYYN 2553 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) PSTGYFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATFYCQQSYSTPMHTFGQGTKLEIK COV2- 1569 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV1-46 IGHJ4 IGKV1-9 IGKJ1 2578 ARDVFWVPA 2554 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) ASSFDY GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYLGTFGQGTKVEIK COV2- 1570 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3- IGHJ4 IGKV1-12 IGKJ3 2579 ARDQEWFRE 2558 GISSWLAWYQQKPGKAPKLLIYDASSL 303 (Human) (Human) (Human) LFLFDY QSGVPSRFSGSGSGTDFTLTISSLQPED (Human) FATYYCQQANSFPPTFGPGTKVDIK COV2- 1571 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2580 ARMRTGWPT 2562 NIGSYTVNWYQQFPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDF QRTSGVPDRFSGSKSGTSASLAISGLQ SEDEANYYCLVWDDSLNGLVFGGGTK LTVL COV2- 1572 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-34 IGHJ4 IGLV2-23 IGU1 2581 ARGWGWGA 2563 VGSYNLVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) VAGRAEYYFD KRPSGVSNRFSGSKSGNTASLTISGLQ Y AEDEADYYCCSYAGSSTWGFGTGTKV TVL COV2- 1573 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3- IGHJ6 IGLV3-21 IGU2 2582 ARAQGGNYY 2564 GTKGVHWYQQKPGQAPVLVVYDDS 303 (Human) (Human) (Human) YGMDV DRPSGIPGRFSGSNSGNTATLTISRVEA (Human) GDEADYFCQVWDSSSDHHVVFGGGT KLTVL COV2- 1574 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV4-61 IGHJ4 IGKV2-28 IGKJ4 2583 ARGAASFDY 2565 LLHSDGYTYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) GSKRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPLTFGGGTK VEIK COV2- 1575 EIVMTQSPGTLSVSPGERATLSCRASQ IGHV4-39 IGHJ5 IGKV3-15 IGKJ2 2584 ARDPRVVVTA 2570 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) RMYNWFDP RATGVPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPPMYTFGQGTKL EIK COV2- 1576 EIVMTQSPATLSVSPGERATLSCRASQ IGHV4-59 IGHJ5 IGKV3-15 IGKJ1 2585 ARDQRQFQL 2571 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) LGRFGWFDP RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPRTFGQGTKVEIK COV2- 1577 QPVVTQSPSASASLGASVKLTCTLDSG IGHV4-39 IGHJ2 IGLV4-69 IGU2 2586 ARQWKWFG 2574 HRSYAIAWHQQRPEKGPRFLMRITTD (Human) (Human) (Human) (Human) EAWYFDL GRHTKGDGIPDRFSGSGSGTERYLTISS LQSEDEADYYCQTWGTFGGGTRLTVL COV2- 1578 DIVMTQTPLSLSVTPGQPASISCKSSQS IGHV7-4- IGHJ6 IGKV2D-29 IGKJ4 2587 ARDQDSGYP 2582 LLHSDGKTYLYWYLQKPGQSPQLLIYE 1 (Human) (Human) (Human) TYYYYYMDV VSNRFSGVPDRFSGSGSGTDFTLKISR (Human) VEAEDVGVYYCMQSIQPPLTFGGGTK VEIK COV2- 1579 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV1-8 IGHJ6 IGKV4-1 IGKJ4 2588 ARGGIYYLVR 2583 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) GFIIGYYGMD YWASTRESGVPDRFSGSGSGTDFTLTI V SSLQAEDVAVYYCQQYYSTPLTFGGGT KVEIK COV2- 1580 QSALTQPASVSGSPGQLITIFCNGSISD IGHV3-15 IGHJ4 IGLV2-14 IGU2 2589 TTGGYSSYAA 2584 VGGWNYVSWYQQHPDKAPKMMIY (Human) (Human) (Human) (Human) SDY DVRHRPSGVSSRFSGSKSGNTASLTIS GLQAEDEGDYYCSSFTSRGALVLFGG GTKLTVL COV2- 1581 QSALTQPRSVSGSPGQSVTISCTGTSS IGHV3-48 IGHJ2 IGLV2-11 IGU2 2590 ARVDYYGSGS 2585 DVGGYNYVSWYQQHPGKAPKLMIYD (Human) (Human) (Human) (Human) VYWYFDL VSKRPSGVPDRFSGSKSGNTASLTISGL QAEDEADYYCCSYAGIWVFGGGTKLT VL COV2- 1582 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-9 IGHJ3 IGKV3-20 IGKJ2 2591 AKVGWELSID 2586 VSSSYLGWYHQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) AFDL ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQHYGSSRSTFGQGTKLEIK COV2- 1583 DIQMTQSPSSLSASVGDRVTITCRARQ IGHV2-5 IGHJ3 IGKV1-39 IGKJ4 2592 AHRLWFRDA 2587 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDI HSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPTFGGGTKVEIK COV2- 1584 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-70 IGHJ6 IGKV1-39 IGKJ2 2593 ARIQYQLNG 2589 SISSYLNWYQQKPGKAPKLLIYAASSLH (Human) (Human) (Human) (Human) MDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYTFGQGTKLEIK COV2- 1585 SSELTQDPAVSVALGQTVRITCQGDSL IGHV1-8 IGHJ6 IGLV3-19 IGU2 2594 ARGRVGYVG 2590 RSYYASWYQQKPRQAPVLIISGNNNR (Human) (Human) (Human) (Human) SGSRGYYYYY PSGIPDRFSGSSSGNTASLTITGAQAED DMDV EADYYCNSRDSSGNHLRVFGGGTKLT VL COV2- 1586 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV5-51 IGHJ2 IGKV3-20 IGKJ5 2595 ARPDYSSGW 2602 VSSNFLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) FSYWYFDL RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGRSPITFGQGTRLEIK COV2- 1587 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV7-4- IGHJ4 IGKV1-33 IGKJ3 2596 ARGRSYGLSL 2610 DISNYLNWYQQKPGKAPKLLIYAASNL 1 (Human) (Human) (Human) GY ETGVPSRFSGSGSGTDFTFTISSLQPED (Human) IATYYCQQYDNLLQFTFGPGTKVDIK COV2- 1588 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-33 IGHJ4 IGLV3-10 IGU1 2597 ARESADISSRL 2611 TKYAYWYQQKSGQAPVLVIYDDSKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSSSGTMATLTISGAQVED EADYYCYSTDSSGNVFGTGTKVTVL COV2- 1589 EIVMTQSPATLSVSAGERATLSCRASQ IGHV2-5 IGHJ3 IGKV3-15 IGKJ4 2598 AHRLWFRDA 2614 SISSNLAWYHQKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) FDI ATGIPARFSGSGSGTEFTLTISSLQSED FAVYYCQQYNSYSLTFGGGTKVEIK COV2- 1590 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-72 IGHJ4 IGKV3-20 IGKJ3 2599 ASVITFGGVIV 2616 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) RSY ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQYYGSSPFGFGPGTKVDIK COV2- 1591 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2600 ARVSGYGDY 2617 VSRFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) GAYSDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPRLTFGGGTKVEIK COV2- 1592 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV3-20 IGHJ4 IGLV1-44 IGU2 2601 ASVITFGGVIV 2618 NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) RSY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDENNYYCAVWDDSLNGVVFGGGT KLTVL COV2- 1593 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV3-23 IGHJ6 IGLV1-47 IGU2 2602 ARVEGDWLL 2619 NIGSNYVYWYQQLPGTAPKLLISRNN (Human) (Human) (Human) (Human) GGPYYHYYG QRPSGVPDRFSGSKSGTSASLAISGLQ MDV SEDEANYYCLVWDDSLNGLVFGGGTK LTVL COV2- 1594 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3- IGHJ4 IGLV2-14 IGU2 2603 ARADTMVRG 2620 VGGYNYVSWYQQHPGKAPKLMIYDV 303 (Human) (Human) (Human) TYFEY SNRPSGVSNRFSGSKSGNTASLTISGL (Human) QAEDEADYCCSSYTSSRAVLFGGGTKL TVL COV2- 1595 DFVMTQSPGSLAVSLGERATINCRSSQ IGHV3-33 IGHJ4 IGKV4-1 IGKJ1 2604 ARDYCNGVT 2621 SVLDNSSNKNHLAWHQQKPGQPPKL (Human) (Human) (Human) (Human) CNSNY LIYWASTRESGVPDRFSGSGSGTDFTL TISSLQAEDVAVYYCQQYYSSHWTFG QGTKVEIK COV2- 1596 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ4 IGLV2-23 IGU3 2605 ARGWYFDY 2622 VGSYNLVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCYSYAGSSTWVFGGGTKL TVL COV2- 1597 SYELTQPPSVSVSPGQTARITCSADALP IGHV1-69 IGHJ6 IGLV3-25 IGU2 2606 ARVEGEGVD 2624 KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) SYYYGMDV SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSTDSSGSYVVFGGGTKLTVL COV2- 1598 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ6 IGKV1-39 IGKJ2 2607 AKDIIRQGED 2628 NIASYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) GMDV QSGVPSRFSGSGSGTDFTLTISSLQPEE FATYYCHQSYFTPQTFGQGTKLEIK COV2- 1599 EIVLTQSPATLALSVGERATLSCVASQR IGHV4-39 IGHJ5 IGKV3D-20 IGKJ3 2608 ARHPVDGYN 2631 VSSDYIAWYQKKPGLAPRLLVYHGSA (Human) (Human) (Human) (Human) YGYSDL WATGSSARFSGSGSGTAFTLTISSLEPE DFAVYYCQQYGNSPFTFGPGTKVEFK COV2- 1600 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-2 IGHJ4 IGKV3-20 IGKJ2 2609 ARVVVLGYGR 2632 VSSSYLAWYQEKPGQAPRLLMYSASS (Human) (Human) (Human) (Human) PNNYYDGRN RATGIPDRFSGSGSATDFTLTINRLEPE VWDY DFAVYYCQQYVEPPFTFGQGTKLEIK COV2- 1601 QSALTQPRSVSGSPGQSVTISCTGTSS IGHV3-30 IGHJ4 IGLV2-11 IGU2 2610 ARAGGGSYR 2639 DVGGYNYVSWYQQHPGKAPKLMIYD (Human) (Human) (Human) (Human) GPFDY VSKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEAEYYCSAYAGSNNLVFGGGT KLTVL COV2- 1602 EIVLTQSPGTLSLSPGERATLSCRAGQT IGHV3-30 IGHJ3 IGKV3-20 IGKJ2 2611 AKSYNGNYYD 2641 VSSSYLAWYQHKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) AFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSYTFGQGTKLEIK COV2- 1603 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ6 IGKV1-39 IGKJ5 2612 ARGSAGNYYY 2643 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) GMDV SGVPSRFSGSGSGTDFTLTISSLQPEDY ATYYCQQSYSTPGTFGQGTRLEIK COV2- 1604 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV5-51 IGHJ6 IGKV3-20 IGKJ1 2613 ARLTFGGSGS 2656 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YYFYYNGMD ATGIPDRFSGSGSGTDFTLTISRLEPED V FAVYYCQQYGRSSGTFGQGTKVEIK COV2- 1605 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-13 IGHJ6 IGKV3-20 IGKJ5 2614 ARADPYQLLG 2660 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) QHYYYGMDV ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPLITFGQGTRLEIK COV2- 1606 DIVMTQSPDFLAVSLGERATISCKSSQS IGHV3-30 IGHJ4 IGKV4-1 IGKJ4 2615 AKGGDGSG 2669 VLYTPKNKNYLAWYKQKPGQPPKVLIY (Human) (Human) (Human) (Human) WAWDGDNP WASTRESGVPDRFSGSGSGTDFTLIISS PTDY LQAEDAAVYYCQQYYTAPLTFGGGTR VEIK COV2- 1607 QTVVTQEPSLTVSPGGTVTLTCASSAG IGHV2-26 IGHJ5 IGLV7-43 IGU3 2616 ARIVLGASGT 2673 AVTSGYYPNWFQQKPGQAPRALIYST (Human) (Human) (Human) (Human) YPSPGFDP ANKHSWTPARFSGSLLGGKAALTLSG VQPEDEAEYYCLLYYGGAWVFGGGTK LTVL COV2- 1608 EIVLTQSPDFQSVTPKEKVTITCRASQN IGHV3-30 IGHJ5 IGKV6-21 IGKJ4 2617 AKDGSGSYYG 2675 IGSSLHWYQQKPDQSPKVIIKYASQSF (Human) (Human) (Human) (Human) WFDP SGVPSRFSGSGSGTDFTLTINSLEAEDA ATYYCHQSSSLPPTFGGGTKVEIK COV2- 1609 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ3 2618 ARSCGDCYSA 2676 ISSFLAWYQQKPGQAPRLLIYDASNRA (Human) (Human) (Human) (Human) DLDF TGIPARFSGSGSGTDFTLTISSLEPEDF AVYYCQRRSNWPPFTFGPGTKVDIK COV2- 1610 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV4-39 IGHJ4 IGLV6-57 IGU3 2619 ARLLWLRGHF 2677 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNYWVFGGGTK LTVL COV2- 1611 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-20 IGHJ3 IGLV3-19 IGU3 2620 AVIMSPIPRYS 2678 RSYYASWYQQKPGQVPILVIYDKNNR (Human) (Human) (Human) (Human) GYDWAGGAF PSGIPDRFSGSSSGNTASLTITGAQAED DI EADYYCNSRDSSGNAVVFGGGTKLTV L COV2- 1612 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ5 IGKV4-1 IGKJ2 2621 ARALNKGFDP 2681 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSSPYTFGQGT KLEIK COV2- 1613 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2622 AAPHCNRTSC 2684 VSSSYLGWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YDAFDL ATGIPDRFSGSGSGTDFTLTISRLESED FALYYCQQYNNWWRTFGQGTKVEIK COV2- 1614 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-46 IGHJ6 IGKV3-20 IGKJ4 2623 ARDRLGDGSY 2685 VSSSYLAWYQQKRGQAPRLLIYGASSR (Human) (Human) (Human) (Human) LGGGYYGMD ATGIPDRFSGSGSGTDFTLTISRLEPED V FAVYYCQQYGSSPRLTFGGGTKVEIK COV2- 1615 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ5 IGLV1-44 IGU2 2624 ARMRSGWPT 2693 NIGSYTVNWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) HGRPDDL QRTSGVPDRLSGSKSGTSASLAISGLQS EDEANYYCAVWDDSLNGLVFGGGTK LTVL COV2- 1616 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-69 IGHJ4 IGLV1-40 IGU3 2625 ARDHSGYYDS 2694 NIGAGYDVHWYQQLPGTAPKLLIFGN (Human) (Human) (Human) (Human) TSLMSPFFDY TNRPSGVPDRFSGSKSGTSTSLAITGLQ AEDEADYYCQSYDSSLNGDVFGGGTK LTVL COV2- 1617 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-46 IGHJ5 IGKV3-11 IGKJ3 2626 ARDLAGVPA 2697 VSSYLAWYQQKPGQAPRLLIYDAYKR (Human) (Human) (Human) (Human) ALGCWFDP DTGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPLIFTFGPGTKVDIK COV2- 1618 QSVLTQPPSVSGVPGQRVTVSCTGSSS IGHV3-30 IGHJ4 IGLV1-40 IGU1 2627 AKNLGPYCSG 2700 NIGAGFDVYWYQQFLGTAPKLLIYGN 3 (Human) (Human) (Human) GTCYSLVGDY NNRPSGVPDRFSASKSGTSASLAITGL (Human) QAEDEADYYCQSYDSSLSGYVFGTGTK VTVL COV2- 1619 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ4 IGKV1-39 IGKJ5 2628 ARARGGYNW 2703 SISSYLNWYQQKPGKAPKLLIYDASSLQ (Human) (Human) (Human) (Human) NFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPPITFGQGTRLEIK COV2- 1620 DIQMTQSPSSLSTSVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ1 2629 ARDQGTVVT 2705 SIRSYLNWYQQKPGKAPKLLIYVASSL (Human) (Human) (Human) (Human) HFDY QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPPWTFGQGTKVEIK COV2- 1621 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ3 2630 AKNLGPYCSG 2709 DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GTCYSLVGDY ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYANLPFTFGPGTKVDIK COV2- 1622 QSVLTQPPSASGTPGQRVTISCSGSNS IGHV1-8 IGHJ4 IGLV1-44 IGU2 2631 ARMRSGWPT 2710 NIGSYTVNWYQQLPGTAPKLLIFGNN (Human) (Human) (Human) (Human) HGRPDDH QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCVAWDDSRNGLVFGGGA KLTVL COV2- 1623 SYELTQPPSVSVSPGQTARITCSTDALP IGHV3-43 IGHJ6 IGLV3-25 IGU2 2632 AKDEMAYPP 2713 NEYIYWYQQKPGQAPVLVIYKDSERPS (Human) (Human) (Human) (Human) SHHYYYYYMD GIPERFSGSSSGTTVTLTISGVQAEDEA V DYYCQSVDSSGTYPHVIFGGGTKLTVL COV2- 1624 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-8 IGHJ4 IGKV1-39 IGKJ2 2633 ARGPSILTGFY 2717 SIISYLNWYHQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) NPLDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYTFGQGTKLEIK COV2- 1625 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV4-39 IGHJ6 IGKV1-9 IGKJ4 2634 ARRTYYDLWS 2718 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) AYSSTAYYCM GVPSRFSGSGSGTEFTLTISSLQPEDFA DV TYYCQQLNSYPLTFGGGTKVEIK COV2- 1626 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-69 IGHJ6 IGLV2-14 IGU2 2635 ARLSGSGWL 2722 VGGYNFVSWYQQHPGKAPKLIIYDVS (Human) (Human) (Human) (Human) GYAMDV NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCTSYTSSSTLNVVFGGGTK LTVL COV2- 1627 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ2 IGLV2-23 IGU2 2636 ARPSNWYFD 2726 VGSYNLVSWYQQHPGKAPKLMIYEVS (Human) (Human) (Human) (Human) L KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYASSSIVVFGGGTKLTV L COV2- 1628 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ4 IGKV1-39 IGKJ1 2637 AKAGYYAYV 2730 SISSYLNWYQQKPGKAPKLLLYAASSL (Human) (Human) (Human) (Human) WGSYRFEYFD QSGVPSRFSGSGSGTDFTLTISSLQPED N FATYYCQQSYSTPPWTFGQGTKVEIK COV2- 1629 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-53 IGHJ3 IGKV1-9 IGKJ3 2638 ARGPEPDAFD 2733 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYSFETFGPGTKVAIK COV2- 1630 NFMLTQPHSVSESPGKTVTFSCTGSSG IGHV4-61 IGHJ4 IGLV6-57 IGU2 2639 AGSPVPPTIV 2734 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) GASY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDGINRWLVFGGGT KLTVL COV2- 1631 DIQMTQSPSTLSASIGDRVTITCRASQS IGHV3- IGHJ3 IGKV1-5 IGKJ2 2640 ARDLSTTWYL 2736 ISSWLAWYQQIPGKAPKLLIYKASSLES 303 (Human) (Human) (Human) EMWGPDAF GVPSRFSGSGSGTEFTLTISSLQPDDFA (Human) DI TYYCQQYNSYPYTFGQGTKLEIK COV2- 1632 DIQMTQSPSSLSASIGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ2 2641 AKKGGPYCG 2740 NIRSYLNWYQHKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) GGNCYAGYF QSGVPSRFSGSESGTDFTLTISSLQPED DY FATYYCQQSSSSPITFGQGTKLEIK COV2- 1633 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-34 IGHJ6 IGKV1-39 IGKJ4 2642 ARVGYSQGYY 2749 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) YYYMDV QSGVPSRFSGSGSGTDFSLTISSLQPED FATYSCQQSYTTLLTFGGGTKVEIK COV2- 1634 SYELAQPPSVSVAPGETATIFCRATYIG IGHV3-9 IGHJ6 IGLV3-21 IGU2 2643 ARDYCSSTTC 2751 RKNVQWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) PAETYYYMDV RPSGIPGRFSGSNSGDTATLTISRIEAG DEAAYYCQVWDGINDRVVFGGGTKL TVL COV2- 1635 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ5 IGKV1-33 IGKJ4 2644 ARDFLRWHD 2752 DINNYLNWYQQKPGKAPKLLIYDASN (Human) (Human) (Human) (Human) L LETGVPLRFSGSGSGTDFTFTISSLQPE DIATYYCQQYDNLPPVFGGGTKVEIK COV2- 1636 DFQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ4 IGKV1-39 IGKJ1 2645 ARVDFDILTG 2753 SISTYLNWYQQKPGKAPNLLIFAASSLH (Human) (Human) (Human) (Human) YYSN SGVPSRFSGSGSGTDFTLSISSLQPEDF ATYYCQQSYSSEWTFGQGTKVEIK COV2- 1637 QSLLTQPPSVSGAPGQRVTLSCAGATS IGHV3-23 IGHJ4 IGLV1-40 IGU3 2646 AKWAGPIVM 2756 NIGAGSDVHWYQQLPGTAPKLLIYYN (Human) (Human) (Human) (Human) KYYLQY TNRPSGVPDRFSGSKSATSASLVITGL QTEDEADYYCQSYDISLGGWVFGGGT KLTVL COV2- 1638 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ2 IGKV1-39 IGKJ5 2647 ARGGDSGYD 2758 SVSIYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) LGAWYFDL QSGVPSRFSGSGSGTDFTLTVSSLQPE DFATYYCQQSYSMPPITFGQGTRLEIK COV2- 1639 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV5-51 IGHJ5 IGLV1-44 IGU3 2648 ARTPTLYNWF 2759 NIGSNSLNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) HP QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGSWVFGGG TKLTVL COV2- 1640 QSVLTQPPSASGTPGQRVTISCSGSRY IGHV2-70 IGHJ6 IGLV1-47 IGU2 2649 ARATTFFYGM 2760 NIGSNYVYWYQQLPGTAPRLLIYSNN (Human) (Human) (Human) (Human) DV QRPSGVPDRFSGSKSGTSASLAISGLRS EDEADYYCAAWDDSLSGLIFGGGTKLT VQ COV2- 1641 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ4 IGLV2-23 IGU3 2650 ARHQRYCSSS 2762 VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) SCHVWDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSSTWLFGGGTKLT VL COV2- 1642 SYVLTQPPSVSVAPGKTARITCEGNNI IGHV3-9 IGHJ6 IGLV3-21 IGU2 2651 AKGRGAGYTS 2765 GSKSVHWYQQKPGQAPVLVVYDDSG (Human) (Human) (Human) (Human) YMDV RPSGIPERFSGSNSGNTATLTISRVEAG DEADYFCQVWDSSSDHHVVFGGGTK LTVL COV2- 1643 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-53 IGHJ3 IGLV1-50 IGU2 2652 ARSYDILTGYR 2767 NIGAGYDVHWYQQLPETAPKLLIYAN (Human) (Human) (Human) (Human) DAFDI SNRPSGVPDRFSGSKSGTSASLAISGL QSEAEADYYCVAWDDSRNGLVFGGG AKLTVL COV2- 1644 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV3- IGHJ6 IGLV1-51 IGU1 2653 ARDDNSPQG 2768 NIGNNYVSWYQQLPGTAPKLLIYDNN 303 (Human) (Human) (Human) SGWYFYYYYA ERPSGIPDRFSGSKSGTSATLGITGLQT (Human) MDV GDEADYYCGTWDSSLSAYVFGTGTKV TVL COV2- 1645 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3- IGHJ3 IGLV3-21 IGU3 2654 ARDWAPTYY 2769 GNKGVHWYQQKPGQAPVLVVDDDS 303 (Human) (Human) (Human) DMPSAFDI DRPSGIPERFSGSNSGNTATLIISSVEV (Human) GDEADFYCQVWDSSSDHPGVFGGGT KLTVL COV2- 1646 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV3-7 IGHJ4 IGLV3-1 IGU3 2655 VRLGVSSWYF 2774 DKYACWYQQKPGQSPVLVIYQDTKRP (Human) (Human) (Human) (Human) DY SGIPERFSGSNSGNTATLTISGTQAMD EADYYCQAWGSSRGVFGGGTKLTVL COV2- 1647 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-7 IGHJ6 IGLV3-19 IGU3 2656 ARWVEVAT 2776 RSYYASWYQQKPGQAPVVVIYGKNN (Human) (Human) (Human) (Human) NKGIHGVDYY RPSGIPDRFSGSSSGNKASLTITGAQA YYYYMDV GDEADYYCNSRDNSGNLNWVFGGGT KLTVL COV2- 1648 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV4-34 IGHJ4 IGKV1-33 IGKJ2 2657 ARLRYSSSGG 2780 DINNYLNWYQQKSGKAPKLLIYDASNL (Human) (Human) (Human) (Human) HIFDY ETGVPSRFSGSGSGTDFTFTINSLQPED IATYYCQQYDNLPYTFGQGTKLEIK COV2- 1649 SYELTQPPSVSVSPGQTARITCSGDALP IGHV1-69 IGHJ4 IGLV3-25 IGU2 2658 ARGLTGSSAY 2783 KQYAYWYQQKPGQAPVLVIYKDTERP (Human) (Human) (Human) (Human) KDEIYFDY SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGSRFGGGTKLTVL COV2- 1650 EIVMTQSPATLSVSPGERATLSCRASQ IGHV4-59 IGHJ6 IGKV3-15 IGKJ2 2659 ARDGGNAYS 2784 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) SGWYRYYYH RATVIPARFSGSGSGTEFTLTISSLQSE MDV DFAVYYCQQYNNWPYTFGQGTKLEIK COV2- 1651 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ5 IGKV1-39 IGKJ1 2660 ARVLYDSSGF 2786 SISSYLNWYQQKPGKAPKLLIYAASSLE (Human) (Human) (Human) (Human) YNWFDP SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYEIPPWTFGQGTKVEIK COV2- 1652 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV1-46 IGHJ5 IGLV1-44 IGU2 2661 ARGFHVPAAL 2789 NIGSNTVNWYQQLPGTAPKLLIYNNN (Human) (Human) (Human) (Human) RNWFDP QRPSGVPDRLSGSKSGTSASLAISGLQ SEDEADYYCATWDDSLNGPVFGGGT KLTVL COV2- 1653 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-53 IGHJ3 IGLV1-40 IGU2 2662 ARSYDILTGYR 2790 NIGSGSDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) DAFDI TNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSRLSGFVVFGGG TKLTVL COV2- 1654 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-7 IGHJ4 IGLV3-25 IGU2 2663 ARVNDGRPN 2794 KQYAYWYHQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) PLEYYFDY SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTSVLFGGGTKLTVL COV2- 1655 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-31 IGHJ4 IGLV2-23 IGU3 2664 ARETYSAYEM 2796 VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) PPYFDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYARSSTRVFGGGTKLT VL COV2- 1656 SYELTQPPSVSVSPGQTARITCSGDAFP IGHV5-51 IGHJ6 IGLV3-25 IGU1 2665 ARDLIIESTIAA 2797 KQYGYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) RPGYYGMDV SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSRGAVFGSGTKVTVL COV2- 1657 QSVLTQPPSASGTPGQSVTISCSGSSS IGHV1-46 IGHJ4 IGLV1-44 IGU1 2666 ARERSGTYFF 2801 NIGNNKVNWYQQLPGTAPKVLIYNSN (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAVWDDSLHSYVFGTETK VTVL COV2- 1658 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV2-70 IGHJ4 IGKV1-39 IGKJ1 2667 ARETPVTAID 2807 SISRYLNWYQQKPGKAPKLLIYTASSLQ (Human) (Human) (Human) (Human) Y SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPRTFGQGTKVEIK COV2- 1659 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-58 IGHJ3 IGKV1-33 IGKJ3 2668 AAPYCSSISCN 2808 SISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) DGFDI ETGVPSRFSGSGSGTDFTFTISSLQPDD IATYYCQQYDNLPLAFGPGTKVDIK COV2- 1660 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-3 IGHJ6 IGKV1-39 IGKJ4 2669 ASMTRMSEQ 2809 SISNYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) TYYGMDV QSGVPSRFSGSGSGTDFSLTISSLQPED FATYSCQQSYTTLLTFGGGTKVEIK COV2- 1661 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-30 IGHJ4 IGLV1-40 IGU3 2670 ARELMSVG 2811 NIGARYDVHWYQQLPGTAPKLLMYG (Human) (Human) (Human) (Human) NNNRPSGVPDRFSGSKSGTSVSLAITG LQAEDEADYYCQSYDSSLSGWVFGGG TKLTVL COV2- 1662 VIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ6 IGKV1-33 IGKJ3 2671 ARDALYYNGP 2812 DINKYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GRDGMDV ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYANLPFTFGPGTKVDIK COV2- 1663 VIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-53 IGHJ6 IGKV1-33 IGKJ2 2672 ARDALYYNGP 2813 DINKYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GRDGMDV ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLPRTFGQGTKLEIK COV2- 1664 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-30 IGHJ6 IGLV1-40 IGU1 2673 AKDMVEPLFS 2814 NIGAGYDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) HYYYYGMDV SNRPSGVPDRFSGSKSGTSASLAISGL QAEDEADYSCQSYDSSLSGYVFGTGTK VTVL COV2- 1665 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-59 IGHJ4 IGLV2-23 IGU2 2674 ARAPRERLQ 2816 VGSYNLVSWYQQHAGKAPKLMIYEVI (Human) (Human) (Human) (Human) WGEYYFDY KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAVSTTYVIFGGGTKLT VL COV2- 1666 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ6 IGKV1-39 IGKJ2 2675 ARVFETKVIR 2817 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) GGRYYYYYYM SGVPSRFSGSGSGTDFTLTISSLQPEDF DV ATYYCQQSYSNPSYTFGQGTKLEIK COV2- 1667 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV4-34 IGHJ6 IGKV3-20 IGKJ2 2676 ARCRQMGNF 2818 VASSYLAWYQQKPGQAPRLLIYGASG (Human) (Human) (Human) (Human) YYYYMDV RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSPPRYTFGQGTKLEI K COV2- 1668 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-31 IGHJ5 IGKV1-39 IGKJ2 2677 ARVVPTRGPV 2819 SISSYLNWYQQRPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) AWFDP SGVPSRFSGSGSGTDFTLTISTLQPEDF ATYYCQQSYSTLLYTFGQGTKLEIK COV2- 1669 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV3-33 IGHJ6 IGKV2-28 IGKJ3 2678 ARDQSQGAYI 2820 LLHSNGYNYLDWYLQKPGQSPQFLIYL (Human) (Human) (Human) (Human) LTGYRGYGM GSNRASGVPDRFSGSGSGTDFILKISR DV VEAEDVGVYYCMQALQTPFTFGPGTK VDIK COV2- 1670 SYVLTQPPSVSVAPGKTASITCEGNNI IGHV1-69 IGHJ4 IGLV3-21 IGU1 2679 TTTQGGDYG 2821 GSKSVHWYQQKPGQAPVLVIYYDSDR (Human) (Human) (Human) (Human) DNLYYLDY PSGIPERFSGSNSGNTATLTISRVEAGD EADYYCQVWDSSSDRLYVFGTGTKVT VL COV2- 1671 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-53 IGHJ3 IGKV1-9 IGKJ2 2680 ARGPEPDAFD 2822 ISSYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) GVPSRFSGSGSGTDFTLTISSLQPEDFA TYYCQQSYSNPSYTFGQGTKLEIK COV2- 1672 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-46 IGHJ4 IGLV2-23 IGU3 2681 ARGYGFVPN 2826 VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) VLYYFDY KRPSGVSNRFSGSKSGITASLTISGLQA EDEADYYCCSYAGSSTWLFGGGTKLTV L COV2- 1673 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-21 IGHJ4 IGLV6-57 IGU2 2682 ARGGSILWW 2828 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) LIDY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSTSRVVFGGGTKL TVL COV2- 1674 SYVLTQPPSVSVAPGRTARITCGGNNI IGHV3-23 IGHJ3 IGLV3-21 IGU2 2683 AKDSRSGIAG 2830 GSKSVHWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) VDAFDI RPSGIPERFSGSKFGNTATLIISRVEAG DEADYSCQVWDSGSDHVVFGGGTKV TVL COV2- 1675 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-66 IGHJ4 IGKV1-39 IGKJ1 2684 ARGDGGYYS 2832 SISSYLNWYQQKPGKAPKVLIYAASTM (Human) (Human) (Human) (Human) PFDY QSGVPSRFRGSGSGTDFTLTISSLQLED FATYYCQQSYSTPQTFGQGTKVEIK COV2- 1676 QSVLTQPPSVSEAPRQRVTISCSGGSS IGHV2-5 IGHJ5 IGLV1-36 IGU2 2685 AHRLPTPQLL 2834 NIGNNAVNWYQQLPGKAPKLLIYYDD (Human) (Human) (Human) (Human) PSFENWFDP LLPSGVSDRFSGSKSGTSASLAISGLQS EDEADYYCASWDDSLIGPVFGGGTKL TVL COV2- 1677 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-66 IGHJ4 IGKV1-9 IGKJ2 2686 AREVVGYFDC 2835 ISTYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) GVPSRFSGSGSGTEFTLTISSLQPEDFA TYYCQQLNSYPGYTFGQGTKLEIK COV2- 1678 NLMLTQPHSVSESPGKTVTISCTGSSG IGHV4-59 IGHJ4 IGLV6-57 IGU3 2687 ARLRWLRGGI 2841 SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) DF QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSNNQVFGGGTKL TVL COV2- 1679 NFMLTQPHSVSESPGKTVTISCTRSSG IGHV1-46 IGHJ4 IGLV6-57 IGU2 2688 ARGYGFVPN 2842 SIASSYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) VLYYFDY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSDVVFGGGTKLT VL COV2- 1680 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3- IGHJ6 IGLV3-21 IGU2 2689 ARAQGGNYY 2844 GSKNVHWYQQKPGQAPVKVVYHDG 303 (Human) (Human) (Human) YGMDV DRPSGIPERFSGSNSGNTATLTINRVE (Human) AGDEADYSCQVWDSSSDHHVVFGGG TKLTVL COV2- 1681 SYELTQPPSVSVSPGQTARITCFGDALP IGHV3-30 IGHJ6 IGLV3-25 IGU3 2690 ARDLAYHPYR 2848 KQYAYWYQQKPGQGPVLVIYKDSERP (Human) (Human) (Human) (Human) DYGDDDYYYY SGIPERFSGSTSGTTVTLTISGVQAEDE YGMDV ADYYCQSADSSGTYRVFGGGTKLTVL COV2- 1682 EIVMTQSPATLSVSPGERVTLSCRASQ IGHV1-46 IGHJ4 IGKV3-15 IGKJ4 2691 ARGAIPPNSR 2853 SVSSNLAWCQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) AEIDY RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYYNWPLTFGGGTKVEIK COV2- 1683 SYELTQPPSVSVSPGQTARITCSGDALP IGHV1-46 IGHJ6 IGLV3-25 IGU2 2692 ARENDYGDY 2863 KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) VEPRDYYYG SGIPERFSGSSSGTTVTLTISGVQAEDE MDV ADYYCQSADSSAAYVVFGGGTKLTVL COV2- 1684 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-33 IGHJ3 IGLV3-10 IGU3 2693 AREGPFGDRE 2872 KKYTYWYQQKSGQAPVVVIYEDSKRP (Human) (Human) (Human) (Human) ASGAFDV SGIPERFSGSSSGTMATLTISGAQVED EADYYCYSTDSSGKGVFGGGTKLTVL COV2- 1685 SYVLTQPPSVSVAPGKTARITCGGNNI IGHV3-11 IGHJ1 IGLV3-21 IGU1 2694 TGVVAAPAEY 2873 GSKSVHWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) FQH RPSGIPERFSGSNSGNTATLTISRVEAG DEADYYCQVWDSSSDPFYVFGTGTKV TVL COV2- 1686 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-7 IGHJ4 IGLV6-57 IGU3 2695 ARLGFYYGGA 2878 SIASNYVQWYQQRPGSAPTTVISEDN (Human) (Human) (Human) (Human) DY QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDGINRAWVFGGGT KLTVL COV2- 1687 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ4 IGKV4-1 IGKJ1 2696 AKDGSIAAAD 2883 SVLHSSNNKDSLVWYQQKPGQPPKLL (Human) (Human) (Human) (Human) Y IYWASSRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPWTFGQG TKVEIK COV2- 1688 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV1-46 IGHJ4 IGKV1-5 IGKJ2 2697 ARGAAVPAA 2891 SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) GEFDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYSYTFGQGTKLEIK COV2- 1689 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-15 IGKJ4 2698 AKGDGSYLM 2894 SVSNNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) DYFDY RATGIPVRFSGSGSGTEFTLTISSLQSE DFAVYYCQQYDDWPPEVTFGG GTKVEIK COV2- 1690 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-53 IGHJ3 IGLV1-40 IGU2 2699 ARSYDILTGYR 2901 NIGSGSDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) DAFDI TNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCVAWDDSRNGLVFGGG AKLTVL COV2- 1691 QSVLTQPPSVSGVPGQRVTVSCTGSSS IGHV4-34 IGHJ6 IGLV1-40 IGU2 2700 ARCRQMGNF 2904 NIGAGFDVYWYQQFLGTAPKLLIYGN (Human) (Human) (Human) (Human) YYYYMDV NNRPSGVPDRFSASKSGTSASLAITGL QAEDEADYYCQSFDIGRGGWIFGGGT KLTVL COV2- 1692 DIQMTQSPSSLSASVGDRVTITCRPSQ IGHV5-51 IGHJ6 IGKV1-39 IGKJ5 2701 ARLGSESKIDY 2906 SITTYLNWYQQKPGKAPRLLIYAVSSLQ (Human) (Human) (Human) (Human) YYYGMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPPTFGQGTRLEIK COV2- 1693 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-69 IGHJ6 IGLV1-40 IGU2 2702 ARGRGYSNY 2909 NIGAGYDVHWYQQLPETAPKLLIYAN (Human) (Human) (Human) (Human) GASYYMDV SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGSVFGGGT KLTVL COV2- 1694 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ3 IGLV2-23 IGU2 2703 ARMSRGYNY 2911 VGSYNLVSWYQQHPGKAPKLKIYEGS (Human) (Human) (Human) (Human) AYTFDI KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSVLFGGGTKLTVL COV2- 1695 DIQMTQSPSSLSASAGDRVTITCRASQ IGHV2-70 IGHJ3 IGKV1-39 IGKJ2 2704 ARTMATINAF 2919 SIRYYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) DI QSGVPSRFSGSGSGTDFTLTISSLQPED FAAYYCQQSFSTPRTFGQGTKLEIK COV2- 1696 SYVLTQPPSVSVAPGKTANITCGGNNI IGHV3- IGHJ4 IGLV3-21 IGU3 2705 ARGGATNFD 2933 GRKSVHWYQQKSGQAPVLVVYDDSD 303 (Human) (Human) (Human) Y RPSGIPERFSGSNSGNTATLTISRVEAG (Human) DEADYYCQVWDSSSDHPEWVFGGGT KLTVL COV2- 1697 DIVMTQSPLSLPVTPGEPASISCRSSQS IGHV7-4- IGHJ4 IGKV2-28 IGKJ1 2706 ARPGKAAAF 2934 LLHSNGYNFLDWYLQKPGQSPQLLIYL 1 (Human) (Human) (Human) DY GSNRASGVPDRFSGSGSGTDFTLKISR (Human) VQAEDVGVYYCMQALQTPWTFGQG TKVEIK COV2- 1698 SSELTQDPAVSVALGQTVRITCQGDSL IGHV3-33 IGHJ6 IGLV3-19 IGU3 2707 ARDLHQDWV 2939 RRYYASWYQQKPGQAPVLVIYGKNN (Human) (Human) (Human) (Human) VVVAANVYG RPSGIPDRFSGSSSGNTASLTITGAQAE MDV DEADYYCNSRDSSGNPRWFGGGTKLT VL COV2- 1699 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ2 2708 AAPYCSSISCN 2941 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DGFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPPRYTFGQGTKLEIK COV2- 1700 SYELTQPPSVSVSPGQTARITCSTDALP IGHV2-70 IGHJ6 IGLV3-25 IGU3 2709 ARATTFFYGM 2942 NEYIYWYQQKPGQAPVLVIYKDSERPS (Human) (Human) (Human) (Human) DV GIPERFSGSSSGTTVTLTISGVQAEDEA DYYCQSVDSSGTYRVFGGGTKLTVL COV2- 1701 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ3 2710 AKKGGPYCG 2944 DISNYLNWYQQKAGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GGNCYAGYF ETGVPSRFSGSGSGTDFTFTISSLQPDD DY IATYYCQQYDNLPLAFGPGTKVDVK COV2- 1702 DVVMTQSPLSLPVTLGQPASISCRSSQ IGHV3-9 IGHJ3 IGKV2-30 IGKJ2 2711 AKLDVGGYDF 2945 SLVYSDGNTYLNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) VSGHYYAFDI YKVSSRDSGVPDRFSGSGSGTAFTLKIS RVEAEDVGVYYCMQGTHWPYTFGQ GTKLEIK COV2- 1703 QSALTQPRSVSGSPGQSVTISCTGTSS IGHV7-4- IGHJ6 IGLV2-11 IGU3 2712 ARGLISLFRGA 2947 DVGGYTYVSWYQQHPGKAPKLMIYD 1 (Human) (Human) (Human) IFHYYYGMDV VNKRPSGVPDRFSGSKSGITASLTISGL (Human) QAEDEADYYCCSYAGRYTWVFGGGTT LTVL COV2- 1704 DIQLTQSPSFLSASVGDRVTITCRASQG IGHV3-66 IGHJ6 IGKV1-9 IGKJ5 2713 ARDLVTYGLD 2952 ISNYLAWYQQKPGTAPNLLIYAASTLQ (Human) (Human) (Human) (Human) V SGVPSRFSGSGSGTEFTLTISSLQPEDF ATYYCQLLNSHPLTFGQGTRLEIK COV2- 1705 SYELTQPPSVSVSPGQTARITCSGDALP IGHV2-5 IGHJ5 IGLV3-25 IGU3 2714 AHSGPPDLSP 2953 KQYAYWYQQKPGQAPVLVIYRDSERP (Human) (Human) (Human) (Human) VLSQGWFDP SGIPERFSGSTSGTTVTLTISGVQAEDE ADYYCQSADSTGWVFGGGTKLTVL COV2- 1706 DIVMTQTPLSLSVTPGQPASFSCKSSQ IGHV3-30 IGHJ6 IGKV2D-29 IGKJ2 2715 AKGGPNKEVL 2955 SLLHSDGKTYLYWYLQKPGQSPQLLIY (Human) (Human) (Human) (Human) YFGELLDYGM AVSNRFSGVPDRFSGSGSGTDFTLKIS DV RVEAEDVGVYYCMQSIQLPYTFGQGT KLEIK COV2- 1707 DIVVTQTPLSLSVTPGQPASISCKSSET IGHV1-18 IGHJ4 IGKV2D-29 IGKJ5 2716 ARVQRRRLDY 2960 LLHSDGKTYLSWYLQKPGQPPQLLIYEV (Human) (Human) (Human) (Human) SNRFSGVPDRFSGSGSGTDFTLKIGRV EAEDVGLYYCMQSIQLAFGQGTRLEIE COV2- 1708 ETVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2717 AAPYCSSISCN 2961 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DGFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQHYGSSRGWTFGQGTKVEIK COV2- 1709 EIVMTQSPATLSVSPGERVTLSCRASQ IGHV1-46 IGHJ4 IGKV3-15 IGKJ4 2718 ARGAIPPNSR 2997 SVSSNLAWCQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) AEIDY RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYYNWPLTFGGGTKVEIK COV2- 1710 DIQMTQSPSTLSASIGDRVTITCRASQS IGHV3-30 IGHJ3 IGKV1-5 IGKJ2 2719 ARDLSTTWYL 3010 ISSWLAWYQQIPGKAPKLLIYKASSLES 3 (Human) (Human) (Human) EMWGPDAF GVPSRFSGSGSGTEFTLTISSLQPDDFA (Human) DI TYYCQQYNSYPYTFGQGTKLEIK COV2- 1711 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ5 IGKV1-39 IGKJ1 2720 ARVLYDSSGF 3012 SISSYLNWYQQKPGKAPKLLIYAASSLE (Human) (Human) (Human) (Human) YNWFDP SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYEIPPWTFGQGTKVEIK COV2- 1712 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV3-30 IGHJ4 IGKV1-33 IGKJ3 2721 AKNLGPYCSG 3013 DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) GTCYSLVGDY ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYANLPFTFGPGTKVDIK COV2- 1713 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2722 AAPYCSSISCN 3025 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DGFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQHYGSSRGWTFGQGTKVEIK COV2- 1714 SYELTQPPSVSVSPGQTARITCSTDALP IGHV3-43 IGHJ6 IGLV3-25 IGU2 2723 AKDEMAYPP 3029 NEYIYWYQQKPGQAPVLVIYKDSERPS (Human) (Human) (Human) (Human) SHHYYYYYMD GIPERFSGSSSGTTVTLTISGVQAEDEA V DYYCQSVDSSGTYPHVIFGGGTKLTVL COV2- 1715 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-7 IGHJ6 IGLV1-40 IGU2 2724 ARLVTTVTTA 3057 NIGAGYDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) NGLYYYSYYY TNRPSGVPDRFSGSKSGTSASLAITGL MDV QAEDEADYYCQSYASSLSAHVVFGGG TKLTVL COV2- 1716 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-30 IGHJ3 IGKV4-1 IGKJ2 2725 ARDRSGNYR 3058 SVLYSSNNENYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) DAFDI YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSSYTFGQGTK VEIK COVA1- 1717 EIVMTQSPGTLSLSPGERATLSCRASQ IGHV4-39 IGHJ4 IGKV3-20 IGKJ3 2726 ARVSSGYYFT 01 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) PFDY RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSPPPFTFGPGTKVDI K COVA1- 1718 NFMLTQPASVSGSPGQSITISCTGASS IGHV3-30 IGHJ3 IGLV2-14 IGU3 2727 ARARGGSYN 02 DVGGYNYVSWYQQHPGKAPKLMIYD (Human) (Human) (Human) (Human) DAFDI VSNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTPVVFGGGTE LTVL COVA1- 1719 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ6 IGKV1-27 IGKJ3 2728 AKDGQYYDF 03 GISNYLAWYQQKPGKVPKLLIYAASTL (Human) (Human) (Human) (Human) WSGYLGART QSGVPSRFSGSGSGTDFTLTISSLQPED NPHYYYYMD VATYYCQKYNSAPPAFGQGTKVDIK V COVA1- 1720 QSALTQPPSVSVSPGQTASIPCSGDKL IGHV3-9 IGHJ6 IGLV3-1 IGU3 2729 AKDMGEAVA 06 GDIYACWYQQKPGQSPVLVIYQDTKR (Human) (Human) (Human) (Human) GTHYGMDV PSGIPERFSGSNSGNTATLTISGTOAM DEADYYCQAWGSTTAKVFGGGTKLTV P COVA1- 1721 DIQLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2730 ARVGAYDSSG 07 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YSNDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPRVTFGGGTKVEIK COVA1- 1722 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ4 IGLV2-14 IGU3 2731 AREDYYDSSG 08 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) SFDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTRHWVFGGG TKLTVL COVA1- 1723 DIQMTQSPSSLSASVRDRVTITCRASQ IGHV4-59 IGHJ3 IGKV1-39 IGKJ1 2732 ARHSQGWLQ 09 SITSSLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) QAVAFDI SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYTFGQGTKVEIK COVA1- 1724 NFMLTQPASVSGSPGQSITISCTGSSS IGHV3-66 IGHJ4 IGLV2-14 IGU3 2733 ARGGYYYDPS 10 DIAPYTFVSWYQQHSGTAPKLIIYDVR (Human) (Human) (Human) (Human) GYYSRSFSFDY NRPSGISDRFSGSRSGNTASLSISGLQA EDEADYYCSAYTTTSTSWVFGGGTKLT VL COVA1- 1725 QSALTQPPSASGSPGQSVTISCTGTSS IGHV1-2 IGHJ6 IGLV2-8 IGU3 2734 ARDLVWATV 12 DIGTYNYVSWYQQHPGKAPKLMIYEV (Human) (Human) (Human) (Human) SGTMDV TKRPSGVPDRFSGSKSGNTASLTVSGL QADDEGDYYCSSYVGNNNWVFGGG TKLTVL COVA1- 1726 DIQLTQSPSSLSASVGDRVTITCQASQ IGHV1-46 IGHJ1 IGKV1-33 IGKJ4 2735 ARPPRNYYDR 16 DISNYLNWYQQRPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) SGYYQRAEYF ETGVPSRFSGSGSGTDFTFTISSLQPED QH IATYYCQQYDNPPLTFGGGTKLEIK COVA1- 1727 QSALTQEPSLTVSPGGTVTLTCGSSTG IGHV3-66 IGHJ4 IGLV7-46 IGU3 2736 ARVEWAAAG 18 AVTSGHYPYWFQQKPGQAPRTLIYDT (Human) (Human) (Human) (Human) TFY SNKRSWTPARFSGSLLGGKAALTLSGA QPEDEAEYYCLLSYSGVWVFGGGTKL TVL COVA1- 1728 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-21 IGHJ3 IGKV3-15 IGKJ1 2737 ARWKSDYYD 19 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) SSGYYPAAFDI RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPPWTFGQGTKV EIK COVA1- 1729 NFMLTQPPSVSVAPGKTARITCGGNN IGHV3-21 IGHJ6 IGLV3-21 IGU3 2738 AGDQNLYCS 20 IGSKSVHWYQQKPGQAPVLVIYYDSD (Human) (Human) (Human) (Human) GDSCYYHYYG RPSGIPERFSGSNSGNTATLTISRVEAG MDV DEADYYCQVWDSSSDHWVFGGGTKL TVL COVA1- 1730 EIVMTQSPATLSVSPGERATLSYRASQ IGHV3-30 IGHJ6 IGKV3-15 IGKJ2 2739 ARDSEYYDILT 21 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) GYLAPTHYYY RATGIPARFSGSGSGTEFTLTISSLQSE YYMDV DFAVYYCQQYNNWPPGTFGQGTKLEI K COVA1- 1731 SYELTQPPSVSVSPGQTASITCSGDKLG IGHV1-18 IGHJ6 IGLV3-1 IGU3 2740 ARDLVDTAM 22 DKYACWYQQKPGQSPVLVTYQDNKR (Human) (Human) (Human) (Human) VQTLDDYGM PSGIPERFSGSNSGNTATLTISGTQAM DV DEADYYCQAWDSSTAVFGGGTKLTVL COVA1- 1732 SYELTQPPSVSVSPGQTARITCSGDALP IGHV5-51 IGHJ4 IGLV3-25 IGU3 2741 ARYYYDSRGY 23 KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) TSIDF SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTYSVVFGGGTKLTVL COVA1- 1733 DIQLTQSPSTLSASVGDRVTITCRASQS IGHV4-39 IGHJ6 IGKV1-5 IGKJ3 2742 ARLNYDFWS 25 ISSWLAWYQQKPGKAPKLLIYKASSLE (Human) (Human) (Human) (Human) GYYSYALYYM SGVPSRFSGSGSGTEFTLTISSLQPDDF DV ATYYCQQYNSYSITFGPGTKVDIK COVA1- 1734 DIVMTQSPSFLSASVGDRVTITCRASQ IGHV4-31 IGHJ4 IGKV1-9 IGKJ4 2743 ARQQLDYYDS 26 GISSYLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) SGCFDY QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCQQLHSYPLTFGGGTKVDIK COVA1- 1735 DVVMTQSPGTLSLSPGERATLSCRAS IGHV4-59 IGHJ4 IGKV3-20 IGKJ3 2744 ARAMGSYRS 27 QNVSSSYLAWYQQKPGQAPRLLIYGA (Human) (Human) (Human) (Human) PFDY SSRATGIPDRFSGSGSGTDFTLTISRLE PEDFAVYYCQQYGSSPLFTFGPGTKVEI K COVA2- 1736 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3-13 IGHJ2 IGKV1-39 IGKJ4 2745 ARGGDRYPV 01 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) GYFDL SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPPVTFGGGTKVEIK COVA2- 1737 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV4-39 IGHJ6 IGKV1-39 IGKJ3 2746 ARRSTSRWG 02 SISNYLNWYQQKPGKAPKLLLYAASDL (Human) (Human) (Human) (Human) YYYMDV QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTHMSTFGQGTKVDIK COVA2- 1738 EIVMTQSPATLSLSPGERATLSCRASQS IGHV3-48 IGHJ4 IGKV3-11 IGKJ5 2747 AREANSDFW 03 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) SGYLGYFDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPQVTFGQGTRLEIK COVA2- 1739 EIVMTQSPGTLSLSPGERATLSCRASQ IGHV3-53 IGHJ6 IGKV3-20 IGKJ3 2748 ARDLERAGG 04 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) MDV RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSLYTFGQGTKVDIK COVA2- 1740 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV5-51 IGHJ6 IGKV1-33 IGKJ4 2749 ARHMRPSIAA 05 DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) RPGYQYYMD ETGVPSRFSGSGSGTDFTFTISSLQPED V IATYYCQQYDNLPLTFGGGTKLEIK COVA2- 1741 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ6 IGKV3-20 IGKJ3 2750 AREAYGMDV 07 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) ATGIPDRFSGSWSGTDFTLTISRLEPED FAVYYCQQYGSSPGTFGQGTKVDIK COVA2- 1742 DIVMTQSPGTLSLSPGERATLSCRASQ IGHV3-23 IGHJ1 IGKV3-20 IGKJ4 2751 AKGLRGQQL 10 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) VIPTEYFQH RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSLLTFGGGTKVEIK COVA2- 1743 DIQLTQSPGTLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-20 IGKJ4 2752 ARGPRGCSST 11 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) SCYGSYFDY ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPRLTFGGGTKVDIK COVA2- 1744 EIVLTQSPATLSVSPGERATLSCRASQS IGHV3-21 IGHJ4 IGKV3-15 IGKJ1 2753 ARDQPLPDIL 12 VSSSLAWYQQKPGQAPRLLIYAASTRA (Human) (Human) (Human) (Human) TGYYTGPLDY TGIPARFSGSGSGTEFTLTISSLQSEDF AVYYCQQYNNWPPWTFGQGTKLEIK COVA2- 1745 EIVMTQSPGTLSLSPGERATLSCRASQ IGHV3-53 IGHJ6 IGKV3-20 IGKJ1 2754 ARDLDTMGG 13 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) MDV RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSPGTFGQGTKVEIK COVA2- 1746 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ1 2755 ARVRYYDSSG 14 VSSYLAWYQQEPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYEDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPMYTFGQGTKVEI K COVA2- 1747 DIVMTQSPLSLPVTLGQPASISCRSSQS IGHV3-23 IGHJ4 IGKV2-30 IGKJ2 2756 AKDTGYCGD 15 LVYSDGNTFLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) DCYIKLIRGGP QVSNRDSGVPDRFSGSGSGTDFTLKIS DY RVEAEDVGVYYCMQGTHWPRTFGQ GTKLEIK COVA2- 1748 DIQLTQSPSSLSASVGDRVTITCRASQG IGHV1-69 IGHJ4 IGKV1-17 IGKJ1 2757 ASSDSSGFVG 16 IRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) SRGFDY QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPPLFGQGTKVEIK COVA2- 1749 EIVMTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ1 2758 ASFGDDSGDE 17 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) GVR ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPYTFGQGTKVEIK COVA2- 1750 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ5 2759 ARVYSYDSSG 18 VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) YYLEY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPSITFGQGTRLEIK COVA2- 1751 DVVMTQSPSSLSVSVGDRVTITCRASQ IGHV3-53 IGHJ6 IGKV1-17 IGKJ1 2760 ASPLLLTPPDY 20 GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) YYYMDV QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYLWTFGQGTKLEIK COVA2- 1752 AIRMTQSPSSLSASVGDRVTITCQASQ IGHV4-4 IGHJ4 IGKV1-33 IGKJ5 2761 ARGPRYCSST 22 DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) SCYAGVYFDY ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLPITFGQGTRLEIK COVA2- 1753 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-20 IGKJ4 2762 ARDGFGDVE 23 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) EMATIKDAFD ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPGVTFGGGTKLEIK COVA2- 1754 AIRMTQSPSSLSASVGDRVTITCRASQ IGHV5-101 IGHJ3 IGKV1-39 IGKJ2 2763 ARPNPAGGY 24 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) DSSGWVDAF SGVPSRFSGSGSGTDFTLTISSLQPEDF DI ATYYCQQSYSTPQTFGQGTKLEIK COVA2- 1755 QPVLTQPASVSGSPGQSITISCTGTSSD IGHV1-24 IGHJ5 IGLV2-14 IGU3 2764 ATGPTIAAAA 25 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) TNWFDP SNRPSGVSNRFSGSRSGDTASLTISGL QAEDEADYYCSSYTSSSTWVFGGGTKL TVL COVA2- 1756 QLVLTQPPSVSVSPGQTASITCSGDKL IGHV3-15 IGHJ6 IGLV3-1 IGU3 2765 TTDRGDSYGY 26 GDKYACWYQQKPGQSPVLVIYQDSKR (Human) (Human) (Human) (Human) YYCMDV PSGIPERFSGSNSGNTATLTISGTQAM DEADYYCQAWDSSTAVVFGGGTKLTV L COVA2- 1757 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-33 IGHJ4 IGKV3-15 IGKJ5 2766 AKDKAPPCSS 28 SVSSNLAWYQHKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) GWYYFDY ATGIPARFSGSGSGTEFTLTISSLQSED FAVYYCQQYNYWPLITFGQGTRLEIK COVA2- 1758 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ3 IGKV1-39 IGKJ1 2767 ARGVEDPVV 29 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) PAAIPWCWF SGVPSRFSGSGSGTDFTLTISSLQPEDF DP ATYYCQQSYSTPRTFGQGTKVEIK COVA2- 1759 QSVLTQPPSVSVAPGQTARITCGGNNI IGHV4-30 IGHJ5 IGLV3-21 IGU3 2768 ASLPVVPAAI 30 GSKSVHWYQQKPGQAPVLVVYDDSD (Human) (Human) (Human) (Human) GPLPAFDI RPSGIPERFSGSNSGNTATLTISRVEAG DEADYYCQVWASSSVVFGGGTKLTVL COVA2- 1760 DIVMTQTPLSLSVTPGQPASISCKSGQ IGHV1-2 IGHJ3 IGKV2D-29 IGKJ1 2769 RKMLTIFGKV 31 SLLHSDGKTYLYWYLQKPGQPPQLLIY (Human) (Human) (Human) (Human) NQTMLLISGA EVSNRFSGVPDRFSGSGSGTDFTLKISR KGQ VEAEDVGVYYCMQSIQLPPTFGQGTK VEIK COVA2- 1761 DIVMTQSPATLSLSPGERATLSCRASQ IGHV1-69 IGHJ4 IGKV3-11 IGKJ4 2770 ARTHSYDNSG 32 SVSSFLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) QYFDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPRLTFGGGTKVDIK COVA2- 1762 QSALTQPASVSGSPGQSITISCTGTSSD IGHV5-101 IGHJ6 IGLV2-23 IGU3 2771 ARLKVITIFGV 33 VGSYNLVSWYQQHPGKAPKLMIYDSS (Human) (Human) (Human) (Human) VRDDYGMDV KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSVFGGGTKLTVL COVA2- 1763 QTVVTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ4 IGLV2-14 IGU1 2772 ARSASGSYYG 34 VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) AFDY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTLGLYVFGTGT KVTVL COVA2- 1764 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-24 IGHJ5 IGLV1-40 IGU3 2773 ATSPAVMSV 37 NIGAGYDVHWYQQLPGTAPKVLIYDN (Human) (Human) (Human) (Human) GWVDP NNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGSVFGGGT KLTVL COVA2- 1765 DIQLTQSPSSLSASVGDRVTITCRASQG IGHV4-39 IGHJ3 IGKV1-17 IGKJ4 2774 ARQVRQWLE 38 IRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) DDAFDI QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPLTFGGGTKVDIK COVA2- 1766 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-53 IGHJ3 IGLV2-23 IGU3 2775 ARAHVDTAM 39 VGSYNLVSWYQQHPGKAPKLMIYEVT (Human) (Human) (Human) (Human) VESGAFDI KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSSTWVFGGGTKL TVL COVA2- 1767 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ5 IGLV2-23 IGU3 2776 AGRYCSGGRC 40 VGSYNLVSWYQQHPGKAPKLMIYEAS (Human) (Human) (Human) (Human) GWFDP KRPSGISNRFSGSKSGNTASLTISGLQA EDEADYYCCSYAGSSTWVFGGGTKPT VL COVA2- 1768 DIVMTQSPATLSVSPGERATLSCRASQ IGHV3-21 IGHJ6 IGKV3-15 IGKJ1 2777 ARVQKDIVVV 41 SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) PVALADYYYY RATGIPARFSGSGSGTEFTLTISSLQPE GMDV DFAVYYCQQCYNWPPWTFGQGTRVE FK COVA2- 1769 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV1-18 IGHJ4 IGKV1-17 IGKJ4 2778 ARFDYGYPYS 43 GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) SWSVLSIDY QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPLTFGGGTKLEIK COVA2- 1770 AIRMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ2 2779 AREGSRQWL 44 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) VIYFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYTTFIYTFGQGTKLEIK COVA2- 1771 DIVMTQSPGTLSLSPGERATLSCRASQ IGHV1-2 IGHJ5 IGKV3-20 IGKJ1 2780 ARGDGDYYD 45 SVSSSYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) SSGYYRPTLY RATGIPDRFSGSGSGTDFTLTISRLEPE NWLDP DFAVYYCQQYGSSPYTFGQGTKVEIK COVA2- 1772 AIRMTQSPSSLSASVGDRVTITCQASQ IGHV4-39 IGHJ4 IGKV1-33 IGKJ4 2781 ARHPSGLYQL 46 DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) LN ETGVPSRFSGSGSGTDFTFTISSLQPED IATYYCQQYDNLLSLTFGGGTKVEIK COVA2- 1773 EIVLTQSPDSLAVSLGERATINCKSSQS IGHV3-9 IGHJ4 IGKV4-1 IGKJ4 2782 AKVATYYYDR 47 VLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) SGYYYGGALD YWASTRESGVPDRFSGSGSGTHFTLTI Y SSLQAEDVAVYYCQQYYSTPPLTFGGG TKVDIK COVA3- 1774 EIVMTQSPSSLSASVGDRVTITCRASQS IGHV4-59 IGHJ6 IGKV1-39 IGKJ4 2783 ARGPAATYYY 01 MSSYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) YMDV QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTLTFGGGTKVEIK COVA3- 1775 QTVVTQPPSVSVSPGQTARITCSGDAL IGHV3-23 IGHJ4 IGLV3-25 IGU3 2784 AKEIAVAGCF 03 PKQYAYWYQQKPGQAPVLVIYKDSER (Human) (Human) (Human) (Human) DY PSGIPERFSGSSSGTTVTLTISGVQAED EADYYCQSADSSGTYRVFGGGTKLTVL COVA3- 1776 QPVLTQPPSVSVAPGQTARITCGGNN IGHV3-33 IGHJ4 IGLV3-21 IGU1 2785 ARVGSVKSTA 04 IGSKSVHWYQQKPGQAPVLVVYDDS (Human) (Human) (Human) (Human) GYDFWSGDP DRPSGIPERFSGSNSGNTATLTISRVEA FDY GDEADYYCQVWDSSSDHYVFGTGTK VTVL COVA3- 1777 NFMLTQPPSASGTPGQRVTISCSGSSS IGHV1-24 IGHJ4 IGLV1-44 IGU3 2786 ATAYSVDTA 05 NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) MVRGVGY QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGPHWVFGG GTKLTVL COVA3- 1778 DVVMTQSPDSLAVSLGERATINCKSS IGHV1-69 IGHJ4 IGKV4-1 IGKJ4 2787 ARDAPDYYDS 06 QSVLYSSNNKNYLAWYQQKPGQPPKL (Human) (Human) (Human) (Human) SGPTYFDY LIYWASTRESGVPDRFSGSGSGTDFTL TISSLQAEDVAVYYCQQYYSTPLTFGG GTKVDIK COVA3- 1779 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-9 IGHJ6 IGKV3-20 IGKJ3 2788 AKMGPDPAH 07 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DYGRKNDAF ATGIPDRFSGSGSGTDFTLTISRLEPED DI FAVYYCQQYGSSPFTFGPGTKLEIK COVA3- 1780 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV4-59 IGHJ6 IGKV1-39 IGKJ4 2789 AKAEPEVGGY 08 SISSYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) DYYMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPLTFGPGTKLEIK COVA3- 1781 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3-9 IGHJ3 IGKV1-39 IGKJ4 2790 ARGPAATYYY 09 SMSSYLNWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) YMDV QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTLTFGGGTKLEIK COVA3- 1782 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV5-51 IGHJ6 IGKV4-1 IGKJ5 2791 ARRGYTYGAD 10 SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) FYGLDV YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPITFGQGT RLEIK CR3022 1783 DIQLTQSPDSLAVSLGERATINCKSSQS IGHV5-51 IGHJ6 IGKV4-1 IGKJ1 2792 AGGSGISTPM VLYSSINKNYLAWYQQKPGQPPKLLIY (Human) (Human) (Human) (Human) DV WASTRESGVPDRFSGSGSGTDFTLTIS SLQAEDVAVYYCQQYYSTPYTFGQGT KVEIK CV-X1- ND IGHV3-53 IGHJ6 ND ND 2793 ARDLSEGGM 126 (Human) (Human) DV CV-X2- ND IGHV1-69 IGHJ6 ND ND 2794 ATRKETTVTTS 106 (Human) (Human) LVYGMDV CV05-163 ND IGHV1-2 IGHJ6 ND ND 2795 AREVMVRGA (Human) (Human) LPPYGMDV CV07-200 ND IGHV1-2 IGHJ6 ND ND 2796 ARGPFYYDNS (Human) (Human) GTLGGLDV CV07-209 ND IGHV3-11 IGHJ4 ND ND 2797 ARDGVIPPRF (Human) (Human) DY CV07-222 ND IGHV1-2 IGHJ3 ND ND 2798 ARGPYYYDSS (Human) (Human) GSLGAFDI CV07-250 ND IGHV1-18 IGHJ6 ND ND 2799 AGSDNYGFPY (Human) (Human) NGMDV CV07-255 ND IGHV1-2 IGHJ4 ND ND 2800 ARDSRFSYVN (Human) (Human) GEFDY CV07-262 ND IGHV1-2 IGHJ6 ND ND 2801 ARVGWYDFG (Human) (Human) TPGDYYYYYG MDV CV07-270 ND IGHV1-2 IGHJ6 ND ND 2802 ARVFGPGLDC (Human) (Human) SSTSCYTYGM DV CV07-283 ND IGHV1-2 IGHJ6 ND ND 2803 VRGPFYYDSS (Human) (Human) GPLGGMDV CV07-287 ND IGHV1-58 IGHJ3 ND ND 2804 AAPYCSSTNC (Human) (Human) YDAFDI CV07-315 ND IGHV3-9 IGHJ6 ND ND 2805 AKDFLWDLH (Human) (Human) PPRYYGMDV CV1 1784 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV4- IGHJ2 IGLV1-44 IGU3 2806 ARTPLSLRLRY NIGSNTVNWYQQLPGTAPKLLIYSNN 382 (Human) (Human) (Human) NWYFDL QRPSGVPDRFSGSKSGTSASLAISGLQ (Human) SEDEADYYCAAWDDSLNGPVFGGGT KLTVL CV10 1785 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV4-59 IGHJ4 IGKV3-20 IGKJ1 2807 ARGFDY VSSIYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYAGSPWTFGQGTKVEIK CV11 1786 EIVLTQSPATLSLSPGERATLSCRASQS IGHV4-31 IGHJ4 IGKV3-11 IGKJ3 2808 ARETTGHFDY VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPIFTFGPGTKVDIK CV12 1787 DVVMTQSPLSLPVTLGQPATISCRSSQ IGHV3-30 IGHJ4 IGKV2-30 IGKJ1 2809 VRGGVSGPN SLVYSDGNTYVNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) SFDM YQVSIRASGVPDRFSGSGSGTDFALKIS RVEAEDVGVYYCMQGTHWPVTFGQ GTKVEIK CV13 1788 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV7-4- IGHJ4 IGKV1-39 IGKJ3 2810 ARASARPGVA NIDNYLNWYQQKPGKAPKLLIYAASRL 1 (Human) (Human) (Human) TNLDF HSGVPSRFSGSGSGTDFTLIISSLQPED (Human) LATYYCQQSYSNPLTFGPGTKVDIR CV15 1789 QSALTQPRSVSGSPGQSVTISCTGTSS IGHV3-7 IGHJ6 IGLV2-11 IGU3 2811 ARDFNSYQLL DVGGYNYVSWYQQHPGKAPKLMIYD (Human) (Human) (Human) (Human) WYYYYGMDV VSKRPSGVPDRFSGSKSGNTASLTISGL QAEDEADYYCCSYAGSYTWVFGGGTK LTVL CV16 1790 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV5-51 IGHJ6 IGKV3-20 IGKJ1 2812 ARQSSFYSSG VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) WYSYGMDV ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSRGTFGQGTKVEIK CV17 1791 QSALTQPASVSGSPGQSITISCTGTSSD IGHV1-2 IGHJ5 IGLV2-23 IGU1 2813 ARVDYGSGSY VGSYNLVSWYQQHPGKAPKLMIYEGS (Human) (Human) (Human) (Human) GWGWFDP KRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCCSYAGSSTYVFGTGTKVT VL CV18 1792 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV1-24 IGHJ5 IGLV1-51 IGU3 2814 ATTSPIVGAIT NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) WFDP KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSSLSAGPVFGGGT KLTVL CV19 1793 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-2 IGHJ6 IGKV3-20 IGKJ2 2815 AREYYYDSSV VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YPYYYYAMDV ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPPKYTFGQGTKLEIK CV2 1794 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-15 IGKJ4 2816 ARVRGSYYLF SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) DY RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPPSLTFGGGTKV EIK CV21 1795 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-15 IGHJ4 IGKV3-11 IGKJ4 2817 TTDRVYDYIW VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) GSYRYLDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPLTFGGGTKVEIK CV22 1796 QLVLTQSPSASASLGASVKLTCTLSSGH IGHV3-21 IGHJ4 IGLV4-69 IGU3 2818 ARDRESYDILT SSYAIAWHQQQPEKGPRYLMKLNSD (Human) (Human) (Human) (Human) GYSMEGCFD GSHSKGDGIPDRFSGSSSGAERYLTISS Y LQSEDEADYYCQTWGTGIRVFGGGTK LTVL CV23 1797 SYELTQPPSVSVSPGQTARITCSGDALP IGHV1-3 IGHJ3 IGLV3-25 IGU3 2819 ARVWGYCSG KQYAYWYQQKPGQAPVLVIYKDSERP (Human) (Human) (Human) (Human) GSCYVDAFDI SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTYVVFGGGTKLTVL CV24 1798 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV1-24 IGHJ5 IGLV1-51 IGU1 2820 ATAPPYSPPSS NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) WFDP KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSSLSASYVFGTGTK VTVL CV25 1799 EIVMTQSPATLSVSPGERATLSCRASQ IGHV4-30 IGHJ6 IGKV3-15 IGKJ2 2821 ARDHHYDFW SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) SGYSSYYYYG RATGIPARFSGSGSGTEFTLTISSLQSE MDV DFAVYYCQQYNNWPYTFGQGTKLEIK CV26 1800 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ6 IGKV1-17 IGKJ3 2822 ARDEAYYDILT GIRNDLGWYQQKPGKAPKRLIYAASSL 3 (Human) (Human) (Human) GYINAPKNYY QSGVPSRFSGSGSGTEFTLTISSLQPED (Human) YYGMDV FATYYCLQHNSYPFTFGPGTKVDIK CV27 1801 QSALTQPASVSGSPGQSITISCTGTSSD IGHV3-30 IGHJ6 IGLV2-14 IGU1 2823 ARSFGGSYYY VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) GMDV SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSSSTPYVFGTGTK VTVL CV3 1802 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV7-4- IGHJ4 IGKV1-39 IGKJ3 2824 ARASARPGVA NIDNYLNWYQQKPGKAPKLLIYAASRL 1 (Human) (Human) (Human) TNLDF HSGVPSRFSGSGSGTDFTLIISSLQPED (Human) LATYYCQQSYSNPLTFGPGTKVDIR CV30 1803 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-53 IGHJ6 IGKV3-20 IGKJ2 2825 ARDLDVSGG VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) MDV ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGSSPQTFGQGTKLEIK CV31 1804 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV1-24 IGHJ5 IGLV1-51 IGU1 2826 ATAPPYSPPSS NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) WFDP KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSSLSASYVFGTGTK VTVL CV32 1805 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV1-2 IGHJ4 IGLV1-51 IGU3 2827 AREARDYYGS NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) GSLDY KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSSLSAVVFGGGTKL TVL CV33 1806 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-18 IGHJ6 IGLV1-40 IGU3 2828 ARDSVAGIYY NIGAGYDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) YYGMDV SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSGPVVFGGG TKLTVL CV34 1807 SYELTQPHSVSVATAQMARITCGGNN IGHV3-30 IGHJ6 IGLV3-12 IGU3 2829 ARSYGGSYYY IGSKAVHWYQQKPGQDPVLVIYSDSN 3 (Human) (Human) (Human) GMDV RPSGIPERFSGSNPGNTATLTISRIEAG (Human) DEADYYCQVWDSSSDHVVFGGGTKL TVL CV35 1808 QSVLTQPPSASGTPGQRVTISCSGSSS IGHV4-38 IGHJ2 IGLV1-44 IGU3 2830 ARTPLSLRLRY NIGSNTVNWYQQLPGTAPKLLIYSNN (Human) (Human) (Human) (Human) NWYFDL QRPSGVPDRFSGSKSGTSASLAISGLQ SEDEADYYCAAWDDSLNGPVFGGGT KLTVL CV36 1809 SYELTQPPSVSVSPGQTARITCSGDALP IGHV1-2 IGHJ6 IGLV3-25 IGU1 2831 ARDLTTTAGT KQYAYWYQQKPGQAPVLVIYKDTERP (Human) (Human) (Human) (Human) DYYYGMDV SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTYMIFGTGTKVTVL CV37 1810 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV1-18 IGHJ4 IGKV1-33 IGKJ3 2832 ARARVAYDYl DISNYLNWYQQKPGKAPKLLIYDASNL (Human) (Human) (Human) (Human) WGSYRYKAF ETGVPSRFSGSGSGTDFTFTISSLQPED DY IATYYCQQYDNLPRFGPGTKVDIKR CV38 1811 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ4 IGKV3-11 IGKJ5 2833 ARAQTAHYSS VSSYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) SFDY ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPITFGQGTRLEIK CV38-113 ND IGHV3-53 IGHJ4 ND ND 2834 ARGGRLADA (Human) (Human) AGDY CV38-139 ND IGHV3-53 IGHJ4 ND ND 2835 ARGHYDLFDY (Human) (Human) CV38-142 ND IGHV5-51 IGHJ4 ND ND 2836 ARIRGVYSSG (Human) (Human) WIGGDY CV38-183 ND IGHV3-53 IGHJ6 ND ND 2837 ARGDGWDN (Human) (Human) YYYGMDV CV38-221 ND IGHV3-66 IGHJ4 ND ND 2838 ARGFGDYYFD (Human) (Human) Y CV39 1812 DVVMTQSPLSLPVTLGQPASISCRSSQ IGHV3-30 IGHJ3 IGKV2-30 IGKJ1 2839 VRGGVSGPN SLVYSDGNTYVNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) AFDI YKVSNRDSGVPDRFSGSGSGTDFALKI SRVEAEDVGVYYCMQGTHWPVTFGQ GTKVEIK CV4 1813 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ2 2840 ARSISGSYLGA SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) FDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYTFGQGTKLEIK CV40 1814 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-18 IGHJ3 IGKV1-17 IGKJ4 2841 ARVGLWWL GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) GHPDAFDI QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPLTFGGGTKVEIK CV41 1815 EIVMTQSPATLSVSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-15 IGKJ4 2842 ARTKGGSYFA SVSSNLAWYQQKPGQAPRLLIYGAST (Human) (Human) (Human) (Human) PFDY RATGIPARFSGSGSGTEFTLTISSLQSE DFAVYYCQQYNNWPLTFGGGTKVEIK CV42 1816 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-18 IGHJ4 IGKV1-39 IGKJ3 2843 ARDRGYAATF SISSYLNWYQQKPGKAPKFLIYAASSLQ (Human) (Human) (Human) (Human) GVFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQTYITAFTFGPGTKVDIK CV43 1817 NFMLTQPHSVSESPGKTVTISCTGSSG IGHV3-30 IGHJ4 IGLV6-57 IGU3 2844 ARVTVVHFDY SIASNYVQWYQQRPGSAPTTVIYEDN (Human) (Human) (Human) (Human) QRPSGVPDRFSGSIDSSSNSASLTISGL KTEDEADYYCQSYDSSNWVFGGGTKL TVL CV44 1818 SYELTQPPSVSVSPGQTARITCSGDALP IGHV1-46 IGHJ6 IGLV3-25 IGU3 2845 ARDLTSTSSSP KQYAYWYQQKPGQAPVVVIYKDSERP (Human) (Human) (Human) (Human) YSYYYGMDV SGIPERFSGSSSGTTVTLTISGVQAEDE ADYYCQSADSSGTYVVFGGGTKLTVL CV45 1819 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV1-18 IGHJ5 IGLV1-40 IGU1 2846 ARVTVEAIFG NIGAGYDVHWYQQLPGTAPKLLIYGN (Human) (Human) (Human) (Human) VVILPLKNWF SNRPSGVPDRFSGSKSGTSASLAITGL DP QAEDEADYYCQSYDSSLTLYVFGTGTK VTVL CV46 1820 DVVMTQSPLSLPVTLGQPASISCRSSQ IGHV3-30 IGHJ4 IGKV2-30 IGKJ1 2847 VRGGVSGPN SLVYSDGNTYVNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) SFDM YQVSIRASGVPDRFSGSGSGTDFALKIS RVEAEDVGVYYCMQGTHWPVTFGQ GTKVEIK CV47 1821 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-18 IGHJ3 IGKV1-17 IGKJ4 2848 ARVGLWWL GIRNDLGWYQQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) GHPDVFDI QSGVPSRFSGSGSGTEFTLTISSLQPED FATYYCLQHNSYPLTFGGGTKVEIK CV48 1822 DVVMTQSPLSLPVTLGQPASISCRSSQ IGHV1-69 IGHJ4 IGKV2-30 IGKJ1 2849 ARDLVEDTA SLVYSDGNTYLNWFQQRPGQSPRRLI (Human) (Human) (Human) (Human) MVTGAAAGT YKVSNRDSGVPDKFSGSGSGTDFTLKI SRVEAEDVGVYYCMQGTHWPPTFGQ GTKVEIK CV5 1823 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV1-46 IGHJ3 IGKV4-1 IGKJ2 2850 ARAGRRYSSS NVLYSSNNKNYLAWYQQKPGQPPKLL (Human) (Human) (Human) (Human) DDGAFDI IYWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYITPYTFGQGT KLEIK CV50 1824 SYELTQPPSVSVSPGQTARITCSGDALP IGHV3-33 IGHJ4 IGLV3-10 IGU1 2851 ARDIMFGDD KKYAYWYQQKSGQAPVLVIYEDSKRP (Human) (Human) (Human) (Human) WLQKQPDY SGIPERFSGSSSGTMATLTISGAQVED EADYYCYSTDSSGNLYVFGTGTKVTVL CV7 1825 DIQMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ2 2852 ARSISGSYLGA SISSWLAWYQQKPGKAPKLLIYKASSL (Human) (Human) (Human) (Human) FDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSYTFGQGTKLEIK CV8 1826 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-18 IGHJ6 IGKV3-20 IGKJ5 2853 ARLVPTWASY VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YDFWSGYPG ATGIPDRFSGSGSGTDFTLTISRLEPED GYGMDV FAVYYCQQYGSSPGTFGQGTRLEIK CV9 1827 QSALTQPASVSGSPGQSITISCTGTSSD IGHV4-39 IGHJ2 IGLV2-14 IGU3 2854 ATHIVVVTAT VGGYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) PNWYFDL SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEADYYCSSYTSISTWVFGGGTKL TVL EY6A 1828 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-39 IGKJ4 2855 AKDGGKLWV SISSYLNWYQQKPGKAPKLLIYAASSLQ 3 (Human) (Human) (Human) YYFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYSTLALTFGGGTKVEIK Fab 2-4 1829 QSALTQPPSASGSPGQSVTISCTGTSS IGHV1-2 IGHJ6 IGLV2-8 IGU3 2856 ARDRSWAVV DVGGYNYVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) YYYMDV VSKRPSGVPDRFSGSKSGNTASLTVSG LQAEDEADYYCSSYAGSNNLVFGGGT KLTVL FnC1t1p2_ 1830 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-8 IGHJ4 IGKV3-20 IGKJ1 2857 ARATTDCSST A5 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) SCWSLDFWS ATGIPDRFSGSGSGTDFTLTISRLEPED GYYTGGREKI FAVYYCQQYGSSPGTFGQGTKVEIK FD FnC1t2p1_ 1831 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV7-4- IGHJ5 IGKV1-33 IGKJ4 2858 ARSLRGANLV D4 DVSNYLNWYQQQPGKAPKLLIYDAFN 1 (Human) (Human) (Human) P LETGVPSRFSGSGSGTDFTFTISSLQPE (Human) DIATYYCQQYDNLPLTFGGGTKVEIK FnC1t2p1_ 1832 DIQMTQSPSSLSASVGDRVTITCQASQ IGHV7-4- IGHJ5 IGKV1-33 IGKJ4 2859 ARSLRGANLV G5 DVSNYLNWYQQQPGKAPKLLIYDAFN 1 (Human) (Human) (Human) P LETGVPSRFSGSGSGTDFTFTISSLQPE (Human) DIATYYCQQYDNLPLTFGGGTKVEIK H014 ND ND ND ND ND ND H11-D4 N/A IGHV3-3 IGHJ4 N/A N/A 2860 ARTENVRSLL (Alpaca) (Alpaca) SDYATWPYDY H11-H4 N/A IGHV3-3 IGHJ4 N/A N/A 2861 AQTHYVSYLL (Alpaca) (Alpaca) SDYATWPYDY H4 1833 DIQMTQSPLSLPVTPGEPASISCRSSQS IGHV1-2 IGHJ2 IGKV2-40 IGKJ4 2862 ARVPYCSSTSC LLDSDDGNTYLDWYLQKPGQSPQLLIY (Human) (Human) (Human) (Human) HRDWYFDL TLSYRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQRIEFPLTFGGGTK VEIK HbnC2t1p2_ 1834 EIVLTQSPATLSLSPGERATLSCRASLS IGHV3-33 IGHJ6 IGKV3-11 IGKJ1 2863 ARAARRPVVT D9 LSSYLAWYQQKPGQAPRLLIYDASNRA (Human) (Human) (Human) (Human) DTMAYYMDV TGIPARFSGSGSGTDFTLTISSLEPEDF AVYYCQQRSNWPPTWTFGQGTKAEIK HbnC3t1p1_ 1835 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2864 AAPHCSSTICY C6 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DGFDI ATGIPDRFSGSGSGTDFTLTISRVEPED FAVYYCQQYGSSPWTFGQGTKVEIK HbnC3t1p1_ 1836 DIQMTQSPSTVSASVGDRVTITCRASQ IGHV3-30 IGHJ5 IGKV1-5 IGKJ4 2865 AKGGDYEWE F4 SIDNWLAWYQEKPGKAPKVLIYKASSL (Human) (Human) (Human) (Human) LLES ESGVPSRFSGRGSGTEFTLTISSLQPGD FATYYCQHYHSFPLTFGGGTKVDIK HbnC3t1p1_ 1837 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-66 IGHJ4 IGKV3-20 IGKJ1 2866 ARDFGDFFFD G4 VSSYLAWYQQKPGQAPRLLIYGVSSRA (Human) (Human) (Human) (Human) Y TGIPDRFSGSGSGTDFTLTISRLEPEDF AVYYCQQYGSSPRTFGQGTKVEIK HbnC3t1p2_ 1838 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-66 IGHJ4 IGKV3-20 IGKJ2 2867 ARDYGDYFFD B10 VSSYLAWYQQKPGQAPRLLISGASSRA (Human) (Human) (Human) (Human) Y AGIPDRFSGSGSGTDFTLTINRLEPEDF AVYYCQQYGSSPRTFGQGTKLEIK HbnC3t1p2_ 1839 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 2868 AAPYCSSTRC C6 VSSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) YDAFDI ATGIPDRFSGSGSGTDFTLTISRLEPED FAVYYCQQYGRSPWTFGQGTKVEI HbnC4t1p1_ 1840 DIQMTQSPSSLSASVGDRATITCRASQ IGHV3-9 IGHJ4 IGKV1-39 IGKJ4 2869 AKDINYDSGG D5 SISSYLNWYQEKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) YHKNYFDY SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSNPLTFGGGTKVEIK Ju et al., 205 Various Various Various Various Various 2020 Kim et Various Various Various Various Various Various al., 2020 LR1 N/A IGHV3-3 IGHJ4 N/A N/A 2870 AAAEWGYE (Alpaca) (Alpaca) WPLYYASSW Y LR11 N/A IGHV3-3 IGHJ4 N/A N/A 2871 AAAYWGWD (Alpaca) (Alpaca) WPLNSQDYW LR15 N/A IGHV3-3 IGHJ4 N/A N/A 2872 AAADWGYN (Alpaca) (Alpaca) WPLIREEYEY LR16 N/A IGHV3-3 IGHJ4 N/A N/A 2873 AAADWGYNI (Alpaca) (Alpaca) PLNITDYWY LR2 N/A IGHV3-3 IGHJ4 N/A N/A 2874 AAAMNGYNE (Alpaca) (Alpaca) PLYSYDYEY LR3 N/A IGHV3-3 IGHJ4 N/A N/A 2875 AAASWGYEW (Alpaca) (Alpaca) PLVYDDYWY LR5 N/A IGHV3-3 IGHJ4 N/A N/A 2876 AAATWGYH (Alpaca) (Alpaca) WPLGAWDY WY LR6 N/A IGHV3-3 IGHJ4 N/A N/A 2877 AAATWGYSW (Alpaca) (Alpaca) PLEHDEYWY LR7 N/A IGHV3-3 IGHJ4 N/A N/A 2878 AAAFHGEQY (Alpaca) (Alpaca) PLYTNKYHY LR8 N/A IGHV3-3 IGHJ4 N/A N/A 2879 AAANYGANF (Alpaca) (Alpaca) PLQANTYFY mAb-1 1841 QPVLTQPPSVSGAPGQRITISCTGSSS IGHV3-21 IGHJ4 IGLV1-40 IGU1 2880 ARDFSGHTAV NIGAGYDVHWYQQLPGTAPKLLIYGS (Human) (Human) (Human) (Human) AGTGFEY SSRPSGVPDRFSGSKSGTSASLAITGLQ AEDEADYYCQSYDSSLSVLYVFGTGTK VTVL mAb-10 1842 DIVLTQTPATLSVSPGEGATLSCRASQS IGHV3-66 IGHJ4 IGKV3-15 IGKJ4 2881 VRASPPGGN VRSNLAWFQQRPGQVPRLLIYDASTR (Human) (Human) (Human) (Human) TGWPFFED ATGVPARFTGSGSGTYFTLTISSLQSED FAVYYCQQYNSWPPLTFGGGTKLEIK mAb-100 1843 EIVMTQSPATLSVSPGETATLSCRASQ IGHV3-30 IGHJ4 IGKV3-11 IGKJ1 2882 ARDNALQNA SVGRFMGWYQQKPGQAPRLLIFDAS (Human) (Human) (Human) (Human) QIGYLDY NRVTGVPDRFRGSGSGTDFILTINSLEP EDSASYYCQRRGDGYNFGQGTKVEIK mAb-101 1844 ETTLTQSPLSLPVTLGQPASISCRSSQG IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2883 VLDSDPYTAT LVHSDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) FSHNHYWYA KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTEWPRTFGQG TKVEIK mAb-102 1845 DIRVTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2884 ARDPSIHYTG IVHTDGNTYLNWFLQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQGTEWPRTFGQGT KVDIK mAb-103 1846 EIVMTQSPSSLSASVGDRVTITCRAGH IGHV7-4- IGHJ4 IGKV1-39 IGKJ3 2885 AREEHYDFSS TISTYLNWYQQKPGKAPKILISGASSLQ 1 (Human) (Human) (Human) GYFRPAY SGVPSRFSGSGSGTDFTLTIGSLQPEDF (Human) ATYYCQQSYSTPYTFGQGTKVDIK mAb-104 1847 QPVLTQPASVSGSPGQSSTLSCSGTSS IGHV4-34 IGHJ4 IGLV2-23 IGU3 2886 ARGMTSPVV DVGSYDLVSWYQQHPGKAPKLMIYE (Human) (Human) (Human) (Human) HLYSSGRPSR GTKRPSGVSDRFSGSTSGNTASLTISGL WFDF QAEDEANYYCCSYAGSGTWIFGGGTK LTVL mAb-105 1848 EIVLTQSPGTLSLSPGDRVTLFCRASQN IGHV4-4 IGHJ6 IGKV3-20 IGKJ1 2887 ARSFISFDSSG IANNHLAWYQQKPGQAPRVLIYGAST (Human) (Human) (Human) (Human) HPYYYYAMD TATDIPDRFSGRVSGTDFTLTISRLDPE V DFAVYYCHQYGSSPWTFGQGTKLEIK mAb-106 1849 ETTLTQSPATLSVSPGETATLSCRASQS IGHV3-30 IGHJ4 IGKV3-11 IGKJ1 2888 ARDNALQNA VGRFMGWYQQKPGQAPRLLIFDASN (Human) (Human) (Human) (Human) QIGYLDY RVTGVPDRFRGSGSGTDFILTINSLEPE DSASYYCQRRGDGYNFGQGTKVEIK mAb-107 1850 DIRMTQSPLSLPVDLGQSASISCRSSQ IGHV1-69 IGHJ6 IGKV2-30 IGKJ2 2889 ARDPSILNTG RVVHTNGNTYLHWFHQRPGQAPRRL (Human) (Human) (Human) (Human) NHHWYDLD IYKVSNRESGVPDRFSGSGSGTDFTLRI M SRVEAEDVGVYYCMQATDWPRTFGQ GTKLEIK mAb-108 1851 DIVMTQSPLSLSVTLGQAASISCTCSQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2890 ARDPTFLNSG AVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYDVDI KVSNRDSGVPDRFSGSGSGTDFTLKIN RVEAEDVGIYYCMQTTDWPRTFGQG TKVEIK mAb-109 1852 ETTLTQSPVTLPVTLGQPASISCTSSRW IGHV1-69 IGHJ4 IGKV2-30 IGKJ2 2891 ARDASFPNTG LVHTNGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYDFDL QVSNRDSGVPDRFSGSGSGTDFTLQIS RVEAEDVGVYYCMQGTEWPRTFGQ GTKLEIK mAb-11 1853 EIVLTQSPSSLSASVGDRVTITCQASQD IGHV3-30 IGHJ4 IGKV1-33 IGKJ5 2892 AKKGSPYCGV IRKCLNWYQHIPGKAPKLLIHDASSLES (Human) (Human) (Human) (Human) DCYKGYFDY GVPSRFSGSGSGTDFSFTINSLHPEDIA TYYCQQFEDLPITFGQGTRLEIK mAb-110 1854 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV3-33 IGHJ4 IGKV4-1 IGKJ1 2893 ARVGSGRVY SVLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPYTFGQGT KVEIK mAb-111 1855 DIVVTQSPGTLSLSPGERAALSCRASQS IGHV4-4 IGHJ3 IGKV3-20 IGKJ1 2894 ARVRIGASHH VGNNYLAWYQQKPGQAPRLLIYGATS (Human) (Human) (Human) (Human) NFWSGYYTD RATGIPDRFSGSGSGTDFTLTISRLEPE AFDI DFAVYYCQQYGTSPVYTFGQGTKVEIK mAb-112 1856 QPVLTQPPSVSAAPGQKVTISCSGSSS IGHV5-51 IGHJ4 IGLV1-51 IGU3 2895 ARAPLASCSG NIENNYVSWYQQLPGAAPKLLIYDNN (Human) (Human) (Human) (Human) GRCPTYNRFD KRPSGIPDRFSGSKSGTSATLGITGLQT L GDEADYYCGTWDFSLSAGVFGGGTKL TVL mAb-113 1857 ETTLTQSPLSLPVTLGQPASISCRSSQG IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2896 ASEYFDGRSY LVHTNGNLYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) HSFCGLDV QVSNRDSGVPDRFSGSGSGTDFTLRIS RVEAEDVGIYYCMQGTEWPRTFGQG TKVEIK mAb-114 1858 DIQLTQSPSTLSASVGDSVTITCRASQS IGHV3-23 IGHJ6 IGKV1-5 IGKJ4 2897 AKGLSFYGSG ISSWLAWYQQKPGKAPKLLIYKASSLET (Human) (Human) (Human) (Human) SDAFDV GVPSRFSGSGSGTEFTLTISSLQPDDFA TYYCQQYKSPLSFGGGTKVEIK mAb-115 1859 DIQVTQSPATLSLSPGERATLSCRASQS IGHV1-2 IGHJ6 IGKV3-11 IGKJ5 2898 ARDLISVIRGL VSSYLAWYQQKPGQAPRLLIYDASKR (Human) (Human) (Human) (Human) GGGMDV ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSDWHPITFGQGTRLEIK mAb-116 1860 DIQVTQSPSSLSASVGDRVTITCRASQS IGHV1-2 IGHJ4 IGKV1-39 IGKJ3 2899 ARGGPLPWS ISSSLNWYQQKPGKAPTLLIYTASNLQS (Human) (Human) (Human) (Human) DLDIVGTFDY GVPSRFSGSGSGTDFTLTITSLQPEDFA TYYCQQSYSTPGFGPGTKVDIK mAb-117 1861 EIVMTQSPATLSLSPGERATLSCRASQS IGHV3-33 IGHJ2 IGKV3-11 IGKJ3 2900 VKDQSSGDRL VSIYLAWYQQKPGQAPRLLIYDASNRA (Human) (Human) (Human) (Human) LYLGYFDL TGVPARFSGSGSGTDFTLTINNLEPED FAIYYCQQRAKWPPRVTFGPGTKVDIK mAb-118 1862 DIVLTQSPATLSLSPGERATLSCRASQS IGHV3-33 IGHJ2 IGKV3-11 IGKJ3 2901 VKDQSSGDRL VSIYLAWYQQKPGQAPRLLIYDASNRA (Human) (Human) (Human) (Human) LYLGYFDL TGIPARFSGSGSGTDFTLTINNLEPEDF AIYYCQQRAKWPPRVIFGPGTKVEIK mAb-119 1863 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-4 IGHJ6 IGLV3-10 IGU3 2902 ATMWGGLCT RRYAYWYQQRSGQAPVLVIYEDNKRP (Human) (Human) (Human) (Human) ASNCYGNPM SGIPERFSAFSSGTMATLTISGAQVEDE DV ADYYCYSTDSTANYKVFGGGTKLTVL mAb-12 1864 ETTLTQSPLSLPVTLGQPASISCRSSQG IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2903 VRDSDPYTAT LVHSNGNTYVNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) VTSNHYWYA EVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTEWPRTFGQG TKVDIK mAb-120 1865 QSVLIQPASVSGSPGQSITISCTGSSSD IGHV4-34 IGHJ5 IGLV2-23 IGU3 2904 ARGQGGYDL VGSYNLVSWYQQHPGKAPKLMIYEGY (Human) (Human) (Human) (Human) RRVGYGLTS KRPSGVSNRFSGSKSGNTASLTISGLQ WFDP AEDEADYYCCSYAGSSAVVVVFGGGT KLTVL mAb-121 1866 DIRVTQSPDSLAVSLGERATINCRTSQS IGHV1-46 IGHJ3 IGKV4-1 IGKJ3 2905 ARVLAGSSHE VLYSSNNKNYLGWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) WQLTHDAFD YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPYTFGQGT KVDIK mAb-122 1867 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-2 IGHJ6 IGKV3-11 IGKJ5 2906 AKDLITVIRGL VSTYLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) GGGMDV ATGIPARFSGSGSGTDFTLTISSLEPED FALYYCLQRSDWHPITFGQGTRLEIK mAb-123 1868 DIQLTQSPATLSLSPGERATLSCRANQS IGHV1-69 IGHJ1 IGKV3-11 IGKJ4 2907 ARDGPYDSG VSNFLAWYQQKPGQAPRHLIYDASNR (Human) (Human) (Human) (Human) GYHLNH ATGIPARFSGSGSGTDFTLTISSLEPED FAVYYCQQRSNWPPRLTFGGGTKVEIK mAb-124 1869 DIVMTQTPGTLSVSPGERATLSCRASQ IGHV3-11 IGHJ4 IGKV3-20 IGKJ3 2908 ARMGPYGSG IINRSQLGWYQHKPGQPPRLLIFDSSK (Human) (Human) (Human) (Human) TFDY RATGTPDRFSASGSETDFTLTISGVEPE DSGVYYCLQYSLATTFGPGTKVEIK mAb-125 1870 QPVLTQSSSASASLGSSVKLTCTLSSGH IGHV1-69 IGHJ4 IGLV4-60 IGU6 2909 ARDLSTLQPD SSYILAWHQQQPGKAPRFLMKFEVG (Human) (Human) (Human) (Human) AIVNFDY GRYNKGSGVPDRFSGSSSGADRYLTIS NLQSEDEADYYCETWDSNLKGVFGG GTKVTVL mAb-126 1871 QPVLTQSSSASASLGSSVKLTCTLRSGH IGHV1-69 IGHJ4 IGLV4-60 IGU6 2910 ARDLYYDNG SSYIIAWHQQQPGKAPRFLMKVGHSG (Human) (Human) (Human) (Human) GYNYLDY SYNKGSGVPDRFSGSRSGADHYLTISN LQPDDEADYYCEAWDNNNLGVFSGG TKVTVL mAb-127 1872 DIQLTQSPSAMSASVGDRVTITCRASQ IGHV3-48 IGHJ6 IGKV1-17 IGKJ4 2911 VRDYCNSVSC GINDNLAWFQQKPGKVPKRLIYAASN (Human) (Human) (Human) (Human) YTYYYIGMDV LQNGVPSRFSGSGSGTEFTLTISSLQPE DFATYYCLQHNSYPLTFGGGTKLEIK mAb-128 1873 DIRMTQSPLSLPVTPGEPASISCRSSQS IGHV1-18 IGHJ6 IGKV2-28 IGKJ3 2912 ATSASSYSRYY LLHSNGYNYLDWYLQKPGQSPQLLIYL (Human) (Human) (Human) (Human) FGLDV GSNRASGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQALQTPGVTFGGG TKVDIK mAb-129 1874 QPVLTQPPSASGTPGQRVTISCSGSYS IGHV4-31 IGHJ6 IGLV1-44 IGU3 2913 ARDLAKWSY NIGTNPANWYQQLPGTAPKLLIYNND (Human) (Human) (Human) (Human) GYYYSGMDV QRPSGVPDRFSGSKSGTSASLAISGLQ SEDETDYYCATWDDSLNGVVFGGGTK LTVL mAb-13 1875 DIRMTQSPLSLPVTRGQPASISCRSSH IGHV1-69 IGHJ6 IGKV2-30 IGKJ4 2914 AREEYSGTVH NVVHSDGKTYLNWFHQRPGQAPRRL (Human) (Human) (Human) (Human) NFFGMDV IYQVSKRDSGVPDRFSGSGSGSDFTLTI SRVEAEDVGVYYCMQGTDWPRSFGG GTKVEIK mAb-130 1876 EIVLTQSPSSLSASVGDRVTITCRASRS IGHV3-9 IGHJ6 IGKV1-39 IGKJ1 2915 AKDGRYCSGI ISSYLNWYQQKPGKAPNLLIYDASTLQS (Human) (Human) (Human) (Human) SCRTGMDV GVPSRFSGSGSGTDFSLTISSLQPEDFA TYYCLHTYTTPRTFGQGTKVEIK mAb-131 1877 EIVLTQSPATLSVSPGERITLSCRASHS IGHV3-48 IGHJ3 IGKV3-15 IGKJ4 2916 ARGLLDYLHD VSSNLAWYQQKPGQVPRLLIYGASARA (Human) (Human) (Human) (Human) AFDI TGIPARFSGSGSGTEFTLTISSLQSEDF AVYYCQQYNYWPPLTFGGGTKVEIK mAb-132 1878 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-38 IGHJ3 IGKV1-39 IGKJ5 2917 ASRHLDLLPIG SISTYLNWYQQKTGKAPELLIYVASSLQ 2 (Human) (Human) (Human) SFDV SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYRFPITFGQGTRLEIK mAb-133 1879 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-49 IGHJ6 IGKV3-11 IGKJ3 2918 TRGSGMFYG VGTYLAWYQQKHGQAPRLLISDVSKR (Human) (Human) (Human) (Human) SSSGMDV ATGIPARFSGSGSGTDFTLTITSLEPED FAVYYCQQRTNWPGATFGPGTKVDIK mAb-134 1880 QPVLTQSPSASASLGGSVKLTCTLTSG IGHV1-69 IGHJ4 IGLV4-69 IGU3 2919 AIRRDYSDYR HSTYAIAWHQQQPEKGPRFLMKLNS (Human) (Human) (Human) (Human) DFDY DGSHNKGDGIPDRFSGSSSGAERYLTI SSLQSEDEADYYCHTWGTDIQVFGGG TKLTVL mAb-135 1881 NFMLTQPHSVSESPGKTVTISCTRSSG IGHV4-59 IGHJ4 IGLV6-57 IGU6 2920 ARQSSSWYN SIANNYVQWLQQRPGSSPTTIIYEDNQ (Human) (Human) (Human) (Human) PYYFDQ RPSGVPDRFSGSIDASSNSASLTISGLK TEDEADYYCQSYDSSSQVFGGGTKVT VL mAb-136 1882 DIVLTQSPATLSVSPGERITLSCRASHS IGHV3-48 IGHJ3 IGKV3-15 IGKJ4 2921 ARGLLDYLHD VSSNLAWYQQKPGQVPRLLIYGASAR (Human) (Human) (Human) (Human) AFDI ATGIPARFSGSGSGTEFTLTISSLQSED FAVYYCQQYNYWPPLTFGGGTKVEIK mAb-137 1883 ETTLTQSPLSLSVTLGQAASISCRPNLG IGHV1-69 IGHJ4 IGKV2-30 IGKJ2 2922 ARDPSILNTG LMHTDGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) NHHWYDLDL YKVSNRDSGVPDRFAGSGSGTHFTLEI SGVEADDVGVYYCMQGTEWPRTFG QGTKLEIK mAb-138 1884 DIRMTQSPSTLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-5 IGKJ2 2923 ARPRSGSYRQ TIGSWLAWYQQKPGKAPNLLIYKASSL (Human) (Human) (Human) (Human) AIDY ESGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSLYTFGQGTKLEIK mAb-139 1885 ETTLTQSPGTLSVSPGERATLSCRASQS IGHV3-7 IGHJ6 IGKV3-15 IGKJ3 2924 VRQNVAIQYY VISNLAWYQQKPGQAPRLLIYGASTRA (Human) (Human) (Human) (Human) YYAMDV TGVPARFSGSGSGTEFTLTIASLQSEDF AVYYCQQYHHWPPYTFGQGTKVDIK mAb-14 1886 EIVLTQSPDSLAVSLGERATINCKSSQS IGHV3-30 IGHJ4 IGKV4-1 IGKJ3 2925 ARAKGGSYSN VLYSSNNENCLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) AFDY YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYCSTPPYTFGQ GTKVDIK mAb-140 1887 EIVMTQSPLSLPVSLGQPASISCRSSQS IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2926 ARDPSILDTG VIHTDGNTYLNWYHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLDI KVSNRDSGVPDRFSGSGSVTDFTLKIS RVEAEDVGVYYCMQGTEWPRTFGQ GTKVEIK mAb-141 1888 DIVMTQSPLSLPVSRGQSASISCRSSHS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2927 AREEYSGTVH VVHSDGKTYVNWFHQRPGQAPRRLI (Human) (Human) (Human) (Human) NFFGMDV YQVSKRDSGVPDRFSGSGSGFDFTLKI SRVEAEDVGVYFCMQGTDWPRSFGG GTKVDIK mAb-142 1889 DIVMTQSPSSLSASVGDRVTITCRASQ IGHV3- IGHJ3 IGKV1-39 IGKJ5 2928 VRDWGSSTH SINIYLNWYQQKPGKAPKLLIYAASSLQ 64D (Human) (Human) (Human) YDVFDL SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQSYSTPLITFGQGTRLEIK mAb-143 1890 DIRLTQSPLSLPVTLGQAASISCKSSHF IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 2929 ARDPSILNTG IVHTDGNTYLNWFHQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDL VSNRDSGVPDRFSGSGSGTDFTLEISG VEAEDVGVYYCMQGTEWPRTFGQGT KVDIK mAb-144 1891 ETTLTQSPLFLPVTLGQPASISCTSSVH IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2930 ARDASIVGTG VVHSDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHLWYGLDF KVSNRDSGVPDRFSGSGSGTYFTLKIS RVEAEDVGVYYCMQGTDWPRTFGQ GTKVDIK mAb-145 1892 ETTLTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ5 IGKV3-11 IGKJ3 2931 ARDNALQDG INDYLGWYQHRPGQAPRLLIHDASTRA (Human) (Human) (Human) (Human) RPGYFDS PGIPVRFSGSGSGTDFTLTISSLEPEDS AVYYCQQRFSWYNFGPGTKVEIK mAb-146 1893 QSVLTQPASVSGSPGQSITISCAVTSSD IGHV3-11 IGHJ5 IGLV2-23 IGU3 2932 ARGHRFLEFP VGSYNLVSWHQQHPGKAPKLMIYEV (Human) (Human) (Human) (Human) LNYFDP NKRPSGVSNRFSGSKSGNTASLTISGL QAEDEAVYYCCSYGGRSTSVVFGGGT KLTVL mAb-147 1894 DIRLTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ5 IGKV3-11 IGKJ2 2933 ARDNALQDG INDYLGWYQHRPGQAPRLLIHDASTRA (Human) (Human) (Human) (Human) RPGYFDS PGIPVRFSGSGSGTDFTLTISSLEPEDS AVYYCQQRFSWYNFGPGTKLEIK mAb-148 1895 QPVLTQPASVSGSPGQSITISCTGTTSD IGHV3-30 IGHJ6 IGLV2-14 IGU3 2934 ALLYGSGSYY VGGYDYVSWYQQRPGKAPKLIIYDVI (Human) (Human) (Human) (Human) NFVFFGWKD NRPSGVSNRFSGSKSGNTASLTISGLQ GSDA ADDETDYYCSSYTSGGTLVFGTGTKLT VL mAb-149 1896 DIQMTQSPLSLPVGLGQSASISCRSSQ IGHV1-69 IGHJ4 IGKV2-30 IGKJ1 2935 ARDPSILNTG WVVHTDGNTYLNWFHQRPGQSPRR (Human) (Human) (Human) (Human) NHHWYDLDL LIYKVSNRDSGVPDRFSGSGSGTDFTL RISRVEAEDVGVYYCMQATEWPRTFG QGTKVEIK mAb-15 1897 DIRLTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 2936 ARDPSIHYTG IVHTDGNTYLNWFLQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQGTEWPRTFGQGT KVDIK mAb-150 1898 DIQLTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2937 ARDPSIHYTG IVHTDGNTYLNWFLQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQGTEWPRTFGQGT KVEIK mAb-151 1899 ETTLTQSPLSLSVTLGQSASISCRASQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2938 VRDSEPYTAT VVHSVDGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) RSQNHYWYD YKVSNRDSGVPDRFSGSGSGTDFTLRI MDV SRVEAEDIGIYYCMQGTDWPRTFGQG TKVEIK mAb-152 1900 DIVMTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2939 ARDPSIHYTG IVHTDGNTYLNWFLQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQGTEWPRTFGQGT KVEIK mAb-153 1901 DIRMTQSPLSLPVTLGQPASISCRSSQF IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 2940 ARDPSIVDSG VVHTDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) PHHWYDLDI KVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGVYYCMQATEWPRTFGQG TKVDIK mAb-154 1902 SYVLTQPPSVSVSPGQTARITCSADGL IGHV1-2 IGHJ4 IGLV3-25 IGU7 2941 ASGPNYFDY PKQYSYWYQQKPGQAPVMVIYKDTE (Human) (Human) (Human) (Human) RPSGIPERFSGSSSGTTATLTISGVQAE DEADYYCQSADSNDSSPVFGGGTQLT VL mAb-155 1903 ETTLTQSPATLSLSPGEGATLSCRASQS IGHV3-21 IGHJ4 IGKV3-11 IGKJ1 2942 ARADRDYDF VSSSLAWYQQKPGQAPRLLIYDASNR (Human) (Human) (Human) (Human) WSDPPLIDH ATGIPARFSGSGSGTDYTLTISSLEPED FAVYYCHQRSNWPYTFGQGTKVEIK mAb-156 1904 DIVLTQTPSSLSASVGDRVTITCRASQT IGHV3-53 IGHJ4 IGKV1-39 IGKJ1 2943 ARGFGNGWS IATYLSWYQQKPGKAPKLLIYAVSSLQS (Human) (Human) (Human) (Human) YYFDY GVPSRFSGSGSGTDFTLTIGSLQPEDF ATYYCQQSYSIPWTFGQGTKVDIK mAb-157 1905 EIVMTQSPSSLSASVGDRVTITCRASQS IGHV3-48 IGHJ6 IGKV1-39 IGKJ4 2944 ARDPGLEYSG ISYYLNWYQQKPGKAPKLLIYAASSLQS (Human) (Human) (Human) (Human) NYFSYYYYAM GVPSRFSGSGSGTDFILTISSLQPEDIA DV TYYCQHSYSSPPLTFGGGTKVEIK mAb-158 1906 ETTLTQSPLSLPVTLGQPASISCRSSQI IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2945 VRDSDPYTAT VVHSDGNTYLNWFHQRPGQSPRRLIYK (Human) (Human) (Human) (Human) SRNNHYWYD VSNRDSGVPDRFSGSGSGTDFTLKISR MDV VEAEDIGVYYCMQGTDWPRTFGQGT KVDIK mAb-159 1907 DIRLTQSPLSLSVTLGQAASISCTCSQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2946 ARDPTFLNSG AVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYAVDI KVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGIYYCMQTTDWPRTFGQG TKVEIK mAb-16 1908 EIVLTQSPLSLPVTLGQPASISCRSSLR IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2947 VRDSDPYTAT LVHTDGNTYLNWFQQRPGQSPRRLIYK (Human) (Human) (Human) (Human) YRNNHYWYA VSNRDSGVPDRFSGSGSGTDFTLKISR MDV VEAEDIGVYYCMQGTEWPRTFGQGT KVDIK mAb-160 1909 DIVMTQSPGTLSLSPGERAALSCRASQ IGHV3-11 IGHJ4 IGKV3-20 IGKJ3 2948 ARMGPSGSG IVTRSQLAWYQHKPGQPPRLLIYDSSS (Human) (Human) (Human) (Human) SLDY RATGTPDRFSGSGSGTDFTLTISRLEPE DSAVYYCHQYSGSATFGPGTKVEIK mAb-161 1910 SYELTQPPSVSGAPRQKVTISCSGSSAN IGHV2-5 IGHJ4 IGLV1-36 IGU3 2949 AHTSELPPRR IASNGVNWYQQLPGKAPKLLIYYDDL (Human) (Human) (Human) (Human) PYAAFDF VSSGVSDRFSGSKSGTSASLAISGLQSE DEADYYCATWDDILNGPVFGGGTKLT VL mAb-162 1911 DIRMTQSPSSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-27 IGKJ1 2950 ARDLPPLDY GFGNKVAWYQQKPGTAPKLLIYETSTL (Human) (Human) (Human) (Human) QSGVPSRFSGSGSGTEFAFTISSLQPED GATYYCQKYNRAPWTFGQGTKVEIK mAb-163 1912 QSALIQPASVSGSPGQSITISCTGTSSD IGHV4-34 IGHJ4 IGLV2-14 IGU3 2951 ARGFTFTYSD VGRYNYVSWYQQHPGKAPKLMIYDV (Human) (Human) (Human) (Human) FLTGQRTFEY SNRPSGVSNRFSGSKSGNTASLTISGL QAEDEAAYYCSSYISDIKLVVFGGGTKL TVL mAb-164 1913 QSALIQPRSVSGSPGQSVTISCTGTSSD IGHV3-30 IGHJ4 IGLV2-11 IGU1 2952 ARSYGGSYST VGGSNYVSWYQQHPGKAPKLLVYDV (Human) (Human) (Human) (Human) VGY TKRPSGVPDRFSGSKSGNTASLTISGL QAEDEADYYCCSYAGTYIFGTGTKLTV L mAb-165 1914 QSVLTQPPSVSGSPGQSVSISCSGTSS IGHV3-15 IGHJ4 IGLV2-18 IGU1 2953 SWNDVGWA DFGNYNRISWYQQTPGTAPKVIIYEVN (Human) (Human) (Human) (Human) FTF SRPSGVPDRFSGSKSGNTASLTITGLQ AEDEADYYCCSYRSDNTYIFGGGTKVT VL mAb-166 1915 ETTLTQSPLFLPVTLGQPASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ4 2954 AAEERSGTNH LVHTNGNTYLNWFQQRPGHSPRRLIY (Human) (Human) (Human) (Human) NYYGLDV QVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGVYYCMQGTEWPRTFGG GTKLEIK mAb-167 1916 QPVLTQPPSASGTPGQRVTISCSGGSS IGHV3-53 IGHJ3 IGLV1-44 IGU1 2955 ARDREMAHT NIGSNSVNWYQQLPGTAPKLLIYSNSQ (Human) (Human) (Human) (Human) ERSYGLDV RPSGVPDRFSGSKSGTSASLAISGLQSE DEADYYCAAWDDSLNTFRYVFGTGTK VTVL mAb-168 1917 ETTLTQSPSSLSASVGDRVNITCRASQS IGHV3-23 IGHJ3 IGKV1-39 IGKJ3 2956 AKDRYCSGGS ISTYLTWYQQKPGKAPKLLIYGASSLHS (Human) (Human) (Human) (Human) CFYDAFDI GVPSRFTGVGSGTEFTLSISSLQPEDFA TYYCQQSYNTFFTFGGGTKVDIK mAb-169 1918 DIRLTQSPSSLSASVGDRVTITCRASQA IGHV3-30 IGHJ4 IGKV1D-16 IGKJ5 2957 AREAQSSGRA IAGWLAWYQQKPGRAPKSLIYRASSL (Human) (Human) (Human) (Human) GCLDA QSGVPSRFSGSGSGTDFSLTISNLQPE DSATYYCQHYDSYPTAFGQGTRLEIK mAb-17 1919 ETGLTQIPFSLPVTFGQPASISCRFSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2958 ARDPSIHYTG LVHTDGNTNLNWFLQRPGQFPRGLIY (Human) (Human) (Human) (Human) NHHWYDLDI KVFNRDSGVPDRFRGSGSGIDFTLKIS RVEVEDVGIYYGMQGTEWLGTFGQG TKVEIK mAb-170 1920 ETTLTQSPLSLAVTLGQPASISCRSSLG IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2959 VRDSDPYTAT LVHTNGNTYLNWFQQRPGQSPRRLIYR (Human) (Human) (Human) (Human) VRSNHYWYA VSNRDSGVPDRFSGSGSVTDFTLTISR MDV VEAEDIGVYYCMQGTEWPRTFGQGT KVEIK mAb-171 1921 ETTLTQSPLSLSVTLGQAASISCTCSQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2960 ARDPTFLNSG AVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYAVDI KVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGIYYCMQTTDWPRTFGQG TKVDIK mAb-172 1922 EIVMTQSPASLSASVGDRVTITCRAGQ IGHV4-39 IGHJ5 IGKV1-39 IGKJ3 2961 AAPAPSNHES SISTNLCWYQQRQGKAPKLLIYAASSL (Human) (Human) (Human) (Human) WSGTDWFDP RSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQSYSTPPTFGGGTKVDIK mAb-173 1923 DIQVTQSPATLSVSPGERVTLSCRASQ IGHV1-18 IGHJ4 IGKV3-15 IGKJ4 2962 ARTTPRGWE SISNTLAWYQQKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) QWPVLEY ATGIPARFSGSGSGTEFTLTISSLQSED FAVYYCHQYNKWPPITFGGGTKVEIK mAb-174 1924 DIQMTQSPSSLSASVGDRVTISCRASQ IGHV3-48 IGHJ6 IGKV1-16 IGKJ2 2963 ARELDSETYY GISTFLAWFQQRPGKAPKSLIYAASKL (Human) (Human) (Human) (Human) NYNSLDV QSGVPSRFSGSDSGPDFTLTIDNLRPE DSATYYCKQYNSYPYTFGQGTKLEIK mAb-175 1925 EIVMTQSPSSLSASVGDSVTITCRASQS IGHV1-18 IGHJ3 IGKV1-39 IGKJ1 2964 ARVVFRHGQ ISNYLNWYQDKPGKAPELLIYAASNLQ (Human) (Human) (Human) (Human) YDDSSGRLAF SGVPSRFSGSGSGTDFTLTISSLQPEDF DI ATYYCQQSYSDSWTFGQGTKVDIK mAb-176 1926 ETTLTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2965 ARDPSIHYTG IVHTDGNTYLNWFLQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHHWYDLDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQGTEWPRTFGQGT KVEIK mAb-177 1927 DIQMTQSPLSLPVTLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2966 VRDSDPYTAT VVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) SRNNHYWYG KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTDWPRTFGQG TKVDIK mAb-178 1928 GIVLTQSPDSLAVSVGERATINCKSSQT IGHV3-30 IGHJ4 IGKV4-1 IGKJ3 2967 AREPDGIGAA VLYSSKNKHYLAWYQQKPGQPPKLLT (Human) (Human) (Human) (Human) GISGY SSPSTREPGVPDRFSGSGSGTDFTLTIS SLQAEDVAVYYCQQYYTTPYTFGQGT KVDIK mAb-179 1929 EIVMTQTPSSLSASVGDRVTITCRASQ IGHV3-11 IGHJ6 IGKV1-39 IGKJ3 2968 AREMATSFGY SISNYVNWYQQKPGRAPNLLIYAASSL (Human) (Human) (Human) (Human) YFVLDV QSGVSSRFSGSGSGTDFTLTISSLQPED FATYYCQQTYSTPPEGPTFGPGTKVEIK mAb-18 1930 QPVLTQPASVSGSPGQSVTISCTGTSS IGHV4-34 IGHJ5 IGLV2-23 IGU3 2969 ARGQESPIVG DVGSYSDVGNYVSWYQHHPGKAPKL (Human) (Human) (Human) (Human) VTGRWFDP MIYEVRTRPSWVSTRFSGSKSGTTASL TISGLQAEDEADYYCCSYAGASPFVVF GGGTKLTVL mAb-180 1931 EIVMTQSPGTLSSSPGERATLSCRASQ IGHV3-30 IGHJ4 IGKV3-20 IGKJ2 2970 VRPYSGSYTN SVSSRYLAWYQQKPGQAPRLLIYGTSN (Human) (Human) (Human) (Human) WFDL RATGIPDRFSGSGSGTDFTLTISRLEPE DFAVYYCQQYGSSYTFGPGTKLEIK mAb-181 1932 DIVMTQSPLSLPVGLGQSASISCRSSQ IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2971 ARDPSILNTG RVVHTDGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) NHHWYDLDI YKVSNRDSGVPDRFSGSGSGTDFTLRI SRVEAEDVGVYYCMQATEWPRTFGQ GTKVEIK mAb-182 1933 DIRLTQSPLSLSVTLGQAASISCTCSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2972 ARDPTFLNTG AVHSDGTTYFNWFHQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHFWYAVDI VSNRDSGVPDRFIGSGSGTHFTLKISR VEAEDVGVYYCMQTTDWPRTFGQGT KVEIK mAb-183 1934 ETTLTQSPLSLPVTLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2973 VRDSDPYTAT VVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) SRNNHYWYA KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTDWPRTFGQG TKVEIK mAb-184 1935 ETTLTQSPLSLPVTLGQPASISCTSSQT IGHV1-69 IGHJ4 IGKV2-30 IGKJ2 2974 ARDPSFLNTG VVHTDRNTYLNWYHQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHFWYDFDL VSNRDSGVPDRFSGSGSGSHFTLKISR VEAEDVGVYYCMQGTEWPRTFGQGT KLEIK mAb-185 1936 QPGLTQPASVSGSPGQSITISCTGTSG IGHV4-34 IGHJ4 IGLV2-23 IGU3 2975 ARGMISPRIP DVGSDNLVSWYQRHPGKAPKLMIYE (Human) (Human) (Human) (Human) RTTRQRWFD GSKRPSGVSHRFSGSNSGNTASLTISG T LQAEDDADYYCCSYAGDDTVVFGGGT KLTVL mAb-186 1937 DIVLTQSPGTLSLSPGERVTLSCRASQS IGHV4-34 IGHJ5 IGKV3-20 IGKJ1 2976 ARGKAHRND ISSNYLAWYQQKPGQAPRLLISDASSRA (Human) (Human) (Human) (Human) FWSGYYPHW TGIPDRFSGSGSGADFTLIISRLEPEDF FDP AVYFCHQYGGSPTTFGQGTKVEIK mAb-187 1938 ETTLTQSPLSLPVTLGQPASISCRSSQI IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2977 ARDSDPYTAT AMHSDGNTYLSWFHQRPGQPPRRLIYK (Human) (Human) (Human) (Human) RRHNHYWYA ISNRDSGVPDRFSGSGSGTDFTLKISRV MDV EAEDIGTFYCMQGTDWPRTFGQGTK VEIK mAb-188 1939 ETTLTQSPATLSLSPGERATLSCRASQS IGHV4-59 IGHJ3 IGKV3-11 IGKJ4 2978 ARGLVVRYFD VSSYLAWYQQKPGQAPRLLIYDAFNR (Human) (Human) (Human) (Human) GFPSGPIIGAF ATGVPARFSGSGSGTDFTLTISSLEPED DI FAVYYCQQRTSTLTFGGGTKVDIK mAb-189 1940 ETTLTQSPLSLPVTLGQAASISCRSSQA IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2979 VRDPDPYTAT VVHSDGNTYLNWFQQRPGQPPRRLIY (Human) (Human) (Human) (Human) VRHNHYWH KVSNRDSGVPDRFSGSGSGTVFTLKIS GMDV RVEAEDIGVYYCMQGTEWPRTFGQG TKVEIK mAb-19 1941 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV4-34 IGHJ5 IGLV1-51 IGU3 2980 ARGSLSREYD NLGNNYVSWYQQLPGTAPKLLIYDNH (Human) (Human) (Human) (Human) FLTAPQNGP KRPSGIPDRFSGSKSGTSATLGITGLQT WFDS GDEADYYCETWDSSLSVVVFGGGTKV TVL mAb-190 1942 QSVLTQPPSVSATPGQKVTISCSGSSS IGHV4-39 IGHJ4 IGLV1-51 IGU3 2981 ARHSQKDIVLI NIGNNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) PAAQSPIFDY KRPSGIPDRFSGSKSGTSATLGITGLQT GDEADYYCGTWDSRLSAVVFGGGTKL TVL mAb-191 1943 DIRVTQSPATLSLSPGERATLSCRASEN IGHV3- IGHJ1 IGKV3-11 IGKJ3 2982 VKDGGYYDSS IAHYLAWYQQKPGQAPRLVIYDASSR 64D (Human) (Human) (Human) GPGH ATGIPGRFSGSGAGTDFTLTINSLEPED (Human) FAVYYCQQRSNWPQNFGGGTKVDIK mAb-192 1944 DIRLTQSPSSLSASVGDRVTITCRASQD IGHV3-30 IGHJ5 IGKV1D-16 IGKJ5 2983 ARESRSSGRA ISSWLAWYQQKSGKAPKSLIYAASSLQ (Human) (Human) (Human) (Human) GCFDS NGVPSRFSGSRSGTDFTLTISSLQPEDL GTYYCQQYDSYPVTFGQGTRLEIK mAb-193 1945 DIVLTQTPDSLAVSLGERATINCKSSQS IGHV3-30 IGHJ4 IGKV4-1 IGKJ1 2984 ARAYGGNYQ VLYSSNNKNYLAWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) NHFDH YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYTMWTFGQG TKVEIK mAb-194 1946 QSVLTQPPSVSAAPGQKVTISCSGSSS IGHV4-34 IGHJ5 IGLV1-51 IGU1 2985 ARGTISPIVGV NIGNDYVSWYQQLPGTAPKLLIYENYK (Human) (Human) (Human) (Human) PTPVVPRRGR RPSGIPDRFSGSKSGTSATLDITGLQTG SWFDP DEADYYCGTWDSSLSVDNYVFGTGTK LTVL mAb-195 1947 DIVLTQSPLSLPVTLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2986 VRDSDPYTAT VVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) SRNNHYWYA KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTDWPRTFGQG TKVDIK mAb-196 1948 ETTLTQSPLSLPVTLGQPASISCRSSQV IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 2987 VRDSDPYTAT LVHSDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) SSHNHYWYA KVSNRDSGVPDRFSGSGSGIDFTLKISR MDV VEAEDIGVYYCMQGTEWPRTFGQGT KVDIK mAb-197 1949 DIQLTQSPSSLSASVGDRVTITCRASQS IGHV3-11 IGHJ5 IGKV1-39 IGKJ4 2988 ARDRGSGVID ISHYLNWYQQKPGKAPKLLIYAASNLQ (Human) (Human) (Human) (Human) P SGVPSRFSGNGSGTDFTLTISSLQPEDF ATYFCQQSYSTPLTFGGGTKVDIK mAb-2 1950 EIVLTQSPATLSLSPGERATLSCRASEN IGHV3- IGHJ1 IGKV3-11 IGKJ4 2989 VKDGGYYDSS IAHYLAWYQQKPGQAPRLVIYDASSRA 64D (Human) (Human) (Human) GPGH TGIPGRFSGSGAGTDFTLTINSLEPEDF (Human) AVYYCQQRSNWPQNFGGGTKVEIK mAb-20 1951 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV4-59 IGHJ2 IGLV1-40 IGU6 2990 ARVGWVRYF NIGAGYYVHWYQQLPGTAPKLLIYDN (Human) (Human) (Human) (Human) DWSKPYYYFD NNRPSGVPDRFSGSRSGTSASLAITGL L QAEDEGDYFCQSYDSSLSASFGGGTK VTVL mAb-21 1952 QSVLTQPPSVSGAPGQRVTISCTGSNS IGHV3-23 IGHJ5 IGLV1-40 IGU3 2991 AKCDLVRYFD NIGAGYDVHWYQQLPETAPKLLIYAN (Human) (Human) (Human) (Human) WLGEENNWF GNRPSGVPDRFSGSKSGTSASLAITGL DP QAEDEADYYCQSYDSSLSGVLFGGGT KLTVL mAb-22 1953 DIQLTQSPLSLPVTLGQPASISCRSSQH IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 2992 VRDSDPYTAT LVHSDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) VRNNHYWYA KVSNRDSGVPDRFSGSGSGIDFTLKISR LDV VEAEDIGVYYCMQGTEWPRTFGQGT KVEIK mAb-23 1954 DIQVTQSPATVSVSPGEGASLSCRASQ IGHV3-66 IGHJ4 IGKV3-15 IGKJ4 2993 ARATPPGGG SVRSNLAWFQQKPGQAPRLLISDAST (Human) (Human) (Human) (Human) TGWPYFDF RASGVPARFTGSGFGTEFTLTISSLQSE DFAIYYCQQYNTWPPLTFGGGTKVEIK mAb-24 1955 DIRLTQSPLSLPVTLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ4 2994 AREEPSGTYH LVHSNGNTYLNWFQQRPGQSPRRLIYE (Human) (Human) (Human) (Human) NYYGLDV VSNRDSGVPDRFTGSGSGTDFTLKISR VEAEDVGVYYCMQGTHWPRSFGGG TKVEIK mAb-25 1956 ETTLTQSPGTLSLSPGERATLSCRASQS IGHV4-4 IGHJ3 IGKV3-20 IGKJ1 2995 AARIRGATHY IGSSYLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) DFWSGFWA ATGIPDRFSGSGSGTDFTLTISRLEPED GPFDI FAVYYCQQYGSAPLYTFGQGTKVEIK mAb-26 1957 EIVLTQSPGTLSLSPGERASLSCRASQS IGHV4-4 IGHJ3 IGKV3-20 IGKJ3 2996 ARTQSNDFW VSSSYLAWYQHRPGQAPRLLIYDASSR (Human) (Human) (Human) (Human) SGYYTAAFDL ATGIPDRFSGSGSGTDFTLTISRLESED FAVYYCQQYGNSPRTFGQGTKVDIK mAb-27 1958 QPVLTQPPSVSAAPGQKVTISCSGSSS IGHV4-34 IGHJ5 IGLV1-51 IGU3 2997 ARGSLSREYD NIGDNYVSWYQQLPGTAPKLLIYDNN (Human) (Human) (Human) (Human) FLTAPQNGP KRPSGIPDRFSGSKSGTSATLGITGLQT WFDS GDEADYYCETWDTSLSVVVFGGGTKL TVL mAb-28 1959 DIVMTQTPLSLAVTLGQPASISCRSSH IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 2998 VLDTTSANPH GLVHTNGNTYLNWFHQRPGQPPRRL (Human) (Human) (Human) (Human) NWYGMDV IYKISNRDSGVPDRFSGSGSGTDFTLKI SRVEADDVGVYYCMQGTDWPRTFG QGTKVEIK mAb-29 1960 EIVLTQSPGTLSLSPGERATLSCRASQT IGHV3-11 IGHJ4 IGKV3-20 IGKJ2 2999 ARMGPYGSG VTRSQLAWYQHKPGQPPRLLIYDSSKR (Human) (Human) (Human) (Human) SFDY ATGSPDRFSASGSGTDFTLTISGLEPED TGIYYCLQYSDATTFGPGTKLEIK mAb-3 1961 EIVMTQSPSSLSASIGDRVTISCRASQN IGHV4-38 IGHJ4 IGKV1-39 IGKJ5 3000 AGRHQELLP IGSYLNWYQQRPGKAPNLLIFVASSLQ 2 (Human) (Human) (Human) MGSFDM SGVPSRFSGSGSGTDFTLTISSLQAEDF (Human) ATYYCQQSYTTPITFGQGTRLEIK mAb-30 1962 DIVMTQSPLSLPVGLGQSASISCRSSQ IGHV1-69 IGHJ3 IGKV2-30 IGKJ1 3001 ARDPSILNTG RVVHTDGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) NHHWYDLDI YKVSNRDSGVPDRFSGSGSGTDFTLRI SRVEAEDVGVYYCMQATEWPRTFGQ GTKVEIK mAb-31 1963 EIVLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ2 3002 VRDGAYDSS VSNFLAWYQQKPGQPPRLLIYDASNR (Human) (Human) (Human) (Human) GYYSTQ ASGIAARFSGRGSGTDFTLTISSLEPED FAVYYCQQRRNWPPMYTFGQGTKLEI K mAb-32 1964 EIVLTQSPLSLSVTLGQAASISCTCSQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ2 3003 ARDPTFLNSG AVHSDGNTYLNWFHQRPGQSPRRLIYK (Human) (Human) (Human) (Human) NHFWYAVDI VSNRDSGVPDRFSGSGSGTDFTLKISR VEAEDVGIYYCMQTTDWPRTFGQGT KLEIK mAb-33 1965 ETTLTQSPLSLSVTLGQAASISCTCSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3004 ARDPTFLNTG AVHSDGNTYFNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYAVDI KVSNRDSGVPERFSGSGSGTHFTLIISR VEAEDVGVYYCMQTTDWPRTFGQGT KVDIK mAb-34 1966 NFMLTQPHSVSESPGKAVIISCTRSSG IGHV1-2 IGHJ5 IGLV6-57 IGU3 3005 ARDFGVRYD NIASNFVQWYQQRPGSSPTPVIYEDKL (Human) (Human) (Human) (Human) DSRQLMKYC RPSGVPDRFSGSIDRSSNSASLTISGLK DS TEDEADYYCQSYDSGNLVVFGGGTKL TVL mAb-35 1967 DIQMTQSPLSLPVTLGQAASISCRSSQ IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3006 ARDPSILNTG PIPHTDGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) NHHWYDLDL HKVSNRDSGVPDRFSGSGSGLDFTLEI SGVEAEDVGIYYCMQGTEWPRTFGQ GTKVEIK mAb-36 1968 EIVMTQTPLSLPVTLGQPASISCRSSHG IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3007 VVDTTMADP LVHTNGNTYLNWFHQRPGQPPRRLIY (Human) (Human) (Human) (Human) HNWYGLDV QVSHRDSGVPDRFSGSGSGTDFTLKIS RVEADDVGVYYCMQGTDWPRTFGQ GTKVDIK mAb-37 1969 ETTLTQSPGTLSLSPGERATLSCRASQS IGHV4-4 IGHJ3 IGKV3-20 IGKJ1 3008 ARVRVGASH VGNNYLAWYQQKPGQAPRLLIYGASS (Human) (Human) (Human) (Human) HNFWSGYYT RATGIPDRFSGSGSGTDFTLTISRLEPE DAFDI DFAVYYCQQYGTSPVYTFGQGTKVEIK mAb-38 1970 DIQLTQSPLSLPVTLGQPASISCTSSQN IGHV1-69 IGHJ4 IGKV2-30 IGKJ1 3009 ARDPSFLNTG VVHTDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFWYDFD KVSNRDSGVPDRFSGSGSGSHFTLKIS M RVEAEDVGIYYCMQGTDWPRTFGQG TKVEIK mAb-39 1971 DIVLTQTPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ1 3010 VRDGAYDSS VSNFLAWYQQKPGQPPRLLIYDASNR (Human) (Human) (Human) (Human) GYYSTQ ASGIAARFSGRGSGTDFTLTISSLEPED FAVYYCQQRRNWPPMYTFGQGTKVE IK mAb-4 1972 QSVLTQPPSVSGAPGQRVTISCTGSSS IGHV3-21 IGHJ4 IGLV1-40 IGU1 3011 ARDFPGDTA NIGAGYDVHWYQQVPGTAPKLLIYGN (Human) (Human) (Human) (Human) VAGTGFNY SNRPSGVPDRFSGSKSGTSASLAITGL QAEDEADYYCQSYDSSLSVLYVFGTGT KVTVL mAb-40 1973 DIRLTQSPATLSLSPGERATLSCRASQS IGHV3-49 IGHJ4 IGKV3-11 IGKJ1 3012 SRDLRRGYYD IGYYLAWFQQKPGQAPRLLIYDASKRA (Human) (Human) (Human) (Human) SNGHQQFDL TGIPARFSGSGSGTDFTLTISSLEPEDF AVYYCQHRTNWPYTFGQGTKVEIK mAb-41 1974 QPGLTQEPSLTVSPGGTVTLTCGSSAG IGHV3-30 IGHJ6 IGLV7-46 IGU3 3013 ARDPGPITFF AVTSGHYPYWFQQKPGQAPRTLIYDT (Human) (Human) (Human) (Human) DWSPDKSRK NNKYSWTPARFSGSLLGGKAALTLSG SYYDYNGMD AQPEDEAEYFCFLSYRGAPPVFGGGT V HLTVL mAb-42 1975 DIRMTQSPFSLSASVGDRVTITCRASQ IGHV3-30 IGHJ4 IGKV1-27 IGKJ1 3014 ARDLPPLDY GFGNRLAWYQQKPGRAPKLLIYDAST (Human) (Human) (Human) (Human) LQSGVPSRFSGSGSETDFALTISSLQPE DVATYYCQKHDRDPWTFGQGTKVEIK mAb-43 1976 DIVMTQSPLSLPVTLGQPASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3015 VRDSDPYTTT LVHSDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) FSHNHYWYA KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTEWPRTFGQG TKVEIK mAb-44 1977 ETTLTQSPASVSASVGDRVTISCRASQ IGHV3- IGHJ4 IGKV1-12 IGKJ4 3016 VKDNVILPGA GIGRWLAWYQQKPGRAPKLLIFSASSL 64D (Human) (Human) (Human) IVRPQFDY QSGVPSRFSGSGSGTDFTLTISSLQPED (Human) FATYYCQQAESFPFTFGGGTKVEIK mAb-45 1978 ETTLTQSPLSLPVDLGQSASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3017 ARDPSILNTG VVHTNGNTYLHWFHQRPGQAPRRLI (Human) (Human) (Human) (Human) NHHWYDLD YKVSNRESGVPDRFSGSGSGTDFTLRI M SRVEAEDVGVYYCMQATDWPRTFGQ GTKVEIK mAb-46 1979 CIRLTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ4 IGKV3-11 IGKJ3 3018 ARDNVVQQN VTSYLAWYQQRPGQAPRLLIYDTSNR (Human) (Human) (Human) (Human) ADNVGYFDF VTGVPVRFSGSGYGTDFTLTISSLEPED FAVYYCQQRGNGYTFGPGTKVEIK mAb-47 1980 ETTLTQSPLSLPVGLGQSASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3019 ARDPSILNTG VVHTDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLDL KVSNRDSGVPDRFSGSGSGTDFTLRIS RVEAEDVGVYYCMQATEWPRTFGQG TKVDIK mAb-48 1981 EIVMTQSPLSLPVTLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ2 3020 VRDSDPYTAT VVHSDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) SRNNHYWYG KVSNRDSGVPDRFSGSGSGTDFTLKIS MDV RVEAEDIGVYYCMQGTDWPRTFGQG TKLEIK mAb-49 1982 DIVMTQSPLSLPVDLGQSASISCRSSQT IGHV1-69 IGHJ3 IGKV2-30 IGKJ2 3021 ARDPSILNTG AVHTNGNTYLHWFHQRPGQAPRRLI (Human) (Human) (Human) (Human) NHHWYDLD YKVSNRESGVPDRFSGSGSGTDFTLRI M NRVEAEDVGVYYCMQATDWPRTFG QGTKLEIK mAb-5 1983 DIVLTQTPSSLSASVGDRVTITCRASQT IGHV3-49 IGHJ6 IGKV1-39 IGKJ3 3022 AREGTSLGYY ISYYLNWYQQKVGKAPQLLVYAASSLQ (Human) (Human) (Human) (Human) YYYAMDV SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSVPLTLGQGTKVDIK mAb-50 1984 DIQMTQSPLSLPVDLGQSASISCRSSQ IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3023 ARDPSILNTG RVVHTNGNTYLHWFHQRPGQAPRRL (Human) (Human) (Human) (Human) NHHWYDLD YKVSNRESGVPDRFSGSGSGTDFTLRI M SRVEAEDVGVYYCMQATDWPRTFGQ GTKVEIK mAb-51 1985 QPGLTQPASVSGSPGQSITISCTRTSG IGHV3-7 IGHJ3 IGLV2-14 IGU3 3024 ARGPIRHFGL DVGDYNSVSWYVSWYQQHPGRAPKL (Human) (Human) (Human) (Human) DAFDI MLYDVSNRPSGVSNRFSGSKLGDTAS LTISELQAEDEADYYCSTYTSTSTIFGG GTKLTVL mAb-52 1986 DIQMTQSPLSLPVTLGQPASISCRASQ IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3025 VRDSDPYTAT TVVHTNGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) SRNNHYWYG YEVSNRDSGVPDRFSGSGSGTDFTLSI MDV SRVEAEDIGVYYCMQGTDWPRTFGP GTKVEIK mAb-53 1987 DIRLTQSPLSLPVDLGQSASISCRSSQT IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 3026 ARDPSILNTG VVHTNGNTYLHWFHQRPGQAPRRLI (Human) (Human) (Human) (Human) NHHWYDLD YKVSNRESGVPDRFSGSGSGTDFTLRI M SRVEAEDVGVYYCMQATDWPRTFGQ GTKVDIK mAb-54 1988 DIRVTQSPSSLSATVGDRVTITCRASQT IGHV3- IGHJ3 IGKV1-39 IGKJ5 3027 VKDLGATVTY ITKYLNWYQQKPGKAPKLLLYGASSLQ 64D (Human) (Human) (Human) DVFDV SGVPSRFSGSGSGTDFTLTISSLQPEDF (Human) ATYYCQQTYITPGTFGQGTRLEIK mAb-55 1989 DIRLTQSPDSLALSLGERATINCKSSQS IGHV3-23 IGHJ4 IGKV4-1 IGKJ1 3028 AKERDLPGRG VLFSSNNNNYLGWYQQKPGQPPKLLI (Human) (Human) (Human) (Human) GYFDH YWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYLTPWTFGQG TKVDIK mAb-56 1990 QPVLTQPASVSGSPGQSITISCTGTSSD IGHV4-34 IGHJ5 IGLV2-23 IGU3 3029 ARGYTAPIIRE VGNYNVVSWYQQHPGKAPQLFIYED (Human) (Human) (Human) (Human) VPITFRPRWF TKRPSGVSDRFSGSKSGITASLTISRLQ DP PEDEADYYCCSYAVSGTVLFGGGTKVT VL mAb-57 1991 EIVLTQSPGTLSVSPGERATLSCRASQI IGHV3-11 IGHJ4 IGKV3-20 IGKJ3 3030 ARMGPYGSG INRSQLGWYQHKPGQAPRLLIFDSSKR (Human) (Human) (Human) (Human) TFDY ATGTPDRFSASGSETDFTLTISGVEPED SGVYYCLQYSLATTFGPGTKVDIK mAb-58 1992 DIQLTQSPATLSLSPGERATLSCRASPS IGHV3-30 IGHJ5 IGKV3-11 IGKJ3 3031 ARDHALQNG VFTFLAWYQQRPGQPPRLLIHDVSNR (Human) (Human) (Human) (Human) RPGYFDS APGIPARFSGSGSGTDFTLIISSLEPDD SAVYFCQQRSDGYNFGPGTKVDIK mAb-59 1993 DIRVTQSPSSLSASVGDRVTITCRASQT IGHV3-64 IGHJ4 IGKV1-39 IGKJ1 3032 VREGQQWLG INNYLNWYQQKPGKAPNLLIYAASTLQ (Human) (Human) (Human) (Human) LYFDH NGVPSRFSGSGSGTDFTLTISSVQPED FATYYCQQTYITPTWTFGQGTKVEIK mAb-6 1994 EIVMTQSPSSLSASVGDRVTITCRASQS IGHV1-8 IGHJ4 IGKV1-39 IGKJ3 3033 AREKKSFGPQ ISNYLYWYQQKPGKAPKLLIYVASNLQ (Human) (Human) (Human) (Human) YYYGSGED SGVPSRFSGSGSGTDFTLTISSLQPEDF ATYYCQQSYSTPYNFGQGTKVDIK mAb-60 1995 EIVLTQSPSTLSASVGDRVTITCRASQN IGHV5-51 IGHJ3 IGKV1-5 IGKJ3 3034 VRQRYCSGGS VNNWLAWYQQKPGKAPKLLIYEASTL (Human) (Human) (Human) (Human) CFLFEDAFEI KSGVPSRFSGSGSGTEFTLTISSLQPDD FATYYCQQYNSQYTFGQGTKVDIK mAb-61 1996 QPVLTQPRSVSGSPGQSVTISCTGSSST IGHV3-48 IGHJ5 IGLV2-11 IGU3 3035 VRDTDWAFD FGTDNHISWYQQLPGKVPKLIIHAVSQ (Human) (Human) (Human) (Human) s RPSVVPDRFSGSRSGNTASLTISGLQA EDEADYYCCSSPGTITWVFGGGTKVT VL mAb-62 1997 QSVLTQPPSVSGVPRQKVTISCSGSTA IGHV2-5 IGHJ4 IGLV1-36 IGU3 3036 AHTSELPPRR NIASNGVNWYQLVPGKAPRLLISYDDL (Human) (Human) (Human) (Human) PYAAFDF VPSGVSARFSGSKSGTSASLAISGLQAE DEADYYCATWDDILNGPVFGGGTKLT VL mAb-63 1998 DIVLTQSPLSLPVTLGQSASISCRSSQG IGHV3-23 IGHJ4 IGKV2-30 IGKJ2 3037 ANTNFLDY LVHSDGNIYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) KVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGLYYCMQATHWPRAFGQ GTKLEIK mAb-64 1999 EIVMTQSPGTLSLSPGERVTLSCRATQ IGHV4-4 IGHJ6 IGKV3-20 IGKJ1 3038 TRSFISFDSSG SVSNNHLAWYQQKPGQAPRLLIYGAS (Human) (Human) (Human) (Human) HPYYYYAMD TTATDIPDRFSGRVAGTDFTLTISRLDP V EDFAVYYCHQYGSSPWTFGQGTKVEI K mAb-65 2000 DIRLTQSPATLSLSPGERATLSCRASQS IGHV1-69 IGHJ4 IGKV3-11 IGKJ1 3039 TRETGTDEFD VSSSLAWYQQKPGQAPRLLIYEASNRA (Human) (Human) (Human) (Human) F TGVPARFSGSGSGTDFTLAISSLEPEDF AVYYCQHRSNWPPRYTFGQGTKVEIK mAb-66 2001 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-4 IGHJ6 IGLV3-10 IGU6 3040 ATMWGGLCT RRYAYWYQQRSGQAPVLVIYEDNKRP (Human) (Human) (Human) (Human) ASNCYGNPM SGIPERFSAFSSGTRATLTISGAQVEDE DV ADYYCYSTDSTANYKVFGGGTKVTVL mAb-67 2002 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-4 IGHJ6 IGLV3-10 IGU3 3041 ATMWGGLCT RRYAYWYQQRSGQAPVLVIYEDNKRP (Human) (Human) (Human) (Human) ASNCYGNPM SGIPERFSAFSSGTRATLTISGAQVEDE DV ADYYCYSTDSTANYKVFGGGTKLTVL mAb-68 2003 SYELTQPPSVSVSPGQTARITCSGDALP IGHV4-4 IGHJ6 IGLV3-10 IGU3 3042 ATMWGGLCT RRYAYWYQQRSGQAPVLVIYEDNKRP (Human) (Human) (Human) (Human) ASNCYGNPM SGIPERFSAFSSGTRATLTISGAQVEDE DV ADYYCYSTDSTANYKVFGGGTKLTVL mAb-69 2004 QSVLTQPSSLSASPGASASLTCTLHSGF IGHV3-74 IGHJ4 IGLV5-45 IGU3 3043 ARDLAWTFF NVGDHTINWYQQRPGSPPRYLLKYKS (Human) (Human) (Human) (Human) DY DSDKEQGSGVPIRFSGSKDASANAGFL LISGLRSEDEADYYCMIWHDNAVVFG GGTKLTVL mAb-7 2005 EIVLTQSPATLSVSPGDGASLSCRASQS IGHV3-66 IGHJ4 IGKV3-15 IGKJ4 3044 ARATPPGGTT VGSNLAWYQQKPGQAPRLLISDASAR (Human) (Human) (Human) (Human) GWPYIDL ATGVPARFTGSGSGTDFTLTISSLQSED FAVYYCHQYNTWPPLTFGGGTKLEIK mAb-70 2006 EIVMTQSPLSLPVTLGQSASISCRSSQG IGHV3-23 IGHJ4 IGKV2-30 IGKJ3 3045 ANTNFLDY LVHSDGNIYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) KVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGLYYCMQATHWPRAFGQ GTKVDIK mAb-71 2007 DIVMTQSPLALSVTPGQPASISCKSSQ IGHV3-9 IGHJ6 IGKV2D-29 IGKJ5 3046 AKLGTDHPIG SLLHSDGKTYFYWYLQKPGQSPHLLIY (Human) (Human) (Human) (Human) VDV EVSNRFSGVPDRFSGSGSGTDFTLKISR VEAEDVGVYYCMQSIQVPITFGGGTK LEIK mAb-72 2008 DIVMTQSPATLSVSPGERATLSCRASQ IGHV3- IGHJ4 IGKV3-15 IGKJ3 3047 VKALYSSSWC SVSSNLAWYQQKPGQAPRLLIYGAST 64D (Human) (Human) (Human) PFDY RATNIPARFSGSGSGTEFTLTISSLQSE (Human) DFAVYYCQQYNLWPYTFGQGTKVDIK mAb-73 2009 EIVLTQSPSSLSASVGDRVTISCRASQG IGHV3-48 IGHJ6 IGKV1-16 IGKJ2 3048 ARELDSETYY ISTFLAWFQQRPGKAPKSLIYAASKLQS (Human) (Human) (Human) (Human) NYNSLDV GVPSRFSGSDSGPDFTLTIDNLQPEDS ATYYCKQYNSYPYTFGQGTKLEIK mAb-74 2010 QSVVTQPPSVSAAPGQKVTISCSGSSS IGHV4-59 IGHJ5 IGLV1-51 IGU3 3049 AKAQGIYYRG NIGNNYVSWYQQLPGTAPKLLIYDSD (Human) (Human) (Human) (Human) WSYWFDP KRPSGIPERFSGSKSATSATLGITGLQT GDEADYYCETWDDSLSAVVFGGGTKL TVL mAb-75 2011 DIVLTQSPLSLSVTPGQPASISCRSSQS IGHV1-46 IGHJ5 IGKV2D-29 IGKJ5 3050 AREARRQVT LQHTDGKTYLYWYLQKPGQSPQLLIYEL (Human) (Human) (Human) (Human) QWFGEFWG FNRFSGVPERFSGSGSGTDFTLKISRVE PYNWFDP AEDVGIYYCMQSIQTPITFGQGTRLEIK mAb-76 2012 DIRVTQSPDSLAVSLGERATINCKSSQS IGHV4-34 IGHJ4 IGKV4-1 IGKJ4 3051 ARGLISYTLW VLYSSNNKNYLAWYQQKIGQPPKLLIY (Human) (Human) (Human) (Human) LRESYFDY WASIRESGVPDRFTGSGSGTDFTLTISS LQAEDVAVYYCQQYYSTPPTFGGGTK LEIK mAb-77 2013 EIVMTQTPLSLPVTLGQPASISCRSSQF IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3052 ARDPSILNTG VSHTDGNTYLNWFQQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLDI KVSKRDSGVPDRFSGSGSGTDFTLTIS RVEAEDVGVYYCMQATEWPRTFGQG TKVEYQ mAb-78 2014 DIVMTQSPDSLAVSLGERATINCKSSQ IGHV1-18 IGHJ4 IGKV4-1 IGKJ3 3053 ARDYGDGPP SVLFSSNNKNYLAWYQQKPGLPPKLLI (Human) (Human) (Human) (Human) DH YWASTRKSGVSDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYTTPLFTFGPG TKVDIK mAb-79 2015 DIVMTQSPLSLPVTLGQPASISCRSSHS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3054 VLDTTMSHP LVHTNGNTYLNWFQQRPGQPPRRLIY (Human) (Human) (Human) (Human) HNWYGMDV QVSNRDSGVPDRFSGSGSGTDFTLKIS RVEADDVGIYYCMQGTDWPRTFGQG TKVDIK mAb-8 2016 ETTLTQSPLSLPVTLGQPASISCRSSQG IGHV1-69 IGHJ4 IGKV2-30 IGKJ1 3055 ASEYFDGRSY LAHSNGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) HSFCGLDV QVSNRDSGVPDRFSGSGSGTDFTLKIS RVEAEDVGVYYCMQGTEWPRTFGQ GTKVEIK mAb-80 2017 DIVMTQSPLSLPVSLGQPASISCRSSQS IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3056 ARDPSILNTG VVHTDGNTYLNWYQQRPGQSPRRLIY (Human) (Human) (Human) (Human) PHHWYDLDI KVSNRDSGVPDRFSGSGSVTDFTLKIS RVEAEDVAVYYCMQGTEWPRTFGQG TKVDIK mAb-81 2018 DIQMTQSPLSLSVTLGQSASISCRASQT IGHV1-69 IGHJ6 IGKV2-30 IGKJ1 3057 VRDSEPYTAT VVHSVDGNTYLNWFHQRPGQSPRRLL (Human) (Human) (Human) (Human) RSQNHYWYD YKVSNRDSGVPDRFSGSGSGTDFTLRI MDV SRVEAEDIGIYYCMQGTDWPRTFGQG TKVEIK mAb-82 2019 QPVLTQPASVSGSPGQSITISCTGTSSD IGHV4-4 IGHJ6 IGLV2-14 IGU1 3058 AREFGVRFLD VGSFNYVSWYQQHPGKAPKLVIYDVY (Human) (Human) (Human) (Human) RSLFGAMDV NRPSGVSNRFSGSKSGNTASLTISGLQ AEDEADYYCSSYTSSSTLYVFGTGTKVT VL mAb-83 2020 DIRLTQSPSTLSASVGDRVTITCRASQS IGHV3-30 IGHJ3 IGKV1-5 IGKJ1 3059 ARAGGYLSAF ISSWLAWYQQKPGKAPNLLIYKASTLES (Human) (Human) (Human) (Human) DI GVPSRFSGSGSGTEFTLTISSLQPDDFA TYYCQQYNSGWTFGQGTKVEIK mAb-84 2021 DIRLTQSPLSLPVTLGQPASISCTSSQD IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 3060 ARDPSFLNAG VVHTDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHFYYDFDV KVSNRDSGVPDRFSGSGSGSHFTLKIS RVEAEDAGIYYCMQGTDWPRTFGQG TKVDIK mAb-85 2022 EIVLTQSPSSLSASVGDRVTITCRASQD IGHV4-4 IGHJ4 IGKV1-9 IGKJ3 3061 ARAGNIVVM ISNYLAWYQQKPGKAPKLLIYAASTLQS (Human) (Human) (Human) (Human) PAAQYYFDY GVPLRFSGSGSGTDFTLTISSLQPEDFA TYYCLQLHNYSSFGGGTKVDIK mAb-86 2023 EIVLTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ5 IGKV3-11 IGKJ2 3062 VRDDVLQHS VSTFLGWYQQRPGQPPRLLIYDASYR (Human) (Human) (Human) (Human) RPSGPGYFVS APDIPVRFSGSGSGTDFTLTINSLEPED SAVYYCQQRSDGYNFGPGTKLEIK mAb-87 2024 QSVLTQPASVSGSPGQSITISCTGTSSD IGHV4-59 IGHJ4 IGLV2-14 IGU3 3063 ARGSQIDLRG VGAYNYVSWYQQHPGKAPKLTVYDV (Human) (Human) (Human) (Human) GLGATFFDY RNRPSGVSNRFSGSKSGNTASLTISGL QAEDEAHYYCSSYTSTNTVFGGGTKLT VL mAb-88 2025 DIRLTQTPLSLPVTLGQPASISCRSSQI IGHV1-69 IGHJ6 IGKV2-24 IGKJ3 3064 ARDSDPYTAT AMHSDGNTYLSWFHQRPGQPPRRLIYK (Human) (Human) (Human) (Human) RRHNHYWYA ISNRDSGVPDRFSGSGSGTDFTLKISRV MDV EAEDIGTFYCMQGTDWPRTFGQGTK VDIK mAb-89 2026 QSALIQPRSVSGSPGQSVTISCTGSSST IGHV3-48 IGHJ5 IGLV2-11 IGU3 3065 VRDTDWAFD FGTDNHISWYQQLPGKVPKLIIHAVSQ (Human) (Human) (Human) (Human) s RPSVVPDRFSGSRSGNTASLTISGLQA EDEADYYCCSSPGTITWVFGGGTKVT VL mAb-9 2027 DIRLTQSPSSLSASVGDRVTIACRASQS IGHV1-8 IGHJ6 IGKV1-39 IGKJ1 3066 ARRGNNFGY VSNYLNWYQQKPGKAPKLLIYAASSLQ (Human) (Human) (Human) (Human) YYYYTVDV NGVPSRFGGSGSGTDFTLTISSLQPED FATYYCQQCYSYPPTFGHGTKVEIK mAb-90 2028 DIRMTQSPDSLAVSLGERATINCRTSQ IGHV1-46 IGHJ3 IGKV4-1 IGKJ3 3067 ARVLAGSSHE SVLYSSNNKNYLGWYQQKPGQPPKLL (Human) (Human) (Human) (Human) WQLTHDAFD IYWASTRESGVPDRFSGSGSGTDFTLTI SSLQAEDVAVYYCQQYYSTPYTFGQGT KVDIK mAb-91 2029 QSALTQPASVSGSPGQSITISCTGTNSD IGHV3-23 IGHJ4 IGLV2-14 IGU3 3068 AKGDWIRYF ISNSYSVSWYQQYPGKAPKLVIFDVIN (Human) (Human) (Human) (Human) DWSLPISFFD RPSGVSNRFSGSKSGNTASLTISGLQA Y DDEADYYCCSYTRTNTPVLFGGGTKLT VL mAb-92 2030 DIQLTQSPATLSVSPGERATLSCRASQS IGHV4-61 IGHJ4 IGKV3-15 IGKJ4 3069 ARTTSPLTYSG VTKHLAWYQQKPGQAPRLLIYGASTR (Human) (Human) (Human) (Human) HWPLFDY ATGVPARFSGSGSDTEFSLTISSLQSED FAVYYCQQYYSWPPLTFGGGTKLEIK mAb-93 2031 DIVMTQTPLSLPVTLGQPASISCRASQ IGHV1-69 IGHJ6 IGKV2-30 IGKJ3 3070 VRDSDPYTAT TVVHTNGNTYLNWFHQRPGQSPRRLI (Human) (Human) (Human) (Human) SRNNHYWYG YEVSNRDSGVPDRFSGSGSGTDFTLSI MDV SRVEAEDIGVYYCMQGTDWPRTFGP GTKVEIK mAb-94 2032 DIQLTQSPLSLPVGLGQSASISCRSSQR IGHV1-69 IGHJ6 IGKV2-30 IGKJ2 3071 ARDPSILNTG VVHTDGNTYLNWYHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLDI KVSNRDSGVPDRFSGSGSGTDFTLRIS RVEAEDVGVYYCMQSTDWPRTFGQG TKLEIK mAb-95 2033 DIVLTQSPLSLPVGLGQSASISCRSSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ2 3072 ARDPSILNTG VVHTDGNTYLHWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLDI KVSNRDSGVPDRFSGSGSGTDFTLRIS RVEAEDVGVYYCMQGTEWPRTFGQ GTKLEIK mAb-96 2034 ETTLTQSPVTLSVSPGERATLSCRASQS IGHV3-66 IGHJ5 IGKV3-15 IGKJ4 3073 VRMDWME VISNLAWYQQKPGQAPRLLIFGASTRA (Human) (Human) (Human) (Human) WMKYYFDS TGVPARFSGSGSGTEFTLTISSLQSEDF AVYYCQQYNNWPSLTFGGGTKLEIK mAb-97 2035 DIQVTQSPLSLPVGLGQSASISCRSSQR IGHV1-69 IGHJ3 IGKV2-30 IGKJ3 3074 ARDPSILNTG VVHTDGNTYLNWFHQRPGQSPRRLIY (Human) (Human) (Human) (Human) NHHWYDLD KVSNRDSGVPDRFSGSGSGTDFTLRIS M RVEAEDVGVYYCMQATEWPRTFGQG TKVDIK mAb-98 2036 EIVMTQSPATLSLSPGERATLSCRASQS IGHV3-30 IGHJ5 IGKV3-11 IGKJ2 3075 VRDDVLQHS VSTFLGWYQQRPGQPPRLLIYDASYR (Human) (Human) (Human) (Human) RPSGPGYFVS APDIPVRFSGSGSGTDFTLTINSLEPED SAVYYCQQRSDGYNFGPGTKLEIK mAb-99 2037 QPVLTQPPSVSVSPGQTARITCSGDAL IGHV4-4 IGHJ6 IGLV3-10 IGU3 3076 ATMWGGLCT PRRYAYWYQQRSGQAPVLVIYEDNKR (Human) (Human) (Human) (Human) ASNCYGNPM PSGIPERFSAFSSGTRATLTISGAQVED DV QADYYCYSTDSTANYKVFGGGTKLTVL mBG17 2038 DIVMSQSPSSLAVSVGEKITMSCKSSQ IGHV6-6 IGHJ4 IGKV8-30 IGKJ1 3077 TRSAMDY SLLYTSDQKNYLAWFQQKPGQSPKLLI (Mouse) (Mouse) (Mouse) (Mouse) FWASTRDSGVPDRFTGSGSGTDFTLTI SSVKAEDLAVYYCQQFYNYPRTFGGG TKLEIK mBG21 2039 IVMTQTPKFLLVSAGDRVTITCKASQS IGHV9-2- IGHJ3 IGKV6-32 IGKJ1 3078 ALRR VSNDVAWFQQKPGQSPKKLLIYFASN 1 (Mouse) (Mouse) (Mouse) RYTGVPDRFTGSGYGTDFTFTITTVQA (Mouse) EDLAVYFCQQDYSSPWTFGGGTKLEIK mBG22 2040 IVMTQTPKFLLVSAGDRVTITCKASQS IGHV9-2- IGHJ3 IGKV6-32 IGKJ1 3079 ALRR VSNDVAWFQQKPGQSPKLLIYFASNR 1 (Mouse) (Mouse) (Mouse) YTGVPDRFTGSGYGTDFTFTITTVQAE (Mouse) DLAVYFCQQDYSSPWTFGGGTKLEIK mBG57 2041 DIVMTQAAPSEPVTPGESVSISCGSSK IGHV9-2- IGHJ3 IGKV2-137 IGKJ5 3080 ALRR SLLHSNDNTYLYWFLQRPGQSPQLLIY 1 (Mouse) (Mouse) (Mouse) RMSNLASGVPDRFTGSGSGTAFTLRIS (Mouse) RVEAEDVGVYYCMQHLENPLGVRWR HQAGNQT mBG67 2042 QIVLTQSPAIMSASLGERVTMTCTASS IGHV5-6- IGHJ1 IGKV4-74 IGKJ1 3081 ARIYDFDEDY SVSSSYLHWYQQKPGSSPKLWIYSTSN 3 (Mouse) (Mouse) (Mouse) FDV LASGVPARFSGSGSGTSYSLTISSMEAE (Mouse) DAATYYCLQYHRSPWTFGGGTKLEIK MD17 ND IGHV3-64 ND IGKV1-39 ND 3082 VKDQDSSSW (Human) (Human) YDAFDI MD29 ND IGHV3-64 ND IGKV1-39 ND 3083 VKDQDSSSW (Human) (Human) YDAFDI MD45 ND IGHV3-53 ND IGKV3-20 ND 3084 ARDLSVRGG (Human) (Human) MDV MD47 ND IGHV3-23 ND IGLV3-21 ND 3085 AKDLVTAPSY (Human) (Human) EAFDI MD62 ND IGHV3-53 ND IGKV1-12 ND 3086 ARDLQYYGM (Human) (Human) DV MD63 ND IGHV3-64 ND IGKV1-39 ND 3087 VKDQDSNSW (Human) (Human) YDAFDI MD65 ND IGHV3-66 ND IGKV3-20 ND 3088 ARDLAVAGAF (Human) (Human) DI MD67 ND IGHV3-53 ND IGKV3-20 ND 3089 ARDLSVRGG (Human) (Human) MDV mNb6 ND ND ND ND ND ND mNb6-tri ND ND ND ND ND ND MnCit3p1_ 2043 QAVVTQEPSLTVSPGGTVTLTCGSSTG IGHV3-23 IGHJ4 IGLV7-46 IGU3 3090 ALASGSYFGG G9 PVTSDHYPYWFQQKPGQAPTTLIYDT (Human) (Human) (Human) (Human) ANY NNKHSWTPARFSGSLLGGKAALTLSG AQPEDEAEYYCLLSYTGARVFGGGTKL TVL MnC2t1p1_ 2044 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3-66 IGHJ4 IGKV1D-12 IGKJ1 3091 ATGARFGESP A3 GISSWLAWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDY QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQANSFPGTFGQGTKVEIK MnC2t1p1_ 2045 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3-66 IGHJ4 IGKV1D-12 IGKJ1 3092 ATGARFGESP C5 GISSWLAWYQQKPGKAPKLLIYAASSL (Human) (Human) (Human) (Human) FDY QSGVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQANSFPGTFGQGTKVEIK MnC2t2p1_ 2046 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV1-69 IGHJ5 IGKV1-39 IGKJ2 3093 AREGGLDYFG C11 NISSYLNWYQQKPGKAPNLLIYAASSL (Human) (Human) (Human) (Human) SRNSGWTYT QSGVPPRFSGSGSGTDFTLTISSLQPED WFDP FATYYCQQSYSTLYSFGQGTKLEIK MnC4t1p1_ 2047 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-39 IGHJ3 IGKV1-17 IGKJ3 3094 ARGVNYYDR A10 GIRNDLGWYEQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) NGYYRNDGF ESGVPSRFSGSGSGTEFTLTISSLQPED DI FATYYCLQHNTYPFTFGPGTRVDIK MnC4t1p1_ 2048 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV3-48 IGHJ4 IGKV3-20 IGKJ1 3095 ASSKGFCSGG A11 VSSSYLAWYQQKPGQAPRLLIYGVSSR (Human) (Human) (Human) (Human) SCSDY ATGIPDRFSGSGSGTDFTLTISRLEPED FVVYYCHQYGSSPWTFGQGTKVEIK MnC4t2p1_ 2049 DIQMIQSPSSVSASVGDRVTITCRASQ IGHV3-9 IGHJ2 IGKV1-12 IGKJ3 3096 AKDLRRQDYY B3 GISSWLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) ADWYFDL LSAVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQGNSFPFTFGPGTIVDV MnC4t2p1_ 2050 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-39 IGHJ3 IGKV1-17 IGKJ3 3097 ARGVNYYDR D10 GIRNDLGWYEQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) NGYYRNDGF ESGVPSRFSGSGSGTEFTLTISSLQPED DI FATYYCLQHNTYPFTFGPGTRVDIK MnC4t2p1_ 2051 DIQMTQSPSSVSASVGDRVTITCRASQ IGHV3-9 IGHJ2 IGKV1-12 IGKJ3 3098 AKDLRRQDYY E6 GISSWLAWYQQKPGKAPKLLIYAASTL (Human) (Human) (Human) (Human) ADWYFDL LSAVPSRFSGSGSGTDFTLTISSLQPED FATYYCQQGNSFPFTFGPGTKVDV MnC4t2p1_ 2052 DIQMTQSPSSLSASVGDRVTITCRASQ IGHV4-39 IGHJ3 IGKV1-17 IGKJ3 3099 ARGVNYYDR F5 GIRNDLGWYEQKPGKAPKRLIYAASSL (Human) (Human) (Human) (Human) NGYYRNDGF ESGVPSRFSGSGSGTEFTLTISSLQPED DI FATYYCLQHNTYPFTFGPGTRVDIK MnC4t2p2_ 2053 EIVLTQSPGTLSLSPGERATLSCRASHS IGHV7-4- IGHJ4 IGKV3-20 IGKJ5 3100 AKIGSRNSLG A4 VDRSYLAWYQQKPGLAPRLLIYGASSR 1 (Human) (Human) (Human) V ATGIPDRFSGSGSGTDFTLTISRLEPED (Human) FALYYCQHFGTSSVTFGRGTRLEIK MnC5t2p1_ 2054 EIVLTQSPGTLSLSPGERATLSCRASQS IGHV1-58 IGHJ3 IGKV3-20 IGKJ1 3101 AAPRCSGGSC G1 VSSSYLAWYQHKPGQAPRLLICGASSR (Human) (Human) (Human) (Human) YDGFDI ATGIPDRFSGSGSGTGFTLTISRLEPED FAVYYCQQYGSSPWTFGQGTKVEIK MR10 N/A IGHV3S53 IGHJ4 N/A N/A 3102 NVKDEGATTK (Alpaca) (Alpaca) VYDY MR14 N/A IGHV3S53 IGHJ4 N/A N/A 3103 NVKDWGAA (Alpaca) (Alpaca) NKYYDY MR17 N/A IGHV3S53 IGHJ4 N/A N/A 3104 NVKDDGQLA (Alpaca) (Alpaca) YHYDY MR17_K56W N/A IGHV3S53 IGHJ4 N/A N/A 3105 NVKDDGQLA (Alpaca) (Alpaca) YHYDY MR17_K99W N/A IGHV3S5 IGHJ4 N/A N/A 3106 NVWDDGQL (Alpaca) (Alpaca) AYHYDY MR17_K99Y N/A IGHV3S53 IGHJ4 N/A N/A 3107 NVYDDGQLA (Alpaca) (Alpaca) YHYDY MR2 N/A IGHV3S53 IGHJ4 N/A N/A 3108 NVKDYGWYN (Alpaca) (Alpaca) SQYDY MR3 N/A IGHV3S53 IGHJ4 N/A N/A 3109 NVKDYGAAS (Alpaca) (Alpaca) WEYDY MR4 N/A IGHV3S53 IGHJ4 N/A N/A 3110 NVKDFGGHQ (Alpaca) (Alpaca) AYYDY MR6 N/A IGHV3S53 IGHJ4 N/A N/A 3111 NVKDEGDTS (Alpaca) (Alpaca) ASYDY MR7 N/A IGHV3S53 IGHJ4 N/A N/A 3112 NVKDEGYFSD (Alpaca) (Alpaca) EYDY MR8 N/A IGHV3S53 IGHJ4 N/A N/A 3113 NVKDWGSSN (Alpaca) (Alpaca) QYYDY Nb11 ND ND ND ND ND ND Nb11-59 ND ND ND ND ND ND Nb3 ND ND ND ND ND ND Nb3-bi ND ND ND ND ND ND Nb3-tri ND ND ND ND ND ND Nb4-43 ND ND ND ND ND ND Nb6 ND ND ND ND ND ND Nb6-tri ND ND ND ND ND ND NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3114 AAVPSTYYNG CoVnb- (Alpaca) (Alpaca) SYYYTCHPGG 101 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3115 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) TYYYNCHPGG 102 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3116 ATAPGTYYKG CoVnb- (Alpaca) (Alpaca) SYYPMCHYYG 103 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3117 ATRPLTYYSGS CoVnb- (Alpaca) (Alpaca) YYTTCSDYGM 104 DY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3118 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) SYYYTCHPGG 105 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3119 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) SYYYTCHPGG 106 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3120 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) SYYYTCHPGG 107 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3121 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) SYYYTCHPGG 108 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3122 ASFPSTYYSGS CoVnb- (Alpaca) (Alpaca) YYYTCHPGG 109 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3123 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) TYYYNCHPGA 110 MHY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3124 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) TYYYNCHPGA 111 MHY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3125 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) TYYYTCHPGG 112 MDY NIH- N/A IGHV3-3 IGHJ7 N/A N/A 3126 AAVPSTYYSG CoVnb- (Alpaca) (Alpaca) TYYYTCHPGG 113 MDY P2B-2F6 2055 QSALTQPPSASGSPGQSVTISCTGTSS IGHV4- IGHJ3 IGLV2-8 IGU3 3127 ARAVVGIVVV DVGGYNYVSWYQQHPGKAPKLMIYE 382 (Human) (Human) (Human) PAAGRRAFDI VSKRPSGVPDRFSGSKSGNTASLTVSG (Human) LQAEDEADYYCSSYAGSNNLVFGGGT KLTVL S110 ND IGHV3-30 ND IGKV2-30 ND 3128 AKDRFQFARS (Human) (Human) WYGDYFDY S124 ND IGHV2-26 ND IGKV1-39 ND 3129 ARINTAAYDY (Human) (Human) DSTTFDI S303 ND IGHV3-23 ND IGKV1-5 ND 3130 ARERDDIFPM (Human) (Human) GLNAFDI S304 ND IGHV3-13 ND IGKV1-39 ND 3131 ARGDSSGYYY (Human) (Human) YFDY S306 ND IGHV1-18 ND IGKV3-11 ND 3132 ASDYFDSSGY (Human) (Human) YHSFDY S309 2056 EIVLTQSPGTLSLSPGERATLSCRASQT IGHV1-18 IGHJ4 IGKV3-20 IGKJ4 3133 ARDYTRGAW VSSTSLAWYQQKPGQAPRLLIYGASSR (Human) (Human) (Human) (Human) FGESLIGGFD ATGIPDRFSGSGSGTDFTLTISRLEPED N FAVYYCQQHDTSLTFGGGTKVEIK S310 ND IGHV1-69 ND IGLV2-23 ND 3134 ATRTYDSSGY (Human) (Human) RPYYYGLDV S315 ND IGHV3-7 ND IGLV3-25 ND 3135 ARDLWWND (Human) (Human) QAHYYGMDV Sb#1 N/A IGHV3-3 IGHJ4 N/A N/A 3136 RVFVGWHY (Alpaca) (Alpaca) Sb#10 N/A IGHV3-3 IGHJ4 N/A N/A 3137 TVYVGYEY (Alpaca) (Alpaca) Sb#11 N/A IGHV3-3 IGHJ4 N/A N/A 3138 EVEVGKWY (Alpaca) (Alpaca) Sb#12 N/A IGHV3-3 IGHJ5 N/A N/A 3139 YVWVGQEY (Alpaca) (Alpaca) Sb#13 N/A IGHV3-3 IGHJ4 N/A N/A 3140 WVIVGEYY (Alpaca) (Alpaca) Sb#14 N/A IGHV3-3 IGHJ4 N/A N/A 3141 YVYVGSSY (Alpaca) (Alpaca) Sb#15 N/A IGHV3-3 IGHJ4 N/A N/A 3142 FVYVGRSY (Alpaca) (Alpaca) Sb#16 N/A IGHV3S53 IGHJ4 N/A N/A 3143 IVWVGAQY (Alpaca) (Alpaca) Sb#17 N/A IGHV3-3 IGHJ4 N/A N/A 3144 HVWVGSLY (Alpaca) (Alpaca) Sb#18 N/A IGHV3-3 IGHJ4 N/A N/A 3145 YVYVGASY (Alpaca) (Alpaca) Sb#19 N/A IGHV3-3 IGHJ4 N/A N/A 3146 YVYVGSSY (Alpaca) (Alpaca) Sb#2 N/A IGHV3-3 IGHJ4 N/A N/A 3147 RAVYVGMHY (Alpaca) (Alpaca) Sb#20 N/A IGHV3-3 IGHJ4 N/A N/A 3148 YVYVGKSY (Alpaca) (Alpaca) Sb#21 N/A IGHV3-3 IGHJ4 N/A N/A 3149 FVGVGTHY (Alpaca) (Alpaca) Sb#22 N/A IGHV3-3 IGHJ4 N/A N/A 3150 FVYVGKSY (Alpaca) (Alpaca) Sb#23 N/A IGHV3-3 IGHJ4 N/A N/A 3151 FVYVGKSY (Alpaca) (Alpaca) Sb#25 N/A IGHV3S53 IGHJ4 N/A N/A 3152 NVKDFGTHH (Alpaca) (Alpaca) YAYDY Sb#26 N/A IGHV3S53 IGHJ4 N/A N/A 3153 NVKDKGMAV (Alpaca) (Alpaca) QWYDY Sb#27 N/A IGHV3S53 IGHJ4 N/A N/A 3154 NVKDEGDMF (Alpaca) (Alpaca) TAYDY Sb#28 N/A IGHV3-3 IGHJ4 N/A N/A 3155 NVKDSGQWR (Alpaca) (Alpaca) QEYDY Sb#29 N/A IGHV3S53 IGHJ4 N/A N/A 3156 NVKDFGYTW (Alpaca) (Alpaca) HEYDY Sb#3 N/A IGHV3-3 IGHJ4 N/A N/A 3157 VVWVGHNY (Alpaca) (Alpaca) Sb#30 N/A IGHV3-3 IGHJ4 N/A N/A 3158 NVKDYGQAH (Alpaca) (Alpaca) AYYDY Sb#31 N/A IGHV3-3 IGHJ4 N/A N/A 3159 NVKDTGTTED (Alpaca) (Alpaca) YDY Sb#32 N/A IGHV3-3 IGHJ4 N/A N/A 3160 NVKDAGRVY (Alpaca) (Alpaca) NSYDY Sb#33 N/A IGHV3S53 IGHJ4 N/A N/A 3161 NVKDTGTYRF (Alpaca) (Alpaca) YYDY Sb#34 N/A IGHV3S53 IGHJ4 N/A N/A 3162 NVKDAGVYN (Alpaca) (Alpaca) RYYDY Sb#35 N/A IGHV3-3 IGHJ4 N/A N/A 3163 NVKDWGFAS (Alpaca) (Alpaca) HAYDY Sb#36 N/A IGHV3S53 IGHJ4 N/A N/A 3164 NVKDFGWQ (Alpaca) (Alpaca) HQEYDY Sb#37 N/A IGHV3-3 IGHJ4 N/A N/A 3165 NVKDSGSFN (Alpaca) (Alpaca) QAYDY Sb#38 N/A IGHV3S53 IGHJ4 N/A N/A 3166 NVKDYGVHF (Alpaca) (Alpaca) KRYDY Sb#39 N/A IGHV3-3 IGHJ4 N/A N/A 3167 NVKDAGNTT (Alpaca) (Alpaca) SAYDY Sb#4 N/A IGHV3-3 IGHJ4 N/A N/A 3168 EVQVGAWY (Alpaca) (Alpaca) Sb#40 N/A IGHV3S53 IGHJ4 N/A N/A 3169 NVKDIDAEAY (Alpaca) (Alpaca) AYDY Sb#41 N/A IGHV3-3 IGHJ4 N/A N/A 3170 NVKDSGQWR (Alpaca) (Alpaca) VQYDY Sb#42 N/A IGHV3S53 IGHJ4 N/A N/A 3171 NVKDHGAQN (Alpaca) (Alpaca) QMYDY Sb#45 N/A IGHV3S53 IGHJ4 N/A N/A 3172 NVKDVGHHY (Alpaca) (Alpaca) EYYDY Sb#46 N/A IGHV3S53 IGHJ4 N/A N/A 3173 NVKDKGQM (Alpaca) (Alpaca) RAAYDY Sb#47 N/A IGHV3-3 IGHJ4 N/A N/A 3174 NVKDYGSSYY (Alpaca) (Alpaca) KYDY Sb#48 N/A IGHV3S53 IGHJ4 N/A N/A 3175 NVKDAGSSY (Alpaca) (Alpaca) WDYD Sb#49 N/A IGHV3-3 IGHJ4 N/A N/A 3176 AAARWGRTK (Alpaca) (Alpaca) PLNTYYYSY Sb#5 N/A IGHV3-3 IGHJ4 N/A N/A 3177 RVHVGAHY (Alpaca) (Alpaca) Sb#50 N/A IGHV3-3 IGHJ4 N/A N/A 3178 AAATEGHAH (Alpaca) (Alpaca) ALYRLHYY Sb#51 N/A IGHV3-3 IGHJ4 N/A N/A 3179 RVWVGTHY (Alpaca) (Alpaca) Sb#52 N/A IGHV3-3 IGHJ4 N/A N/A 3180 AAAYVGAEN (Alpaca) (Alpaca) PLPYSMYGY Sb#53 N/A IGHV3-3 IGHJ4 N/A N/A 3181 AAADYGASD (Alpaca) (Alpaca) PLWFIHYLY Sb#55 N/A IGHV3-3 IGHJ4 N/A N/A 3182 AAANYGSNFP (Alpaca) (Alpaca) LAEEDYWY Sb#56 N/A IGHV3-3 IGHJ4 N/A N/A 3183 AAAYYFGDDI (Alpaca) (Alpaca) PLWWEAYSY Sb#58 N/A IGHV3-3 IGHJ4 N/A N/A 3184 AAARWGRH (Alpaca) (Alpaca) MPLSATEYSY Sb#59 N/A IGHV3-3 IGHJ4 N/A N/A 3185 AAAAWGNSA (Alpaca) (Alpaca) PLTTYRYYY Sb#6 N/A IGHV3-3 IGHJ4 N/A N/A 3186 YVYVGAQY (Alpaca) (Alpaca) Sb#61 N/A IGHV3-3 IGHJ4 N/A N/A 3187 AAADWGYD (Alpaca) (Alpaca) WPLWDEWY WY Sb#62 N/A IGHV3-3 IGHJ4 N/A N/A 3188 AAANYGANY (Alpaca) (Alpaca) PLYSQQYSY Sb#63 N/A IGHV3-3 IGHJ4 N/A N/A 3189 AAANYGANE (Alpaca) (Alpaca) PLQYTHYNY Sb#64 N/A IGHV3-3 IGHJ4 N/A N/A 3190 AAASYGAAHP (Alpaca) (Alpaca) LSIMRYYY Sb#65 N/A IGHV3-3 IGHJ4 N/A N/A 3191 AAASYGANFP (Alpaca) (Alpaca) LKASDYSY Sb#66 N/A IGHV3-3 IGHJ4 N/A N/A 3192 AAADWGYD (Alpaca) (Alpaca) WPLWDEWY WY Sb#67 N/A IGHV3-3 IGHJ4 N/A N/A 3193 AAATWGHS (Alpaca) (Alpaca) WPLYNDEYW Y Sb#68 N/A IGHV3-3 IGHJ4 N/A N/A 3194 AAAAWGYA (Alpaca) (Alpaca) WPLHQDDY WY Sb#69 N/A IGHV3-3 IGHJ5 N/A N/A 3195 AAATWGYSW (Alpaca) (Alpaca) PLIAEYNWY Sb#7 N/A IGHV3-3 IGHJ4 N/A N/A 3196 FVKVGNWY (Alpaca) (Alpaca) Sb#71 N/A IGHV3-3 IGHJ4 N/A N/A 3197 AAANWGYS (Alpaca) (Alpaca) WPLYEADDW Y Sb#8 N/A IGHV3-3 IGHJ4 N/A N/A 3198 YVYVGGSY (Alpaca) (Alpaca) Sb#9 N/A IGHV3-3 IGHJ4 N/A N/A 3199 RVFVGMHY (Alpaca) (Alpaca) Sb100 N/A IGHV3-3 IGHJ4 N/A N/A 3200 AAANWGYS (Alpaca) (Alpaca) WPLYQTEYW Y Sb12 N/A IGHV3-3 IGHJ4 N/A N/A 3201 YVKVGEWY (Alpaca) (Alpaca) Sb13 N/A IGHV3-3 IGHJ4 N/A N/A 3202 YVVVGWGY (Alpaca) (Alpaca) Sb15 N/A IGHV3-3 IGHJ4 N/A N/A 3203 FVVVGNGY (Alpaca) (Alpaca) Sb16 N/A IGHV3-3 IGHJ4 N/A N/A 3204 YVYVGGSY (Alpaca) (Alpaca) Sb17 N/A IGHV3-3 IGHJ4 N/A N/A 3205 LVYVGATY (Alpaca) (Alpaca) Sb2 N/A IGHV3-3 IGHJ4 N/A N/A 3206 YVYVGASY (Alpaca) (Alpaca) Sb21 N/A IGHV3-3 IGHJ4 N/A N/A 3207 YVYVGGSY (Alpaca) (Alpaca) Sb22 N/A IGHV3-3 IGHJ4 N/A N/A 3208 YVYVGASY (Alpaca) (Alpaca) Sb23 N/A IGHV3-3 IGHJ4 N/A N/A 3209 AVQVGYWY (Alpaca) (Alpaca) Sb25 N/A IGHV3-3 IGHJ4 N/A N/A 3210 YVYVGAGY (Alpaca) (Alpaca) Sb27 N/A IGHV3-3 IGHJ4 N/A N/A 3211 YVWVGRSY (Alpaca) (Alpaca) Sb28 N/A IGHV3-3 IGHJ4 N/A N/A 3212 YVYVGSSY (Alpaca) (Alpaca) Sb30 N/A IGHV3-3 IGHJ4 N/A N/A 3213 YVYVGESY (Alpaca) (Alpaca) Sb32 N/A IGHV3-3 IGHJ4 N/A N/A 3214 VVWVGEVY (Alpaca) (Alpaca) Sb37 N/A IGHV3S53 IGHJ4 N/A N/A 3215 NVKDEGNTT (Alpaca) (Alpaca) AYYDY Sb38 N/A IGHV3S53 IGHJ4 N/A N/A 3216 NVKDFGTQE (Alpaca) (Alpaca) HYYDY Sb39 N/A IGHV3S53 IGHJ4 N/A N/A 3217 NVKDFGGYR (Alpaca) (Alpaca) YYYDY Sb40 N/A IGHV3S53 IGHJ4 N/A N/A 3218 NVKDEGAIAK (Alpaca) (Alpaca) NYDY Sb42 N/A IGHV3S53 IGHJ4 N/A N/A 3219 NVKDEGYTGY (Alpaca) (Alpaca) YYDY Sb43 N/A IGHV3-3 IGHJ4 N/A N/A 3220 NVKDWGSQ (Alpaca) (Alpaca) DRYYDY Sb45 N/A IGHV3S53 IGHJ4 N/A N/A 3221 NVKDEGKSS (Alpaca) (Alpaca) QVYDY Sb46 N/A IGHV3S53 IGHJ4 N/A N/A 3222 NVKDVGNDQ (Alpaca) (Alpaca) KSYDY Sb47 N/A IGHV3S53 IGHJ4 N/A N/A 3223 NVKDWGTYS (Alpaca) (Alpaca) TYYDY Sb5 N/A IGHV3-3 IGHJ4 N/A N/A 3224 YVYVGASY (Alpaca) (Alpaca) Sb50 N/A IGHV3S53 IGHJ4 N/A N/A 3225 NVKDWGWL (Alpaca) (Alpaca) AQYYDY Sb52 N/A IGHV3S53 IGHJ4 N/A N/A 3226 NVKDEGMW (Alpaca) (Alpaca) QHYYDY Sb54 N/A IGHV3S53 IGHJ4 N/A N/A 3227 NVKDEGNSQ (Alpaca) (Alpaca) SHYDY Sb56 N/A IGHV3S53 IGHJ4 N/A N/A 3228 NVKDAGNSK (Alpaca) (Alpaca) ALYDY Sb57 N/A IGHV3S53 IGHJ4 N/A N/A 3229 NVKDWGRA (Alpaca) (Alpaca) GARYDY Sb58 N/A IGHV3S53 IGHJ4 N/A N/A 3230 NVKDMDRW (Alpaca) (Alpaca) RTTYDY Sb6 N/A IGHV3-3 IGHJ4 N/A N/A 3231 YVWVGNQY (Alpaca) (Alpaca) Sb60 N/A IGHV3S53 IGHJ4 N/A N/A 3232 NVKDWGYEY (Alpaca) (Alpaca) EGYDY Sb61 N/A IGHV3S53 IGHJ4 N/A N/A 3233 NVKDTGTYQ (Alpaca) (Alpaca) AWYDY Sb62 N/A IGHV3S53 IGHJ4 N/A N/A 3234 NVKDWGGY (Alpaca) (Alpaca) QWYYDY Sb63 N/A IGHV3S53 IGHJ4 N/A N/A 3235 NVKDYGAQA (Alpaca) (Alpaca) HYYDY Sb67 N/A IGHV3S53 IGHJ4 N/A N/A 3236 NVKDWGTYN (Alpaca) (Alpaca) SYYDY Sb7 N/A IGHV3-3 IGHJ4 N/A N/A 3237 LVYVGSTY (Alpaca) (Alpaca) Sb71 N/A IGHV3-3 IGHJ4 N/A N/A 3238 AAAHYGDNF (Alpaca) (Alpaca) PLAYQAYLY Sb75 N/A IGHV3-3 IGHJ4 N/A N/A 3239 AAARWGRDE (Alpaca) (Alpaca) PLYHYYYSY Sb76 N/A IGHV3-3 IGHJ4 N/A N/A 3240 NVKDIGAQEV (Alpaca) (Alpaca) HYDY Sb78 N/A IGHV3-3 IGHJ4 N/A N/A 3241 AAANYGNN (Alpaca) (Alpaca) WPLTGVNYW Sb8 N/A IGHV3-3 IGHJ4 N/A N/A 3242 YVWVGDSY (Alpaca) (Alpaca) Sb83 N/A IGHV3-3 IGHJ4 N/A N/A 3243 AAAKYGQNF (Alpaca) (Alpaca) PLSYHAYRY Sb84 N/A IGHV3-3 IGHJ4 N/A N/A 3244 AAARYGRSDP (Alpaca) (Alpaca) LHYHEYSY Sb85 N/A IGHV3-3 IGHJ4 N/A N/A 3245 AAASWGYTW (Alpaca) (Alpaca) PLYTYDYWY Sb88 N/A IGHV3S53 IGHJ4 N/A N/A 3246 NVKDSGQYR (Alpaca) (Alpaca) ENYDY Sb9 N/A IGHV3-3 IGHJ4 N/A N/A 3247 WVYVGDYY (Alpaca) (Alpaca) Sb90 N/A IGHV3-3 IGHJ4 N/A N/A 3248 AAARWGRQY (Alpaca) (Alpaca) PLTFVYYSY Sb93 N/A IGHV3-3 IGHJ4 N/A N/A 3249 AAARWGRTY (Alpaca) (Alpaca) PLSYMAYTY Sb94 N/A IGHV3-3 IGHJ4 N/A N/A 3250 AAARWGRYE (Alpaca) (Alpaca) PLHYAYYSY Sb95 N/A IGHV3-3 IGHJ4 N/A N/A 3251 AAASYGANW (Alpaca) (Alpaca) PLVSAAYTY Sb97 N/A IGHV3-3 IGHJ4 N/A N/A 3252 AAARYGHAQ (Alpaca) (Alpaca) APLHYFWYGY SR1 N/A IGHV3-3 IGHJ4 N/A N/A 3253 YVYVGFSY (Alpaca) (Alpaca) SR13 N/A IGHV3-3 IGHJ4 N/A N/A 3254 YVYVGSSY (Alpaca) (Alpaca) SR18 N/A IGHV3-3 IGHJ4 N/A N/A 3255 YVYVGASY (Alpaca) (Alpaca) SR31 N/A IGHV3-3 IGHJ4 N/A N/A 3256 AVMVGFWY (Alpaca) (Alpaca) SR34 N/A IGHV3-3 IGHJ4 N/A N/A 3257 YVYVGSSY (Alpaca) (Alpaca) SR38 N/A IGHV3-3 IGHJ4 N/A N/A 3258 AVHVGQTY (Alpaca) (Alpaca) SR4 N/A IGHV3-3 IGHJ4 N/A N/A 3259 YVWVGHTY (Alpaca) (Alpaca) SR5 N/A IGHV3-3 IGHJ4 N/A N/A 3260 YVYVGTSY (Alpaca) (Alpaca) SR7 N/A IGHV3S53 IGHJ4 N/A N/A 3261 YVYVGYSY (Alpaca) (Alpaca) Ty1 N/A IGHV3S1 IGHJ4 N/A N/A 3262 AIGLNLSSSSV (Alpaca) (Alpaca) VH-Fc- ND ND ND ND ND ND B01 VH2-A01- ND ND ND ND ND ND B01 VH2-A01- ND ND ND ND ND ND B02 VH3-B01 ND ND ND ND ND ND VHH-72 N/A IGHV3-3 IGHJ4 N/A N/A 3263 AAAGLGTVVS (Alpaca) (Alpaca) EWDYDYDY W23UACh N/A IGHV3S53 IGHJ4 N/A N/A 3264 HALIKNELGFL (Alpaca) (Alpaca) DY W25UACh N/A IGHV3S53 IGHJ4 N/A N/A 3265 HALIKNELGFL (Alpaca) (Alpaca) DY SEQ ID Name NO.: CDRL3 Sources 0304-2F8 3266 MQALQTP Xiangyang Chi et al., 2020 QT (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0304-3H3 3267 QQYNKWP Xiangyang Chi et al., 2020 PWT (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0304- 3268 QQYYSSPY Xiangyang Chi et al., 2020 4A10 (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0304-4A2 3269 HQYYNTPR Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A1 3270 RQRSNWP Xiangyang Chi et al., 2020 PT (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A2 3271 QQSYSTPP Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A3 3272 QQTYRPP Xiangyang Chi et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A7 3273 MQTLQTP Xiangyang Chi et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A8 3274 QQYDNLPL Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-A9 3275 MQATQFP Xiangyang Chi et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-B1 3276 QQYYSTYG Xiangyang Chi et al., 2020 S (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-C4 3277 GTWDSSLS Xiangyang Chi et al., 2020 VW (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 0317-C9 3278 AAWDDSL Xiangyang Chi et al., 2020 NGW (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 10C10 3279 LQHNNYPL Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 1A09 3280 ALWYSNH Wafaa Alsoussi et al., WV 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1A10 3281 QQGNTLP Wafaa Alsoussi et al., 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1A12 3282 LQYDEFRT Wafaa Alsoussi et al., 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1B07 3283 ALWYSNQ Wafaa Alsoussi et al., FI 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1610 3284 ALWYSNH Wafaa Alsoussi et al., WV 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1C05 3285 QQNNEDP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1C06 3286 FQGSHVPP Wafaa Alsoussi et al., T 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1C07 3287 QQNNEDP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1D04 3288 LQYDEFRT Wafaa Alsoussi et al., 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1D05 3289 ALWYSNQ Wafaa Alsoussi et al., FI 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1E02 3290 QQNNEDP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1E07 3291 QQSRKVP Wafaa Alsoussi et al., WT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1E10 3292 QQWSSNP Wafaa Alsoussi et al., PT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1H06 3293 QQSRKVP Wafaa Alsoussi et al., WT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1H10 3294 ALWYSNH Wafaa Alsoussi et al., WV 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 1M-1D2 3295 AAWDDSLI Xiangyang Chi et al., 2020 YVL (https://science.sciencemag. org/content/early/ 2020/06/19/science. abc6952/tab-pdf) 2B04 3296 ALWYNNH Wafaa Alsoussi et al., WV 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2C02 3297 QQWSSYP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2C03 3298 FQGSHVPY Wafaa Alsoussi et al., T 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2C04 3299 QQSRKVP Wafaa Alsoussi et al., WT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2D01 3300 QQWSSYP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2D08 3301 QQSRKVP Wafaa Alsoussi et al., WT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2D11 3302 QQSKEVP Wafaa Alsoussi et al., WT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2E06 3303 QQSNEDP Wafaa Alsoussi et al., 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2E10 3304 QQNNEDP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2F04 3305 QQSSSWP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2H04 3306 QQSSSWP Wafaa Alsoussi et al., LT 2020 (https://www.jimmunol. org/content/early/ 2020/06/23/jimmunol. 2000583) 2M- 3307 QSYDSSNH Xiangyang Chi et al., 2020 10B11 WV (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-12D7 3308 QQSYSTPR Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-13A3 3309 QQYYSTPF Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M- 3310 QQYGSSRS Xiangyang Chi et al., 2020 13D11 WT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-14B2 3311 QQSYSTFT Xiangyang Chi et al., 2020 LYT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-14E4 3312 QQSHSFPF Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-14E5 3313 QQLNSYVT Xiangyang Chi et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-2D1 3314 AARDDSLS Xiangyang Chi et al., 2020 GWV (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-2D4 3315 QQRTNWP Xiangyang Chi et al., 2020 L (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-2G12 3316 QQNYSTW Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-4G4 3317 CSYAVSST Xiangyang Chi et al., 2020 WV (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-7E9 3318 QQRSNWP Xiangyang Chi et al., 2020 PAFT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-8E7 3319 QQRSNWP Xiangyang Chi et al., 2020 PKIT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-8H10 3320 QQYYNNQ Xiangyang Chi et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-9F10 3321 QQSFVSPR Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 2M-9H1 3322 LQHKSYPL Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) +0O  31B5 ND Xiangyu Chen et al., 2020 (https://www.nature.com/ articles/s41423-020- 0426-7) 31B9 ND Xiangyu Chen et al., 2020 (https://www.nature.com/ articles/s41423-020- 0426-7) 32D4 ND Xiangyu Chen et al., 2020 (https://www.nature.com/ articles/s41423-020- 0426-7) 413-2 3323 QQYGSSPP Jinkai Wan et al., 2020 LT (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 414-1 3324 AAWDDSL Jinkai Wan et al., 2020 NGW (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 47D11 ND Chunyan Wang et al., 2020 (https://www.nature.com/ articles/s41467-020- 16256-y) 4A8 3325 TQATQFPY Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc6952/ tab-pdf) 505-3 3326 MQGTHW Jinkai Wan et al., 2020 PPT (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 505-5 3327 MQGTHW Jinkai Wan et al., 2020 PPT (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 505-8 3328 SSYTSSSIV Jinkai Wan et al., 2020 V (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 515-1 3329 MQGTHW Jinkai Wan et al., 2020 PPT (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 515-5 3330 LQHNSYPI Jinkai Wan et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 553-15 3331 QSYDGSN Jinkai Wan et al., 2020 HNVV (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 553-49 3332 QSYDSSNH Jinkai Wan et al., 2020 W (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 553-60 3333 QQYGSSPP Jinkai Wan et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 553-63 3334 QQSYSIPR Jinkai Wan et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S2211124720308998) 8D2 3335 LQHNSYPL Xiangyang Chi et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc 6952/tab-pdf) 8D9 3336 QAWDSST Xiangyang Chi et al., 2020 GV (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc 6952/tab-pdf) 9A1 3337 HQYSKWP Xiangyang Chi et al., 2020 VT (https://science.sciencemag. org/content/early/ 2020/06/19/science.abc 6952/tab-pdf) Ab_510A 3338 MQALQM Xiaojian Han et al., 2020 GT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510A5 3339 QQSYSTPP Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510D7 3340 QQYGSSRT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510G 3341 QQYDTLPL Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510H10 3342 QQSYSTPR Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510H2 3343 QQLNSYPR Xiaojian Han et al., 2020 MT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510H 3344 QQRSNWP Xiaojian Han et al., 2020 GT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_510H7 3345 QQFNNFLL Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511A1 3346 QQYNNWP Xiaojian Han et al., 2020 PWT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511A5 3347 QVWDSSA Xiaojian Han et al., 2020 DHYV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511B11 3348 QSYDRSLS Xiaojian Han et al., 2020 VLYV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511B 3349 QQANSFRL Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511D11 3350 QQYGRSPY Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511E5 3351 NSRDSSGN Xiaojian Han et al., 2020 TVV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511E7 3352 QQYHNLPI Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511E9 3353 HQSSSLPY Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511G5 3354 TTWDASR Xiaojian Han et al., 2020 GGWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511G7 3355 QQYHNVP Xiaojian Han et al., 2020 PA (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511H11 3356 QQSYSSPP Xiaojian Han et al., 2020 WT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_511H7 3357 AAWDDSL Xiaojian Han et al., 2020 SGPV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51A1 3358 QHLNIDPIT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51A3 3359 QQRGNSIT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51D2 3360 QQSYNTLA Xiaojian Han et al., 2020 LS (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51D3 3361 QQYADLPY Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51D4 3362 QQSYSPPH Xiaojian Han et al., 2020 S (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51D7 3363 QQSYSTPC Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51E10 3364 QQYYITPQ Xiaojian Han et al., 2020 LT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51E12 3365 QQYYGYPT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51E7 3366 QQSYSAPP Xiaojian Han et al., 2020 WT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_51F11 3367 QQYGSSRT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_52C1 3368 QSYDSSLS Xiaojian Han et al., 2020 GSWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_52C6 3369 VLYMGSGI Xiaojian Han et al., 2020 W (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_52F7 3370 MQGTHW Xiaojian Han et al., 2020 PPGT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_52G9 3371 QQYDNLP Xiaojian Han et al., 2020 RT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_53C10 3372 QVWDSSS Xiaojian Han et al., 2020 DPYV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_53C5 3373 QQYNNLYT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_53F12 3374 QHYNNWP Xiaojian Han et al., 2020 LYT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_53F9 3375 MQGTHW Xiaojian Han et al., 2020 PPGT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_53H3 3376 QQYDNLPL Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_55A8 3377 QQYNSYSH Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html)   Ab_55C9 3378 QQSYSTPP Xiaojian Han et al., 2020 YT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_56C12 3379 QQTYSTPR Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_56D7 3380 QQLNSYPP Xiaojian Han et al., 2020 IT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_56E1 3381 AAWDDSL Xiaojian Han et al., 2020 NGWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_56H11 3382 ATWDDSL Xiaojian Han et al., 2020 NGRV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_56H3 3383 QQYGSSPR Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57A6 3384 NSRDSSGN Xiaojian Han et al., 2020 HWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57A8 3385 QQYNSYSP Xiaojian Han et al., 2020 LT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57A9 3386 QQYYSFW Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57B8 3387 QLLNTDPI Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57C4 3388 QQSYSTPL Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57E11 3389 AAWDDSL Xiaojian Han et al., 2020 NGWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57F7 3390 AVWDDSL Xiaojian Han et al., 2020 NGWV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_57G9 3391 QQSYSIPR Xiaojian Han et al., 2020 T (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_58A4 3392 QQYGSSP Xiaojian Han et al., 2020 WT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_58D2 3393 QQLGT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_58G1 3394 QQTNSFPT Xiaojian Han et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_58G6 3395 QQYDNSP Xiaojian Han et al., 2020 WT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_59A2 3396 QQSDNVP Xiaojian Han et al., 2020 VT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_59D6 3397 QSYDSALV Xiaojian Han et al., 2020 V (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81A11 3398 QSYDSSLS Xiaojian Han et al., 2020 VW (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81C3 3399 SSFTSSSTP Xiaojian Han et al., 2020 YV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81C7 3400 AAWDDSL Xiaojian Han et al., 2020 NGPV (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81C8 3401 QQSYNTPP Xiaojian Han et al., 2020 WT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81E1 3402 AAWDDSL Xiaojian Han et al., 2020 SRW (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81E10 3403 AAWDDSL Xiaojian Han et al., 2020 SGVI (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_81F2 3404 MQALQTP Xiaojian Han et al., 2020 RT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_82B6 3405 CMQGTH Xiaojian Han et al., 2020 WPPT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_82C6 3406 MQGTHW Xiaojian Han et al., 2020 PMYT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Ab_82F6 3407 QQHDNVP Xiaojian Han et al., 2020 LT (https://www.biorxiv. org/content/10.1101/ 2020.08.19.253369v2.full. pdf + html) Acharya Various Priyamvada Acharya et et al., al., 2020 2020 (https://www.biorxiv.or g/content/10.1101/ 2020.06.30.178897v1); Wilton Williams et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.06.30.178921V1) B38 3408 QQLNSYPP Yan Wu et al., 2020 (https://science.sciencemag. org/content/early/ 2020/05/12/science.abc2241) BD-236 ND Shuo Du et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.07.09.195263v1) BD-368-2 ND Shuo Du et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.07.09.195263v1) BD-494 3409 QQLNSYPF Yunlong Cao et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-498 3410 QQLNSYPL Yunlong Cao et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-500 3411 QQSYSTPP Yunlong Cao et al., 2020 DT (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-503 3412 QQSYTTPL Yunlong Cao et al., 2020 (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-504 3413 QQSYTTPL Yunlong Cao et al., 2020 (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-505 3414 HQYDNLPP Yunlong Cao et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-506 3415 QQLNSYPL Yunlong Cao et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-507 3416 QQLNSNP Yunlong Cao et al., 2020 PIT (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-508 3417 QQSYSTPP Yunlong Cao et al., 2020 (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-515 ND Yunlong Cao et al., 2020 (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) BD-604 ND Shuo Du et al., 2020 (https://www.biorxiv.or g/content/10.1101/ 2020.07.09.195263vl) BD-629 ND Shuo Du et al., 2020 (https://www.biorxiv.or g/content/10.1101/ 2020.07.09.195263V1) BD23 3418 QQYNSYPY Yunlong Cao et al., 2020 T (https://www.sciencedirect. com/science/article/ pii/S0092867420306206) Bertoglio Various Federico Bertoglio et et al., al., 2020 2020 (https://www.biorxiv. org/content/10.1101/ 2020.06.05.135921V1) C002 3419 QQSYSTPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C003 3420 QQYGSSPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C004 3421 QQYDNLPI Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C005 3422 QQYGSSP Davide Robbiani et al., WT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C006 3423 AAWDDSL Davide Robbiani et al., 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3433 QQYNNYR Davide Robbiani et al., 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C027 3434 QQYNSYST Davide Robbiani et al., 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C029 3435 MQALQTP Davide Robbiani et al., HT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C030 3436 QQYNSYST Davide Robbiani et al., 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C031 3437 QQSYSTPP Davide Robbiani et al., LT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C101 3438 QQYGSSPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C102 3439 QQYGSSPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C103 3440 QQYTTTPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C104 3441 QQYGTTPR Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C105 3442 SSYEGSNN Davide Robbiani et al., FVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9); Christopher Barnes et al., 2020 (https://www.sciencedirect. com/science/article/ pii/S0092867420307571) C106 3443 QVWDSSR Davide Robbiani et al., DHVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C107 3444 AAWDDSL Davide Robbiani et al., SGFW 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C108 3445 NSYTSSSTR Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C109 3446 SSYAGSNN Davide Robbiani et al., YVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C110 3447 QQYNSYPY Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C111 3448 AAWDDSL Davide Robbiani et al., NGAWV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C112 3449 SSYTSSST Davide Robbiani et al., WV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C113 3450 QQHNSSPL Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C114 3451 QSYDSSLY Davide Robbiani et al., AV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C115 3452 MQVLQIPY Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C116 3453 QSYDSGN Davide Robbiani et al., HWVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C117 3454 GAWDSSLS Davide Robbiani et al., AGGVYV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C118 3455 QTWGTGIL Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C119 3456 SSYTSSSTS Davide Robbiani et al., W 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C120 3457 QQYDNLP Davide Robbiani et al., QT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C121 3458 CSYAGSSTL Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C122 3459 QQLNSDSY Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C123 3460 QQLNSYPP Davide Robbiani et al., 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C124 3461 QQRNNW Davide Robbiani et al., PPEWT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C125 3462 QQYGSSP Davide Robbiani et al., WT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C126 3463 QSYDSSNL Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C127 3464 AAWDDSL Davide Robbiani et al., NGW 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C128 3465 QQYGSSRA Davide Robbiani et al., LT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C130 3466 QVWDSSS Davide Robbiani et al., DHPGVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C131 3467 QQYNNWP Davide Robbiani et al., IT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C132 3468 SSYTSSSTL Davide Robbiani et al., L 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C133 3469 QQSYSTPP Davide Robbiani et al., WT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C134 3470 QVWDSSS Davide Robbiani et al., DRPGVV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C135 3471 QQYNSYP Davide Robbiani et al., WT 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C138 3472 QSYDSSN Davide Robbiani et al., WV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C139 3473 QQYDNLPL Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C140 3474 QQLNSYSY Davide Robbiani et al., T 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C141 3475 QSYDSSN Davide Robbiani et al., WV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C143 3476 CSYAGAST Davide Robbiani et al., FV 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C144 3477 SSYTSSSTR Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C145 3478 SSYTSSTTR Davide Robbiani et al., V 2020 (https://www.nature.com/ articles/s41586-020- 2456-9) C146 3479 SSYRGSSTP Davide Robbiani et al., YV 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org/content/10.1101/ 2020.05.13.092619v2) C212 3498 CSYAGSST Davide Robbiani et al., RL 2020 (https://www.biorxiv. org/content/10.1101/ 2020.05.13.092619v2) C214 3499 QQSYSTPP Davide Robbiani et al., WT 2020 (https://www.biorxiv. org/content/10.1101/ 2020.05.13.092619v2) C215 3500 QQSYSTPP Davide Robbiani et al., WT 2020 (https://www.biorxiv. org/content/10.1101/ 2020.05.13.092619v2) C216 3501 QQSYSTPPI Davide Robbiani et al., T 2020 (https://www.biorxiv. org/content/10.1101/ 2020.05.13.092619v2) CA1 3502 QQRRNW Rui Shi et al., 2020 GT (https://www.nature.com/ articles/s41586-020- 2381- y_reference.pdf); NCBI (https://www.ncbi.nlm. nih.gov/nuccore/MT470194); NCBI (https://www.ncbi.nlm. nih.gov/nuccore/MT4701945) CB6 3503 QQSYSTPP Rui Shi et al., 2020 EYT (https://www.nature.com/ articles/s41586-020- 2381- y_reference.pdf); NCBI (https://www.ncbi.nlm. nih.gov/nuccore/MT470 194);NCBI (https://www.ncbi.nlm. nih.gov/nuccore/MT4701945) CC12.1 3504 QQLNSYPP Thomas Rogers et al., KFT 2020 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Thomas Rogers et al., WT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.25 3520 AAWDDSL Thomas Rogers et al., NGPV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.26 3521 LLYYGGAQ Thomas Rogers et al., RWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.27 3522 YSYAGSSTF Thomas Rogers et al., V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.28 3523 AAWDDSL Thomas Rogers et al., SGWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.3 3524 QQYGSSPR Thomas Rogers et al., T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520); Meng Yuan et al., 2020 (https://www.biorxiv. org/content/10.1101/ 2020.06.08.141267v1) CC12.4 3525 TSYAGSNN Thomas Rogers et al., FV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.5 3526 SSYTSSSTQ Thomas Rogers et al., V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.6 3527 SSYTSSSTQ Thomas Rogers et al., V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.7 3528 SSYTVSSTQ Thomas Rogers et al., V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.8 3529 SSYTSSSAQ Thomas Rogers et al., L 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC12.9 3530 SSYTSSSAQ Thomas Rogers et al., V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC6.29 3531 QQSYSTPP Thomas Rogers et al., T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC6.30 3532 QQSYSTPR Thomas Rogers et al., T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC6.31 3533 LQHNSYPIL Thomas Rogers et al., T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC6.32 3534 QVWDSSS Thomas Rogers et al., DHPYV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) CC6.33 3535 QHYGSSL Thomas Rogers et al., WT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7520) Clone11- 3536 FQGSHVPL Nadezhda Antipova et 9 T al., 2020 CnC2t1p1_ 3537 QQRSNWP Christoph Kreer et al., B10 PALT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) CnC2t1p1_ 3538 CSYAGSST Christoph Kreer et al., B4 WV 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) CnC2t1p1_ 3539 MQALQTP Christoph Kreer et al., D6 GT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) CnC2t1p1_ 3540 MQALQTP Christoph Kreer et al., E12 GT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) CnC2t1p1_ 3541 CSYAGVRT Christoph Kreer et al., E8 W 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) CnC2t1p1_ 3542 CSYAGVRT Christoph Kreer et al., G6 W 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) COV2- 3543 QQYGSSP Seth Zost et al., 2020 2006 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3544 QQYDNLLF Seth Zost et al., 2020 2007 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3545 SSYTSSSTL Seth Zost et al., 2020 2009 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3546 QQSYSTFT Seth Zost et al., 2020 2011 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3547 QQYYTAPL Seth Zost et al., 2020 2013 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3548 QQRSNWP Seth Zost et al., 2020 2015 PYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3549 SSYTSSTT Seth Zost et al., 2020 2016 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3550 QSFDSSLS Seth Zost et al., 2020 2017 GSDV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3551 AAWDASL Seth Zost et al., 2020 2021 SGHVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3552 MQRIEFP Seth Zost et al., 2020 2022 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3553 QQYYTAPL Seth Zost et al., 2020 2025 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3554 QQYNSYP Seth Zost et al., 2020 2026 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3555 QSADSSGT Seth Zost et al., 2020 2027 YFWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3556 QQYYTAPL Seth Zost et al., 2020 2028 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3557 SVWDDSL Seth Zost et al., 2020 2029 NGPL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3558 QSSDSSGV Seth Zost et al., 2020 2031 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3559 QQYNSYS Seth Zost et al., 2020 2032 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3560 SVWDDSL Seth Zost et al., 2020 2033 NGPL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3561 QQSYSTPP Seth Zost et al., 2020 2034 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3562 QQSYNTPR Seth Zost et al., 2020 2035 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3563 QQTNSFPT Seth Zost et al., 2020 2037 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3564 QQYGNSP Seth Zost et al., 2020 2039 Q (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3565 QQYNSYST Seth Zost et al., 2020 2041 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3566 QQSYNTPY Seth Zost et al., 2020 2046 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3567 AAWDDSL Seth Zost et al., 2020 2050 NALV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3568 QQSYSTPG Seth Zost et al., 2020 2051 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3569 QQSDNLP Seth Zost et al., 2020 2054 MYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3570 QVWDSSS Seth Zost et al., 2020 2055 DHHW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3571 LVWDDSL Seth Zost et al., 2020 2064 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3572 QSYDSRLS Seth Zost et al., 2020 2068 GFW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3573 QQSYTTLL Seth Zost et al., 2020 2070 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3574 QQYGSSP Seth Zost et al., 2020 2072 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3575 QSYDSSLS Seth Zost et al., 2020 2078 DSV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3576 QLLSSHPL Seth Zost et al., 2020 2080 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3577 SSRDSSGS Seth Zost et al., 2020 2082 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3578 QQYASLPF Seth Zost et al., 2020 2083 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3579 SSRDSSGS Seth Zost et al., 2020 2094 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3580 AVWDDSL Seth Zost et al., 2020 2096 SGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3581 QQSYSTP Seth Zost et al., 2020 2097 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3582 HQYSSWP Seth Zost et al., 2020 2098 QT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3583 QSYDGISR Seth Zost et al., 2020 2103 AWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3584 MQALQTP Seth Zost et al., 2020 2108 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3585 QQSYSSLSI Seth Zost et al., 2020 2110 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3586 QQSYEIPP Seth Zost et al., 2020 2111 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3587 QQYDSLP Seth Zost et al., 2020 2113 PV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3588 QSYDSSLS Seth Zost et al., 2020 2114 GSV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3589 QSYDSGNP Seth Zost et al., 2020 2128 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3590 QQYYSTLT Seth Zost et al., 2020 2130 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3591 QQYDNLP Seth Zost et al., 2020 2132 PV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3592 QSYDGINR Seth Zost et al., 2020 2137 WLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3593 GADHGSG Seth Zost et al., 2020 2142 SNFEYVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3594 AAWDDSL Seth Zost et al., 2020 2143 NGYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3595 QQLNSYPV Seth Zost et al., 2020 2146 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3596 SSYTSSSTL Seth Zost et al., 2020 2147 LYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3597 QVWDSSS Seth Zost et al., 2020 2150 DHPGV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3598 HYRSNWP Seth Zost et al., 2020 2151 PVLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3599 QQYDNLYS Seth Zost et al., 2020 2158 VH (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3600 SSYTSSSTL Seth Zost et al., 2020 2159 LYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3601 SSYTSSSTL Seth Zost et al., 2020 2160 LYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3602 QLLNSHPL Seth Zost et al., 2020 2165 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3603 QHRTNWP Seth Zost et al., 2020 2166 PLFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3604 QAWDSST Seth Zost et al., 2020 2171 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3605 QQYNTYSG Seth Zost et al., 2020 2173 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3606 QAWDSST Seth Zost et al., 2020 2175 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3607 QQTYSTF Seth Zost et al., 2020 2177 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3608 QAWDSST Seth Zost et al., 2020 2178 AV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3609 SSYTSSRAV Seth Zost et al., 2020 2183 L (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3610 QVWDSSS Seth Zost et al., 2020 2187 DHPEWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3611 QQSYSTPT Seth Zost et al., 2020 2189 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3612 SSYTSSSTH Seth Zost et al., 2020 2190 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3613 QQYNTYSG Seth Zost et al., 2020 2191 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3614 QQYYTAPL Seth Zost et al., 2020 2195 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3615 QHYGSSRG Seth Zost et al., 2020 2196 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3616 QQYGRSPI Seth Zost et al., 2020 2197 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3617 QAWDSST Seth Zost et al., 2020 2199 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3618 QQSYSTPY Seth Zost et al., 2020 2203 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3619 QSYDSSLG Seth Zost et al., 2020 2207 AL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3620 QQANSFPP Seth Zost et al., 2020 2210 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3621 QQRGNW Seth Zost et al., 2020 2212 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3622 QHRTNWP Seth Zost et al., 2020 2214 PLFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3623 QQCYNWP Seth Zost et al., 2020 2215 PWT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3624 HKRSNWP Seth Zost et al., 2020 2216 PSLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3625 QQYYSISW Seth Zost et al., 2020 2218 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3626 CSYAVSTTY Seth Zost et al., 2020 2222 VI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3627 QQYYSTP Seth Zost et al., 2020 2224 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3628 GADHGSG Seth Zost et al., 2020 2226 SNFVFVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3629 MQALQTP Seth Zost et al., 2020 2227 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3630 QQYNYWP Seth Zost et al., 2020 2228 PLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3631 QVWDSSS Seth Zost et al., 2020 2231 DHHW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3632 QQYNTYS Seth Zost et al., 2020 2235 QT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3633 QAWDND Seth Zost et al., 2020 2238 AGW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3634 QQYNSHP Seth Zost et al., 2020 2239 PT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3635 SAYAGSNN Seth Zost et al., 2020 2240 LV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3636 GADHGSG Seth Zost et al., 2020 2241 SNFEYVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3637 CSYAGIVL Seth Zost et al., 2020 2243 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3638 QSGDSSGT Seth Zost et al., 2020 2245 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3639 QSVDRSGT Seth Zost et al., 2020 2248 YFNWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3640 QQSYSTPY Seth Zost et al., 2020 2250 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3641 LLYYGGA Seth Zost et al., 2020 2251 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3642 QSYDGSN Seth Zost et al., 2020 2253 HAW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3643 QVWDSSS Seth Zost et al., 2020 2256 DPW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3644 MQALQTP Seth Zost et al., 2020 2257 QT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3645 QQYGGSLT Seth Zost et al., 2020 2258 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3646 QAWDSSL Seth Zost et al., 2020 2260 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3647 SSYTSSSLR Seth Zost et al., 2020 2262 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3648 QQLNSYPV Seth Zost et al., 2020 2263 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3649 CSYAGSYT Seth Zost et al., 2020 2266 YV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3650 SSYTSSSTL Seth Zost et al., 2020 2268 VL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3651 QQRSNWP Seth Zost et al., 2020 2270 PSYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3652 SSYTSISTW Seth Zost et al., 2020 2273 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3653 FSMDSSG Seth Zost et al., 2020 2274 DLRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3654 QQSYSTPG Seth Zost et al., 2020 2277 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3655 ISYTSSRTL Seth Zost et al., 2020 2281 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3656 QVWDSSY Seth Zost et al., 2020 2287 YHPW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3657 LVWDDSL Seth Zost et al., 2020 2290 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3658 GTWDSSLS Seth Zost et al., 2020 2293 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3659 QQYSIYSW Seth Zost et al., 2020 2296 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3660 QQSYSTP Seth Zost et al., 2020 2299 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3661 QQANSLPL Seth Zost et al., 2020 2300 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3662 AAWDDSL Seth Zost et al., 2020 2304 NGW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3663 AAWDDSL Seth Zost et al., 2020 2305 NGWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3664 QAWDSST Seth Zost et al., 2020 2307 AV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3665 HQYNNWP Seth Zost et al., 2020 2308 QT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3666 QQSYSTLT Seth Zost et al., 2020 2310 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3667 QHRSNWP Seth Zost et al., 2020 2313 PRLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3668 QQSYSTPG Seth Zost et al., 2020 2318 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3669 QQYGSSYT Seth Zost et al., 2020 2322 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3670 QQTYSTF Seth Zost et al., 2020 2325 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3671 AAWDDSL Seth Zost et al., 2020 2329 SSWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3672 QSYDSGNP Seth Zost et al., 2020 2331 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3673 QAWSSST Seth Zost et al., 2020 2333 AV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3674 SSYTSSTLN Seth Zost et al., 2020 2335 VL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3675 QQSYSTPG Seth Zost et al., 2020 2337 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3676 QSYDSSLS Seth Zost et al., 2020 2340 GWSV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3677 SSYTSSSTL Seth Zost et al., 2020 2341 LYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3678 QQSYSTH Seth Zost et al., 2020 2342 MST (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3679 MQSIQLA Seth Zost et al., 2020 2343 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3680 QQYNYWP Seth Zost et al., 2020 2346 PLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3681 SSGDSSTD Seth Zost et al., 2020 2351 HHVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3682 HQSYGVPI Seth Zost et al., 2020 2352 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3683 QQYNNWP Seth Zost et al., 2020 2353 PMYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3684 QSYDSSKY Seth Zost et al., 2020 2354 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3685 QQYGSSP Seth Zost et al., 2020 2355 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3686 MQALQTP Seth Zost et al., 2020 2357 LYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3687 QQSYSSLSI Seth Zost et al., 2020 2358 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3688 HKRSNWP Seth Zost et al., 2020 2367 PSLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3689 QSTASSGT Seth Zost et al., 2020 2368 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3690 QQYNSYSP Seth Zost et al., 2020 2369 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3691 QSYDGINR Seth Zost et al., 2020 2370 WLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3692 QQYNNWP Seth Zost et al., 2020 2371 GT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3693 QQYGSSPP Seth Zost et al., 2020 2373 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3694 GADHGSG Seth Zost et al., 2020 2378 SNFVYVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3695 QHFGSSSQ Seth Zost et al., 2020 2381 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3696 LLYYGGPW Seth Zost et al., 2020 2382 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3697 QQYNNWP Seth Zost et al., 2020 2383 LA (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3698 CSYAGGNT Seth Zost et al., 2020 2384 FVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3699 QQYNNWP Seth Zost et al., 2020 2386 RT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3700 SSYTSSSTP Seth Zost et al., 2020 2387 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3701 MQALQTP Seth Zost et al., 2020 2388 RT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3702 QQSYSTP Seth Zost et al., 2020 2389 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3703 AVWDDSL Seth Zost et al., 2020 2391 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3704 QQCYNWP Seth Zost et al., 2020 2394 PWT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3705 QAWDSST Seth Zost et al., 2020 2397 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3706 QQYHNLP Seth Zost et al., 2020 2399 RT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3707 QQLNSYPF Seth Zost et al., 2020 2400 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3708 QQYYSISW Seth Zost et al., 2020 2401 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3709 SSYTSSSTL Seth Zost et al., 2020 2403 YV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3710 QKYNSAP Seth Zost et al., 2020 2405 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3711 QAWDSST Seth Zost et al., 2020 2406 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3712 QQLNSYPI Seth Zost et al., 2020 2408 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3713 AVWDDSL Seth Zost et al., 2020 2413 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3714 AAWDDSL Seth Zost et al., 2020 2416 NGW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3715 QQSYTTLL Seth Zost et al., 2020 2417 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3716 SSYTSTSTP Seth Zost et al., 2020 2418 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3717 QQYHVWP Seth Zost et al., 2020 2420 PIT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3718 QQYYSTPL Seth Zost et al., 2020 2422 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3719 QQGNSFPL Seth Zost et al., 2020 2427 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3720 QSYDSSLS Seth Zost et al., 2020 2428 AWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3721 QQYNTYS Seth Zost et al., 2020 2429 QT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3722 QQRSNWP Seth Zost et al., 2020 2430 PGVT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3723 HQYDYLPY Seth Zost et al., 2020 2434 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3724 QQTYSTPL Seth Zost et al., 2020 2438 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3725 QHRTNWP Seth Zost et al., 2020 2441 PLFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3726 QSADSSGT Seth Zost et al., 2020 2444 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3727 QQYNTYSG Seth Zost et al., 2020 2445 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3728 GADHGSG Seth Zost et al., 2020 2446 SNFVFVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3729 QQYYSPP Seth Zost et al., 2020 2449 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3730 QQYHNLP Seth Zost et al., 2020 2450 PIT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3731 QAWDSST Seth Zost et al., 2020 2451 GGV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3732 QQYDNLP Seth Zost et al., 2020 2453 PGVSTT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3733 CSTDSSGN Seth Zost et al., 2020 2454 QRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3734 SSYTSSSTH Seth Zost et al., 2020 2455 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3735 QSADTIGT Seth Zost et al., 2020 2458 YWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3736 QQYNNWP Seth Zost et al., 2020 2459 PMYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3737 QQYDNLYS Seth Zost et al., 2020 2461 VH (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3738 QQSYEMP Seth Zost et al., 2020 2462 PWT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3739 QSADSSGY Seth Zost et al., 2020 2464 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3740 SSYTSSSIPY Seth Zost et al., 2020 2465 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3741 QQRGNW Seth Zost et al., 2020 2466 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3742 YSTDTSGN Seth Zost et al., 2020 2473 HWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3743 YSTDSSGN Seth Zost et al., 2020 2474 HRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3744 HQYGTSPY Seth Zost et al., 2020 2478 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3745 QQYNNFLT Seth Zost et al., 2020 2479 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3746 QQYYSTPG Seth Zost et al., 2020 2481 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3747 QSYDSSLS Seth Zost et al., 2020 2485 DSV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3748 QSADSSGT Seth Zost et al., 2020 2488 SWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3749 QQYGSSPF Seth Zost et al., 2020 2489 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3750 QQYNSYSL Seth Zost et al., 2020 2490 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3751 QQYNNW Seth Zost et al., 2020 2495 WRT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3752 YSTDSSGN Seth Zost et al., 2020 2496 HWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3753 NFRDSSGH Seth Zost et al., 2020 2499 HPV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3754 AAWDDSL Seth Zost et al., 2020 2504 NALV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3755 QQYNNWP Seth Zost et al., 2020 2509 GT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3756 YSAADNN Seth Zost et al., 2020 2510 RV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3757 NSRDSSGN Seth Zost et al., 2020 2514 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3758 QQYDNLLL Seth Zost et al., 2020 2515 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3759 QQRSNWP Seth Zost et al., 2020 2516 PRTWT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3760 HYRSNWP Seth Zost et al., 2020 2517 PVLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3761 NSRDSSGN Seth Zost et al., 2020 2518 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3762 NSRDSSGY Seth Zost et al., 2020 2520 IWGWM (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3763 QVWDSSS Seth Zost et al., 2020 2521 DHWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3764 QSYDSSLG Seth Zost et al., 2020 2524 AL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3765 QSWDTGI Seth Zost et al., 2020 2525 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3766 QAWDSST Seth Zost et al., 2020 2526 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3767 CSYVGSST Seth Zost et al., 2020 2527 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3768 QSADSSSH Seth Zost et al., 2020 2529 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3769 QSFDSGNV Seth Zost et al., 2020 2531 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3770 VAWDDSR Seth Zost et al., 2020 2532 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3771 QQYYSTRT Seth Zost et al., 2020 2533 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3772 QQYYSTPP Seth Zost et al., 2020 2536 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3773 LAWDDSL Seth Zost et al., 2020 2539 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3774 AAWDASL Seth Zost et al., 2020 2545 SGWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3775 QSVDGSGS Seth Zost et al., 2020 2546 SVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3776 QAWDSST Seth Zost et al., 2020 2549 HVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3777 SSYTSSSTP Seth Zost et al., 2020 2551 FV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3778 ETWDSNT Seth Zost et al., 2020 2552 RV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3779 QQSYSTP Seth Zost et al., 2020 2553 MHT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3780 QQLNSYLG Seth Zost et al., 2020 2554 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3781 QQANSFPP Seth Zost et al., 2020 2558 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3782 LVWDDSL Seth Zost et al., 2020 2562 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3783 CSYAGSST Seth Zost et al., 2020 2563 WG (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3784 QVWDSSS Seth Zost et al., 2020 2564 DHHW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3785 MQALQTP Seth Zost et al., 2020 2565 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3786 QQYNNWP Seth Zost et al., 2020 2570 PMYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3787 QQYNNWP Seth Zost et al., 2020 2571 RT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3788 QTWGT Seth Zost et al., 2020 2574 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3789 MQSIQPPL Seth Zost et al., 2020 2582 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3790 QQYYSTPL Seth Zost et al., 2020 2583 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3791 SSFTSRGAL Seth Zost et al., 2020 2584 VL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3792 CSYAGIWV Seth Zost et al., 2020 2585 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3793 QHYGSSRS Seth Zost et al., 2020 2586 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3794 QQSYSTPT Seth Zost et al., 2020 2587 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3795 QQSYSTPY Seth Zost et al., 2020 2589 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3796 NSRDSSGN Seth Zost et al., 2020 2590 HLRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3797 QQYGRSPI Seth Zost et al., 2020 2602 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3798 QQYDNLL Seth Zost et al., 2020 2610 QFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3799 YSTDSSGN Seth Zost et al., 2020 2611 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3800 QQYNSYSL Seth Zost et al., 2020 2614 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3801 QYYGSSPF Seth Zost et al., 2020 2616 G (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3802 QQRSNWP Seth Zost et al., 2020 2617 PRLT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3803 AVWDDSL Seth Zost et al., 2020 2618 NGVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3804 LVWDDSL Seth Zost et al., 2020 2619 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3805 SSYTSSRAV Seth Zost et al., 2020 2620 L (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3806 QQYYSSH Seth Zost et al., 2020 2621 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3807 YSYAGSST Seth Zost et al., 2020 2622 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3808 QSTDSSGS Seth Zost et al., 2020 2624 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3809 HQSYFTPQ Seth Zost et al., 2020 2628 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3810 QQYGNSP Seth Zost et al., 2020 2631 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3811 QQYVEPPF Seth Zost et al., 2020 2632 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3812 SAYAGSNN Seth Zost et al., 2020 2639 LV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3813 QQYGSSYT Seth Zost et al., 2020 2641 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3814 QQSYSTPG Seth Zost et al., 2020 2643 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3815 QQYGRSS Seth Zost et al., 2020 2656 GT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3816 QQYGSSPL Seth Zost et al., 2020 2660 IT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3817 QQYYTAPL Seth Zost et al., 2020 2669 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3818 LLYYGGA Seth Zost et al., 2020 2673 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3819 HQSSSLPP Seth Zost et al., 2020 2675 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3820 QRRSNWP Seth Zost et al., 2020 2676 PFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3821 QSYDSSNY Seth Zost et al., 2020 2677 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3822 NSRDSSGN Seth Zost et al., 2020 2678 AW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3823 QQYYSSPY Seth Zost et al., 2020 2681 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3824 QQYNNW Seth Zost et al., 2020 2684 WRT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3825 QQYGSSPR Seth Zost et al., 2020 2685 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3826 AVWDDSL Seth Zost et al., 2020 2693 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3827 QSYDSSLN Seth Zost et al., 2020 2694 GDV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3828 QQRSNWP Seth Zost et al., 2020 2697 LIFT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3829 QSYDSSLS Seth Zost et al., 2020 2700 GYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3830 QQSYSTPPI Seth Zost et al., 2020 2703 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3831 QQSYSTPP Seth Zost et al., 2020 2705 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3832 QQYANLPF Seth Zost et al., 2020 2709 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3833 VAWDDSR Seth Zost et al., 2020 2710 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3834 QSVDSSGT Seth Zost et al., 2020 2713 YPHVI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3835 QQSYSTPY Seth Zost et al., 2020 2717 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3836 QQLNSYPL Seth Zost et al., 2020 2718 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3837 TSYTSSSTL Seth Zost et al., 2020 2722 NW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3838 CSYASSSIV Seth Zost et al., 2020 2726 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3839 QQSYSTPP Seth Zost et al., 2020 2730 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3840 QQLNSYSF Seth Zost et al., 2020 2733 ET (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3841 QSYDGINR Seth Zost et al., 2020 2734 WLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3842 QQYNSYPY Seth Zost et al., 2020 2736 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3843 QQSSSSPIT Seth Zost et al., 2020 2740 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3844 QQSYTTLL Seth Zost et al., 2020 2749 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3845 QVWDGIN Seth Zost et al., 2020 2751 DRW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3846 QQYDNLP Seth Zost et al., 2020 2752 PV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3847 QQSYSSE Seth Zost et al., 2020 2753 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3848 QSYDISLG Seth Zost et al., 2020 2756 GWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3849 QQSYSMP Seth Zost et al., 2020 2758 PIT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3850 AAWDDSL Seth Zost et al., 2020 2759 NGSWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3851 AAWDDSL Seth Zost et al., 2020 2760 SGLI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3852 CSYAGSST Seth Zost et al., 2020 2762 WL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3853 QVWDSSS Seth Zost et al., 2020 2765 DHHW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3854 VAWDDSR Seth Zost et al., 2020 2767 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3855 GTWDSSLS Seth Zost et al., 2020 2768 AYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3856 QVWDSSS Seth Zost et al., 2020 2769 DHPGV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3857 QAWGSSR Seth Zost et al., 2020 2774 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3858 NSRDNSG Seth Zost et al., 2020 2776 NLNWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3859 QQYDNLPY Seth Zost et al., 2020 2780 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3860 QSADSSGS Seth Zost et al., 2020 2783 R (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3861 QQYNNWP Seth Zost et al., 2020 2784 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3862 QQSYEIPP Seth Zost et al., 2020 2786 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3863 ATWDDSL Seth Zost et al., 2020 2789 NGPV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3864 QSYDSRLS Seth Zost et al., 2020 2790 GFW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3865 QSADSSGT Seth Zost et al., 2020 2794 SVL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3866 CSYARSSTR Seth Zost et al., 2020 2796 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3867 QSADSRG Seth Zost et al., 2020 2797 AV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3868 AVWDDSL Seth Zost et al., 2020 2801 HSYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3869 QQSYSTPR Seth Zost et al., 2020 2807 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3870 QQYDNLPL Seth Zost et al., 2020 2808 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3871 QQSYTTLL Seth Zost et al., 2020 2809 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3872 QSYDSSLS Seth Zost et al., 2020 2811 GWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3873 QQYANLPF Seth Zost et al., 2020 2812 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3874 QQYDNLP Seth Zost et al., 2020 2813 RT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3875 QSYDSSLS Seth Zost et al., 2020 2814 GYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3876 CSYAVSTTY Seth Zost et al., 2020 2816 VI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3877 QQSYSNPS Seth Zost et al., 2020 2817 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3878 QQYGSSPP Seth Zost et al., 2020 2818 RYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3879 QQSYSTLL Seth Zost et al., 2020 2819 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3880 MQALQTP Seth Zost et al., 2020 2820 FT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3881 QVWDSSS Seth Zost et al., 2020 2821 DRLYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3882 QQSYSNPS Seth Zost et al., 2020 2822 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3883 CSYAGSST Seth Zost et al., 2020 2826 WL (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3884 QSYDSTSR Seth Zost et al., 2020 2828 W (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3885 QVWDSGS Seth Zost et al., 2020 2830 DHVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3886 QQSYSTPQ Seth Zost et al., 2020 2832 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3887 ASWDDSLI Seth Zost et al., 2020 2834 GPV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3888 QQLNSYPG Seth Zost et al., 2020 2835 YT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3889 QSYDSNN Seth Zost et al., 2020 2841 QV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3890 QSYDSSDV Seth Zost et al., 2020 2842 V (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3891 QVWDSSS Seth Zost et al., 2020 2844 DHHW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3892 QSADSSGT Seth Zost et al., 2020 2848 YRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3893 QQYYNWP Seth Zost et al., 2020 2853 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3894 QSADSSAA Seth Zost et al., 2020 2863 YVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3895 YSTDSSGK Seth Zost et al., 2020 2872 GV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3896 QVWDSSS Seth Zost et al., 2020 2873 DPFYV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3897 QSYDGINR Seth Zost et al., 2020 2878 AWV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3898 QQYYSTP Seth Zost et al., 2020 2883 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3899 QQYNSYSY Seth Zost et al., 2020 2891 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3900 QQYDDWP Seth Zost et al., 2020 2894 PEVT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3901 VAWDDSR Seth Zost et al., 2020 2901 NGLV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3902 QSFDIGRG Seth Zost et al., 2020 2904 GWI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3903 QQSYSTPP Seth Zost et al., 2020 2906 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3904 QSYDSSLS Seth Zost et al., 2020 2909 GSV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3905 CSYAGSVL Seth Zost et al., 2020 2911 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3906 QQSFSTPR Seth Zost et al., 2020 2919 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3907 QVWDSSS Seth Zost et al., 2020 2933 DHPEWV (https://www.nature.co m/articles/s41591-020- 0998-x) COV2- 3908 MQALQTP Seth Zost et al., 2020 2934 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3909 NSRDSSGN Seth Zost et al., 2020 2939 PRW (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3910 QQYGSSPP Seth Zost et al., 2020 2941 RYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3911 QSVDSSGT Seth Zost et al., 2020 2942 YRV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3912 QQYDNLPL Seth Zost et al., 2020 2944 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3913 MQGTHW Seth Zost et al., 2020 2945 PYT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3914 CSYAGRYT Seth Zost et al., 2020 2947 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3915 QLLNSHPL Seth Zost et al., 2020 2952 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3916 QSADSTG Seth Zost et al., 2020 2953 WV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3917 MQSIQLPY Seth Zost et al., 2020 2955 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3918 MQSIQLA Seth Zost et al., 2020 2960 (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3919 QHYGSSRG Seth Zost et al., 2020 2961 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3920 QQYYNWP Seth Zost et al., 2020 2997 LT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3921 QQYNSYPY Seth Zost et al., 2020 3010 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3922 QQSYEIPP Seth Zost et al., 2020 3012 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3923 QQYANLPF Seth Zost et al., 2020 3013 T (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3924 QHYGSSRG Seth Zost et al., 2020 3025 WT (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3925 QSVDSSGT Seth Zost et al., 2020 3029 YPHVI (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3926 QSYASSLS Seth Zost et al., 2020 3057 AHVV (https://www.nature.com/ articles/s41591-020- 0998-x) COV2- 3927 QQYYSSYT Seth Zost et al., 2020 3058 (https://www.nature.co m/articles/s41591-020- 0998-x) COVA1- 3928 QQYGSSPP Philip Brouwer et al., 01 PFT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3929 SSYTSSSTP Philip Brouwer et al., 02 W 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3930 QKYNSAPP Philip Brouwer et al., 03 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3931 QAWGSTT Philip Brouwer et al., 06 AKV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3932 QQRSNWP Philip Brouwer et al., 07 PRVT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3933 SSYTSSSTR Philip Brouwer et al., 08 HWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3934 QQSYSTPY Philip Brouwer et al., 09 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3935 SAYTTTSTS Philip Brouwer et al., 10 WV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3936 SSYVGNN Philip Brouwer et al., 12 NWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3937 QQYDNPP Philip Brouwer et al., 16 LT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902),  Hejun Liu et al 2020 (https://www.biorxiv.or g/content/10.1101/ 2020.08.02.233536v1.full. pdf) COVA1- 3938 LLSYSGVW Philip Brouwer et al., 18 V 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3939 QQYNNWP Philip Brouwer et al., 19 PWT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3940 QVWDSSS Philip Brouwer et al., 20 DHWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3941 QQYNNWP Philip Brouwer et al., 21 PGT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3942 QAWDSST Philip Brouwer et al., 22 AV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3943 QSADSSGT Philip Brouwer et al., 23 YSW 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3944 QQYNSYSI Philip Brouwer et al., 25 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3945 QQLHSYPL Philip Brouwer et al., 26 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA1- 3946 QQYGSSPL Philip Brouwer et al., 27 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3947 QQSYSTPP Philip Brouwer et al., 01 VT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3948 QQSYSTH Philip Brouwer et al., 02 MST 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3949 QQRSNWP Philip Brouwer et al., 03 QVT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3950 QQYGSLYT Philip Brouwer et al., 04 2020 (https://science.sciencemag. org/content/early 2020/06/15/science.abc5902); Nicholas Wu (https://www.biorxiv.org/ content/10.1101/ 2020.07.26.222232v1) COVA2- 3951 QQYDNLPL Philip Brouwer et al., 05 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3952 QQYGSSP Philip Brouwer et al., 07 GT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3953 QQYGSSLL Philip Brouwer et al., 10 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3954 QQYGSSPR Philip Brouwer et al., 11 LT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3955 QQYNNWP Philip Brouwer et al., 12 PWT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3956 QQYGSSP Philip Brouwer et al., 13 GT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3957 QQRSNWP Philip Brouwer et al., 14 PMYT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3958 MQGTHW Philip Brouwer et al., 15 PRT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3959 LQHNSYPP Philip Brouwer et al., 16 L 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3960 QQRSNWP Philip Brouwer et al., 17 PYT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3961 QQRSNWP Philip Brouwer et al., 18 PSIT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3962 LQHNSYL Philip Brouwer et al., 20 WT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3963 QQYDNLPI Philip Brouwer et al., 22 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3964 QQYGSSP Philip Brouwer et al., 23 GVT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3965 QQSYSTPQ Philip Brouwer et al., 24 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3966 SSYTSSST Philip Brouwer et al., 25 WV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3967 QAWDSST Philip Brouwer et al., 26 AW 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3968 QQYNYWP Philip Brouwer et al., 28 LIT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3969 QQSYSTPR Philip Brouwer et al., 29 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3970 QVWASSS Philip Brouwer et al., 30 W 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3971 MQSIQLPP Philip Brouwer et al., 31 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3972 QQRSNWP Philip Brouwer et al., 32 PRLT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3973 CSYAGSV Philip Brouwer et al., 33 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3974 SSYTSSSTL Philip Brouwer et al., 34 GLYV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3975 QSYDSSLS Philip Brouwer et al., 37 GSV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3976 LQHNSYPL Philip Brouwer et al., 38 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3977 CSYAGSST Philip Brouwer et al., 39 WV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902); Nicholas Wu (https://www.biorxiv. org/content/10.1101/ 2020.07.26.222232v1) COVA2- 3978 CSYAGSST Philip Brouwer et al., 40 WV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3979 QQCYNWP Philip Brouwer et al., 41 PWT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3980 LQHNSYPL Philip Brouwer et al., 43 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3981 QQSYTTFIY Philip Brouwer et al., 44 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3982 QQYGSSPY Philip Brouwer et al., 45 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3983 QQYDNLLS Philip Brouwer et al., 46 LT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA2- 3984 QQYYSTPP Philip Brouwer et al., 47 LT 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3985 QQSYSTLT Philip Brouwer et al., 01 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3986 QSADSSGT Philip Brouwer et al., 03 YRV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3987 QVWDSSS Philip Brouwer et al., 04 DHYV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3988 AAWDDSL Philip Brouwer et al., 05 NGPHWV 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3989 QQYYSTPL Philip Brouwer et al., 06 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3990 QQYGSSPF Philip Brouwer et al., 07 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3991 QQSYSTPL Philip Brouwer et al., 08 T 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3992 QQSYSTLT Philip Brouwer et al., 09 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) COVA3- 3993 QQYYSTPIT Philip Brouwer et al., 10 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc5902) CR3022 3994 QQYYSTPY Jan ter Meulen et al., T 2006 (https://journals.plos.org/ plosmedicine/article?id = 10.1371/journal.pmed. 003 0237); Meng Yuan et al., 2020a (https://science.sciencemag. org/content/early/ 2020/04/02/science.abb7269); Meng Yuan et al.,2020b (https://www.biorxiv. org/content/10.1101/ 2020.06.08.141267vl) CV-X1- 3995 QQANGFP Jakob Kreye et al., 2020 126 PL (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV-X2- 3996 QQSYSTPY Jakob Kreye et al., 2020 106 T (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV05-163 3997 QQRSNWP Jakob Kreye et al., 2020 PVT (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-200 3998 SSYTSSSTY Jakob Kreye et al., 2020 V (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-209 3999 QQYDNLPL Jakob Kreye et al., 2020 T (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-222 4000 CSYAGGST Jakob Kreye et al., 2020 SYV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-250 4001 SSYAGNND Jakob Kreye et al., 2020 FV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-255 4002 CSYAGHST Jakob Kreye et al., 2020 WV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-262 4003 CSYAGTST Jakob Kreye et al., 2020 FV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-270 4004 CSYAGSSS Jakob Kreye et al., 2020 WV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-283 4005 SSYTSSSTY Jakob Kreye et al., 2020 V (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-287 4006 QQYYGSSP Jakob Kreye et al., 2020 WT (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV07-315 4007 QQSYSTHA Jakob Kreye et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV1 4008 AAWDDSL Emilie Seydoux et al., NGPV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV10 4009 QQYAGSP Emilie Seydoux et al., WT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV11 4010 QQRSNWP Emilie Seydoux et al., PIFT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV12 4011 MQGTHW Emilie Seydoux et al., PVT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV13 4012 QQSYSNPL Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV15 4013 CSYAGSYT Emilie Seydoux et al., WV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV16 4014 QQYGSSR Emilie Seydoux et al., GT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV17 4015 CSYAGSST Emilie Seydoux et al., YV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV18 4016 GTWDSSLS Emilie Seydoux et al., AGPV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV19 4017 QQYGSSPP Emilie Seydoux et al., KYT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV2 4018 QQYNNWP Emilie Seydoux et al., PSLT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV21 4019 QQRSNWP Emilie Seydoux et al., LT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV22 4020 QTWGTGI Emilie Seydoux et al., RV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV23 4021 QSADSSGT Emilie Seydoux et al., YVV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV24 4022 GTWDSSLS Emilie Seydoux et al., ASYV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV25 4023 QQYNNWP Emilie Seydoux et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV26 4024 LQHNSYPF Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV27 4025 SSYTSSSTP Emilie Seydoux et al., YV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV3 4026 QQSYSNPL Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV30 4027 QQYGSSP Emilie Seydoux et al., QT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1); Nicholas Hurlburt et al., 2020 (https://www.biorxiv.or g/content/10.1101/202 0.06.12.148692V1) CV31 4028 GTWDSSLS Emilie Seydoux et al., ASYV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV32 4029 GTWDSSLS Emilie Seydoux et al., AW 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV33 4030 QSYDSSLS Emilie Seydoux et al., GPVV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV34 4031 QVWDSSS Emilie Seydoux et al., DHVV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV35 4032 AAWDDSL Emilie Seydoux et al., NGPV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV36 4033 QSADSSGT Emilie Seydoux et al., YMI 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV37 4034 QQYDNLP Emilie Seydoux et al., R 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV38 4035 QQRSNWP Emilie Seydoux et al., PIT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV38-113 4036 QQYDNLPS Jakob Kreye et al., 2020 WT (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV38-139 4037 QQLNSYPP Jakob Kreye et al., 2020 GT (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV38-142 4038 QQSYSTPR Jakob Kreye et al., 2020 QWT (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV38-183 4039 QSYDSSLS Jakob Kreye et al., 2020 GSV (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV38-221 4040 QQLYT Jakob Kreye et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.08.15.252320v1.full. pdf) CV39 4041 MQGTHW Emilie Seydoux et al., PVT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV4 4042 QQYNSYT Emilie Seydoux et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV40 4043 LQHNSYPL Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV41 4044 QQYNNWP Emilie Seydoux et al., LT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV42 4045 QQTYITAF Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV43 4046 QSYDSSN Emilie Seydoux et al., WV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV44 4047 QSADSSGT Emilie Seydoux et al., YVV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV45 4048 QSYDSSLTL Emilie Seydoux et al., YV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV46 4049 MQGTHW Emilie Seydoux et al., PVT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV47 4050 LQHNSYPL Emilie Seydoux et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV48 4051 MQGTHW Emilie Seydoux et al., PPT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV5 4052 QQYYITPYT Emilie Seydoux et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV50 4053 YSTDSSGN Emilie Seydoux et al., LYV 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV7 4054 QQYNSYT Emilie Seydoux et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV8 4055 QQYGSSP Emilie Seydoux et al., GT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) CV9 4056 SSYTSISTW Emilie Seydoux et al., V 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.12.091298v1) EY6A 4057 QQSYSTLA Darning Zhou et al., LT 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.12.148387V1) Fab 2-4 4058 SSYAGSNN David Ho et al., 2020 LV (https://www.biorxiv.org/ content/10.1101/ 2020.06.17.153486V1) FnC1t1p2_ 4059 QQYGSSP Christoph Kreer et al., A5 GT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) FnC1t2p1_ 4060 QQYDNLPL Christoph Kreer et al., D4 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) FnC1t2p1_ 4061 QQYDNLPL Christoph Kreer et al., G5 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) H014 ND Zhe Lv et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.02.129098v2) H11-D4 N/A Jiangdong Huo et al., 2020 (https://www.nature.com/ articles/s41594-020- 0469-6) H11-H4 N/A Jiangdong Huo et al., 2020 (https://www.nature.com/ articles/s41594-020- 0469-6) H4 4062 MQRIEFPL Yan Wu et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/05/12/science.abc2241) HbnC2t1p2_ 4063 QQRSNWP Christoph Kreer et al., D9 PTWT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC3t1p1_ 4064 QQYGSSP Christoph Kreer et al., C6 WT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC3t1p1_ 4065 QHYHSFPL Christoph Kreer et al., F4 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC3t1p1_ 4066 QQYGSSPR Christoph Kreer et al., G4 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC3t1p2_ 4067 QQYGSSPR Christoph Kreer et al., B10 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC3t1p2_ 4068 QQYGRSP Christoph Kreer et al., C6 WT 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) HbnC4t1p1_ 4069 QQSYSNPL Christoph Kreer et al., D5 T 2020 (https://doi.org/10.1016/ j.cell.2020.06.044) Ju et al., Various Bin Ju et al., 2020 2020 (https://www.nature.com/ articles/s41586-020- 2380-z) Kim et Various Sang II Kim et al., 2020 al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.26.174557v2) LR1 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR11 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR15 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR16 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR2 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR3 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR5 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR6 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR7 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) LR8 N/A Tingting Li et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.09.143438v1) mAb-1 4070 QSYDSSLS Anna Wee et al., 2020 VLYV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-10 4071 QQYNSWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-100 4072 QRRGDGY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-101 4073 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-102 4074 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-103 4075 QQSYSTPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-104 4076 CSYAGSGT Anna Wee et al., 2020 WI (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-105 4077 HQYGSSP Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-106 4078 QRRGDGY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-107 4079 MQATDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-108 4080 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-109 4081 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-11 4082 QQFEDLPI Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-110 4083 QQYYSTPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-111 4084 QQYGTSPV Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-112 4085 GTWDFSLS Anna Wee et al., 2020 AGV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-113 4086 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-114 4087 QQYKSPLS Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-115 4088 QQRSDWH Anna Wee et al., 2020 PIT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-116 4089 QQSYSTPG Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-117 4090 QQRAKWP Anna Wee et al., 2020 PRVT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-118 4091 QQRAKWP Anna Wee et al., 2020 PRVI (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-119 4092 YSTDSTAN Anna Wee et al., 2020 YKV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-12 4093 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-120 4094 CSYAGSSA Anna Wee et al., 2020 VVVV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-121 4095 QQYYSTPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-122 4096 LQRSDWH Anna Wee et al., 2020 PIT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-123 4097 QQRSNWP Anna Wee et al., 2020 PRLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-124 4098 LQYSLATT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-125 4099 ETWDSNL Anna Wee et al., 2020 KGV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-126 4100 EAWDNNN Anna Wee et al., 2020 LGV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-127 4101 LQHNSYPL Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-128 4102 MQALQTP Anna Wee et al., 2020 GVT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-129 4103 ATWDDSL Anna Wee et al., 2020 NGVV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-13 4104 MQGTDW Anna Wee et al., 2020 PRS (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-130 4105 LHTYTTPRT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-131 4106 QQYNYWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-132 4107 QQSYRFPI Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-133 4108 QQRTNWP Anna Wee et al., 2020 GAT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-134 4109 HTWGTDI Anna Wee et al., 2020 QV (https://science. science mag.org/content/early/ 2020/06/15/science.abc 7424) mAb-135 4110 QSYDSSSQ Anna Wee et al., 2020 V (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-136 4111 QQYNYWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-137 4112 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-138 4113 QQYNSLYT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-139 4114 QQYHHWP Anna Wee et al., 2020 PYT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-14 4115 QQYCSTPP Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-140 4116 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-141 4117 MQGTDW Anna Wee et al., 2020 PRS (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-142 4118 QQSYSTPLI Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-143 4119 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-144 4120 MQGTDW Anna Wee et al., 2020 PRT (https://science. science mag.org/content/early/ 2020/06/15/science.abc 7424) mAb-145 4121 QQRFSWY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-146 4122 CSYGGRST Anna Wee et al., 2020 SVV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-147 4123 QQRFSWY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-148 4124 SSYTSGGTL Anna Wee et al., 2020 V (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-149 4125 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-15 4126 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-150 4127 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-151 4128 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-152 4129 MQGTEW Anna Wee et al., 2020 PRT (https://science. science mag.org/content/early/ 2020/06/15/science.abc 7424) mAb-153 4130 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-154 4131 QSADSNDS Anna Wee et al., 2020 SPV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-155 4132 HQRSNWP Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-156 4133 QQSYSIPW Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-157 4134 QHSYSSPP Anna Wee et al., 2020 LT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-158 4135 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-159 4136 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-16 4137 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-160 4138 HQYSGSAT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-161 4139 ATWDDILN Anna Wee et al., 2020 GPV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-162 4140 QKYNRAP Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-163 4141 SSYISDIKLV Anna Wee et al., 2020 V (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-164 4142 CSYAGTYI Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-165 4143 CSYRSDNT Anna Wee et al., 2020 YI (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-166 4144 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-167 4145 AAWDDSL Anna Wee et al., 2020 NTFRYV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-168 4146 QQSYNTFF Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-169 4147 QHYDSYPT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-17 4148 MQGTEWL Anna Wee et al., 2020 GT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-170 4149 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-171 4150 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-172 4151 QQSYSTPP Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-173 4152 HQYNKWP Anna Wee et al., 2020 PIT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-174 4153 KQYNSYPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-175 4154 QQSYSDS Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-176 4155 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-177 4156 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-178 4157 QQYYTTPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-179 4158 QQTYSTPP Anna Wee et al., 2020 EGPT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-18 4159 CSYAGASP Anna Wee et al., 2020 FVV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-180 4160 QQYGSSYT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-181 4161 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-182 4162 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-183 4163 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-184 4164 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-185 4165 CSYAGDDT Anna Wee et al., 2020 W (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-186 4166 HQYGGSPT Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-187 4167 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-188 4168 QQRTSTLT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-189 4169 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-19 4170 ETWDSSLS Anna Wee et al., 2020 VW (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-190 4171 GTWDSRLS Anna Wee et al., 2020 AW (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-191 4172 QQRSNWP Anna Wee et al., 2020 QN (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-192 4173 QQYDSYPV Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-193 4174 QQYYTMW Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-194 4175 GTWDSSLS Anna Wee et al., 2020 VDNYV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-195 4176 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-196 4177 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-197 4178 QQSYSTPL Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-2 4179 QQRSNWP Anna Wee et al., 2020 QN (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-20 4180 QSYDSSLS Anna Wee et al., 2020 AS (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-21 4181 QSYDSSLS Anna Wee et al., 2020 GVL (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-22 4182 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-23 4183 QQYNTWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-24 4184 MQGTHW Anna Wee et al., 2020 PRS (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-25 4185 QQYGSAPL Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-26 4186 QQYGNSP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-27 4187 ETWDTSLS Anna Wee et al., 2020 VW (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-28 4188 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-29 4189 LQYSDATT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-3 4190 QQSYTTPIT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-30 4191 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-31 4192 QQRRNWP Anna Wee et al., 2020 PMYT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-32 4193 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-33 4194 MQTTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-34 4195 QSYDSGNL Anna Wee et al., 2020 W (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-35 4196 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-36 4197 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-37 4198 QQYGTSPV Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-38 4199 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-39 4200 QQRRNWP Anna Wee et al., 2020 PMYT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-4 4201 QSYDSSLS Anna Wee et al., 2020 VLYV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-40 4202 QHRTNWP Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-41 4203 FLSYRGAP Anna Wee et al., 2020 PV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-42 4204 QKHDRDP Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-43 4205 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-44 4206 QQAESFPF Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-45 4207 MQATDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-46 4208 QQRGNGY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-47 4209 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-48 4210 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-49 4211 MQATDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-5 4212 QQSYSVPL Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-50 4213 MQATDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-51 4214 STYTSTSTI Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-52 4215 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-53 4216 MQATDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-54 4217 QQTYITPG Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-55 4218 QQYYLTP Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-56 4219 CSYAVSGT Anna Wee et al., 2020 VL (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-57 4220 LQYSLATT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-58 4221 QQRSDGY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-59 4222 QQTYITPT Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-6 4223 QQSYSTPY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-60 4224 QQYNSOY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-61 4225 CSSPGTIT Anna Wee et al., 2020 WV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-62 4226 ATWDDILN Anna Wee et al., 2020 GPV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-63 4227 MOATHW Anna Wee et al., 2020 PRA (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-64 4228 HQYGSSP Anna Wee et al., 2020 WT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-65 4229 QHRSNWP Anna Wee et al., 2020 PRYT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-66 4230 YSTDSTAN Anna Wee et al., 2020 YKV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-67 4231 YSTDSTAN Anna Wee et al., 2020 YKV (https://science. science mag.org/content/early/ 2020/06/15/science.abc 7424) mAb-68 4232 YSTDSTAN Anna Wee et al., 2020 YKV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-69 4233 MIWHDNA Anna Wee et al., 2020 W (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-7 4234 HQYNTWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-70 4235 MQATHW Anna Wee et al., 2020 PRA (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-71 4236 MQSIQVPI Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-72 4237 QQYNLWP Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-73 4238 KQYNSYPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-74 4239 ETWDDSLS Anna Wee et al., 2020 AW (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-75 4240 MQSIQTPI Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-76 4241 QQYYSTPP Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-77 4242 MQATEWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-78 4243 QQYYTTPL Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-79 4244 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-8 4245 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) 7424) mAb-80 4246 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-81 4247 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-82 4248 SSYTSSSTL Anna Wee et al., 2020 YV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-83 4249 QQYNSGW Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-84 4250 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-85 4251 LQLHNYSS Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-86 4252 QQRSDGY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-87 4253 SSYTSTNTV Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-88 4254 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-89 4255 CSSPGTIT Anna Wee et al., 2020 (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-9 4256 QQCYSYPP Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-90 4257 QQYYSTPY Anna Wee et al., 2020 T (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-91 4258 CSYTRTNT Anna Wee et al., 2020 PVL (https://science. science mag.org/content/early/ 2020/06/15/science.abc 7424) mAb-92 4259 QQYYSWP Anna Wee et al., 2020 PLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-93 4260 MQGTDW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-94 4261 MQSTDWP Anna Wee et al., 2020 RT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-95 4262 MQGTEW Anna Wee et al., 2020 PRT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-96 4263 QQYNNWP Anna Wee et al., 2020 SLT (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-97 4264 MQATEWP Anna Wee et al., 2020 RT (https://science.science mag.org/content/early/ 2020/06/15/science.abc7424) mAb-98 4265 QQRSDGY Anna Wee et al., 2020 N (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mAb-99 4266 YSTDSTAN Anna Wee et al., 2020 YKV (https://science.sciencemag. org/content/early/ 2020/06/15/science.abc7424) mBG17 4267 QQFYNYPR James Terry et al., 2020 T (https://www.biorxiv.org/ content/10.1101/ 2020.09.03.280370v1.full) mBG21 4268 QQDYSSP James Terry et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.09.03.280370v1.full) mBG22 4269 QQDYSSP James Terry et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.09.03.280370v1.full) mBG57 4270 MQHLENP James Terry et al., 2020 LGVR (https://www.biorxiv.org/ content/10.1101/ 2020.09.03.280370v1.full) mBG67 4271 LQYHRSP James Terry et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.09.03.280370v1.full) MD17 4272 QQSYTTPL Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD29 4273 HQTYTSPY Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD45 4274 QQYGVSPE Tal Noy-Porat et al., II 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD47 4275 QVWDSSS Tal Noy-Porat et al., HHHW 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD62 4276 QQANSFPL Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD63 4277 QQSYSTPY Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD65 4278 QQYGSSPL Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) MD67 4279 QQFGSSPL Tal Noy-Porat et al., T 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.05.20.106609v2) mNb6 ND Michael Schoof et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.08.08.238469v1.full. pdf) mNb6-tri ND Michael Schoof et al., 2020 (https://www.biorxiv.org/ 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Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#12 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#13 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#14 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#15 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#16 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#17 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#18 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#19 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#2 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) 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Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#62 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#63 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#64 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#65 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#66 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#67 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#68 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#69 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) Sb#7 N/A Justin Walter et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.04.16.045419v2) 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Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb60 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb61 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb62 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb63 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb67 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb7 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb71 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb75 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb76 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb78 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb8 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb83 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb84 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb85 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb88 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) Sb9 N/A Tania Custodia et al., 2020 (https://www.biorxiv.org/ content/10.1101/ 2020.06.23.165415v1.full. pdf + html) 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EXAMPLES

The examples in this section are offered by way of illustration, and not by way of limitation.

General Method: Plasmid Construction:

To construct single-gene expression plasmids, ORF (with Kosak and stop codon) of interested gene was used to simply replace existing gene at BstEII-BglII of BV2 vector (Kan resistant plasmid). For constructing multi-gene expression plasmids, the second ORF was inserted into expression-shuttle vector (Amp resistant plasmid) at BstEII-BglII. The expression cassette of resulting plasmid was then digested (RI-XbaI) and inserted into existing single expression plasmid at RI-NheI. This process yielded two expression cassette vectors with RI-NheI site available to another round of insertion.

Example 1: Subcutaneous Injection of Plasmids in Mice with Successful Serum Expression

This Example describes subcutaneous injections of plasmids in mice with successful serum expression.

Methods:

Three mice per group were injected subcutaneously (SC) with plasmid DNA encoding either an anti-CoV-2 mAb (experiment 375) or hGCSF (experiment 382). Mice were given subcutaneous injections in the interscapular region (scap) or shaved and given subcutaneous injections targeted to the 4^(th) and 5^(th) inguinal mammary fat pads (ing). DNA was suspended either in normal Lactated Ringer's or with hypertonic Ringer's (3%) (both without a particular carrier agent). Some mice were also given 1000 nmol DMPC neutral liposomes with the DNA, or low dose Chloroquine.

Results:

Results of experiment 375 (anti-CoV-2 mAb) are shown in FIG. 1 , showing serum levels of protein expression. A significant number of different mouse groups each received a different subcutaneous regimen as described in the methods as well as in FIG. 1 . Mice 58 and 59 from experiment 375 each produced significant serum levels of an anti-SARS-CoV-2 neutralizing mAb 24 hours after subcutaneous injection. In contrast, none of the other subcutaneous injected mice produce detectable levels of this same mAb. Mice 58 and 59 produced detectable levels plasmid DNA encoded protein after subcutaneous injection. Furthermore, each of these two mice produced sufficiently high serum protein levels of the DNA therapeutic protein to produce a therapeutic anti-covid effect. It is noted that all the mice without significant expression had weights of between about 30 and 40 grams (considered non-overweight), while mice 58 and 59 had weights of between about 42 and 53 grams (considered grossly obese). It is believed that showing significant serum protein levels after plasmid injection subcutaneously in mice, without an expression aid of any type, is a fundamental, World changing achievement that may progressively replace all bio reactor produced recombinant proteins including monoclonal antibodies worldwide.

Results of experiment 382 (hGCSF) are shown in FIG. 2 , showing serum levels of protein expression. A significant number of different mouse groups each received a different subcutaneous regimen as described in the methods as well as in FIG. 2 . A variety of different mouse groups from experiment 382 each produced significant serum levels of the human G-CSF protein 24 hours after subcutaneous injection. These included mouse groups that received hG-CSF plasmid DNA alone (no added expression aids), hG-CSF plasmid DNA in hypertonic saline (3%) (no added expression aids), hG-CSF plasmid DNA mixed with low or high dose chloroquine hG-CSF plasmid, and/or DNA mixed with neutral MLV liposomes. Experiment 382 demonstrates that a variety of different subcutaneous injection approaches, including plasmid DNA alone or plasma DNA mixed with either chloroquine, hypertonic saline 5 or neutral MLV liposomes can each produce significant serum levels of the human G-CSF protein 24 hours after subcutaneous injection. Experiment 382 shows that a variety of different compositions containing either plasmid DNA alone or plasmid DNA with a variety of different drugs or diluents as well as with neutral MLV liposomes alone each produces significant serum levels of the plasmid DNA encoded protein product.

Example 2: Subcutaneous Injection of Plasmids in Rats with Successful Serum Expression

This Example describes subcutaneous injections of plasmids in rats with successful serum expression.

Methods:

On day 0, rats were given subcutaneous injection of plasmid DNA encoding anti-human IL-5 mAb (17 mg, left) or anti-IL5 mAb plus anti-a5J8 mAb (5 mg, right). On day 23, rats were both injected subcutaneously with 25 mg plasmid encoding anti-CoV-2 mAb 209K, one with hyaluronidase (right side of FIG. 3 ) and one without any expression aid (left side of FIG. 3 ). On day 36, both rats were injected subcutaneously with 20 mg plasmid DNA encoding anti-CD20 (rituximab).

Results:

The results are shown in FIG. 3 and FIG. 6 . Two different rat groups each received the same subcutaneous regimen as described in the methods as well as in FIG. 3 and FIG. 6 . From day 44 on (day 267 was the most recent weekly blood draw), serum anti-human IgG levels of anti-CoV2 antibody were above one microgram per ml. These serum levels directly correlated with essentially 90 to 100 percent neutralization of the CoV-2 virus and for at least 127 days after a single subcutaneous injection. 127 days is the human equivalent of approximately 25 years. FIG. 6 further shows that the antibody level in serum peaked at about 115 days after administration and remained detectable for at least 267 days after initial administration.

This example shows two rats (#2 and #4) who produced detectable serum levels of plasmid DNA encoded protein following subcutaneous injection. Each of these two rats produced sufficiently high serum mAb protein levels of the plasmid DNA-encoded anti-CoV-2 mAb therapeutic protein to produce nearly 100% anti-CoV-2 neutralization. It is believed that showing significant serum protein levels after plasmid injection subcutaneously in rats, with and without an expression aid of any type, is an important achievement.

Example 3: Subcutaneous Injection of Plasmids in Rats with Successful Serum Expression

This Example describes subcutaneous injections of plasmids in rats with successful serum expression with or without various pre-treatments.

Methods:

Two rats (rats #1 and #2) were given IV pre-injections of liposomes composed of 4400 nmol DOTAP SUV with 2.5% dex palmitate and 2000 nmol DMPC MLV with 5% dex palmitate, followed by IV injection of 400 ug plasmid DNA encoding rituximab. This was followed by subcutaneous injection of 20 mg plasmid DNA encoding 5J8 in 3% hypertonic saline with hyaluronidase. The third rat (#3) was given 5 IP injection of an anti-CD20 antibody, followed by the same subcutaneous injection as the first two. Rat #4 was given IP injection of rituximab followed by the same subcutaneous injection as previous. Note that there is no cross-reactivity between the serum anti-human CD20 mAb ELISA and the serum anti-human 5J8 mAb used to measure serum levels of these two different mAbs

In addition, rats #5-8 were given subcutaneous injections only of the same liposomes as in rats 1 and 2, with the total divided into 7 injection sites. This was followed by subcutaneous injection of 20 mg plasmid DNA encoding 5J8. All subcutaneous injections were divided into 7 sites: the ₃rd 4th _(and 5)th mammary fat pads, and the interscapular region.

Results:

The results are shown in FIG. 4 and FIG. 7 . A total of eight different rat groups each received one of the eight different subcutaneous regimens as described in the methods and above. All the rat groups receiving plasmid DNA encoding either of the two different mAb proteins showed detectable mAb serum protein levels. These results further confirm the ability of rat administered subcutaneous plasmid DNA to produce significant ongoing DNA plasmid encoded serum proteins in injected rats. FIG. 7 further shows long-term expression of protein in serum, which remained detectable for at least 50 days.

Example 4: Subcutaneous Injection of Plasmids in Rats with Successful Serum Expression, With and Without, Lipid Pre-Treatment

This Example describes subcutaneous injections of plasmids in rats with successful serum expression with or without Lipid pre-treatment.

Methods:

Two rats per group were injected subcutaneously with 5, 15, 25, or 40 mg plasmid DNA encoding an anti-CoV2 antibody (without expression aid). Two rats were also injected with 25 mg the same DNA but after being given liposome injections of 4,400 nmol of pure DOTAP SUV mixed with 2.5% dex palmitate and 2000 nmol DMPC neutral MLV with 5% dex palmitate.

Results:

The results are shown in FIG. 5 and FIG. 8 . A total of five different rat groups of two each received one of five different subcutaneous DNA does regimens as described in the methods. All five rat groups receiving plasmid DNA encoding an anti-CoV-2 mAb protein showed detectable anti-CoV-2 mAb serum protein levels on days one and eight after subcutaneous injection. This includes not only the four groups receiving subcutaneous plasmid DNA alone but also the fifth group that received a sequential subcutaneous injection, of cationic SUV liposomes mixed with neutral MLV liposomes followed 30 seconds later by subcutaneous injection of plasmid DNA only. These experimental results demonstrate that sequential liposome then plasmid DNA injection produced significant serum levels of the plasmid DNA encoded protein at very early time points after injection. FIG. 8 further shows that the long-term expression of proteins in serum, which was detectable for at least 106 days.

Example 5: In Vitro Transfection of Human Preadipocyte Primary Cells

This example describes in vitro transfection of human derived preadipocyte cells in culture with successful expression.

Methods:

Preadiopcytes were grown and then plated for transfection at a concentration of 0.25×10⁵ cells per well in a 24-well plate. The cells were transfected with 1 or 5μg plasmid DNA encoding an anti-CoV-2 mAb complexed with either 2.7 μl Expifectamine (ThermoFisher)/μg DNA, 1.334 or 3.335 molar ratio of PEI/μg DNA, or 10, 20, or 30 nmol DOTAP/μg DNA. Thin-film transfections were performed by adding the DNA-lipid complexes to already plated cells, while direct transfections were performed by combining the DNA-lipid complexes with the cell suspension before adding to the cell culture plate. The media was collected every three days and assayed for hIgG levels.

Results:

The results are shown in FIG. 9 , showing protein expression levels. The best condition identified was the thin-film transfection with 1 μg DNA-2.7 μl Expifectamine which consistently showed the highest expression levels from day 1 to day 12. In contrast, the cells transfected with the different DNA-DOTAP ratios did not express from day 1 to day 12. The other expifectamine and PEI groups showed consistent low-level expression across the timeline. These results show that the preadipocyte cells were highly transfectable.

Example 6: In Vitro Transfection of Human Preadipocyte Primary Cells in Various Stages of Differentiation into Mature Adipocytes

This example describes the in vitro transfection of the various stages of differentiation of human derived preadipocytes into fully mature adipocytes.

Methods:

Human derived preadipocytes were differentiated into mature adipocytes over the course of 21 days. The cells were transfected every three days, starting with preadipocytes and ending with the mature adipocytes, with a plasmid DNA vector encoding an anti-CoV-2 mAb complexed with Expifectamine (ThermoFisher) at a ratio of 5 μg DNA:2.7 μl lipid. The media was changed every three days and assayed for hIgG levels.

Results:

The results are shown in FIG. 10 , showing protein expression levels following transfection of the various stages of preadipocyte differentiation into mature adipocytes. The most efficiently transfected stage was the preadipocytes as seen by the elevated expression levels of hIgG compared to the other stages of differentiating cells. The final mature adipocytes were the least transfectable as shown by the low levels of hIgG expression detected at day 3 (5 ng/ml) all the way up to day 21. There was reduced expression levels for stages 3, 4, and 5 compared to the preadipocyte group, but compared to the mature adipocytes the expression level was higher on days 3 and 6. These results show that targeting a mixed population of preadipocytes along with maturing adipocytes resulted in high levels of protein expression. Additionally, transfected preadipocytes maintained their expression levels as they mature into adipocytes.

Example 7: In Vitro Transfection of Mature Human Adipocytes.

This example describes the in vitro transfection of matures human adipocytes.

Methods:

Human derived preadipocytes were differentiated into mature adipocytes for 21 days before they were transfected with a plasmid DNA vector encoding an anti-CoV-2 mAb complexed with either 0.54 μl Expifectamine (ThermoFisher)/μg DNA, 1.334 molar ratio of PEI/μg DNA, or 2 nmol DOTAP/μg DNA. Transfections were done by either thin-film or direct transfection. Thin-film transfections were performed by adding the DNA-lipid complexes to already plated adipocytes, while direct transfections were performed by combining the DNA-lipid complexes and pipetting the mixture up and down in the well with the attached adipocytes to generate a single cell suspension. The media was collected every two days and assayed for hIgG levels.

Results:

The results are shown in FIG. 11 . The highest expression levels were seen in the thin-film PEI group transfected with 1 μg of plasmid DNA and a 1.334 molar ratio of PEI. Overall expression in the adipocytes took at least one week to start increasing in every group tested. The DOTAP groups were the least successful for each method and DNA-lipid ratio tested. The Expifectamine treated groups with the highest expression at day 18 were those transfected with the direct transfection method (both 1 and 5 μg plasmid DNA), while the other expifectamine thin-film groups did not express as highly. These results show that mature human adipocytes expressed the anti-CoV-2 mAb following transfection. The expression was both delayed and reduced compared to the predipocytes in previous examples.

Example 8: Use of Obese Mice for Subcutaneous Injection Methods:

Three obsess mice (ob-/ob- or B6.Cg-Lepob/J strain) per group were injected subcutaneously with 800, 1600, or 3200 μg of a plasmid encoding hGH and hGCSF in Lactated Ringer's solution. Obese mice that received injections of lactated Ringer's solution (blank) were included as the negative control.

Blood samples were taken on both 1 day and 15 days post injection from the mice injected with the plasmid and control group, and the expression level of hGH and hGCSF were assessed by ELISA. Additionally, whole blood samples collected from the Day 15 bleeds were submitted for a complete blood count to assess absolute neutrophil count (ANC).

Results:

The obese mice, while having larger fat deposits in both visceral and subcutaneous fat compartments, did not express hGH and hGCSF faster or at higher levels as compared to the control group. The hGH and hGCSF ELISAs returned values that were indistinguishable from background (data not shown). The ANC count using Day 15 bleeds also did not differ between un-injected mice and subcutaneously injected mice (FIG. 12 ).

Example 9: Injection of hGLA in 1 mL Volume Methods:

A total of 18 mice were group into 6 groups of three mice per group. The groups of three mice were each injected subcutaneously with 300, 900, 1800, or 3200 μg of a plasmid encoding hGLA-1×L-hyFc in 1 mL of Lactated Ringer's solution or 1 mL of hypotonic (.5%) Ringer's solution. The total 1 mL Volume was divided into 200 uL per inguinal fat pad and 600 uL into the subscapular region for each injected mice. Mice were bled at day 1 and then every 7 or 14 days thereafter and hGLA expression level assessed by ELISA.

Results:

The results are shown in FIG. 13 . Using the 1 mL volume, 2 of the 18 mice still expressed significant levels of hGLA at day 119.

Example 10: Injection of hGLA in Smaller Volumes Methods:

Mice were treated with antibodies against CD4 and B220 to deplete B and T cell populations. A first group of five mice were injected subcutaneously with 800 μg of a plasmid encoding hGLA-1×L-hyFc in 800 μL Lactated Ringer's solution. A second group of five mice were injected subcutaneously with 800 μg of a plasmid encoding hGLA-1×L-hyFc in 200 μL Lactated Ringer's solution. A third group of five mice were injected subcutaneously with 1600 μg of a plasmid encoding hGLA-1×L-hyFc in 800 μL Lactated Ringer's solution. A fourth group of five mice were injected subcutaneously with 1600 μg of a plasmid encoding hGLA-1×L-hyFc in 400 μL Lactated Ringer's solution. A fifth group of five mice were injected subcutaneously with 3200 μg of a plasmid encoding hGLA-1×L-hyFc in 800 μL Lactated Ringer's solution. A final sixth group of five mice were injected with 1600 μg plasmid in 800 μL hypotonic (0.5%) Ringer's solution. The groups of mice were bled at day 1 and then every 7 or 14 days thereafter and hGLA expression level assessed by ELISA.

Results:

The results are shown in FIG. 14 . The results indicate that 800 μg of hGLA plasmid injected one time was sufficient to produce protein expression well above the minimal therapeutic level (dotted line), starting between 22 and 28 days after injection. Smaller volumes of the same dose (group 4 vs group 1 and group 5 vs group 2) yielded higher expression. This high level of expression was maintained at least 119 days after injection.

Example 11: Expression of Factor VIII or IX Related to Hemophilia Methods:

Five mice per group were treated with antibodies against CD4 and B220 to deplete B and T cell populations. Mice were injected subcutaneously with 400, 800, or 1600 μg of a plasmid encoding Factor IX in 800 μL (standard) or 1 mL (higher volume) volumes of Lactated Ringer's solution. Mice were bled at day 1 and then every 7 days thereafter and Factor IX expression level assessed by ELISA.

Results:

The results are shown in FIG. 15 . The results indicate that Factor IX did not express when injected using the standard subcutaneous plasmid delivery that generated hGLA expression.

Example 12: Expression of Antibody Against SARS-Cov-2 by Inguinal Injection Methods:

Three mice per group were injected subcutaneously with 400, 800,1600, or 3200 μg of a plasmid encoding an anti-CoV2 antibody in 100, 200, 400, or 800 μL volumes of Lactated Ringer's solution. In the final group, the volume was divided into 6 smaller injections distributed along the length of the inguinal fat pad. Mice were bled at day 1 and then every 7 or 14 days thereafter and protein expression level assessed by ELISA.

Results:

The results are shown in FIG. 16 . The results indicate that anti-CoV2 antibody expressed at a low level in mice injected subcutaneously with at least 800 μg plasmid. Smaller volumes of the same dose of plasmid expressed at a slightly higher level.

Furthermore, to investigate whether the body weight of an individual mouse correlates with the expression level of the anti-CoV2 antibody in the mouse, measured expression levels of the SARS-CoV-2 antibody were plotted against body weights of test animal in FIG. 33 . As shown in the figure, no clear correlation between expression level and mice weight was observed. These data demonstrate that long-term expression of the encoded protein using the present method does not require the subject to have obesity or have certain amount of body fat.

Example 13: Mammary Fat Pad Implantation of Plasmid Encoding Anti-CoV2 Antibody Methods:

Three mice per group were administered with 800 μg of a plasmid encoding an anti-CoV2 antibody in 100, 200, or 400 μL volumes of Lactated Ringer's solution. Administration were made after mice were shaved and an ˜1 cm incision was made over the inguinal region to expose the fat pad and the fat pad was teased out with forceps. After injection, mice were closed with wound clips. Mice were bled at day 1 and then every 7 or 14 days thereafter and protein expression level assessed by ELISA.

Results:

The results are shown in FIG. 18 . The results indicate that anti-CoV2 antibodies expressed at a low level in mice given 800 μg plasmid via incision surgery. Mice given 100 and 200 μL volume expressed similarly to the mice given the same volumes via regular subcutaneous injection. Mice given 400 μL via incision surgery did not express significant levels of protein. Overall, less injection volume resulted in higher protein expression.

Example 14: Expression of Anti-CoV2 Antibodies in Mice Previously Injected with Factor IX Plasmid Methods:

Mice that were previously injected with Factor IX were used for reinjection. Three mice per group were injected subcutaneously with 400, 800, or 1600 μg of a plasmid encoding the anti-CoV2 antibody in indicated volumes of Lactated Ringer's solution. Mice were bled at day 1 and then every 7 or 14 days thereafter and protein expression level assessed by ELISA.

Results:

The results are shown in FIG. 19 . The results indicate that anti-CoV2 antibodies did not express to appreciable levels in mice previously injected subcutaneously with a different plasmid that did not yield high expression.

Example 15: Expression of hGLA at Various Plasmid Concentrations and Hyaluronidase Conditions Methods:

Three mice per group were treated with antibodies against CD4 and B220 to deplete B and T cell populations. Mice were injected subcutaneously with 800 μg of a plasmid encoding hGLA-1×L-hyFc in indicated volumes of Lactated Ringer's solution. The final group was injected with 60 Units of hyaluronidase per animal. Mice were bled at day 1 and then every 7 days thereafter and hGLA expression level assessed by ELISA.

Results:

The results are shown in FIG. 20 . The results indicate that 800 μg of hGLA plasmid injected one time was sufficient to produce protein expression well above the minimal therapeutic level (dotted line), starting roughly 22 days after injection, and that the group given higher dosage of hyaluronidase reached higher levels of expression faster.

Furthermore, to investigate whether the body weight of an individual mouse correlates with the hGLA expression level in the mouse, measured expression levels of hGLA were plotted against body weights of test animal in FIG. 34 . As shown in the figure, no clear correlation between expression level and mice body weight was observed. These data demonstrate that long-term expression of the encoded protein using the present method does not require the subject to have obesity or have certain amount of body fat.

Example 16

This example describes in vitro transfection of primary mouse preadipocytes cells and subsequent transplantation into mouse.

Methods:

Two to three-week old C57BL/6 J female mice is euthanized and inguinal fat tissue is harvested and placed in HBSS buffer containing 3% (w/v) bovine serum albumin (BSA). Cells are incubated in 2 mg/mL collagenase in HBSS BSA 3% (w/v) for 30 min to digest the tissue. Cells are cultured to 80% confluence in DMEM/F12 cell culture media containing 1% Penicillin/streptomycin, 10% Fetal bovine serum, 100 μg/mL Normocin. The Preadiopcytes are then grown and plated for transfection at a concentration of 2×10⁶ cells per mL in a cell culture flask. The cells are transfected with 5 μg plasmid DNA comprising the sequence of GLA gene that encodes alpha-galactosidase A. The plasmid is complexed with 2.7 μl of Expifectamine (ThermoFisher)/μg DNA before being added to the cells. The cells are transfected overnight in an incubator. The cells are then collected, washed twice with 1× PBS, counted on a cell counter and pelleted. Each cell pellets contains about 10×10⁶ live cells and are kept on ice until implantation. Each pellet was mixed with matrigel up for a total volume of 400 μL on ice and the cell and matrigel suspension was slowly drawn into a 1 mL syringe, which is then slowly injected into three mice by tenting the subcutaneous subscapular area. Mice serum is collected every 3 days to measure the expression level of alpha-galactosidase A. The weight of mice is also monitored.

Results:

Elevated expression of alpha-galactosidase A is detected in mouse serum and remains detectable over a course of 3 months. The mice remain healthy during the observation period.

Example 17: Inclusion of Dexamethasone or TGF-β3 to Improve Expression of hGLA After Subcutaneous Injection Methods:

Groups of three mice were injected intraperitoneally or subcutaneously with 20 mg/kg body weight (high) or 2 mg/kg body weight (low) water-soluble dexamethasone along with monoclonal antibodies (mABs) to deplete B or T cells. One additional group of three mice were injected intraperitoneally with 50 or 200 ng human TGF-β3 along with mAbs to deplete B and T cells. Two groups of mice (control) were injected intraperitoneally with only depletion mAbs. 30 minutes subsequently, all mice were injected subcutaneously with 800 ug plasmid DNA encoding hGLA-1×L-hyFc in 200 uL Lactated Ringer's, along with 60U/animal hyaluronidase. Mice were bled on the 5^(th) days after injection and serum samples were collected and evaluated by ELISA.

Results:

The results are shown in FIG. 22 . The higher dexamethasone group performed similarly to the control group. Mice receiving intraperitoneal injection or subcutaneous injection of the low dose of dexamethasone, as well as mice receiving the higher TGF-beta3 dose performed better than the DNA and hyaluronidase alone control group.

Example 18: Vectors Encoding Human GLA (hGLA-hyFc) Fusion Proteins Methods:

Groups of three mice are intraperitoneally injected with mAbs to deplete B and T Cells. The mice are subsequently injected subcutaneously once with plasmid DNAs encoding hGLA-hyFc (SEQ ID NO:49), hGLA-1×L-hyFc (SEQ ID NO:50), hGLA-2×L-hyFc (SEQ ID NO:51), and hGLA-3×L-hyFc (SEQ ID NO:52), respectively. Particularly, the 1×L linker has the sequence of GGGGS (SEQ ID NO:53), the 2×L linker has the sequence of GGGGSGGGGS (SEQ ID NO:54), and the 3×L linker has the sequence of GGGGSGGGGSGGGGS (SEQ ID NO:55). Each plasmid is mixed with 60U/ms hyaluronidase in 200 uL Lactated Ringer's before injection. Each plasmid is administered at three tested doses (400 ug/mouse, 800 ug/mouse, and 1600 ug/mouse) to three groups of mice, respectively. The following day and every week thereafter for 8 weeks, mice are bled into serum separator tubes. Resulting serum is tested for expression of hGLA protein by ELISA assay.

Results:

For each plasmid, following the subcutaneous injection at the various doses, the tested subjects show injection-dose-dependent expressions of the encoded GLA fusion protein, with the lowest tested dose (400 ug/mouse) sufficient to produce stable expression of the encoded protein at a therapeutic level in the subject's blood. Higher dosage injection results in a higher expression level.

All publications and patents mentioned in the present application are herein incorporated by reference. Various modification and variation of the described methods and compositions of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention that are obvious to those skilled in the relevant fields are intended to be within the scope of the following claims. 

What is claimed is:
 1. A method comprising: treating a subject, and/or said subject's subcutaneous pre-adipocytes and/or adipocytes, with a composition, wherein said composition comprises, or consists essentially of, a nucleic acid sequence, or a vector containing said nucleic acid sequence, wherein said nucleic acid sequence encodes at least one protein or at least one biologically active nucleic acid molecule, and wherein said treating comprises at least one of the following: a) injecting said composition into one or more subcutaneous regions of said subject such that said at least one protein, or said at least one biologically active nucleic acid molecule, is detectable in a blood, serum, or plasma sample from said subject; and/or b) injecting said composition into one or more subcutaneous regions of said subject such that a plurality of in-vivo transfected pre-adipocytes and/or adipocytes are generated in said subcutaneous region; c) performing the following: i) contacting a plurality said pre-adipocytes and/or adipocytes from said subject ex-vivo with said composition such that a plurality of ex-vivo transfected pre-adipocytes and/or adipocytes are generated, and ii) injecting at least some of said plurality of ex-vivo transfected pre-adipocytes and/or adipocytes into one or more subcutaneous regions of said subject; and/or d) implanting a solid medium carrying said composition into the one or more subcutaneous regions.
 2. The method of claim 1, wherein said plurality of in-vivo transfected pre-adipocytes and/or adipocytes and/or said ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 60 μg of lipid.
 3. The method of claim 1, wherein said plurality of in-vivo transfected pre-adipocytes and/or adipocytes and/or said ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they contain at least 80 ug of lipid.
 4. The method of claim 1, wherein said plurality of in-vivo transfected pre-adipocytes and/or adipocytes and/or said ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 70 μm.
 5. The method of claim 1, wherein said plurality of in-vivo transfected pre-adipocytes and/or adipocytes and/or said ex-vivo transfected pre-adipocytes and/or adipocytes are enlarged such that, on average, they have a diameter of at least 90 μm.
 6. The method of claim 1, wherein said composition is free of any reagents that serve as aids to transfection.
 7. The method of claim 1, wherein said composition comprises chloroquine, hyaluronidase, neutral liposomes, cationic liposomes, hypertonic saline, Ringer's solution, Lactated Ringer's solution, hypertonic Ringer's solution, hypotonic saline, hypotonic Ringers, hypotonic dextrose, pure water, or any combination thereof.
 8. The method of claim 1, wherein said subject is overweight by BMI standards and/or is clinically obese, or wherein said subject is not overweight by BMI standards and/or is clinically obese.
 9. The method of claim 1, wherein said injecting in a), b), or c) ii) is into a fat pad of said subject.
 10. The method of claim 1, wherein said at least one protein comprises an antibody variable region.
 11. The method of claim 10, wherein said antibody variable region is a light chain or heavy chain variable region.
 12. The method of claim 1, wherein said at least one protein comprises a least a portion of an antibody light chain and at least a portion of an antibody heavy chain.
 13. The method of claim 1, wherein said at least one protein comprises an antibody light chain and an antibody heavy chain, wherein said light and heavy chains together form a monoclonal antibody or antigen binding fragment thereof.
 14. The method of claim 13, wherein said monoclonal antibody, or antigen binding portion thereof, are specific for SARS-CoV-2 or influenza.
 15. The method of claim 13, wherein said monoclonal antibody, or antigen binding portion thereof, is selected from those listed in Table
 4. 16. The method of claim 13, wherein said subject is infected with a pathogen, and wherein said monoclonal antibody, or antigen binding portion thereof, is expressed in said blood, serum, or plasma at pathogen-neutralizing levels.
 17. The method of claim 1, further comprising, prior to said injecting in a), b), or c) ii), administering a solution comprising cationic liposomes and/or neutral liposomes to said subject.
 18. The method of claim 17, wherein said solution comprises dexamethasone and/or dexamethasone palmitate.
 19. The method of claim 17, wherein said administering said cationic and/or neutral liposomes is performed intravenously or subcutaneously.
 20. The method of claim 1, wherein said injecting in a), b), or c) ii) is performed at a plurality of sites in said subject.
 21. The method of claim 1, wherein said injecting in a) and/or b) causes said subject to receive between 1 and 60 micrograms, or between 0.00001 and 1.0 micrograms, per microliter of said composition of said nucleic acid sequence, or said vector containing said nucleic acid sequence.
 22. The method of claim 1, wherein said vector comprises a non-viral vector, optionally wherein the vector further comprises one or more DNA expression cassettes; optionally wherein said vector is a plasmid.
 23. The method of claim 1, wherein said nucleic acid sequence comprises DNA.
 24. The method of claim 1, wherein said nucleic acid comprises mRNA, and wherein said mRNA is optionally capped and composed of at least some modified bases that reduce immunogenicity.
 25. The method of claim 1, wherein said subject is a human.
 26. The method of claim 1, wherein said at least one biologically active nucleic acid molecule comprises a sequence selected from: an siRNA, shRNA sequence, a miRNA sequence, an antisense sequence, a CRISPR single guide RNA sequence (sgRNA), piRNA, snoRNA, tsRNA, and srRNA.
 27. The method of claim 1, wherein said nucleic acid sequence or vector are CPG-free or CPG-reduced.
 28. The method of claim 1, wherein said at least one protein is selected from the group consisting of: human growth hormone, G-CSF protein, erythropoietin, Etanercept, Bevacizumab, Rituximab, Adalimumab, Infliximab, Trastuzumab, Insulin, Insulin glargine, Epoetin alfa, Pegfilgrastim, Ranibizumab, Darbepoetin alfa, Interferon beta-1a, Interferon beta-1a (Rebif), Insulin aspart, Rhu insulin, Octocog alfa, Insulin lispro, Cetuximab, Peginterferon alfa-2a, Interferon beta-1b, Eptacog alfa, Insulin aspart, OnabotulinumtoxinA, Epoetin beta, Rec antihemophilic factor, Filgrastin, Insulin detemir, Natalizumab, Insulin (humulin), ACE2, Palivizumab, and a-galactosidase A (GLA).
 29. The method of claim 1, wherein said at least one protein and/or said at least one biologically active nucleic acid, is expressed in said subject at a level of at least 50 μg/ml or at least 100 ng/ml, in blood, serum, or plasma, for at least 10 days, or at least 25 days.
 30. The method of claim 1, wherein said at least one protein and/or said at least one biologically active nucleic acid, is expressed in said subject at a level of at least 1000 ng/ml, in blood, serum, or plasma, for at least 10 days, or at least 25 days or at least 114 days after subcutaneous injection.
 31. The method of claim 29, wherein said expression level is maintained in said subject for at least one month without any further treatment.
 32. The method of claim 17, wherein said cationic and neutral lipids are selected from the group consisting of: DOTAP (1,2-dioleoyl-3-trimethylammonium-propane); distearoyl phosphatidyl choline (DSPC); hydrogenated or non-hydrogenated soya phosphatidylcholine (HSPC); distearoylphosphatidylethanolamine (DSPE); egg phosphatidylcholine (EPC); 1,2-Distearoyl-sn-glycero-3-phospho-rac-glycerol (DSPG); dimyristoyl phosphatidylcholine (DMPC); 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG); 1,2-Dipalmitoyl-sn-glycero-3-phosphate (DPPA); trimethylammonium propane lipids; DOTIM (1-[2-9(2)-octadecenoylloxy)ethyl]-2-(8(2)-heptadecenyl)-3-(2-hydroxyethyl) midizolinium chloride) lipids; and mixtures of two or more thereof.
 33. The method of claim 1, wherein said one or more non-viral expression vectors comprise plasmids, wherein said plasmids are not attached to, or encapsulated in, any delivery agent.
 34. The method of claim 1, wherein said at least one protein comprises at least one anti-SARS-CoV-2 monoclonal antibody, or antigen-binding portion thereof, and is optionally selected from the group consisting of: VIR-7831; LY-CoV1404; LY3853113; Zost 2355K; CV07-209K; C121L; Zost 2504L; CV38-183L; COVA215K; RBD215; CV07-250L; C144L; COVA118L; C135K; and B38.
 35. The method of claim 34, wherein said at least one anti-SARS-CoV-2 antibody, or antigen-binding portion thereof, comprises at least two anti-SARS-CoV-2 antibodies, and/or antigen-binding portions thereof, which are expressed in said subject at an expression level sufficient to reduce: i) the SARS-CoV-2 viral load in said subject, and/or ii) at least one symptom in said subject caused by said SARS-CoV-2 infection.
 36. The method of claim 34, wherein said at least one anti-SARS-CoV-2 antibody, or antigen-binding portion thereof, comprises at least four, or at least eight, or at least 11, anti-SARS-CoV-2 antibodies and/or antigen-binding portions thereof.
 37. The method of claim 1, wherein, prior to said injecting, said subject is treated with dexamethasone fatty acid ester.
 38. The method of claim 1, wherein said composition further comprise a physiologically tolerable buffer or intravenous solution.
 39. The method of claim 1, wherein prior to said injecting, the method further comprises administering a solution to said subject comprising liposomes comprising said polycationic structures, wherein said liposomes further comprising one or more macrophage targeting moieties selected from the group consisting of: mannose moieties, maleimide moieties, a folate receptor ligand, folate, folate receptor antibody or fragment thereof, formyl peptide receptor ligands, N-formyl-Met-Leu-Phe, tetrapeptide Thr-Lys-Pro-Arg, galactose, lactobionic acid, a lipid bi-layer integrating peptide and/or a target peptide.
 40. The method of claim 1, wherein 0.05-60 mg/mL of said vectors are present in said composition.
 41. The method of claim 1, wherein in d) the implanting a is performed via an incision surgery.
 42. The method of claim 1, further comprising, prior to said injecting in a), b), or c) ii) or said implanting in d), administering a composition comprising TGF-β3 to said subject, optionally wherein the composition comprising TGF-β3 is administered intravenously.
 43. The method of claim 1, wherein prior to said injecting, said subject is treated with TGF-133.
 44. A system comprising: a) a plurality of transfected and enlarged adipocytes or pre-adipocytes, wherein each of said plurality of transfected and enlarged adipocytes or pre-adipocytes comprises an exogenous nucleic acid sequence, or a vector containing said nucleic acid sequence, wherein said nucleic acid sequence encodes at least one protein or at least one biologically active nucleic acid molecule, and b) a first container, wherein said plurality of transfected and enlarged adipocytes or pre-adipocytes are present in said first container.
 45. The system of claim 44, wherein said first container comprises a syringe configured for injecting said plurality of transfected and enlarged adipocytes or pre-adipocytes into a subject subcutaneously.
 46. The system of claim 44, further comprising: c) a solution comprising at least one of the following: i) cationic liposomes, ii) neutral liposomes, iii) dexamethasone, and iv) dexamethasone palmitate.
 47. The system of claim 44, wherein the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 60 pg of lipid.
 48. The system of claim 44, wherein the plurality transfected and enlarged adipocytes or pre-adipocytes contain, on average, at least 80 pg of lipid.
 49. The system of claim 44, wherein said transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 70 μm.
 50. The system of claim 44, wherein said transfected and enlarged adipocytes or pre-adipocytes have, on average, a diameter of at least 90 μm.
 51. The system of claim 44, wherein said transfected and enlarged adipocytes or pre-adipocytes are derived from one or more subcutaneous regions of a subject. 